1.Identification
1.1 GHS Product identifier
Product name | vinclozolin |
---|
1.2 Other means of identification
Product number | - |
---|---|
Other names | rac-(5R)-3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-1,3-oxazolidine-2,4-dione |
1.3 Recommended use of the chemical and restrictions on use
Identified uses | For industry use only. |
---|---|
Uses advised against | no data available |
1.4 Supplier's details
Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
---|---|
Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
Telephone | +86(21)64956998 |
Fax | +86(21)54365166 |
1.5 Emergency phone number
Emergency phone number | +86-400-6021-666 |
---|---|
Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Skin sensitization, Category 1
Carcinogenicity, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
Reproductive toxicity, Category 1B
2.2 GHS label elements, including precautionary statements
Pictogram(s) | ![]() ![]() ![]() |
---|---|
Signal word | Danger |
Hazard statement(s) | H317 May cause an allergic skin reaction H351 Suspected of causing cancer H411 Toxic to aquatic life with long lasting effects H360FD |
Precautionary statement(s) | |
Prevention | P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection. P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P273 Avoid release to the environment. |
Response | P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P308+P313 IF exposed or concerned: Get medical advice/ attention. P391 Collect spillage. |
Storage | P405 Store locked up. |
Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
---|---|---|---|---|
vinclozolin | vinclozolin | 50471-44-8 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms/effects, acute and delayed
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Inhalation of material may be harmful. Contact may cause burns to skin and eyes. Inhalation of Asbestos dust may have a damaging effect on the lungs. Fire may produce irritating, corrosive and/or toxic gases. Some liquids produce vapors that may cause dizziness or suffocation. Runoff from fire control may cause pollution. (ERG, 2016)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: SMALL FIRE: Dry chemical, CO2, water spray or regular foam. LARGE FIRE: Water spray, fog or regular foam. Do not scatter spilled material with high-pressure water streams. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal. FIRE INVOLVING TANKS: Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)
5.2 Specific hazards arising from the chemical
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. For UN3508, be aware of possible short circuiting as this product is transported in a charged state. (ERG, 2016)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state | Vinclozolin is a colorless crystal with a slight aromatic odor |
---|---|
Colour | Colorless crystals. |
Odour | Slight aromatic odor |
Melting point/ freezing point | 108ºC |
Boiling point or initial boiling point and boiling range | 369.9ºC at 760 mmHg |
Flammability | no data available |
Lower and upper explosion limit / flammability limit | no data available |
Flash point | >30°C |
Auto-ignition temperature | no data available |
Decomposition temperature | no data available |
pH | no data available |
Kinematic viscosity | no data available |
Solubility | In methanol 1.54, acetone 33.4, ethyl acetate 23.3, n-heptane 0.45, toluene 10.9, dichloromethane 47.5 (all in g/100 mL at 20°C). |
Partition coefficient n-octanol/water (log value) | log Kow = 3.10 |
Vapour pressure | 1.2X10-7 mm Hg at 20°C |
Density and/or relative density | 1.496 g/cm3 |
Relative vapour density | no data available |
Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Stable up to 50 degrees C. Stable in neutral and weakly acidic media.
10.3 Possibility of hazardous reactions
A halogenated dicarboximide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
no data available
10.6 Hazardous decomposition products
When heated to decomposition it emits very toxic fumes of /hydrogen chloride/ and nitrous oxides.
