2-ethoxyethanol

CAS No. 110-80-5

Formula: C4H10O2
Basic Info

2-Ethoxyethanol, also known by the trademark Cellosolve or ethyl cellosolve, is a solvent used widely in commercial and industrial applications. It is a clear, colorless, nearly odorless liquid that is miscible with water, ethanol, diethyl ether, acetone, and ethyl acetate.
2-Ethoxyethanol can be manufactured by the reaction of ethylene oxide with ethanol.
As with other glycol ethers, 2-ethoxyethanol has the useful property of being able to dissolve chemically diverse compounds. It will dissolve oils, resins, grease, waxes, nitrocellulose, and lacquers. This is an ideal property as a multi-purpose cleaner, and, therefore, 2-ethoxyethanol is used in products, such as varnish removers and degreasing solutions.

Formula
C4H10O2
Molecular Weight
90.121
Exact Mass
90.0681
LogP
0.0152
PSA
29.46
Synonyms

Emkanol

celosolv

Ethyl glycol,Ethylene glycol monoethyl ether

2EE

OXYTOL

Ethyl Cellosolve

egmee

dowanol8

dowanolee

monoethylene glycol ethyl ether

Ethylene Glycol Monoethyl Ether

Ethanol, 2-ethoxy-

Ethyl Glycol

2-ethoxyethyl alcohol

2-Ethoxyethanol

OXITOL

EGEE

2-hydroxyethyl ethyl ether

2-ethoxy-1-ethanol

2-ethoxy-ethanol

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Properties
Appearance & Physical State
clear, colorless, nearly odorless liquid
Density
0.93
Boiling Point
135ºC
Melting Point
-100ºC
Freezing Point
-70℃
Flash Point
44ºC
Refractive Index
1.406-1.41
Water Solubility
miscible
Stability
Stable. Readily forms explosive mixtures with air - note the wide explosion range. Vapour may travel considerable distance to a source of ignition. Flammable. Incompatible with strong acids, strong bases, strong oxidizing agents, aluminium, alkalies.
Storage Condition
Flammables area
Vapor Density
3.1 (vs air)
Vapor Pressure
3.8 mm Hg ( 20 °C)
Safety Info
RTECS
KK8050000
Safety Statements
S45-S53
WGK Germany
1
Risk Statements
R10; R20/21/22; R60; R61
HS Code
2909499000
RIDADR
UN 1171
Hazard Class
3
Packing Group
III
Caution Statement
P201; P210; P280; P304 + P340 + P312; P308 + P313; P370 + P378
Hazard Codes
Hazard Declaration
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-ethoxyethanol

1.2 Other means of identification

Product number -
Other names 2-hydroxyethyl ethyl ether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 3

Acute toxicity - Oral, Category 4

Acute toxicity - Inhalation, Category 3

Reproductive toxicity, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H226 Flammable liquid and vapour

H302 Harmful if swallowed

H331 Toxic if inhaled

H360FD

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P311 Call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P308+P313 IF exposed or concerned: Get medical advice/ attention.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
2-ethoxyethanol 2-ethoxyethanol 110-80-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Some eye irritation. Inhalation of vapors causes irritation of nose. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Emergency and supportive measures. 1. Maintain an open airway and assist ventilation if necessary. Administer supplemental oxygen. 2. Treat coma, convulsions, cardiac arrhythmia and metabolic acidosis if they occur. Observe the patient for several hours to monitor for development of metabolic acidosis, especially if the patient is symptomatic or there is a known co-ingestion of ethanol. 3. Treat hypocalcemia with intravenous calcium gluconate or calcium chloride. /Ethylene glycol and other glycols/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic gases, such as carbon monoxide, may be produced in fire. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Remove all ignition sources. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.

6.3 Methods and materials for containment and cleaning up

Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Cool.Conditions for safe storage: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 0.5 ppm (1.8 mg/cu m). Skin designation.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear, colorless, nearly odorless liquid
Colour Colorless liquid
Odour Sweet, pleasant, ether-like odor
Melting point/ freezing point -100ºC
Boiling point or initial boiling point and boiling range 135°C(lit.)
Flammability Class II Combustible Liquid: Fl.P. at or above 37.78°C and below 60°C.Flammable.
Lower and upper explosion limit / flammability limit Upper 15.6% at 93°C; lower 1.7% at 93°C
Flash point 42°C
Auto-ignition temperature 237.78°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 1.84 centipoise at 25°C
Solubility In water:miscible
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 3.8 mm Hg ( 20 °C)
Density and/or relative density 0.93g/mLat 25°C(lit.)
Relative vapour density 3.1 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Flammable in the presence of a source of ignition when the temperature is above the flash point.ETHYLENE GLYCOL MONOMETHYL ETHER may react with oxidizing materials, i.e. hydrogen peroxide, to form peroxides. It dissolves many oils, resins and waxes.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Polyacrylamide gels were dissolved in 30% peroxide solution and added to a scintillation mixture in 1:1 2-ethoxyethanol-toluene. After counting, the mixtures were bulked and evaporated intermittently with heat during a 4 week period, and the accumulated peroxidised residues eventually exploded violently. A subsequent comment indicated that peroxidised materials may not peroxide are themselves potentially explosive.

