CAS No. 134-32-7

Formula: C10H9N
Basic Info

1-Naphthylamine is an aromatic amine derived from naphthalene. It crystallizes in colorless needles which melt at 50°C. It possesses a disagreeable odor, sublimes readily, and turns brown on exposure to air. It is the precursor to a variety of dyes.

Molecular Weight
Exact Mass








Aminogen I







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Appearance & Physical State
A crystalline solid or a solid dissolved in a liquid.
Boiling Point
Melting Point
Flash Point
Refractive Index
Water Solubility
Insoluble. 0.1698 g/100 mL
Oxidizes in air.
Storage Condition
Vapor Pressure
0.00108mmHg at 25°C
Safety Info
Safety Statements
WGK Germany
Risk Statements
UN 2077
Hazard Class
Packing Group
SDS 1.0
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According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017


1.1 GHS Product identifier

Product name 1-naphthylamine

1.2 Other means of identification

Product number -
Other names 1-Naftylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H302 Harmful if swallowed

H411 Toxic to aquatic life with long lasting effects

Precautionary statement(s)

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.


P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P391 Collect spillage.




P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
1-naphthylamine 1-naphthylamine 134-32-7 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Inhalation may cause cyanosis (blue color in lips and under finger nails). Contact with liquid causes local irritation of eyes. Neither ingestion nor contact with skin produces any recognized immediate effects. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Organic bases/Amines and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Powder, alcohol-resistant foam, water spray, carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic nitrogen oxides are produced in a fire. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. Remove trapped material with suction hoses.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Dry. Keep in the dark. Well closed.Keep well closed and protected from light.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH (NOES Survey 1981-1983) has statistically estimated that 2,132 workers (1,796 of these are female) are potentially exposed to 1-naphthylamine in the US(1). The NOES Survey does not include farm workers. Occupational exposure to 1-naphthylamine may occur through inhalation and dermal contact with this compound at workplaces where 1-naphthylamine is produced or used. Monitoring data indicate that the general population may be exposed to 1-naphthylamine via contact with contaminated surface or groundwaters or by inhalation of cigarette smoke(SRC).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state A crystalline solid or a solid dissolved in a liquid.
Colour Needles from ethanol (aq) or ether
Odour Ammonia-like odor.
Melting point/ freezing point 47-50ºC
Boiling point or initial boiling point and boiling range 301ºC
Flammability Combustible SolidCombustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 157.2ºC
Auto-ignition temperature 485°C
Decomposition temperature no data available
pH Weak base
Kinematic viscosity no data available
Solubility In water:Insoluble. 0.1698 g/100 mL
Partition coefficient n-octanol/water (log value) log Kow = 2.25
Vapour pressure 0.00108mmHg at 25°C
Density and/or relative density 1.114
Relative vapour density 4.93 (Relative to Air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Oxidizes in air

10.3 Possibility of hazardous reactions

ALPHA-NAPHTHYLAMINE is incompatible with oxidizing agents. It is also incompatible with nitrous acid. It reduces warm ammoniacal silver nitrate. .

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Oxidizes in air.

10.6 Hazardous decomposition products

The substance decomposes on burning producing nitrogen oxides and carbon monoxide.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 680 mg/kg bw
  • Inhalation: LC50 Rat inhalation >0.056 mg/L/4 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


Inadequate evidence of carcinogenicity in humans. Inadequate evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Using activated sludge from both domestic and industrial sources and the Warburg technique, 1-naphthylamine depletion after 6 hrs at 25°C was measured to be 80-84% from an initial concn of 20 ppm(1). 1-Naphthylamine, at a concn of 500 ppm, was extensively oxidized by an aniline-acclimated activated sludge after 19 hrs in a Warburg respirometer(2). Over a 20-day period, no biodegradation of 200 ppm 1-naphthylamine as a sole carbon source was observed in a batch system containing an adapted activated sludge(3). 1-Naphthylamine at 500 ppm was found to inhibit oxygen uptake in a Warburg respirometer containing a municipal activated sludge(4). At 1000 ppm, 1-naphthylamine was toxic to an activated sludge(5). 1-Naphthylamine degradation in six different soils after 308 days of incubation at 23°C varied from 16.6-30.7% as measured by radio-labelled carbon dioxide evolution(6). Comparison of carbon dioxide evolution in sterilized (via gamma radiation) versus unsterilized soil suggested that the degradation was predominantly microbial in nature(6). Approximately 16, 28 and 33% of added 1-naphthylamine degraded in Russell soil at temperatures of 12, 23 and 30°C, respectively, indicating the effect of temperature on microbial degradation(6).

