ethyl acetate

CAS No. 141-78-6

Formula: C4H8O2
Basic Info

Ethyl acetate (systematically, ethyl ethanoate, commonly abbreviated EtOAc or EA) is the organic compound with the formula CH3-COO-CH2-CH3, simplified to C4H8O2. This colorless liquid has a characteristic sweet smell (similar to pear drops) and is used in glues, nail polish removers, decaffeinating tea and coffee, and cigarettes (see list of additives in cigarettes). Ethyl acetate is the ester of ethanol and acetic acid; it is manufactured on a large scale for use as a solvent. The combined annual production in 1985 of Japan, North America, and Europe was about 400,000 tons. In 2004, an estimated 1.3M tons were produced worldwide.

Formula
C4H8O2
Molecular Weight
88.1051
Exact Mass
88.0524
LogP
0.5694
PSA
26.3
Synonyms

Acetidin

Vinegar naphtha

Ethyl ethanoate

Ethyl acetic ester

Ethyl acetate

Acetoxyethane

Ethylacetate

Acetic ether

Acetic acid ethyl ester

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Properties
Appearance & Physical State
Colorless liquid
Density
0.902
Boiling Point
75-77.5ºC
Melting Point
-83.5ºC
Flash Point
-4ºC
Refractive Index
1.371-1.374
Water Solubility
80 g/L (20 ºC)
Stability
Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
Storage Condition
2-8°C
Vapor Density
3 (20 °C, vs air)
Vapor Pressure
73 mm Hg ( 20 °C)
Safety Info
RTECS
AH5425000
Safety Statements
S16-S26-S33
WGK Germany
1
Risk Statements
R11; R36; R66; R67
HS Code
2915310000
RIDADR
UN 1173
Hazard Class
3
Packing Group
II
Caution Statement
P210; P305 + P351 + P338; P370 + P378; P403 + P235
Hazard Codes
Hazard Declaration
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl acetate

1.2 Other means of identification

Product number -
Other names Ethyl ethanoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H225 Highly flammable liquid and vapour

H319 Causes serious eye irritation

H336 May cause drowsiness or dizziness

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/…if you feel unwell.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
ethyl acetate ethyl acetate 141-78-6 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Rinse contaminated clothes (fire hazard) with plenty of water. Remove contaminated clothes. Rinse skin with plenty of water or shower.

In case of eye contact

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

If swallowed

Rinse mouth. Seek medical attention if you feel unwell.

4.2 Most important symptoms/effects, acute and delayed

Headache, irritation of respiratory passages and eyes, dizziness and nausea, weakness, loss of consciousness. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Esters and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Cool exposed containers with water.

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

ACCIDENTAL RELEASE MEASURES. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants, strong bases and strong acids.Keep tightly closed in cool place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 400 ppm (1400 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Colorless liquid
Colour Clear, volatile
Odour CHARACTERISTIC ETHER-LIKE ODOR REMINISCENT OF PINEAPPLE.
Melting point/ freezing point 285°C(dec.)(lit.)
Boiling point or initial boiling point and boiling range 76.5-77.5°C(lit.)
Flammability Class IB Flammable Liquid: Fl.P. below 22.78°C and BP at or above 37.78°C.Highly flammable.
Lower and upper explosion limit / flammability limit Lower 2.2%; upper 11.5% by volume in air
Flash point -3°C
Auto-ignition temperature 427.22°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 0.423 mPa.s at 25°C
Solubility In water:80 g/L (20 ºC)
Partition coefficient n-octanol/water (log value) log Kow = 0.73
Vapour pressure 73 mm Hg ( 20 °C)
Density and/or relative density 0.902g/mLat 25°C(lit.)
Relative vapour density 3 (20 °C, vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Slowly decomp by moisture.

10.3 Possibility of hazardous reactions

A very dangerous fire hazard when exposed to heat or flame.The vapour is heavier than air and may travel along the ground; distant ignition possible.ETHYL ACETATE is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. This chemical may ignite or explode with lithium aluminum hydride. It may also ignite with potassium tert-butoxide. It is incompatible with nitrates, strong alkalis and strong acids. It will attack some forms of plastics, rubber and coatings. It is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