10.6 Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 1746 mg/kg bw
  • Inhalation: LC50 Guinea pig inhalation 3000 ppm/8 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill); Concentration: >10000 mg/L for 96hr /Conditions of bioassay not specified in source examined
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Ethylene glycol monoethyl ether, present at 100 mg/L, reached 76% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). In pilot-scale activated sludge systems, ethylene glycol monoethyl ether was reduced from 2,284 mg/L in the feed to 18 mg/L in the effluent(2). No ethylene glycol monoethyl ether was detected in the off-gas or waste mixed liquor samples(2).

12.3 Bioaccumulative potential

An estimated BCF value of 3 was calculated for ethylene glycol monoethyl ether(SRC), using a log Kow of -0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of ethylene glycol monoethyl ether is estimated as 2(SRC), using a log Kow of -0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that ethylene glycol monoethyl ether is expected to have very high mobility in soil(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1171 IMDG: UN1171 IATA: UN1171

14.2 UN Proper Shipping Name

ADR/RID: ETHYLENE GLYCOL MONOETHYL ETHER
IMDG: ETHYLENE GLYCOL MONOETHYL ETHER
IATA: ETHYLENE GLYCOL MONOETHYL ETHER

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
2-ethoxyethanol 2-ethoxyethanol 110-80-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: Ethylene glycol monoethyl ether Material Safety Data Sheet
Synonym: Cellosolve(R); Ethylene glycol ethyl ether; 2-Ethoxyethanol; Oxitol; EGEE; 2-EE
CAS: 110-80-5
Section 1 - Chemical Product   MSDS Name:Ethylene glycol monoethyl ether Material Safety Data Sheet
Synonym:Cellosolve(R); Ethylene glycol ethyl ether; 2-Ethoxyethanol; Oxitol; EGEE; 2-EE

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
110-80-5 Ethylene glycol monoethyl ether > 99 203-804-1
Hazard Symbols: T
Risk Phrases: 10 20/21/22 60 61

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Flammable. Harmful by inhalation, in contact with skin and if swallowed. May impair fertility. May cause harm to the unborn child.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
May cause mild skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis. If absorbed, causes symptoms similar to those of ingestion. May be harmful if absorbed through the skin. Substance is readily absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May cause liver and kidney damage. Exposure may cause anemia and other blood abnormalities. May be harmful if swallowed. May cause central nervous system depression.
Inhalation:
May cause respiratory tract irritation. Inhalation overexposure may lead to central nervous system depression, producing effects such as dizziness, headache, confusion, incoordination, nausea, weakness, and loss of consciousness. Extreme exposures may cause other CNS effects including death.
Chronic:
2-Ethoxyethanol may be a teratogen in humans since it has been shown to be a teratogen in animals. It may damage the testes and decrease fertility in males.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Flammable liquid and vapor. Containers may explode when heated.
Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use dry chemical, carbon dioxide, or appropriate foam. Solid streams of water may be ineffective and spread material.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Provide ventilation. Approach spill from upwind.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Avoid breathing vapor or mist.
Storage:
Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Do not store in aluminum containers. Store protected from light and air. Containers should be dated when opened and tested periodically for the presence of peroxides. Should crystals form in a peroxidizable liquid, peroxidation may have occurred and the product should be considered extremely dangerous. In this instance, the container should only be opened remotely by professionals. All peroxidizable substances should be stored away from heat and light and be protected from ignition sources.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 110-80-5: United Kingdom, WEL - TWA: 10 ppm TWA; 37 mg/m3 TWA United Kingdom, WEL - STEL: 30 ppm STEL; 111 mg/m3 STEL United States OSHA: 200 ppm TWA; 740 mg/m3 TWA Belgium - TWA: 5 ppm VLE; 18 mg/m3 VLE France - VME: 5 ppm VME; 19 mg/m3 VME Germany: 5 ppm TWA; 19 mg/m3 TWA Germany: Skin absorber Japan: 5 ppm OEL; 18 mg/m3 OEL Malaysia: 5 ppm TWA; 18 mg/m3 TWA Netherlands: 5 ppm MAC; 19 mg/m3 MAC Russia: 5 mg/m3 TWA Spain: 5 ppm VLA-ED; 18 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: clear, colorless
Odor: mild odor - pleasant odor - ethereal odor - sweetish
pH: Not available.
Vapor Pressure: 3.8 mm Hg @ 20 deg C
Viscosity: 2.1 cps @ 20 deg C
Boiling Point: 135 deg C
Freezing/Melting Point: -90 deg C
Autoignition Temperature: 235 deg C ( 455.00 deg F)
Flash Point: 43 deg C ( 109.40 deg F)
Explosion Limits, lower: 1.7% @ 93C
Explosion Limits, upper: 15.6% @ 93C
Decomposition Temperature: Not available.
Solubility in water: Soluble.
Specific Gravity/Density: 0.9300
Molecular Formula: C4H10O2
Molecular Weight: 90.12

