1.Identification
1.1 GHS Product identifier
| Product name | fenamiphos |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | Fenamiphos PESTANAL(R),analytical standard |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | For industry use only. |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | MOLBASE (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Address | Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road, Xuhui District, Shanghai, China |
| Telephone | +86(21)64956998 |
| Fax | +86(21)54365166 |
1.5 Emergency phone number
| Emergency phone number | +86-400-6021-666 |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 2
Acute toxicity - Dermal, Category 2
Eye irritation, Category 2
Acute toxicity - Inhalation, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |   |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H300 Fatal if swallowed H310 Fatal in contact with skin H319 Causes serious eye irritation H330 Fatal if inhaled H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P262 Do not get in eyes, on skin, or on clothing. P280 Wear protective gloves/protective clothing/eye protection/face protection. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. P273 Avoid release to the environment. |
| Response | P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P310 Immediately call a POISON CENTER/doctor/… P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P320 Specific treatment is urgent (see ... on this label). P391 Collect spillage. |
| Storage | P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed. |
| Disposal | P501 Dispose of contents/container to ... |
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| fenamiphos | fenamiphos | 22224-92-6 | none | 100% |
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
This material is highly toxic orally, by inhalation, and by absorption through the skin. (Non-Specific -- Parathion) Death may occur from respiratory failure. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
A comatose patient who is diaphoretic, has pinpoint pupils and the odor of an insecticide on clothing or breath, and is noted to have muscle fasciculations represents the classic presentation of organophosphate poisoning. ... Specific steps in management include the following. 1. Decontamination. ... 2. Airway. Establish an airway if necessary. ... 3. Respiratory Status. Respiratory distress, in fact, is commonly found in these patients from multiple causes. ... 4. Cardiac Monitoring. ... 5. Cholinesterase Level. ... 6. Pralidoxime. Pralidoxime is the treatment of choice for organophosphate poisoning and should be used for nearly all patients with clinically significant organophosphate poisoning, particularly those patients with muscular fasciculations and weakness. ... 7. Atropine. Atropine is the physiologic antidote for organophosphate poisoning. A trial dose of atropine should be instituted on clinical ground when one suspects organophosphate intoxication. /Organophosphate poisoning/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. /Organophosphorus pesticides, liquid, flammable, toxic; Organophosphorus pesticides, liquid, toxic/
5.2 Specific hazards arising from the chemical
(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases. Emits toxic fumes of nitrogen oxides, phosphorus oxides, and sulfur oxides when heated to decomposition. (EPA, 1998)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. /Organophosphorus pesticides, liquid, flammable, toxic; Organophosphorus pesticides, liquid, toxic; Organophosphorus pesticides, solid, toxic/
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed.Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
Recommended Exposure Limit: 10 Hour Time-Weighted Average: 0.1 mg/cu m, skin.
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
| Physical state | Brown waxy solid or colorless solid |
|---|---|
| Colour | Colorless crystals |
| Odour | no data available |
| Melting point/ freezing point | 49ºC |
| Boiling point or initial boiling point and boiling range | 375.6ºC at 760 mmHg |
| Flammability | Combustible. Liquid formulations containing organic solvents may be flammable. |
| Lower and upper explosion limit / flammability limit | no data available |
| Flash point | 100°C |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | In water:0.07 g/100 mL |
| Partition coefficient n-octanol/water (log value) | log Kow = 3.23 |
| Vapour pressure | 7.67E-06mmHg at 25°C |
| Density and/or relative density | 1.14 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
In laboratory conditions, fenamiphos is stable at pH 5-7.
10.3 Possibility of hazardous reactions
Flash point data for this compound are not available, however, it is probably combustible.Organothiophosphates, such as FENAMIPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
May hydrolyze under alkaline conditions.
10.6 Hazardous decomposition products
When heated to decomposition it emits very toxic fumes of /phosphorous, nitric and sulfur oxides/.