12.3 Bioaccumulative potential

An estimated BCF of 11 was calculated for 1-naphthylamine(SRC), using a log Kow of 2.25(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC), provided the compound is not altered physically or chemically once released into the environment.

12.4 Mobility in soil

Using a batch equilibrium technique, 1-naphthylamine Koc values of 2,688 and 3,173 were determined for two sandy-silt soils and a Koc value of 3,777 was determined for a silty-clay soil(1). According to a classification scheme(2), this estimated Koc value suggests that 1-naphthylamine is expected to have low mobility in soil. Results of a batch equilibrium study with various soils indicated that 1-naphthylamine binds to soil in two phases with an initial rapid and reversible equilibrium established between the amine and the inorganic and organic components of soil followed subsequently by a strong association with the humic fraction of soil via covalent binding(3,4). In laboratory study, 1-naphthyalmine was found to have a relatively moderate tendency to adsorb to lignite coal in subsurface areas where it may be present as a contaminant from coal-gasification plants(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2077 IMDG: UN2077 IATA: UN2077

14.2 UN Proper Shipping Name


14.3 Transport hazard class(es)


14.4 Packing group, if applicable


14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
1-naphthylamine 1-naphthylamine 134-32-7 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 16, 2017
Revision Date Aug 16, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
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  1-Naphthylamine      Revision number: 5    

  Product name:        1-Naphthylamine    
  Revision number:        5    

  GHS classification
  PHYSICAL HAZARDS        Not classified    
  Acute toxicity (Oral)        Category 4    
    Category 3
  Acute toxicity (Dermal)
  Serious eye damage/eye irritation        Category 2B    
  Specific target organ toxicity
  - Single exposure [Category 2]
  Acute aquatic hazard        Category 2    
    Category 2
  Long-term aquatic hazard
  GHS label elements, including precautionary statements
  Pictograms or hazard symbols
  Signal word        Danger    
    Harmful if swallowed
  Hazard statements
    Toxic in contact with skin
    Causes eye irritation
    May cause damage to organs : Blood
    Toxic to aquatic life
    Toxic to aquatic life with long lasting effects
  Precautionary statements:
  [Prevention]        Do not breathe dust/fume/gas/mist/vapours/spray.    
    Avoid release to the environment.
    Do not eat, drink or smoke when using this product.
    Wash hands thoroughly after handling.
    Wear protective gloves and eye/face protection.

  [Response]        IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.    
    Rinse mouth.
    IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
    if present and easy to do. Continue rinsing.
    If eye irritation persists: Get medical advice/attention.
    IF ON SKIN: Gently wash with plenty of soap and water.
    Remove/Take off immediately all contaminated clothing.
    Wash contaminated clothing before reuse.
    If exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
    Collect spillage.
  [Storage]        Store locked up.    
  [Disposal]        Dispose of contents/container through a waste management company authorized by    
    the local government.

  Substance/mixture:        Substance    
  Percent:        >99.0%(GC)(T)    
  CAS Number:        134-32-7    
  Synonyms:        1-Aminonaphthalene    
  Chemical Formula:        C10H9N    

    Remove victim to fresh air and keep at rest in a position comfortable for breathing.
    Call a POISON CENTER or doctor/physician.
    Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
  Skin contact:
    soap and water. Call a POISON CENTER or doctor/physician.
  Eye contact:        Rinse cautiously with water for several minutes. Remove contact lenses, if present    
    and easy to do. Call a POISON CENTER or doctor/physician.
  Ingestion:        Call a POISON CENTER or doctor/physician. Rinse mouth.    
  Most important        Cyanosis, Confusion, Dizziness, Headache, Shortness of breath, Weakness,    
  symptoms/effects, acute Nausea, Redness, Pain
  and delayed:
  Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
    tight goggles.
  Indication of immediate Medical ovservation is indicated. Depending on the degree of exposure, periodic
    medical examination is indicated.
  medical attantion and
  special treatment needed, if

  Suitable extinguishing        Dry chemical, foam, water spray, carbon dioxide.    
  Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
  from the chemical:        generate poisonous fume.    
  Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
    method according to the surrounding situation is used. Uninvolved persons should
    evacuate to a safe place. In case of fire in the surroundings: Remove movable
    containers if safe to do so.
    When extinguishing fire, be sure to wear personal protective equipment.
  Special protective
  equipment for firefighters:

    Use extra personal protective equipment (P3 filter respirator for toxic particles). Keep
  Personal precautions,
  protective equipment and people away from and upwind of spill/leak. Entry to non-involved personnel should
  emergency procedures: be controlled around the leakage area by roping off, etc.

