Name:	n-Butyllithium 2.2M solution in cyclohexane Material Safety Data Sheet
Synonym:	None Known
CAS:	109-72-8

Section 1 - Chemical Product   MSDS Name:n-Butyllithium 2.2M solution in cyclohexane Material Safety Data Sheet
Synonym:None Known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
109-72-8	Butyl lithium	15-27	203-698-7

Hazard Symbols: F C N
Risk Phrases: 11 14/15 17 35 62 50/53 65 67

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Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Highly flammable. Reacts violently with water liberating extremely flammable gases. Spontaneously flammable in air. Causes severe burns.
Possible risk of impaired fertility. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Harmful: may cause lung damage if swallowed. Vapours may cause drowsiness and dizziness.Corrosive.Water-reactive.Highly flammable.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Causes skin burns. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. May cause cyanosis of the extremities.
Ingestion:
Causes gastrointestinal tract burns. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. Ingestion of large amounts may cause CNS depression. May cause lung damage.
Inhalation:
Causes chemical burns to the respiratory tract. Exposure produces central nervous system depression. Aspiration may lead to pulmonary edema. Inhalation of vapors may cause drowsiness and dizziness.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. Peripheral neuropathy symptoms include: muscular weakness, paresthesia, numbing of the hands, feet, legs and arms, unsteadiness, and difficulty in walking and standing. Chronic exposure may cause effects similar to those of acute exposure. May impair fertility.

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Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give anything by mouth to an unconscious person.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
  General Information:
Evacuate area and fight fire from a safe distance. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Material can spontaneously ignite (pyrophoric) when exposed to air at normal or slightly elevated temperatures. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Flammable liquid and vapor. Will be easily ignited by heat, sparks or flame. May re-ignite after fire is extinguished. Containers may explode if exposed to fire.
Extinguishing Media:
Do NOT use halogenated agents. Do NOT use water, carbon dioxide, or foam. Contact professional fire-fighters immediately. Smother with dry sand, dry clay, dry ground limestone (CaCO3), or use approved Class D extinguishers.

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Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Isolate area and deny entry. Provide ventilation. Do not expose spill to water.

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Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not allow water to get into the container because of violent reaction. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep away from heat, sparks and flame. Do not ingest or inhale. Do not allow contact with water. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.
Flammables-area. Water free area. Store under nitrogen.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 109-72-8: CAS# 110-54-3: United Kingdom, WEL - TWA: 20 ppm TWA; 72 mg/m3 TWA United Kingdom, WEL - STEL: 60 ppm STEL; 216 mg/m3 STEL United States OSHA: 500 ppm TWA; 1800 mg/m3 TWA Belgium - TWA: 50 ppm VLE; 179 mg/m3 VLE France - VME: 50 ppm VME; 170 mg/m3 VME Germany: 50 ppm TWA; 180 mg/m3 TWA Japan: 40 ppm OEL; 140 mg/m3 OEL Malaysia: 50 ppm TWA; 176 mg/m3 TWA Netherlands: 25 ppm MAC; 90 mg/m3 MAC Russia: 300 mg/m3 TWA Spain: 50 ppm VLA-ED; 179 mg/m3 VLA-ED CAS# 110-82-7: United Kingdom, WEL - TWA: 100 ppm TWA; 350 mg/m3 TWA United Kingdom, WEL - STEL: 300 ppm STEL; 1050 mg/m3 STEL United States OSHA: 300 ppm TWA; 1050 mg/m3 TWA Belgium - TWA: 300 ppm VLE; 1045 mg/m3 VLE France - VME: 300 ppm VME; 1050 mg/m3 VME France - VLE: 375 ppm VLE; 1300 mg/m3 VLE Germany: 200 ppm TWA; 700 mg/m3 TWA Japan: 150 ppm OEL; 520 mg/m3 OEL Malaysia: 300 ppm TWA; 1030 mg/m3 TWA Netherlands: 250 ppm MAC; 875 mg/m3 MAC Russia: 80 mg/m3 TWA Spain: 300 ppm VLA-ED; 1050 mg/m3 VLA-ED Spain: 600 ppm VLA-EC; 2100 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: light yellow
Odor: solvent odor
pH: >7
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: vigorous reaction
Specific Gravity/Density: 0.750
Molecular Formula: C4H9Li
Molecular Weight: 64.06

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Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Powder or liquid is pyrophoric. Reacts violently with water.
Conditions to Avoid:
Light, ignition sources, exposure to air, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Water, strong oxidizing agents, carbon dioxide, alcohols, acids, halides, violent reaction with halogens.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, lithium oxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 109-72-8 unlisted.
CAS# 110-54-3: MN9275000 CAS# 110-82-7: GU6300000 LD50/LC50:
Not available.
CAS# 110-54-3: Draize test, rabbit, eye: 10 mg Mild; Inhalation, mouse: LC50 = 150000 mg/m3/2H; Inhalation, rat: LC50 = 48000 ppm/4H; Inhalation, rat: LC50 = 627000 mg/m3/3M; Oral, rat: LD50 = 25 gm/kg.
CAS# 110-82-7: Draize test, rabbit, skin: 1548 mg/2D (Intermittent); Inhalation, mouse: LC50 = 70000 mg/m3/2H; Oral, mouse: LD50 = 813 mg/kg; Oral, rat: LD50 = 12705 mg/kg.
Carcinogenicity:
Butyl lithium - Not listed by ACGIH, IARC, or NTP.
Hexane - Not listed by ACGIH, IARC, or NTP.
Cyclohexane - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Fish: Pseudomonas putida:

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Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: LITHIUM ALKYLS
Hazard Class: 4.2 (4.3)
UN Number: 2445
Packing Group: I
IMO
Shipping Name: LITHIUM ALKYLS
Hazard Class: 4.2 (4.3)
UN Number: 2445
Packing Group: I
RID/ADR
Shipping Name: LITHIUM ALKYLS
Hazard Class: 4.2 (4.3)
UN Number: 2445
Packing group: I
USA RQ: CAS# 110-54-3: 5000 lb final RQ; 2270 kg final RQ
USA RQ: CAS# 110-82-7: 1000 lb final RQ; 454 kg final RQ

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Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: F C N
Risk Phrases:
R 11 Highly flammable.
R 14/15 Reacts violently with water liberating
extremely flammable gases.
R 17 Spontaneously flammable in air.
R 35 Causes severe burns.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
R 62 Possible risk of impaired fertility.
R 65 Harmful: may cause lung damage if swallowed.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 6A Keep under nitrogen.
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 33 Take precautionary measures against static
discharges.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 43B In case of fire, use fire-fighting equipment
on basis of sodium chloride, sodium bicarbonate (never
use water).
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 109-72-8: 2
CAS# 110-54-3: 1
CAS# 110-82-7: 1
Canada
CAS# 109-72-8 is listed on Canada's DSL List.
CAS# 110-54-3 is listed on Canada's DSL List.
CAS# 110-82-7 is listed on Canada's DSL List.
CAS# 109-72-8 is not listed on Canada's Ingredient Disclosure List.
CAS# 110-54-3 is listed on Canada's Ingredient Disclosure List.
CAS# 110-82-7 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 109-72-8 is listed on the TSCA inventory.
CAS# 110-54-3 is listed on the TSCA inventory.
CAS# 110-82-7 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A