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SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Ziprasidone    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

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SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 2), H225
    Skin irritation (Category 2), H315
    Reproductive toxicity (Category 1B), H360FD
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    F Highly flammable        R11    
    R19
    T Toxic        R60    
    T Toxic        R61    
    Xi Irritant        R38    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Danger    
    Hazard statement(s)
    H225        Highly flammable liquid and vapour.    
    H315        Causes skin irritation.    
    H360FD        May damage fertility. May damage the unborn child.    
    Precautionary statement(s)
    P201        Obtain special instructions before use.    
    P210        Keep away from heat/sparks/open flames/hot surfaces. - No smoking.    
    P308 + P313        IF exposed or concerned: Get medical advice/ attention.    
    Supplemental Hazard information (EU)
    EUH019        May form explosive peroxides.    
    Restricted to professional users.
  According to European Directive 67/548/EEC as amended.
    Hazard symbol(s)        F Highly flammable    
    T Toxic
    R-phrase(s)
    R60        May impair fertility.    
    R61        May cause harm to the unborn child.    
    R11        Highly flammable.    
    R19        May form explosive peroxides.    
    R38        Irritating to skin.    
    S-phrase(s)
    S53        Avoid exposure - obtain special instructions before use.    
    S45        In case of accident or if you feel unwell, seek medical advice immediately    
    (show the label where possible).
    Restricted to professional users.
  Other hazards - none

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SECTION 3: Composition/information on ingredients
  Mixtures
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Ethylene glycol dimethyl ether Included in the Candidate List of Substances of Very High Concern
    (SVHC) according to Regulation (EC) No. 1907/2006 (REACH)
    CAS-No.        110-71-4        Flam. Liq. 2; Skin Irrit. 2; Repr. 50 - 100 %    
    EC-No.        203-794-9        1B; H225, H315, H360FD,    
    Index-No.        603-031-00-3        EUH019    
    Registration number 01-2119485981-24-XXXX
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Ethylene glycol dimethyl ether Included in the Candidate List of Substances of Very High Concern
    (SVHC) according to Regulation (EC) No. 1907/2006 (REACH)
    CAS-No.        110-71-4        F, T, Repr.Cat.2, Repr.Cat.2, 50 - 100 %    
    EC-No.        203-794-9        R60 - R61 - R11 - R19 - R38    
    Index-No.        603-031-00-3    
    Registration number 01-2119485981-24-XXXX
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

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SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Flush eyes with water as a precaution.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

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SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    no data available
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

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SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
    Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
    form explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

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SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation
    of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
    Recommended storage temperature: -20 °C
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
  Body Protection
    impervious clothing, Flame retardant antistatic protective clothing, The type of protective
    equipment must be selected according to the concentration and amount of the dangerous
    substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

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SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid    
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        no data available    
    point
    f) Initial boiling point and 85 °C at 1,013 hPa
    boiling range
    g) Flash point        40 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        Upper explosion limit: 19 %(V)    
    flammability or        Lower explosion limit: 12 %(V)    
    explosive limits
    k) Vapour pressure        no data available    
    l) Vapour density        no data available    
    m) Relative density        0,867 g/cm3 at 20 °C    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Auto-ignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

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SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks. Exposure to sunlight.
    Heat, flames and sparks. Extremes of temperature and direct sunlight.
  Incompatible materials
    Alkali metals, Aluminum, Strong oxidizing agents, Bases, Amines, Magnesium, Strong acids and strong
    bases, Vinyl compounds
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

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SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    no data available
  Skin corrosion/irritation
    no data available
  Serious eye damage/eye irritation
    no data available
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: Not available
    Dichloromethane is metabolized in the body producing carbon monoxide which increases and sustains
    carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity of the blood., Acts as a
    simple asphyxiant by displacing air., anesthetic effects, Difficulty in breathing, Headache, Dizziness,
    Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:,
    Redness, Blurred vision, Provokes tears., Effects due to ingestion may include:, Gastrointestinal
    discomfort, Central nervous system depression, Paresthesia., Drowsiness, Convulsions, Conjunctivitis.,
    Pulmonary edema. Effects may be delayed., Irregular breathing., Stomach/intestinal disorders, Nausea,
    Vomiting, Increased liver enzymes., Weakness, Heavy or prolonged skin exposure may result in the
    absorption of harmful amounts of material., Abdominal pain

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SECTION 12: Ecological information
  Toxicity
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    no data available

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SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
    company.
  Contaminated packaging
    Dispose of as unused product.

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SECTION 14: Transport information
  UN number
    ADR/RID: 2252        IMDG: 2252        IATA: 2252    
  UN proper shipping name
    ADR/RID: 1,2-DIMETHOXYETHANE, SOLUTION
    IMDG: 1,2-DIMETHOXYETHANE, SOLUTION
    IATA:        1,2-Dimethoxyethane, SOLUTION    
  Transport hazard class(es)
    ADR/RID: 3        IMDG: 3        IATA: 3    
  Packaging group
    ADR/RID: II        IMDG: II        IATA: II    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available

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SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
  Authorisations and/or restrictions on use
    Ethylene glycol dimethyl ether        CAS-No.: 110-71-4    
    Candidate List of Substances of Very High Concern for Authorisation
    Toxic for reproduction (article 57c)
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

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SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    EUH019        May form explosive peroxides.    
    Flam. Liq.        Flammable liquids    
    H225        Highly flammable liquid and vapour.    
    H315        Causes skin irritation.    
    H360FD        May damage fertility. May damage the unborn child.    
    Repr.        Reproductive toxicity    
    Skin Irrit.        Skin irritation    
  Full text of R-phrases referred to under sections 2 and 3
    F        Highly flammable    
    T        Toxic    
    R11        Highly flammable.    
    R19        May form explosive peroxides.    
    R38        Irritating to skin.    
    R60        May impair fertility.    
    R61        May cause harm to the unborn child.    
    Repr.Cat.2        Toxic to Reproduction Category 2    
  Further information
    Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
    only.
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.