  Environmental precautions: Be careful not to let it flow into rivers, etc., since adverse effects on the environment
    are concerned.
  Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
  containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
  up: appropriate laws and regulations.

  Precautions for safe handling
  Technical measures:        Handling is performed in a well ventilated place. Wear suitable protective equipment.    
    Prevent dispersion of dust. Wash hands and face thoroughly after handling.
    Use a closed system if possible. Use a local exhaust if dust or aerosol will be
  Advice on safe handling: Avoid contact with skin, eyes and clothing.
  Conditions for safe storage, including any
  Storage conditions:        Keep container tightly closed. Store in a cool and dark place.    
    Store under inert gas.
    Store locked up.
    Store away from incompatible materials such as oxidizing agents.
    Light-sensitive, Air-sensitive
    Comply with laws.
  Packaging material:

  Engineering controls:        Install a closed system or local exhaust. Also install safety shower and eye bath.    
  Personal protective equipment
  Respiratory protection: Dust respirator, self-contained breathing apparatus(SCBA), supplied air respirator,
    etc. Use respirators approved under appropriate government standards and follow
    local and national regulations.
    Impervious gloves.
  Hand protection:
  Eye protection:        Safety goggles. A face-shield, if the situation requires.    
  Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

  Physical state (20°C):        Solid    
  Form:        Crystal- Powder    
    White - Pale red
  Odour:        Slight Ammoniacal    
  pH: No data available
  Melting point/freezing point:50°C
  Boiling point/range:        301°C    
  Flash point:        No data available    
  Flammability or explosive
  Lower:        No data available    
  Upper:        No data available    
  Vapour pressure:        0.53Pa/20°C    
  Vapour density:        4.93    
  Relative density:        No data available    
  [Water]        Insoluble (1700ppm, 20°C)    
  [Other solvents]
  Very soluble:        Ether, Alcohols    
  Soluble:        Benzene, Dilute acetic acid    
  Log Pow:        2.25    
  Autoignition temperature:        460°C    

  Chemical stability:        Stable under proper conditions.    
  Possibility of hazardous No special reactivity has been reported.
  Incompatible materials: Oxidizing agents, Acids, Strong bases
  Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx)

    ipr-mus LD50:96 mg/kg
  Acute Toxicity:
    orl-mam LDLo:4 g/kg
    scu-rbt LDLo:300 mg/kg
  Skin corrosion/irritation: No data available
    No data available
  Serious eye
  Germ cell mutagenicity: dns-hmn-fbr 10 mg/L
    mmo-bcs 5 g/L (-S9)
    mmo-sat 10 ug/plate (-S9)
    mmo-sat 50 ug/plate (+S9)
    ipr-rat TDLo:1300 mg/kg/13W-I
  IARC =        Group 3 (Not classifiable as carcinogenic to humans)    
  NTP =        No data available    
  Reproductive toxicity:        No data available    
  RTECS Number:        QM1400000    

  Fish:        48h LC50:25 ppm (Oryzias latipes)    
    No data available
  Algae:        No data available    
  Persistence / degradability: 0 % (by BOD), 3 % (by HPLC)
  Bioaccumulative        13 - 54 (conc. 200 ppb), 9.1 - 27 (conc. 20 ppb)    
  Mobility in soil
  Log Pow:        2.25    
    4.7 x 10-2
  Soil adsorption (Koc):
    2688 - 3777
  Henry's Law

    Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
    with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
    Observe all federal, state and local regulations when disposing of the substance.

  Hazards Class:        6.1: Toxic substance.    
  UN-No:        2077    
  Proper shipping name:
  Packing group:        III    
  Marine pollutant

  Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
  and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
    loading and unloading were prescribed.
  The list of a dangerous chemical(2002)/CN-No.: 61830

NMR Spectrum 1H NMR : 400 MHz in CDCl3
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IR Spectrum IR : CCl4 solution
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Mass Spectrum Mass spectrum (electron ionization)
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Raman Spectrum Raman : 4880 A,200 M,powder
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UV Spectrum UV/Visible spectrum
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