maleic hydrazide

CAS No. 123-33-1

Formula: C4H4N2O2
Basic Info

Maleic Hydrazide is used in plant growth regulator formulations.

Formula
C4H4N2O2
Molecular Weight
112.087
Exact Mass
112.027
LogP
-0.9368
PSA
65.72
Synonyms

Maleic Hydrazide

1,2-dihydropyridazine-3,6-dione

MH-40

Pyridazine-3,6-diol

MG-T

1,2-Dihydro-3,6-pyridazinedione

Fazor

Yadi

gotax

3,6-Pyridazinedione, 1,2-dihydro-

MH-30

maleic hydrazine

3,6-dioxo-1,2,3,6-tetrahydropyridazine

3,6-Pyridazinediol

Yake

Bos MH

6-hydroxy-2H-pyridazin-3-one

KMH

Maleic Acid Hydrazide

3,6-Dihydroxypyridazine

1,2-Dihydro-3,6-pyridazinedione,3,6-Dihydroxypyridazine,3,6-Pyridazinediol

1,2,3,6-tetrahydro-3,6-dioxopyridazine

1,2-dihydro 3,6-pyridazinedione

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Properties
Appearance & Physical State
white cystals
Density
1.6
Boiling Point
477.2ºC at 760mmHg
Melting Point
306-308ºC
Flash Point
300°C
Refractive Index
1.649
Water Solubility
6 g/L
Stability
Stable under normal temperatures and pressures.
Storage Condition
0-6ºC
Vapor Pressure
0.289mmHg at 25°C
Safety Info
RTECS
UR5950000
Safety Statements
S26-S36/37/39-S45
WGK Germany
2
Risk Statements
R36/37/38; R40
HS Code
2928000090
RIDADR
UN 3077
Caution Statement
P261; P281; P305 + P351 + P338
Hazard Codes
Hazard Declaration
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name maleic hydrazide

1.2 Other means of identification

Product number -
Other names 1,2,3,6-tetrahydro-3,6-dioxopyridazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Not classified.

2.2 GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word.

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
maleic hydrazide maleic hydrazide 123-33-1 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

Inhalation of dust causes irritation of nose and throat. Contact with eyes or skin causes irritation. Ingestion has been observed to cause tremors and muscle spasms in test animals. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry, sterile dressings after decontamination ... . /Hydrazine and Related Compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Extinguish with water, dry chemicals, foam or carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic nitrogen oxides are produced. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Ventilate area of spill or leak. Collect for reclamation, or absorb in vermiculite, dry sand, earth, or a similar material.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

De-Cut, Fair Plus, Super De-sprout have indefinite shelf life and should be stored at room temp.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state white cystals
Colour Crystals from water
Odour Odorless
Melting point/ freezing point 142°C(lit.)
Boiling point or initial boiling point and boiling range 123°C/10mmHg(lit.)
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 300°C
Auto-ignition temperature 375°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:6 g/L
Partition coefficient n-octanol/water (log value) log Kow= -0.68 pH = 5; -1.96 at pH = 7; -2.41 at pH = 9
Vapour pressure 0.289mmHg at 25°C
Density and/or relative density 1.6
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Very stable to both acidic & basic hydrolysis.

10.3 Possibility of hazardous reactions

MALEIC HYDRAZIDE can be decomposed by oxidizing agents. It can also be decomposed by strong acids. It forms water-soluble alkali-metal and amine salts. It is slightly acidic and may be titrated as a monobasic acid. Mild oxidation produces a compound which reacts instantly with dienes at -41.67°C to form crystalline derivatives. This chemical is slightly corrosive to iron and zinc. It is incompatible with pesticides that are highly alkaline in reaction. In the presence of heavy metal and iron, zinc, calcium and magnesium ions, sparingly-soluble salts are formed.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

If in presence of strong acid, maleic hydrazide acid may precipitate. Do not use concentrate through brass nozzles as the amine content may cause erosion.

10.6 Hazardous decomposition products

When heated to decomposition it emits highly toxic fumes of /nitrogen oxides/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral >5000 mg/kg
  • Inhalation: LC50 Rat inhalation >20 mg/L/1 hr
  • Dermal: LD50 Rabbit percutaneous >5000 mg/kg

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Cancer Classification: Group E Evidence of Non-carcinogenicity for Humans

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50 Lepomis macrochirus (Bluegill) 1608 mg/L/96 hr /Conditions of bioassay not specified
  • Toxicity to daphnia and other aquatic invertebrates: LC50 Daphnia magna 107.5 ppm /Technical maleic hydrazide, 90% ai
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

... MALEIC HYDRAZIDE CAN SERVE AS SOLE SOURCE OF CARBON & NITROGEN FOR NUMBER OF MICROORGANISMS & ... IS VERY SUBJECT TO BACTERIAL DECOMP IN SOIL ... .

