1.Identification
1.1 GHS Product identifier
Product name | nitroglycerin |
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1.2 Other means of identification
Product number | - |
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Other names | trinitroglycerol |
1.3 Recommended use of the chemical and restrictions on use
Identified uses | For industry use only. Propellants and blowing agents |
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Uses advised against | no data available |
1.4 Supplier's details
Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
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Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
Telephone | +86(21)64956998 |
Fax | +86(21)54365166 |
1.5 Emergency phone number
Emergency phone number | +86-400-6021-666 |
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Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
no data available
2.2 GHS label elements, including precautionary statements
Pictogram(s) | no data available |
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Signal word | no data available |
Hazard statement(s) | no data available |
Precautionary statement(s) | |
Prevention | no data available |
Response | no data available |
Storage | no data available |
Disposal | no data available |
2.3 Other hazards which do not result in classification
no data available
3.Composition/information on ingredients
3.1 Substances
Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
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nitroglycerin | nitroglycerin | 55-63-0 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayed
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Throbbing headache; dizziness; nausea, vomiting, abdominal pain; hypotension; flush; palpitations; methemoglobinemia; delirium, central nervous system depression; angina; skin irritation Target Organs: cardiovascular system, blood, skin, central nervous system (NIOSH, 2016)
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Throbbing headache; dizziness; nausea, vomiting, abdominal pain; hypotension; flush; palpitations; methemoglobinemia; delirium, central nervous system depression; angina; skin irritation Target Organs: cardiovascular system, blood, skin, central nervous system (NIOSH, 2016)
Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution. (ERG, 2016)
Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control may cause pollution. (ERG, 2016)
Excerpt from ERG Guide 112 [Explosives* - Division 1.1, 1.2, 1.3 or 1.5]: Fire may produce irritating, corrosive and/or toxic gases. (ERG, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Maintain an open airway and assist ventilation if necessary. Administer supplemental oxygen. Treat hypotension with supine positioning, intravenous crystalloid fluids, and low-dose pressors if needed. Administer activated charcoal... .
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
If material on fire or involved in fire: Dangerously explosive. Do not fight fires in a cargo of explosives. Evacuate area and let burn. If the material is on fire or involved in fire consider evacuation of one mile radius.
5.2 Specific hazards arising from the chemical
Excerpt from ERG Guide 113 [Flammable Solids - Toxic (Wet/Desensitized Explosive)]: Flammable/combustible material. May be ignited by heat, sparks or flames. DRIED OUT material may explode if exposed to heat, flame, friction or shock; treat as an explosive, refer to ERG Guide 112. Keep material wet with water or treat as an explosive, refer to ERG Guide 112. Runoff to sewer may create fire or explosion hazard. (ERG, 2016)
Excerpt from ERG Guide 112 [Explosives* - Division 1.1, 1.2, 1.3 or 1.5]: MAY EXPLODE AND THROW FRAGMENTS 1600 METERS (1 MILE) OR MORE IF FIRE REACHES CARGO. For information on "Compatibility Group" letters, refer to Glossary section. (ERG, 2016)
Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)
Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)
Excerpt from ERG Guide 112 [Explosives* - Division 1.1, 1.2, 1.3 or 1.5]: MAY EXPLODE AND THROW FRAGMENTS 1600 METERS (1 MILE) OR MORE IF FIRE REACHES CARGO. For information on "Compatibility Group" letters, refer to Glossary section. (ERG, 2016)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Nitro-compounds and nitrate ester are cathodically reduced from industrial wastewaters.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store only if stabilized. Store in an area without drain or sewer access. Fireproof. Well closed. Separated from food and feedstuffs.Nitroglycerin injections are practically colorless and stable in their intact containers. The solutions are not explosive. Storage should be at room temperature; the containers should be protected from freezing. Exposure to light, even high intensity light, does not adversely affect nitroglycerin stability. /nitroglycerin injections/
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 0.1 mg/cu m, skin.