... can react vigorously with oxidizing materials ... Potentially explosive reaction with lithium tetrahydroaluminate. Ignites on contact with potassium teri-butoxide. Violent reaction with chlorosulfonic acid, (LiAIH2 + 2-chloromethyl furan), oleum.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and irritating fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 11.3 mL/kg
  • Inhalation: LC50 Mouse inhalation 1500 ppm/4hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow) age 29-30 days, length 18.2 mm, weight 0.106 g; Conditions: freshwater, flow through, 24.3°C, pH 7.4, hardness 45.0 mg/L CaCO3, alkalinity 37.0 mg/L CaCO3, dissolved oxygen 6.7 mg/L; Concentration: 230000 ug/L for 96 hr (95% confidence interval: 220000-250000 ug/L) /99+% purity
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea); Conditions: freshwater, renewal, 25°C, pH >7; Concentration: 2306000 ug/L for 24 hr; Effect: behvior equilibrium /formulation
  • Toxicity to algae: EC50; Species: Chlorococcales (Green Algae Order); Conditions: freshwater, static; Concentration: 4300000 ug/L for 24 hr; Effect: physiology, assimilation efficiency /formulation
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Ethyl acetate, present at 100 mg/L, reached 95% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). A review concluded that ethyl acetate is easily removed by biological treatment(2). Reported 5 day BOD values using a sewage inoculum range from 36-68% of theoretical(3-6) with the value being somewhat reduced in salt water(3). One investigator reported that ethyl acetate was completely degraded in 20 hr using activated sludge(7). In a bench-scale continuous-flow activated sludge reactor with an 8 hour retention time, 99.9% removal including 17% volatilization loss) was obtained, with 80% of the theoretical BOD(8). Ethyl acetate was 90% biooxidized in a 20-day BOD test using a filtered raw sewage seed; it was biooxidized 77% in a 28-day OECD closed-bottle test(9). A screening procedure that was systematically applied to a large number of organic chemicals ranked ethyl acetate as being completely biodegraded in a short time by general microorganisms(10). After a 5 hr lag, 43 to 53% of theoretical BOD was obtained in 50 to 70 hr(10). In screening tests, ethyl acetate, present at a concentration of 5 ppm, reached 26.6 and 57.1% of its theoretical BOD in 5 days using the standard dilution method and seawater dilution method, respectively(11). 99.9% removal of ethyl acetate was observed in a complete mix continuous-flow activated sludge system; 93% of this removal was attributed to biodegradation(12).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated for ethyl acetate(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of ethyl acetate is estimated as 18(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that ethyl acetate is expected to have very high mobility in soil(SRC). A log Ki (snow surface/air (cu m/sq m)) of -3.69 has been reported for sorption to snow(4).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1173 IMDG: UN1173 IATA: UN1173

14.2 UN Proper Shipping Name

ADR/RID: ETHYL ACETATE
IMDG: ETHYL ACETATE
IATA: ETHYL ACETATE

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
ethyl acetate ethyl acetate 141-78-6 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Ethyl acetate    
    REACH No.        : 01-2119475103-46-XXXX    
    CAS-No.        : 141-78-6    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 2), H225
    Eye irritation (Category 2), H319
    Specific target organ toxicity - single exposure (Category 3), H336
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    F Highly flammable        R11    
    Xi Irritant        R36    
    R66
    R67
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Danger    
    Hazard statement(s)
    H225        Highly flammable liquid and vapour.    
    H319        Causes serious eye irritation.    
    H336        May cause drowsiness or dizziness.    
    Precautionary statement(s)
    P210        Keep away from heat/sparks/open flames/hot surfaces. - No smoking.    
    P261        Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    Supplemental Hazard information (EU)
    EUH066        Repeated exposure may cause skin dryness or cracking.    
  Other hazards - none

