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Section 1. Chemical Product and Company Identification
    Apomorphine Hydrochloride, hemihydrate        Catalog    
    Common Name/
    Number(s).
    Trade Name
    CAS#
    Apomorphine Hydrochloride, hemihydrate

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Section 3. Hazards Identification
    Hazardous in case of ingestion, of inhalation (lung sensitizer). Slightly hazardous in case of skin contact (irritant,
    Potential Acute Health
    sensitizer), of eye contact (irritant).
    Effects
    CARCINOGENIC EFFECTS: Not available.
    Potential Chronic Health
    MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
    Effects
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    The substance may be toxic to kidneys, gastrointestinal tract, central nervous system (CNS).
    Repeated or prolonged exposure to the substance can produce target organs damage.

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Section 4. First Aid Measures
    Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
    Eye Contact
    15 minutes. Cold water may be used. Get medical attention if irritation occurs.
    Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
    Skin Contact
    Cold water may be used.
    Not available.
    Serious Skin Contact
    If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
    Inhalation
    medical attention.
    Not available.
    Serious Inhalation
    Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
    Ingestion
    unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
    clothing such as a collar, tie, belt or waistband.
    Not available.
    Serious Ingestion

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Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Not available.
    Flash Points
    Not available.
    Flammable Limits
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Non-flammable in presence of shocks.
    Various Substances
    Slightly explosive in presence of open flames and sparks.
    Explosion Hazards in
    Non-explosive in presence of shocks.
    Presence of Various
    Substances
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    As with most organic solids, fire is possible at elevated temperatures
    Special Remarks on
    Fire Hazards
    Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
    Special Remarks on
    explosion hazard.
    Explosion Hazards
    Apomorphine Hydrochloride, hemihydrate

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Section 6. Accidental Release Measures
    Use appropriate tools to put the spilled solid in a convenient waste disposal container. If necessary: Neutralize the
    Small Spill
    residue with a dilute solution of sodium carbonate. Finish cleaning by spreading water on the contaminated
    surface and dispose of according to local and regional authority requirements.
    Use a shovel to put the material into a convenient waste disposal container. Neutralize the residue with a dilute
    Large Spill
    solution of sodium carbonate. Finish cleaning by spreading water on the contaminated surface and allow to
    evacuate through the sanitary system.

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Section 7. Handling and Storage
    Keep away from heat. Keep away from sources of ignition. Do not breathe dust. Wear suitable protective clothing.
    Precautions
    In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and
    show the label when possible. Keep away from incompatibles such as oxidizing agents, alkalis.
    Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in
    Storage
    light-resistant containers. Air Sensitive

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Section 8. Exposure Controls/Personal Protection
    Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
    Engineering Controls
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.    
    Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
    avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
    of a Large Spill
    handling this product.
    Not available.
    Exposure Limits

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Section 9. Physical and Chemical Properties
    Solid. (Crystalline powder.)        Odorless.    
    Physical state and        O dor    
    appearance
    Not available.
    Taste
    312.8 g/mole
    Molecular Weight
    White. Off-white.
    Color
    4 - 5[Acidic.]
    pH (1% soln/water)
    Not available.
    Boiling Point
    195°C (383°F)
    Melting Point
    Not available.
    Critical Temperature
    Not available.
    Specific Gravity
    Not applicable.
    Vapor Pressure
    Not available.
    Vapor Density
    Not available.
    Volatility
    Not available.
    Odor Threshold
    Not available.
    Water/Oil Dist. Coeff.
    Not available.
    Ionicity (in Water)
    See solubility in water.
    Dispersion Properties
    Soluble in cold water.
    Solubility
    Slightly soluble in diethyl ether.
    Solubility in water: 20 g/l
    Insoluble in chloroform.
    Apomorphine Hydrochloride, hemihydrate

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Section 10. Stability and Reactivity Data
    The product is stable.
    Stability
    Not available.
    Instability Temperature
    Conditions of Instability Excess heat, incompatible materials, dust generation
    Incompatibility with various Reactive with oxidizing agents, alkalis.
    substances
    Not available.
    Corrosivity
    Air and light sensitive.
    Special Remarks on
    Incompatible with iodides, tannin, iron salts
    Reactivity
    Not available.
    Special Remarks on
    Corrosivity
    Will not occur.
    Polymerization