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Under normal storage conditions, peroxidizable compounds can form and accumulate peroxides which may explode when subjected to heat or shock. This material is most hazardous when peroxide levels are concentrated by distillation or evaporation.
Conditions to Avoid:
Light, ignition sources, excess heat, exposure to flame, prolonged exposure to air.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases, aluminum.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, peroxides.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 110-80-5: KK8050000 LD50/LC50:
CAS# 110-80-5: Draize test, rabbit, eye: 50 mg Moderate; Draize test, rabbit, eye: 500 mg/24H Mild; Inhalation, mouse: LC50 = 1820 ppm/7H; Inhalation, rat: LC50 = 2000 ppm/7H; Oral, mouse: LD50 = 2451 mg/kg; Oral, mouse: LD50 = 4000 mg/kg; Oral, rabbit: LD50 = 1275 mg/kg; Oral, rabbit: LD50 = 1275 mg/kg; Oral, rat: LD50 = 2125 mg/kg; Oral, rat: LD50 = 2125 mg/kg; Skin, rabbit: LD50 = 3.6 mg/kg; Skin, rat: LD50 = 3900 mg/kg.
Carcinogenicity:
Ethylene glycol monoethyl ether - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Fish: Bluegill/Sunfish: LC50 = >10000 mg/L; 96 Hr.; UnspecifiedFish: Bluegill/Sunfish: LC50 = 5400 mg/L; 24 Hr.; Modified ASTM D1345Water flea Daphnia: EC50 = >10000 mg/L; 24 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 430 mg/L; 30 minutes; Microtox test

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: ETHYLENE GLYCOL MONOETHYL ETHER
Hazard Class: 3
UN Number: 1171
Packing Group: III
IMO
Shipping Name: ETHYLENE GLYCOL MONOETHYL ETHER
Hazard Class: 3.3
UN Number: 1171
Packing Group: III
RID/ADR
Shipping Name: ETHYLENE GLYCOL MONOETHYL ETHER
Hazard Class: 3
UN Number: 1171
Packing group: III
USA RQ: CAS# 110-80-5: 1000 lb final RQ; 454 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 61 May cause harm to the unborn child.
R 10 Flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 60 May impair fertility.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 110-80-5: 1
Canada
CAS# 110-80-5 is listed on Canada's DSL List.
CAS# 110-80-5 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 110-80-5 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
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IR Spectrum IR : liquid film
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Mass Spectrum Mass spectrum (electron ionization)
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Raman Spectrum Raman : 4880 A,100M,liquid
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Analysis Methods
Kovats' RI, non-polar column, isothermal
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Column Shape
Capillary
Active Phase(℃)
SPB-1
Retention index
687.
Temperature Control
60.
Method
isothermal
Comments
N2; Column length: 60. m; Column diameter: 0.75 mm
Reference
Castello, G.Vezzani, S.Gerbino, T.Gas chromatographic separation and automatic identification of complex mixtures of organic solvents in indrustrial watesJ. Chromatogr.1991, 585, 2, 273-280.
Kovats' RI, non-polar column, isothermal
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Column Shape
Packed
Active Phase(℃)
Porapack Q
Retention index
671.
Temperature Control
200.
Method
isothermal
Comments
N2
Reference
Goebel, K.-J.Gaschromatographische Identifizierung Niedrig Siedender Substanzen Mittels Retentionsindices und RechnerhilfeJ. Chromatogr.1982, 235, 1, 119-127.
Kovats' RI, non-polar column, isothermal
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Column Shape
Packed
Active Phase(℃)
SE-30
Retention index
694.
Temperature Control
150.
Method
isothermal
Comments
Celatom AW silanized; Column length: 3.7 m
Reference
Haken, J.K.Nguyen, A.Wainwright, M.S.Application of linear extrathermodynamic relationships to alcohols, aldehydes, ketones, amd ethoxy alcoholsJ. Chromatogr.1979, 179, 1, 75-85.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
Apiezon L
Retention index
666.
Temperature Control
120.
Method
isothermal
Comments
Celite 545
Reference
Bogoslovsky, Yu.N.Anvaer, B.I.Vigdergauz, M.S.Chromatographic constants in gas chromatography (in Russian)Standards Publ. House, Moscow, 1978, 192.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
Apiezon L
Retention index
670.
Temperature Control
160.
Method
isothermal
Comments
Celite 545
Reference
Bogoslovsky, Yu.N.Anvaer, B.I.Vigdergauz, M.S.Chromatographic constants in gas chromatography (in Russian)Standards Publ. House, Moscow, 1978, 192.
Toxicity
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Human
Dose/Duration
6000 ppm
Toxic Effects
--
Reference
Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878- Volume(issue)/page/year: 45,1459,1930
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
2125 mg/kg
Toxic Effects
Behavioral--somnolence (general depressed activity)<br>Behavioral--withdrawal<br>Lungs, Thorax, or Respiration--respiratory depression
Reference
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(3),48,1988
ACUTE TOXICITY DATA
expand collapse
Type of Test
LC50 - Lethal concentration, 50 percent kill
Exposure Route
Inhalation
Species Observed
Rodent - rat
Dose/Duration
2000 ppm/7H
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,54,1974

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