532-27-4 structure, C8H7ClO

2-Chloroacetophenone

CAS No.

532-27-4

Formula:

C8H7ClO

Basic Info

Phenacyl chloride is a substituted acetophenone. It is a useful building block in organic chemistry. Apart from that, it has been historically used as a riot control agent, where it is designated CN. It should not be confused with cyanide, another agent used in chemical warfare, which has the chemical structure CN−.

Formula
C8H7ClO
Molecular Weight
154.594
Exact Mass
154.019
LogP
2.1081
PSA
17.07
Synonyms

(2-Chloro-1-oxoethyl)benzene

Ethanone, 2-chloro-1-phenyl-

1-Phenyl-2-chloro-1-ethanone

(Chloroacetyl)benzene

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Properties

Appearance & Physical State
White to light yellow crystalline powder
Density
1.188
Boiling Point
244-245ºC
Melting Point
52-56ºC
Flash Point
118ºC
Refractive Index
1.5438
Water Solubility
insoluble.
Stability
May decompose upon exposure to air or water. Incompatible with bases, amines, alcohols.
Storage Condition
Store in a cool, dry, well-ventilated area away from incompatible substances. Do not store in metal containers. Keep containers tightly closed. Store protected from moisture.

Safety Info

RTECS
AM6300000
Safety Statements
S26-S28-S36/37/39-S45
WGK Germany
3
Risk Statements
R23/25; R36/37/38
HS Code
2914700090
RIDADR
UN 1697
Hazard Class
6.1
Packing Group
II
Hazard Codes

MSDS

SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloroacetophenone

1.2 Other means of identification

Product number -
Other names (2-Chloro-1-oxoethyl)benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. 2-Chloroacetophenone is primarily used as a riot-control agent (tear gas) and in Chemical Mace. (-,) It is also used as a pharmaceutical intermediate and formerly as an alcohol denaturant.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 2

Acute toxicity - Dermal, Category 3

Skin irritation, Category 2

Serious eye damage, Category 1

Acute toxicity - Inhalation, Category 3

Respiratory sensitization, Category 1

Specific target organ toxicity – single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H300 Fatal if swallowed

H311 Toxic in contact with skin

H315 Causes skin irritation

H318 Causes serious eye damage

H331 Toxic if inhaled

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335 May cause respiratory irritation

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P310 Immediately call a POISON CENTER/doctor/…

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P311 Call a POISON CENTER/doctor/…

P342+P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
2-Chloroacetophenone 2-Chloroacetophenone 532-27-4 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Give a slurry of activated charcoal in water to drink. Refer for medical attention . Rest.

4.2 Most important symptoms/effects, acute and delayed

Inhalation causes tearing, burning of the eyes and difficulty in breathing; high concentrations may lead to development of acute pulmonary edema after latencies of 8 hrs. to several days; possible systemic manifestations include agitation, coma, contraction of pupils of eyes, loss of reflexes. External contact causes irritation of skin and intense irritation of eyes. Ingestion causes agitation, coma, contraction of pupils of eye, loss of reflexes. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ketones and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, powder, foam, carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Irritating hydrogen chloride may form. Behavior in Fire: Unburned material may become volatile and cause severe eye irritation. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: self-contained breathing apparatus. Sweep spilled substance into covered sealable, plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Personal protection: self-contained breathing apparatus. Sweep spilled substance into covered sealable, plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs. Keep in a well-ventilated room.Separated from food and feedstuffs. Keep in a well-ventilated room.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 0.3 mg/cu m (0.05 ppm).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state White to light yellow crystalline powder
Colour Crystals from dilute alcohol, carbon tetrachloride, or light petroleum
Odour IN VERY LOW CONCN IN AIR IT HAS AN ODOR RESEMBLING APPLE BLOSSOMS
Melting point/ freezing point 52-56ºC
Boiling point or initial boiling point and boiling range 244-245ºC
Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 118ºC
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:insoluble.
Partition coefficient n-octanol/water (log value) log Kow = 1.93 (est)
Vapour pressure 0.0054 mm Hg at 20°C
Density and/or relative density 1.188
Relative vapour density 5.2 (Relative to Air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Combustible.Vapors may be heavier than air. They will spread along the ground and collect and stay in poorly-ventilated, low-lying, or confined areas (e.g., sewers, basements, and tanks).Hazardous concentrations may develop quickly in enclosed, poorly-ventilated, or low-lying areas. Keep out of these areas. Stay upwind.2-CHLOROACETOPHENONE reacts slowly with metals causing mild corrosion.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Water, steam, strong oxidizers [Note: Slowly corrodes metals].