11.Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 10,000 mg/kg
- Inhalation: LC50 Rat inhalation > 29,100 mg/cu m over 4hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group C Possible Human Carcinogen
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill); Conditions: freshwater, static; Concentration: 47500 ug/L for 96 hr (95% confidence interval: 37100-60300 ug/L) /96.5% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, age 20 hr); Conditions: freshwater, static; Concentration: 3650 ug/L for 48 hr; Effect: intoxication, immobilization /96.5% purity
- Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae, age 7 days); Conditions: freshwater, static; Concentration: 1020 ug/L for 5 days; Effect: population abundance /98% purity
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
Vinclozolin is persistent in soil, being only partly degraded by soil microorganisms(1). When vinclozolin was applied to a previously untreated sandy loam soil (17.7% clay, 67.5% sand, 14.8% silt, pH 6.5, 1.05% organic C), less than 10% of the applied dose remained after 40 days(2). Following re-treatment at 50 days, less than 10% remained 23 days later, and when treated for the third time, less than 10% remained after just 2 days(2). In a clay loam soil (19.1% clay, 68.9% sand, 12.0% silt, pH 6.3, 0.68% organic C), times for 50% loss of the first, second, and third applications of vinclozolin were about 7, 4, and 2.5 days, respectively(2). In a third soil (8.6% clay, 75.7% sand, 15.7% silt, pH 5.0, 1.13% organic carbon), 47% of the initial dose remained after 140 days(2). When treated for the first time after pre-incubation with the fungicide, about 60% of the vinclozolin was recovered after 69 days(2). During an 80 day incubation period, only limited degradation of vinclozolin was observed in soils at pH 4.3 and 5.0(3). In soil with pH 5.7, the time for 50% loss of vinclozolin was about 75 days; times for 50% degradation following the first, second, and third application of vinclozolin were 70, 30, and 6 days, respectively(3). In soil with pH 6.5, the times for 50% degradation following the first, second, and third applications were 30, 22, and 7 days, respectively(3). After 14 days incubation in soil with no pretreatment, and soil pretreated with iprodione, vinclozolin, myclozolin, and procymidone, the concentration of vinclozolin was 5.45, 5.50, 0.05, 5.39, and 5.45 mg/kg, respectively; after 28 days the concentration of vinclozolin was 2.44, 2.44, 1.89, 0, 2.37, and 2.31 mg/kg, respectively(4). In Patumahoe clay loam, the time for 50% loss of vinclozolin following the first, second, and third soil application of the fungicide was 22, 3.5, and 1 days, respectively(5). For five different types of field soil (clay loam, silt loam, loam, sandy loam and sandy clay loam) ranging in pH from 7.98 to 8.35, 90% degradation was reached after one, two and three applications of vinclozolin in approximately 35, 21 and 7 days, respectively(6).
12.3 Bioaccumulative potential
One study predicted worst-case BCF values in fish for vinclozolin of 60 and 1,260(1), respectively, on a wet weight basis with 5% lipid, and on a lipid basis predicted from the log Kow of 3.10(2) if no metabolism occurs or is negligible(1). Another study calculated a BCF range of 78 to 112(3). An estimated BCF of 52 was calculated in fish for vinclozolin(SRC), using a log Kow of 3.10(2) and a regression-derived equation(4). According to a classification scheme(5), these BCF data suggest the potential for bioconcentration in aquatic organisms is moderate to very high(SRC), provided the compound is not metabolized by the organism(SRC).
12.4 Mobility in soil
In laboratory tests, vinclozolin migrated through Ottowa sand more deeply compared to aquatic hapludult soil, where all vinclozolin mass was retained in the upper 5 cm under high (6.7 mm) and low (3.1 mm) rain events(1). One review suggested Koc values range from 100 to 735(2). A Koc value of 1,570 was determined in a Chalmers silty clay loam(3). According to a classification scheme(4), these disparate Koc values suggest that vinclozolin is expected to range from low to high mobility in soil.
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN3077 | IMDG: UN3077 | IATA: UN3077 |
14.2 UN Proper Shipping Name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. |
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. |
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. |
14.3 Transport hazard class(es)
ADR/RID: 9 | IMDG: 9 | IATA: 9 |
14.4 Packing group, if applicable
ADR/RID: III | IMDG: III | IATA: III |
14.5 Environmental hazards
ADR/RID: yes | IMDG: yes | IATA: yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name | Common names and synonyms | CAS number | EC number |
---|---|---|---|
vinclozolin | vinclozolin | 50471-44-8 | none |
European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
EC Inventory | Listed. | ||
United States Toxic Substances Control Act (TSCA) Inventory | Not Listed. | ||
China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
New Zealand Inventory of Chemicals (NZIoC) | Not Listed. | ||
Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
Vietnam National Chemical Inventory | Not Listed. | ||
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
16.Other information
Information on revision
Creation Date | Aug 11, 2017 |
---|---|
Revision Date | Aug 11, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/