11.Toxicological information
Acute toxicity
- Oral: LD50 Mouse oral 22.7 mg/kg
- Inhalation: LC50 Rat inhalation 91 mg/cu m/ 4hr
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Cancer Classification: Group E Evidence of Non-carcinogenicity for Humans
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill) weight 2.5 g; Conditions: freshwater, flow through; Concentration: 4.5 ug/L for 96 hr (95% confidence interval: 3.8-5 ug/L) /36% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: flow through; Concentration: 1.9 ppb for 48 hr; Effect: immobilization /88.7% ai
- Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green Algae) exponential growth phase; Conditions: freshwater, static, 25°C; Concentration: 38490 ug/L for 96 hr; Effect: population biomass, growth inhibition /100% purity
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: Fenamiphos is rapidly degraded in soil by microbial processes(SRC). Within 21 days of field application, 74% of the initially applied fenamiphos was transformed to fenamiphos sulfoxide(1). Only trace quantities of fenamiphos were present after this time period (degradation rate of 0.33/day, half-life 2.1 days)(1). 55 Days following application of 14C-fenamiphos to control soil, 5.4% was fenamiphos, 54.6% was fenamiphos sulfoxide, 15.9% was fenamiphos sulfone, 5% was present as other products, 10.6% was present as volatiles and 14C-CO2, and 8.5% was unextractable(1). Degradation half-lives for fenamiphos in four surface soils ranged from 6 to 11 days and 4 to 10 days in the same soils with subsurface collection (60-80 cm)(2). In soils exposed to repeated applications of fenamiphos, observed increased rates of degradation of fenamiphos were 10 to 20 times higher than untreated soil(3). Degradation rates of up to 35 ug/mg microbial carbon per week were observed for fenamiphos after 4 applications while for untreated soil the rate was 2 ug/mg microbial carbon per week(3). Soil which had received annual applications of fenamiphos for 15 yrs was able to degrade fenamiphos in one day verses three days for non-treated soil(4). Fenamiphos mineralization was <9% over 63 days measured in soils which had no prior application of fenamiphos(5). During a 70 day incubation period, 67.2, 27.8, and 9.8% of applied 14C-fenamiphos was mineralized in soil samples collected 2, 3, and 4 yrs after a previous field application, while 10.8, 11.5, and 9.5% of applied 14C-fenamiphos in the respective corresponding control samples was mineralized(6). In a laboratory incubation study, fenamiphos was reported to biodegrade with half-lives of 24 and 72 days for surface and subsurface soils, respectively, while the metabolites of fenamiphos were reported to biodegrade with half-lives of 26 and 119 days for surface and subsurface soils, respectively(7). In a related study, field half-lives for fenamiphos and its metabolites were reported to be 43 and 98 days, respectively(7). In a laboratory study, the half-lives of fenamiphos and its metabolites (total residues) in soils from temperate and tropic/subtropic regions were 72 and 55 days, respectively(8).
12.3 Bioaccumulative potential
Fenamiphos does not bioaccumulate in fish (species non-specified) to any appreciable extent and any residues taken up by fish are quickly depurated when fish are no longer exposed to the residues(1). After 28 days of exposure, the avg measured BCF were 21 and 61 for fillet and whole fish, respectively(1). The maximum BCF measured for fenamiphos residues were 89 for whole fish and 24 for fillet tissue(1). During the 14-day depuration period, more than 95% of the accumulated 14C-fenamiphos residues depurated(1). According to a classification scheme(2), BCFs ranging from 21 to 89(1) suggest that for bioconcentration in aquatic organisms is moderate(SRC). A BCF for fenamiphos of 468 was measured in earthworms(3).
12.4 Mobility in soil
Koc values of fenamiphos in an Arredondo sand (0.80% organic carbon; pH 6.8; 93.8% sand), a Cecil sandy loam (0.90% organic carbon; pH 5.6; 65.8% sand, 19.5% silt, 14.7% clay), and a Webster silty clay loam (3.97% organic carbon; pH 7.3; 18.4% sand, 45.3% silt, 38.3% clay) were 148, 197, and 249, respectively(1). In soil column leaching studies, fenamiphos was most strongly retained in the Webster soil(1). Fenamiphos had a measured Koc value of 190 in a Batcombe soil (3.53% organic matter; pH 6.1)(2). Adsorption of fenamiphos was measured in four surface and subsurface soils from Hawaii; Koc values were 94 to 344 (organic carbon content 1.3-6.22%; pH 5.3-6.7) measured in surface soil and values of 73 to 202 were measured in subsoil (60-80 cm below surface; organic carbon content 0.55-3.19%; pH 5.3-6.8)(3). A Koc of 370 was measured for Molokai silty clay loam (pH 5.8; 1.2% organic carbon)(4). Adsorption of fenamiphos was measured on five European soils; Koc values were 1686 in clay soil (1.3% organic matter), 178.5 in silt loam (3.7% organic matter), 218.5 in loam (3.45 % organic matter), 207.6 in silt (1.55% organic matter), and 935.7 in loamy sand (9.25% organic matter)(5). Fenamiphos had Koc values of 585 (75.0% clay, 3.29% organic carbon), 290 (22.6% clay, 2.39% organic carbon), 210 (17.0% clay, 3.32% organic carbon), 200 (20.3% clay, 1.36% organic carbon) and 1100 (6.0% clay, 4.43% organic carbon) in five European soils(6). According to a classification scheme(7), Koc values of 73 to 148(1,3) have high mobility in soil, Koc values ranging from 190 to 370(1-6) have moderate mobility in soil, and Koc values of 585 to 1686(5-6) have low mobility in soil, suggesting that mobility is very dependent on soil characteristics(SRC).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1 UN Number
| ADR/RID: UN2811 | IMDG: UN2811 | IATA: UN2811 |
14.2 UN Proper Shipping Name
| ADR/RID: TOXIC SOLID, ORGANIC, N.O.S. |
| IMDG: TOXIC SOLID, ORGANIC, N.O.S. |
| IATA: TOXIC SOLID, ORGANIC, N.O.S. |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 | IMDG: 6.1 | IATA: 6.1 |
14.4 Packing group, if applicable
| ADR/RID: I | IMDG: I | IATA: I |
14.5 Environmental hazards
| ADR/RID: yes | IMDG: yes | IATA: yes |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| fenamiphos | fenamiphos | 22224-92-6 | none |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Not Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Not Listed. | ||
| Vietnam National Chemical Inventory | Not Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
16.Other information
Information on revision
| Creation Date | Aug 13, 2017 |
|---|---|
| Revision Date | Aug 13, 2017 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