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 127 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

A4: Not classifiable as a human carcinogen.

Reproductive toxicity

No information is available on the reproductive or developmental effects of 2-chloroacetophenone in humans or animals.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

ANAEROBIC: 2-Chloroacetophenone was reductively transformed in anaerobic sediments via electron transfer to form acetophenone and via hydride transfer to form 2-chloro-1-phenylethanol(1). An increase in temperature decreases the rate of degradation(1).

12.3 Bioaccumulative potential

An estimated BCF of 2 was calculated in fish for 2-chloroacetophenone(SRC), using an estimated log Kow of 1.93(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 2-chloroacetophenone can be estimated to be 100(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-chloroacetophenone is expected to have high mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1697 IMDG: UN1697 IATA: UN1697

14.2 UN Proper Shipping Name

ADR/RID: CHLOROACETOPHENONE, SOLID
IMDG: CHLOROACETOPHENONE, SOLID
IATA: CHLOROACETOPHENONE, SOLID

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
2-Chloroacetophenone 2-Chloroacetophenone 532-27-4 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 16, 2017
Revision Date Aug 16, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: 2-Chloroacetophenone Material Safety Data Sheet
Synonym: Phenacyl chloride; Chloromethyl phenyl ketone; Mace; 2-Chloro-1-phenylethanone; omega-Chloroacetophenone; Chemical mace; CN; alpha-Chloroacetophenone
CAS: 532-27-4
Section 1 - Chemical Product   MSDS Name:2-Chloroacetophenone Material Safety Data Sheet
Synonym:Phenacyl chloride; Chloromethyl phenyl ketone; Mace; 2-Chloro-1-phenylethanone; omega-Chloroacetophenone; Chemical mace; CN; alpha-Chloroacetophenone

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
532-27-4 2-Chloroacetophenone >98 208-531-1
Hazard Symbols: T
Risk Phrases: 23/25 36/37/38

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed. Irritating to eyes, respiratory system and skin.Moisture sensitive.Lachrymator (substance which increases the flow of tears).
Potential Health Effects
Eye:
Lachrymator (substance which increases the flow of tears). Causes eye irritation and possible burns. May cause reversible inflammation and corneal injury with opacity.
Skin:
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Causes skin irritation and possible severe skin irritation especially if the skin is wet or moist.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema. Inhalation may produce coughing, nausea, and pulmonary edema.
In rare instances, exposure may cause sensitization, resulting in inflammation of the mucous membranes and in eczematous eruptions.
Chronic:
Prolonged and/or repeated skin exposure may cause allergic dermatitis.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water.
Remove contaminated clothing and shoes. Get medical aid. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
POISON material. If inhaled, get medical aid immediately. Remove victim to fresh air. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use carbon dioxide or dry chemical.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation. Do not get water inside containers.

Section 7 - HANDLING and STORAGE
  Handling:
Wash hands before eating. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse. Discard contaminated shoes.
Do not breathe dust. Use only with adequate ventilation.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible substances. Do not store in metal containers. Keep containers tightly closed. Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 532-27-4: United Kingdom, WEL - TWA: 0.05 ppm TWA; 0.32 mg/m3 TWA United Kingdom, WEL - STEL: 0.15 ppm STEL; 0.96 mg/m3 STEL United States OSHA: 0.05 ppm TWA; 0.3 mg/m3 TWA Belgium - TWA: 0.05 ppm VLE; 0.32 mg/m3 VLE France - VME: 0.05 ppm VME; 0.3 mg/m3 VME Germany: 0.3 mg/m3 TWA Malaysia: 0.05 ppm TWA; 0.32 mg/m3 TWA Netherlands: 0.05 ppm MAC; 0.3 mg/m3 MAC Spain: 0.05 ppm VLA-ED; 0.32 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear a chemical apron. Wear butyl rubber gloves, apron, and/or clothing.
Clothing:
Wear a chemical apron. Wear butyl rubber gloves, apron, and/or clothing.
Respirators:
Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystals
Color: white
Odor: floral-like - irritating odor - sharp odor
pH: Not applicable.
Vapor Pressure: 0.0054 mm Hg @ 20 deg C
Viscosity: Not available.
Boiling Point: 244-245 deg C @ 760 mm Hg
Freezing/Melting Point: 52-56 deg C
Autoignition Temperature: Not available.
Flash Point: 118 deg C ( 244.40 deg F)
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water: insoluble
Specific Gravity/Density: 1.324 g/cm3
Molecular Formula: C8H7ClO
Molecular Weight: 154.60

