1.Identification
1.1 GHS Product identifier
| Product name | cumene |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | (1-Methylethyl)sulfamic Acid |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. Cumene is used as a thinner for paints, lacquers, and enamels and as a component of high octane fuels. Cumene is also used in the manufacture of phenol, acetone, acetophenone, and methylstyrene. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
1.5 Emergency phone number
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Flammable liquids, Category 3
Aspiration hazard, Category 1
Specific target organ toxicity – single exposure, Category 3
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |     |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H226 Flammable liquid and vapour H304 May be fatal if swallowed and enters airways H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. |
| Response | P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P331 Do NOT induce vomiting. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. P391 Collect spillage. |
| Storage | P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| cumene | cumene | 98-82-8 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
In case of eye contact
Rinse with plenty of water (remove contact lenses if easily possible).
If swallowed
Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayed
Narcotic action with long-lasting effects; depressant to central nervous system. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aromatic hydrocarbons and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
To fight fire, use foam, carbon dioxide, dry chemical.
5.2 Specific hazards arising from the chemical
Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
6.3 Methods and materials for containment and cleaning up
Personal protection: filter respirator for organic gases and vapors adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong oxidants and acids. Cool. Keep in the dark. Store only if stabilized. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.... Precautions ... such as mounds around storage tanks, sills at doorways or especially designed floors /are needed/ to limit spread of escaping liquid. Open flames & other sources of ignition should be excluded where cumene is stored.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
Recommended Exposure Limit: 10 Hour Time-Weighted Average: 50 ppm (245 mg/cu m). Skin.
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | colourless liquid |
|---|---|
| Colour | Colorless liquid |
| Odour | Gasoline-like odor |
| Melting point/ freezing point | 342°C(lit.) |
| Boiling point or initial boiling point and boiling range | 155°C |
| Flammability | Class IC Flammable Liquid: Fl.P. at or above 22.78°C and below 37.78°C.Flammable. |
| Lower and upper explosion limit / flammability limit | Lower flammable limit: 0.9% by volume; Upper flammable limit: 6.5% by volume |
| Flash point | 34°C(lit.) |
| Auto-ignition temperature | 425°C (USCG, 1999) |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | 0.737 mPa.sec at 25°C |
| Solubility | Insoluble (NIOSH, 2016) |
| Partition coefficient n-octanol/water (log value) | log Kow = 3.66 |
| Vapour pressure | 8 mm Hg ( 20 °C) |
| Density and/or relative density | 0.862 |
| Relative vapour density | 4.1 (vs air) |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Volatile
10.3 Possibility of hazardous reactions
Flammable liquid.As a result of flow, agitation, etc., electrostatic charges can be generated.Mixing CUMENE in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid, oleum, NFPA 1991.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Reacts with oxidizing materials. Reacts with nitric acid and sulfuric acid with release of energy.
10.6 Hazardous decomposition products
Hazardous decomposition products: Toxic gases and vapors (such as carbon monoxide) may be released.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 2.91 g/kg
- Inhalation: LC50 Mouse inhalation 2,000 ppm/7 hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: No data were available from studies in humans. There is sufficient evidence in experimental animals for the carcinogenicity of cumene. There is sufficient evidence in experimental animals for the carcinogenicity of alpha-methylstyrene. Cumene is possibly carcinogenic to humans (Group 2B). alpha-Methylstyrene is possibly carcinogenic to humans (Group 2B).
Reproductive toxicity
No information is available on the reproductive or developmental effects of cumene in humans. Inhalation studies in rats and rabbits reported no significant adverse effects on reproduction or fetal development. No effects on sperm were observed in male rats exposed by inhalation.
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50; Species: Pimephales promelas (fathead minnow); Conditions: flow-through bioassay with measured concentrations, 25.4°C, dissolved oxygen 6.6 mg/L, hardness 44.3 mg/L calcium carbonate, alkalinity 42.1 mg/L calcium carbonate, and pH 7.58; Concentration: 6.32 mg/L for 96 hr (confidence limit 6.04-6.61 mg/L)
- Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea); Concentration: 0.6 ppm for 48 hr /Conditions of bioassay not specified
- Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green Algae); Conditions: freshwater, static; Concentration: 2600 ug/L for 72 hr; Effect: growth, general
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: Isopropylbenzene biodegradation in batch reactors proceeded following about 144 hr of acclimation and after 120 hr, isopropylbenzene was non-detectable. In unacclimated cultures, the half-life of isopropylbenzene was 206 hr (62 hr after acclimation)(1). When isopropylbenzene was incubated with an activated sludge acclimated to benzene, the theoretical BOD was reduced by 37.8% after 192 hr(2). A 20-day biological oxygen demand study was conducted using unacclimated, settled, domestic wastewater as the inoculum. After 10 and 20 days, the theoretical BOD was 62% and 70%, respectively(3). Activated sludge acclimated to aniline degraded isopropylbenzene following an acclimation period of about 30 hr(4). Activated sludge samples from three different communities were able to degrade 50 mg/L isopropylbenzene(5). A biodegradation rate constant of 0.322/day was calculated when 0.235-0.571 g/cu m isopropylbenzene was added to soil microcosms from a weathered petroleum spill site(6).
12.3 Bioaccumulative potential
A BCF of 35.5 was measured in goldfish which were exposed to isopropylbenzene at 1 mg/L(1,2). According to a classification scheme(3), this BCF value suggests the potential for bioconcentration in aquatic organisms is moderate.
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of isopropylbenzene can be estimated to be 700(SRC). According to a classification scheme(2), this estimated Koc value suggests that isopropylbenzene is expected to have low mobility in soil. A Kd value of 0.374 was reported for isopropylbenzene added at 113.1 ug/L to an anaerobic microcosm using aquifer material from Canada Forces Base Borden(3).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: UN1918 | IMDG: UN1918 | IATA: UN1918 |
14.2 UN Proper Shipping Name
| ADR/RID: ISOPROPYLBENZENE |
| IMDG: ISOPROPYLBENZENE |
| IATA: ISOPROPYLBENZENE |
14.3 Transport hazard class(es)
| ADR/RID: 3 | IMDG: 3 | IATA: 3 |
14.4 Packing group, if applicable
| ADR/RID: III | IMDG: III | IATA: III |
14.5 Environmental hazards
| ADR/RID: yes | IMDG: yes | IATA: yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| cumene | cumene | 98-82-8 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 12, 2017 |
|---|---|
| Revision Date | Aug 12, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
