Name:	Arsenic Trioxide Material Safety Data Sheet
Synonym:	Arsenic Oxide; Arsenic Sesquioxide; Arsenous Oxide; Arsenous Acid Anhydride; Arsenous Acid
CAS:	1327-53-3

Section 1 - Chemical Product MSDS Name: Arsenic Trioxide Material Safety Data Sheet
Synonym: Arsenic Oxide; Arsenic Sesquioxide; Arsenous Oxide; Arsenous Acid Anhydride; Arsenous Acid

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SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1327-53-3	Arsenic trioxide	100.0	215-481-4

Hazard Symbols: T+ N
Risk Phrases: 28 34 45 50/53

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SECTION 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Very toxic if swallowed. Causes burns. May cause cancer. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Potential Health Effects
Eye:
Contact produces irritation, tearing, and burning pain. May cause conjunctivitis.
Skin:
Causes irritation with burning pain, itching, and redness. May cause dermatitis. Exposure to arsenic compounds may produce hyperpigmentation of the skin and hyperkeratoses of plantar and palmar surfaces as well as both primary irritation and sensitization types.
Ingestion:
May be fatal if swallowed. Causes severe digestive tract burns with abdominal pain, vomiting, and possible death. May cause hemorrhaging of the digestive tract. Ingestion of arsenical compounds may cause burning of the lips, throat constriction, swallowing difficulties, severe abdominal pain, severe nausea, projectile vomiting, and profuse diarrhea. Ingestion of arsenic compounds can produce convulsions, coma, and possibly death within 24 hours.
Inhalation:
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema. Inhalation of arsenic compounds may lead to irritation of the respiratory tract and to possible nasal perforation. Long-term exposure to arsenic compounds may produce impairment of peripheral circulation.
Chronic:
May cause liver and kidney damage. Chronic inhalation may cause nasal septum ulceration and perforation. May cause anemia and other blood cell abnormalities. Chronic skin effects include: cracking, thickening, pigmentation, and drying of the skin. Arsenic trioxide can cause cancer in humans. Other long term effects include: anemia, liver and kidney damage. Chronic exposure to arsenical dust may cause shortness of breath, nausea, chest pains, and garlic odor.

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SECTION 4 - FIRST AID MEASURES
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:

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SECTION 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use extinguishing media appropriate to the surrounding fire. Substance is noncombustible.
Extinguishing Media:
Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. Do NOT get water inside containers.

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SECTION 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Do not get water inside containers.

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SECTION 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Do not allow contact with water. Use only with adequate ventilation or respiratory protection.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not store in metal containers.

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SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. See 29CFR 1910.1018 for regulatory requirements pertaining to all occupational exposures to inorganic arsenic. Exposure Limits CAS# 1327-53-3: United Kingdom, WEL - TWA: (listed as arsenic compounds, n.o.s.): mg/m3 TWA (except arsine, as As) United Kingdom, WEL - STEL: (listed as arsenic compounds, n.o.s.) 0.3 mg/m3 STEL (except arsine, as As)
United States OSHA: 0.5 mg/m3 TWA (listed under Arsenic).5 g/m3 Action Level (as As); 10 g/m3 PEL (as As. Cancer hazard - see 2 CFR 1 910.1018. Arsine excepted) (listed under Arsenic, inorgani compounds). Belgium - TWA: (listed as arsenic, inorganic compounds): 0.01 mg/ VLE (as As) France - VME: 0.2 mg/m3 VME (as As)
Germany: 0.1 mg/m3 TWA (inhalable fraction)
Japan: (listed as arsenic compounds, n.o.s.): 3 g/m3 OEL (refere value, as As)
Malaysia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 TW (as As, except arsine)
Netherlands: (listed as arsenic, inorganic compounds): 0.1 mg/m3 (as As)
Netherlands: (listed as arsenic, inorganic compounds): 0.050 mg/m MAC (as As)
Russia: (listed as arsenic, inorganic compounds): 0.04 mg/m3 TWA As)
Russia: (listed as arsenic, inorganic compounds): 0.01 mg/m3 STEL As)
Spain: 0.1 mg/m3 VLA-ED (as As) Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Color: white
Odor: odorless
pH: Not available.
Vapor Pressure: 66 mm Hg @ 312C
Viscosity: Not available.
Boiling Point: 465 deg C
Freezing/Melting Point: 312 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: 3.7% in water.
Specific Gravity/Density: 3.738
Molecular Formula: As2O3
Molecular Weight: 197.8414

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SECTION 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, moisture, metals, excess heat.
Incompatibilities with Other Materials:
Incompatible with chlorine trifluoride, fluorine, hydrogen fluoride, oxygen difluoride, and sodium chlorate. Can generate arsine, which is an extremely poisonous gas, when arsenic compounds contact acid, alkalies, or water in the presence of an active metal (zinc, aluminum, magnesium, manganese, sodium, iron, etc).
Hazardous Decomposition Products:
Irritating and toxic fumes and gases, oxides of arsenic, arsine.
Hazardous Polymerization: Has not been reported.

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SECTION 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 1327-53-3: CG3325000
LD50/LC50:
CAS# 1327-53-3: Oral, mouse: LD50 = 20 mg/kg; Oral, rabbit: LD50 = 20190 ug/kg; Oral, rat: LD50 = 10 mg/kg.
Carcinogenicity:
Arsenic trioxide -
California: carcinogen, initial date 2/27/87 (listed as Arsenic, inorg
NTP: Known carcinogen (listed as Arsenic, inorganic compounds).
IARC: Group 1 carcinogen (listed as Arsenic).
Other:
See actual entry in RTECS for complete information.

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SECTION 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Water flea Daphnia: LC50 = 0.038 mg/L; 24 Hr.; UnspecifiedBacteria:
Phytobacterium phosphoreum: EC50 = 31.43-73.73 mg/L; 5,15,30 minutes; Microtox test

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SECTION 13 - DISPOSAL CONSIDERATIONS Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

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SECTION 14 - TRANSPORT INFORMATION IATA
Shipping Name: ARSENIC TRIOXIDE
Hazard Class: 6.1
UN Number: 1561
Packing Group: II IMO
Shipping Name: ARSENIC TRIOXIDE
Hazard Class: 6.1
UN Number: 1561
Packing Group: II RID/ADR
Shipping Name: ARSENIC TRIOXIDE
Hazard Class: 6.1
UN Number: 1561
Packing group: II
USA RQ: CAS# 1327-53-3: 1 lb final RQ; 0.454 kg final RQ

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SECTION 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives
Hazard Symbols: T+ N
Risk Phrases:
R 45 May cause cancer. R 28 Very toxic if swallowed. R 34 Causes burns. R 50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions before use. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S 60 This material and its container must be disposed of as hazardous waste. S 61 Avoid release to the environment. Refer to special instructions/safety data sheets. WGK (Water Danger/Protection) CAS# 1327-53-3: 3 Canada CAS# 1327-53-3 is listed on Canada's DSL List. CAS# 1327-53-3 is listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 1327-53-3 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
MSDS Creation Date: 6/21/1999 Revision #5 Date: 1/03/2003 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages.

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SECTION 16 - ADDITIONAL INFORMATION
N/A