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Section 11. Toxicological Information
    Inhalation. Ingestion.
    Routes of Entry
    Acute oral toxicity (LD50): 300 mg/kg [Mouse].
    Toxicity to Animals
    Chronic Effects on Humans MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
    May cause damage to the following organs: kidneys, gastrointestinal tract, central nervous system (CNS).
    Other Toxic Effects on        Hazardous in case of ingestion, of inhalation (lung sensitizer).    
    Humans        Slightly hazardous in case of skin contact (irritant, sensitizer).    
    Not available.
    Special Remarks on
    Toxicity to Animals
    May affect genetic material (mutagenic).
    Special Remarks on
    Chronic Effects on Humans May cause adverse reproductive effects based on animal test data
    Special Remarks on other        Acute Potential Health Effects:    
    Toxic Effects on Humans        Skin: Skin contact may cause redness, irritation and sensitization. Absorption through skin (e.g. by subcutaneous    
    injection will produce systemic and central nervous symtpoms similar that of ingestion or inhalation.
    Eyes: May cause redness, and irritation.
    Inhalation: Inhalation of dust may cause sensitization, asthma, and respiratory tract irritation. Inhalation of dust may
    also cause nausea, and vomiting, and may affect behavior/central nervous system (symptoms similar to that of
    ingestion)
    Ingestion: May be harmful if swallowed. Causes gastrointestinal tract irritation with abdominal pain, nausa, vomiting
    and diarrhea. May affect behavior/central nervous system and cause stimulation and depression of the central
    nervous system. Symptoms may include restlessness, euphoria, drowsiness or sleepiness, yawning, somnolence,
    dizziness, sedation, cognitive impairment, personality change, lightheadedness, tremors, confusion, halllucinations,
    coma/unconsciousness. Other symptoms may include pin point or dilated pupils, respiratory depression, postural
    hypotension, sore throat, increased cough, rhihitis, flushing, taste disorder, sweating, circulatory failure, death. It may
    also affect the kidneys.
    Chronic Potential Health Effects:
    Ingestion or Skin Absorption/Subcutaneous injection: Prolonged or repeated ingestion or exposure by subcutaneous
    injection may have systemic and nervous system symptoms similar to that of acute ingestion or inhalation and affect
    the kidneys, adrenal gland and cause loss of appetite/weight loss.

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Section 12. Ecological Information
    Not available.
    Ecotoxicity
    Not available.
    BOD5 and COD
    Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    arise.
    Apomorphine Hydrochloride, hemihydrate
    The products of degradation are more toxic than the product itself.
    Toxicity of the Products
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation

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Section 13. Disposal Considerations
    Waste Disposal        Waste must be disposed of in accordance with federal, state and local environmental control    
    regulations.

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Section 14. Transport Information
    Not a DOT controlled material (United States).
    DO T Cl assi fi cati on
    Not applicable.
    Identification
    Not applicable.
    Special Provisions for
    Transport
    DO T (Pi ctograms)

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Section 15. Other Regulatory Information and Pictograms
    No products were found.
    Federal and State
    Regulations
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    California
    cause cancer which would require a warning under the statute: No products were found.
    Proposition 65
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: No products were found.
    Not available.
    Other Regulations
    WHMIS (Canada) Not controlled under WHMIS (Canada).
    Other Classifications
    R20/22- Harmful by inhalation and if        S24- Avoid contact with skin.    
    DSCL (EEC)
    swallowed.        S36/37- Wear suitable protective clothing and    
    R42/43- May cause sensitization by        gloves.    
    inhalation and skin contact.        S46- If swallowed, seek medical advice    
    immediately and show this container or label.
    Health Hazard
    HMIS (U.S.A.)        2 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    2 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection        E    
    WHMIS (Canada)
    (Pictograms)
    Apomorphine Hydrochloride, hemihydrate
    DSCL (Europe)
    (Pictograms)
    TDG(Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or equivalent.

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SECTION 16 - ADDITIONAL INFORMATION
N/A