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SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : (Trimethylsilyl)diazomethane solution    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

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SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 2), H225
    Acute toxicity, Inhalation (Category 1), H330
    Skin irritation (Category 2), H315
    Carcinogenicity (Category 1B), H350
    Reproductive toxicity (Category 2), H361f
    Specific target organ toxicity - single exposure, Inhalation (Category 1), Lungs, H370
    Specific target organ toxicity - single exposure (Category 3), H336
    Aspiration hazard (Category 1), H304
    Chronic aquatic toxicity (Category 2), H411
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    T Toxic        R45    
    F Highly flammable        R11    
    T+ Very toxic        R26    
    Xi Irritant        R38    
    T+ Very toxic        R39/26    
    Xn Harmful        R62    
    Xn Harmful        R65    
    R67
    N Dangerous for the        R51/53    
    environment
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Danger    
    Hazard statement(s)
    H225        Highly flammable liquid and vapour.    
    H304        May be fatal if swallowed and enters airways.    
    H315        Causes skin irritation.    
    H330        Fatal if inhaled.    
    H336        May cause drowsiness or dizziness.    
    H350        May cause cancer.    
    H361f        Suspected of damaging fertility.    
    H370        Causes damage to organs.    
    H411        Toxic to aquatic life with long lasting effects.    
    Precautionary statement(s)
    P201        Obtain special instructions before use.    
    P210        Keep away from heat/sparks/open flames/hot surfaces. - No smoking.    
    P260        Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.    
    P273        Avoid release to the environment.    
    P281        Use personal protective equipment as required.    
    P284        Wear respiratory protection.    
    Supplemental Hazard        none    
    Statements
    Restricted to professional users.
  According to European Directive 67/548/EEC as amended.
    Hazard symbol(s)        F Highly flammable    
    T+ Very toxic
    N Dangerous for the environment
    R-phrase(s)
    R45        May cause cancer.    
    R11        Highly flammable.    
    R26        Very toxic by inhalation.    
    R38        Irritating to skin.    
    R39/26        Very toxic: danger of very serious irreversible effects through inhalation.    
    R62        Possible risk of impaired fertility.    
    R65        Harmful: may cause lung damage if swallowed.    
    R67        Vapours may cause drowsiness and dizziness.    
    R51/53        Toxic to aquatic organisms, may cause long-term adverse effects in the    
    aquatic environment.
    S-phrase(s)
    S53        Avoid exposure - obtain special instructions before use.    
    S28        After contact with skin, wash immediately with plenty of water.    
    S36/37        Wear suitable protective clothing and gloves.    
    S45        In case of accident or if you feel unwell, seek medical advice immediately    
    (show the label where possible).
    S61        Avoid release to the environment. Refer to special instructions/ Safety    
    data sheets.
    S62 If swallowed, do not induce vomiting: seek medical advice immediately
    and show this container or label.
    Caution - this mixture contains a substance not yet fully tested.
    Restricted to professional users.
  Other hazards
    Preliminary data indicates this product may be highly toxic or fatal if inhaled., Inhalation may provoke the
    following symptoms:, pulmonary edema, Symptoms may be delayed for hours after exposure.

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SECTION 3: Composition/information on ingredients
  Mixtures
    Formula        : C4H10N2Si    
    Molecular Weight        : 114,22 g/mol    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  n-Hexane
    CAS-No.        110-54-3        Flam. Liq. 2; Skin Irrit. 2; Repr. 50 - 100 %    
    EC-No.        203-777-6        2; STOT SE 3; STOT RE 2;    
    Index-No.        601-037-00-0        Asp. Tox. 1; Aquatic Chronic    
    2; H225, H304, H315, H336,
    H361f, H373, H411
  (Trimethylsilyl)diazomethane
    CAS-No.        18107-18-1        Acute Tox. 2; Carc. 1B; STOT 25 - 50 %    
    SE 1; H330, H350, H370
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  n-Hexane
    CAS-No.        110-54-3        F, Xn, N, Repr.Cat.3, R11 -        50 - 100 %    
    EC-No.        203-777-6        R38 - R48/20 - R62 - R65 -    
    Index-No.        601-037-00-0        R67 - R51/53    
  (Trimethylsilyl)diazomethane
    CAS-No.        18107-18-1        T+, R45 - R26 - R39/26        25 - 50 %    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

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SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    Symptoms may be delayed for hours after exposure.If breathed in, move person into fresh air. If not
    breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

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SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large
    fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or
    spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of
    water.Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    no data available
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.Use water spray to cool unopened containers.