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state | COLOURLESS TO YELLOW VISCOUS LIQUID OR PALE YELLOW CRYSTALS |
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Colour | VISCOUS LIQUID |
Odour | no data available |
Melting point/ freezing point | 144 - 146ºC |
Boiling point or initial boiling point and boiling range | 295.8ºC at 760 mmHg |
Flammability | Explosive LiquidMany reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire. |
Lower and upper explosion limit / flammability limit | no data available |
Flash point | 12ºC |
Auto-ignition temperature | 270 DEG C (518 DEG F) |
Decomposition temperature | 50-60°C |
pH | no data available |
Kinematic viscosity | 36.0 centipoise @ 20°C |
Solubility | 0.1 % (NIOSH, 2016) |
Partition coefficient n-octanol/water (log value) | no data available |
Vapour pressure | 0.0003 mm Hg (NIOSH, 2016) |
Density and/or relative density | 1.671 g/cm3 |
Relative vapour density | 7.8 (Air= 1) |
Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Tablets of nitorglycerin are stable but should be dispensed in glass containers and protected from moisture, light and extremes of temperature.
10.3 Possibility of hazardous reactions
GLYCERYL TRINITRATE SOLUTION is incompatible with the following: Heat, ozone, shock, acids. Note: An OSHA Class A Explosive (1910.109). (NIOSH, 2016). It may react vigorously with reducing agents, including hydrides, sulfides and nitrides. Incompatible with ozone, acids.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Heat, ozone, shock acids.
10.6 Hazardous decomposition products
Begins to decompose at 50-60°C, appreciable volatile at 100°C evolves nitrous yellow vapors at 135°C.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral (male) 822 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 Bluegill 1.28 mg/l/96 hr @ pH 6.0. /Static bioassay
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
Nitroglycerin and other aliphatic nitric acid esters undergo aerobic biodegradation readily via successive removal of nitrate groups to isomeric derivatives(1). Contrary to some earlier reports that it was recalcitrant to biodegradation, nitroglycerin proved to be readily biodegradable in batch and continuous tests(2). Results of the shake flask test that was run at 30°C with an activated sludge inoculum showed a 53.6% loss of nitroglycerin in 5 days(2). In a continuous bench-scale activated sludge apparatus, a mean reduction of 92.2% was obtained(2). The apparatus was run at room temperature and the residence time was 84 hr. 1,3-Dinitroglycerol and 1,2-dinitroglycerol were identified at intermediate stages of the process, but they were also essentially absent from the effluent(2). The third experiment employing a chemostat, a continuous culture, aerobic system with no solids recycling, was designed to simulate a plant where propellant wastes would be treated. After a 8-15 hr detention period, no nitrate esters were detectable in the effluent(2). It was found that nitroglycerin is not suitable as a source of carbon and nitrogen so nutrients are essential(2). It was speculated that the earlier experiments which showed nitroglycerin to be recalcitrant were conducted using concns of nitroglycerin that were toxic to the microorganisms(2).
12.3 Bioaccumulative potential
An estimated BCF of 4 was calculated for nitroglycerin(SRC), using a log Kow of 1.62(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The Koc of nitroglycerin is estimated as 180(SRC), using a log Kow of 1.62(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that nitroglycerin is expected to have moderate mobility in soil(SRC).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN0143 | IMDG: UN0143 | IATA: UN0143 |
14.2 UN Proper Shipping Name
ADR/RID: NITROGLYCERIN, DESENSITIZED with not less than 40% non-volatile water-insoluble phlegmatizer, by mass† |
IMDG: NITROGLYCERIN, DESENSITIZED with not less than 40% non-volatile water-insoluble phlegmatizer, by mass† |
IATA: NITROGLYCERIN, DESENSITIZED with not less than 40% non-volatile water-insoluble phlegmatizer, by mass† |
14.3 Transport hazard class(es)
ADR/RID: 1.1A | IMDG: 1.1A | IATA: 1.1A |
14.4 Packing group, if applicable
ADR/RID: I | IMDG: I | IATA: I |
14.5 Environmental hazards
ADR/RID: no | IMDG: no | IATA: no |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name | Common names and synonyms | CAS number | EC number |
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nitroglycerin | nitroglycerin | 55-63-0 | none |
European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
EC Inventory | Listed. | ||
United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
China Catalog of Hazardous chemicals 2015 | Listed. | ||
New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
Vietnam National Chemical Inventory | Listed. | ||
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Not Listed. |
16.Other information
Information on revision
Creation Date | Aug 13, 2017 |
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Revision Date | Aug 13, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/