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong bases, water.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 532-27-4: AM6300000 LD50/LC50:
CAS# 532-27-4: Dermal, guinea pig: LD50 = >1 gm/kg; Draize test, rabbit, eye: 1 mg Mild; Draize test, rabbit, eye: 3 mg Severe; Draize test, rabbit, eye: 1%; Draize test, rabbit, skin: 5 mg/24H Mild; Inhalation, mouse: LC50 = 59 mg/m3; Oral, mouse: LD50 = 139 mg/kg; Oral, rabbit: LD50 = 118 mg/kg; Oral, rat: LD50 = 50 mg/kg.
Carcinogenicity:
2-Chloroacetophenone - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: CHLOROACETOPHENONE, LIQUID
Hazard Class: 6.1
UN Number: 1697
Packing Group: II
IMO
Shipping Name: CHLOROACETOPHENONE, LIQUID
Hazard Class: 6.1
UN Number: 1697
Packing Group: II
RID/ADR
Shipping Name: CHLOROACETOPHENONE
Hazard Class: 6.1
UN Number: 1697
Packing group: II
USA RQ: CAS# 532-27-4: 1 lb statutory RQ; 0.454 kg statutory RQ; 100 lb final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/25 Toxic by inhalation and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 532-27-4: No information available.
Canada
CAS# 532-27-4 is listed on Canada's NDSL List.
CAS# 532-27-4 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 532-27-4 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

Spectrum

NMR Spectrum 1H NMR : Predict
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Analysis Methods

Kovats' RI, non-polar column, isothermal
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Column Shape
Capillary
Active Phase(℃)
Methyl Silicone
Retention index
1231.
Temperature Control
100.
Method
isothermal
Comments
H2; Column length: 5. m; Phase thickness: 2.65 μm
Reference
Huber, J.F.K.Kenndler, E.Reich, G.Hack, W.Wolf, J.Optimal Selection of Gas Chromatographic Columns for the Analytical Control of Chemical Warfare Agents by Application of Information Theory to Retention DataAnal. Chem.1993, 65, 20, 2903-2906.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Capillary
Active Phase(℃)
Methyl Silicone
Retention index
1241.
Temperature Control
120.
Method
isothermal
Comments
H2; Column length: 5. m; Phase thickness: 2.65 μm
Reference
Huber, J.F.K.Kenndler, E.Reich, G.Hack, W.Wolf, J.Optimal Selection of Gas Chromatographic Columns for the Analytical Control of Chemical Warfare Agents by Application of Information Theory to Retention DataAnal. Chem.1993, 65, 20, 2903-2906.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Capillary
Active Phase(℃)
PEG-20M
Retention index
2101.
Temperature Control
160.
Method
isothermal
Comments
Column length: 10. m; Phase thickness: 1.33 μm
Reference
Huber, J.F.K.Kenndler, E.Reich, G.Hack, W.Wolf, J.Optimal Selection of Gas Chromatographic Columns for the Analytical Control of Chemical Warfare Agents by Application of Information Theory to Retention DataAnal. Chem.1993, 65, 20, 2903-2906.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Capillary
Active Phase(℃)
PEG-20M
Retention index
2113.
Temperature Control
180.
Method
isothermal
Comments
Column length: 10. m; Phase thickness: 1.33 μm
Reference
Huber, J.F.K.Kenndler, E.Reich, G.Hack, W.Wolf, J.Optimal Selection of Gas Chromatographic Columns for the Analytical Control of Chemical Warfare Agents by Application of Information Theory to Retention DataAnal. Chem.1993, 65, 20, 2903-2906.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Capillary
Active Phase(℃)
PEG-20M
Retention index
2083.4
Temperature Control
130.
Method
isothermal
Comments
Column length: 10. m; Phase thickness: 1.33 μm
Reference
Huber, J.F.K.Kenndler, E.Reich, G.Hack, W.Wolf, J.Optimal Selection of Gas Chromatographic Columns for the Analytical Control of Chemical Warfare Agents by Application of Information Theory to Retention DataAnal. Chem.1993, 65, 20, 2903-2906.

Toxicity

SKIN/EYE IRRITATION DATA
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Type of Test
Open irritation test
Exposure Route
Administration onto the skin
Species Observed
Rodent - rat
Dose/Duration
12%/6H
Toxic Effects
--
Reference
Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,75,1978
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Standard Draize test
Exposure Route
Administration onto the skin
Species Observed
Rodent - rabbit
Dose/Duration
5 mg/24H
Toxic Effects
--
Reference
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,295,1970
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Open irritation test
Exposure Route
Administration onto the skin
Species Observed
Rodent - rabbit
Dose/Duration
12%/6H
Toxic Effects
--
Reference
Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,75,1978

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