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SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove
    all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
    explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

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SECTION 7: Handling and storage
  Precautions for safe handling
    Handle products containing trimethylsilyl diazomethane only in a closed system or effectively ventilated
    laboratory hood.Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes.
    Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
    the product.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,11 mm
    Break through time: 480 min
    Material tested:Dermatril® (KCL 740 / Z677272, Size M)
    Splash contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,11 mm
    Break through time: 480 min
    Material tested:Dermatril® (KCL 740 / Z677272, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
    of protective equipment must be selected according to the concentration and amount of the
    dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

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SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid    
    Colour: yellow
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        no data available    
    point
    f) Initial boiling point and no data available
    boiling range
    g) Flash point        -23 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        no data available    
    l) Vapour density        no data available    
    m) Relative density        0,718 g/cm3 at 25 °C    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Auto-ignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

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SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks. Extremes of temperature and direct sunlight.
  Incompatible materials
    Oxidizing agents, Incompatible with:, Chlorine, Fluorine, Perchlorates.
  Hazardous decomposition products
    Hazardous decomposition products - Trimethylsilyl diazomethane in alcoholic solvents under acidic or
    basic conditions can lead to the formation of diazomethane.
    In the event of fire: see section 5

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SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LC50 Inhalation - rat - 1 h - <= 10 ppm
    LD50 Dermal - rat - > 2.000 mg/kg
  Skin corrosion/irritation
    no data available
  Serious eye damage/eye irritation
    no data available
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    Inhalation - Causes damage to organs. - Lungs
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: Not available
    Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:,
    Redness, Blurred vision, Provokes tears., Effects due to ingestion may include:, Gastrointestinal
    discomfort, Central nervous system depression, Lung irritation, chest pain, pulmonary edema, giddiness,
    slowed reaction time, slurred speech, Headache, Dizziness, Drowsiness, Unconsciousness
    Testes. - Irregularities - Based on Human Evidence (n-Hexane)

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SECTION 12: Ecological information
  Toxicity
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    no data available
    Toxic to aquatic life with long lasting effects.

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SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Observe all federal, state, and local environmental regulations. Burn
    in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as
    this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
    company.
  Contaminated packaging
    Dispose of as unused product.

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SECTION 14: Transport information
  UN number
    ADR/RID: 3383        IMDG: 3383        IATA: 3383    
  UN proper shipping name
    ADR/RID: TOXIC BY INHALATION LIQUID, FLAMMABLE, N.O.S. (n-Hexane,
    (Trimethylsilyl)diazomethane)
    IMDG: TOXIC BY INHALATION LIQUID, FLAMMABLE, N.O.S. (n-Hexane,
    (Trimethylsilyl)diazomethane)
    IATA:        Toxic by inhalation liquid, flammable, n.o.s. (n-Hexane, (Trimethylsilyl)diazomethane)    
    Passenger Aircraft: Not permitted for transport
    Cargo Aircraft: Not permitted for transport
  Transport hazard class(es)
    ADR/RID: 6.1 (3)        IMDG: 6.1 (3)        IATA: 6.1 (3)    
  Packaging group
    ADR/RID: I        IMDG: I        IATA: -    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available

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SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    no data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

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SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    Aquatic Chronic        Chronic aquatic toxicity    
    Asp. Tox.        Aspiration hazard    
    Carc.        Carcinogenicity    
    Flam. Liq.        Flammable liquids    
    H225        Highly flammable liquid and vapour.    
    H304        May be fatal if swallowed and enters airways.    
    H315        Causes skin irritation.    
    H330        Fatal if inhaled.    
    H336        May cause drowsiness or dizziness.    
    H350        May cause cancer.    
    H361f        Suspected of damaging fertility.    
    H370        Causes damage to organs (/$/*_ORG_SING_INHA/$/) if inhaled.    
    H373        May cause damage to organs through prolonged or repeated exposure.    
    H411        Toxic to aquatic life with long lasting effects.    
    Repr.        Reproductive toxicity    
    Skin Irrit.        Skin irritation    
    STOT RE        Specific target organ toxicity - repeated exposure    
    STOT SE        Specific target organ toxicity - single exposure    
  Full text of R-phrases referred to under sections 2 and 3
    F        Highly flammable    
    N        Dangerous for the environment    
    T+        Very toxic    
    R11        Highly flammable.    
    R26        Very toxic by inhalation.    
    R38        Irritating to skin.    
    R39/26        Very toxic: danger of very serious irreversible effects through inhalation.    
    R45        May cause cancer.    
    R48/20        Harmful: danger of serious damage to health by prolonged exposure through    
    inhalation.
    R51/53        Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic    
    environment.
    R62        Possible risk of impaired fertility.    
    R65        Harmful: may cause lung damage if swallowed.    
    R67        Vapours may cause drowsiness and dizziness.    
    Repr.Cat.3        Toxic to Reproduction Category 3    
    Xn        Harmful    
  Further information
    Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
    only.
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.