SECTION 3: Composition/information on ingredients
  Substances
    Formula        : C4H8O2    
    Molecular Weight        : 88,11 g/mol    
    CAS-No.        : 141-78-6    
    EC-No.        : 205-500-4    
    Registration number        : 01-2119475103-46-XXXX    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Ethyl acetate
    CAS-No.        141-78-6        Flam. Liq. 2; Eye Irrit. 2; STOT <= 100 %    
    EC-No.        205-500-4        SE 3; H225, H319, H336,    
    Index-No.        607-022-00-5        EUH066    
    Registration number        01-2119475103-46-XXXX    
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Ethyl acetate
    CAS-No.        141-78-6        F, Xi, R11 - R36 - R66 - R67        <= 100 %    
    EC-No.        205-500-4    
    Index-No.        607-022-00-5    
    Registration number        01-2119475103-46-XXXX    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
    Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
    form explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Derived No Effect Level (DNEL)
    Application Area        Exposure        Health effect        Value    
    routes
    Workers        Inhalation        Acute systemic effects        1468 mg/m3    
    Workers        Inhalation        Acute local effects        1468 mg/m3    
    Workers        Skin contact        Long-term systemic effects        63mg/kg BW/d    
    Workers        Inhalation        Long-term systemic effects        734 mg/m3    
    Workers        Inhalation        Long-term local effects        734 mg/m3    
    Consumers        Inhalation        Acute local effects, Acute systemic        734 mg/m3    
    effects
    Consumers        Skin contact        Long-term systemic effects        37mg/kg BW/d    
    Consumers        Inhalation        Long-term systemic effects        367 mg/m3    
    Consumers        Ingestion        Long-term systemic effects        4,5mg/kg BW/d    
    Consumers        Inhalation        Long-term local effects        367 mg/m3    
  Predicted No Effect Concentration (PNEC)
    Compartment        Value    
    Soil        0,24 mg/kg    
    Marine water        0,026 mg/l    
    Fresh water        0,26 mg/l    
    Marine sediment        0,125 mg/kg    
    Fresh water sediment        1,25 mg/kg    
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Splash contact
    Material: butyl-rubber
    Minimum layer thickness: 0,3 mm
    Break through time: 113 min
    Material tested:Butoject® (KCL 897 / Z677647, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    impervious clothing, Flame retardant antistatic protective clothing, The type of protective
    equipment must be selected according to the concentration and amount of the dangerous
    substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: clear, liquid    
    Colour: colourless
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        Melting point/range: -84 °C    
    point
    f) Initial boiling point and 76,5 - 77,5 °C
    boiling range
    g) Flash point        -3,0 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        Upper explosion limit: 11,5 %(V)    
    flammability or        Lower explosion limit: 2,2 %(V)    
    explosive limits
    k) Vapour pressure        97,3 hPa at 20,0 °C    
    l) Vapour density        no data available    
    m) Relative density        0,90 g/cm3    
    n) Water solubility        soluble    
    o) Partition coefficient: n- log Pow: 0,73
    octanol/water
    p) Auto-ignition        427,0 °C    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    Surface tension        24,0 mN/m at 20,0 °C    

SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks. Extremes of temperature and direct sunlight.
  Incompatible materials
    Strong oxidizing agents
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - rat - 5.620 mg/kg
    LC50 Inhalation - mouse - 2 h - 45.000 mg/m3
    LD50 Dermal - rabbit - > 18.000 mg/kg
  Skin corrosion/irritation
    May cause skin irritation and/or dermatitis.
  Serious eye damage/eye irritation
    no data available
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC,
    ACGIH, NTP, or EPA classification.
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    May cause drowsiness or dizziness.
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: AH5425000
    Inhalation of high concentrations may cause:, Headache, Drowsiness, Dizziness, Vomiting, narcosis,
    anemia, Central nervous system depression
    Kidney - Irregularities - Based on Human Evidence

SECTION 12: Ecological information
  Toxicity
    Toxicity to fish        LC50 - Oncorhynchus mykiss (rainbow trout) - 350,00 - 600,00 mg/l - 96 h    
    LC50 - Pimephales promelas (fathead minnow) - 220,00 - 250,00 mg/l - 96 h
    Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 2.300,00 - 3.090,00 mg/l - 24 h
    other aquatic
    invertebrates
    LC50 - Daphnia magna (Water flea) - 560 mg/l - 48 h
    Toxicity to algae        EC50 - Algae - 4.300,00 mg/l - 24 h    
    EC50 - SELENASTRUM - 1.800,00 - 3.200,00 mg/l - 72 h
  Persistence and degradability
    Biodegradability        Result: 79 % - Readily biodegradable.    
    (OECD Test Guideline 301D)
  Bioaccumulative potential
    Bioaccumulation        -3d    
    Bioconcentration factor (BCF): 30
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    no data available

SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
    company.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 1173        IMDG: 1173        IATA: 1173    
  UN proper shipping name
    ADR/RID: ETHYL ACETATE
    IMDG: ETHYL ACETATE
    IATA:        Ethyl acetate    
  Transport hazard class(es)
    ADR/RID: 3        IMDG: 3        IATA: 3    
  Packaging group
    ADR/RID: II        IMDG: II        IATA: II    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available



SECTION 15 - REGULATORY INFORMATION
N/A


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
expand collapse
IR Spectrum IR : CCl4 solution
expand collapse
Mass Spectrum Mass
expand collapse
Raman Spectrum Raman : 4880 A,100M,liquid
expand collapse
Toxicity
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Human
Dose/Duration
400 ppm
Toxic Effects
--
Reference
Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,282,1943
ACUTE TOXICITY DATA
expand collapse
Type of Test
TCLo - Lowest published toxic concentration
Exposure Route
Inhalation
Species Observed
Human
Dose/Duration
400 ppm
Toxic Effects
Sense Organs and Special Senses (Olfaction)--effect, not otherwise specified<br>Sense Organs and Special Senses (Eye)--conjunctive irritation<br>Lungs, Thorax, or Respiration--other changes
Reference
Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,282,1943
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
5620 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 32,1241,1981

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