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated for maleic hydrazide(SRC), using a log Kow of -1.96 (1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The reported Koc of maleic hydrazide was 264 for a clay soil, and 23 for a sand(1). Based on a classification scheme(2), these Koc values suggest that maleic hydrazide has very high to moderate mobility in soil(SRC). In a field experiment in which 5 and 10 kg/ha of maleic hydrazide were applied, the hydrazide did not migrate below a depth of 10 cm(3). This may be due to extensive biodegradation of maleic hydrazide(3). Maleic hydrazide was shown to bind to the clay component in Aiken clay loam where anion exchange is the predominant process(4). In a study of the adsorption of maleic hydrazide in 22 different soils, adsorption was most significantly correlated to specific surface area, clay content, and pH(5). The lack of correlation of adsorption with organic content of the soils may have been partly caused by the low organic content of the soils studied (<2%)(5). Adsorption of the herbicide ranged from high to low(5). Based upon the above information, maleic hydrazide may generally be expected to be mobile in soils with low clay content and relatively immobile in soils with high clay content. The mobility also may be affected by pH and specific surface area of the soils(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN3428 IMDG: UN3428 IATA: UN3428

14.2 UN Proper Shipping Name

ADR/RID: 3-CHLORO-4-METHYLPHENYL ISOCYANATE, SOLID
IMDG: 3-CHLORO-4-METHYLPHENYL ISOCYANATE, SOLID
IATA: 3-CHLORO-4-METHYLPHENYL ISOCYANATE, SOLID

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
maleic hydrazide maleic hydrazide 123-33-1 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: 3 6-Dihydroxypyridazine 99% Material Safety Data Sheet
Synonym: Maleic Acid Hydrazide; Maleic Hydrazide; 3,6-Pyridazinedio
CAS: 123-33-1
Section 1 - Chemical Product   MSDS Name:3 6-Dihydroxypyridazine 99% Material Safety Data Sheet
Synonym:Maleic Acid Hydrazide; Maleic Hydrazide; 3,6-Pyridazinedio

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
123-33-1 3,6-Dihydroxypyridazine, 99% 204-619-9
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Dust may cause mechanical irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. May cause central nervous system effects.
Inhalation:
Dust is irritating to the respiratory tract.
Chronic:
Chronic ingestion may cause liver damage.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid if irritation or symptoms occur.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 123-33-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystals
Color: white
Odor: odorless
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 306.00 - 308.00 deg C
Autoignition Temperature: 430 deg C ( 806.00 deg F)
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 1.60@25C
Molecular Formula: Not applicable.
Molecular Weight: 112.09

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, slightly corrosive to iron and zinc.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, pesticides which are highly alkaline in reaction.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 123-33-1: UR5950000 LD50/LC50:
CAS# 123-33-1: Inhalation, rat: LC50 = >20 gm/m3; Oral, rat: LD50 = 3800 mg/kg; Skin, rabbit: LD50 = >4 gm/kg.
Carcinogenicity:
3,6-Dihydroxypyridazine, 99% - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
USA RQ: CAS# 123-33-1: 5000 lb final RQ; 2270 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 123-33-1: No information available.
Canada
CAS# 123-33-1 is listed on Canada's DSL List.
CAS# 123-33-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 123-33-1 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 90 MHz in DMSO-d6
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IR Spectrum IR : nujol mull
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Mass Spectrum Mass spectrum (electron ionization)
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Raman Spectrum Raman : 4880 A,200 M,powder
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ESR Spectrum ESR : TI(III) COMPLEX, IN TOLUENE/BENZENE, 77K
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Synthesis Route
1.Synthesis Route
2.Synthesis Route
3.Synthesis Route
Toxicity
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
3800 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970
ACUTE TOXICITY DATA
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Type of Test
LC50 - Lethal concentration, 50 percent kill
Exposure Route
Inhalation
Species Observed
Rodent - rat
Dose/Duration
>20 gm/m3
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,526,1991
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Administration onto the skin
Species Observed
Rodent - rabbit
Dose/Duration
>4 gm/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970

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