phenylhydrazine

CAS No. 100-63-0

Formula: C6H8N2
Basic Info

Phenylhydrazine is the chemical compound with the formula C6H5NHNH2. It is often abbreviated as PhNHNH2.

Formula
C6H8N2
Molecular Weight
108.141
Exact Mass
108.069
LogP
1.7455
PSA
38.05
Synonyms

Fenilidrazina [Italian]

Phenylhydrazine

Hydrazinobenzene

Hydrazine-benzene

Fenylhydrazine [Dutch]

N-phenyl hydrazine

Hydrazine, phenyl-

Phenylhydrazin

Hydrazine,phenyl

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Properties
Appearance & Physical State
yellow to pale brown oily liquid
Density
1.099
Boiling Point
238-241ºC
Melting Point
19ºC
Flash Point
89ºC
Refractive Index
1.604-1.609
Water Solubility
145 g/L (20 ºC)
Stability
Stable, but may decompose in sunlight. May be air or light sensitive. Incompatible with strong oxidizing agents, metal oxides.
Storage Condition
Store at RT.
Vapor Density
4.3 (vs air)
Vapor Pressure
<0.1 mm Hg ( 20 °C)
Safety Info
RTECS
MV8925000
Safety Statements
S45-S53-S61
WGK Germany
3
Risk Statements
R23/24/25; R36/38; R43; R45; R48/23/24/25; R50; R68
HS Code
2928000090
RIDADR
UN 2572
Hazard Class
6.1
Packing Group
II
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name phenylhydrazine

1.2 Other means of identification

Product number -
Other names Fenilidrazina [Italian]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Skin irritation, Category 2

Eye irritation, Category 2

Skin sensitization, Category 1

Acute toxicity - Inhalation, Category 3

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Specific target organ toxicity – repeated exposure, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

H311 Toxic in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H317 May cause an allergic skin reaction

H331 Toxic if inhaled

H341 Suspected of causing genetic defects

H350 May cause cancer

H400 Very toxic to aquatic life

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P311 Call a POISON CENTER/doctor/…

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P314 Get medical advice/attention if you feel unwell.

P391 Collect spillage.

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
phenylhydrazine phenylhydrazine 100-63-0 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Material is corrosive to tissue. Exposure can cause vomiting, diarrhea, fatigue, headache, and irritation and itchiness of the eyes and skin. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Specific treatment for exposure consists of thorough washing of all exposed skin areas with soap and water, copious irrigation of the eyes, and prompt removal of the patient from the source of exposure. /Hydrazines/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire. Behavior in Fire: May ignite spontaneously when spread on a large surface or when in air and in contact with porous materials such as soil, asbestos, wood, or cloth. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Evacuate danger area! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. If liquid: collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. If solid: sweep spilled substance into containers. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and food and feedstuffs. Store in an area without drain or sewer access.Keep well closed and protected from light

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers phenylhydrazine to be a potential occupational carcinogen.

Recommended Exposure Limit: 2 Hr Ceiling value: 0.14 ppm (0.6 mg/cu m), skin.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state yellow to pale brown oily liquid
Colour Monoclinic prisms or oil
Odour Faint, aromatic odor.
Melting point/ freezing point 112°C(lit.)
Boiling point or initial boiling point and boiling range 272°C
Flammability Class IIIA Combustible Liquid: Fl.P. at or above 60°C and below 93.33°C. Combustible SolidCombustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 88°C(lit.)
Auto-ignition temperature 173.89°C (USCG, 1999)
Decomposition temperature 243.5°C
pH no data available
Kinematic viscosity no data available
Solubility In water:145 g/L (20 ºC)
Partition coefficient n-octanol/water (log value) log Kow= 1.25
Vapour pressure <0.1 mm Hg ( 20 °C)
Density and/or relative density 1.099
Relative vapour density 4.3 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Flammable when exposed to heat, flame, or oxidizers.PHENYLHYDRAZINE may ignite spontaneously when in contact with oxidants such as hydrogen peroxide or nitric acid, oxides of iron or copper, or manganese, lead, copper or their alloys. Will not polymerize (USCG, 1999).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Strong oxidizers, lead dioxide.

10.6 Hazardous decomposition products

When heated to decomposition it emits highly toxic fumes of /nitrogen oxides/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 188 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

A3; Confirmed animal carcinogen with unknown relevance to humans.

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50 Brachydanio rerio (Zebrafish) 0.16-0.26 mg/L/96 hr /Conditions of bioassay not specified in source examined
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

In a Warburg respirometer study using aniline-acclimated activated sludge, phenylhydrazine was found to be appreciably more resistant to biological oxidation than aniline(1). Phenylhydrazine, in the static Zahn-Wellens test, was 85% biodegraded in 9-13 days; circa 25% biodegradation of this compound was reported for other laboratories using respirometer tests(2).

12.3 Bioaccumulative potential

An estimated BCF value of 2 was calculated for phenylhydrazine(SRC), using a measured log Kow of 1.25(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of phenylhydrazine is estimated as approximately 110(SRC), using a measured log Kow of 1.25(1) and a regression-derived equation(2). According to a recommended classification scheme(3), this estimated Koc value suggests that phenylhydrazine has high mobility in soil(SRC). The pKa of phenylhydrazine has been reported as 5.21(4), suggesting this compound exists as a cation in moist soils, and cations tend to adsorb more to soils than neutral compounds(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2572 IMDG: UN2572 IATA: UN2572

14.2 UN Proper Shipping Name

ADR/RID: PHENYLHYDRAZINE
IMDG: PHENYLHYDRAZINE
IATA: PHENYLHYDRAZINE

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
phenylhydrazine phenylhydrazine 100-63-0 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: Phenylhydrazine 97% Material Safety Data Sheet
Synonym: Hydrazine, phenyl-; Hydrazine-benzene; Hydrazinobenzene; Phenylhydrazi
CAS: 100-63-0
Section 1 - Chemical Product   MSDS Name:Phenylhydrazine 97% Material Safety Data Sheet
Synonym:Hydrazine, phenyl-; Hydrazine-benzene; Hydrazinobenzene; Phenylhydrazi

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
100-63-0 Phenylhydrazine 97 202-873-5
Hazard Symbols: T N
Risk Phrases: 23/24/25 36/38 43 45 50 48/23/24/25

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes and skin. May cause sensitization by skin contact. May cause cancer. Very toxic to aquatic organisms. Toxic : danger of serious damage to health by prolonged exposure through inhalation, contact with skin and if swallowed.Air sensitive.Light sensitive.Cancer suspect agent.Possible risks of irreversible effects.
Potential Health Effects
Eye:
Causes severe eye irritation. May cause retinal damage.
Skin:
Causes severe skin irritation. May be fatal if absorbed through the skin. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May cause eczematous dermatitis with swelling and vesiculation.
Ingestion:
Harmful if swallowed. May cause kidney, liver and spleen damage. May cause bone marrow damage. May cause systemic effects by ingestion: blood hemolysis with or without anemia, methemoglobinemia-carboxyhemoglobinemia, and pulmonary changes.
Causes digestive tract irritation with possible burns.
Inhalation:
Harmful if inhaled. May cause effects similar to those described for ingestion. Causes severe respiratory tract irritation. Inhalation may produce weakness, fatigue, dizziness, and vertigo. Acute exposure to low concentrations of hydrazines may cause and produce bronchial mucous destruction, pulmonary edema, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood) and possible death.
Chronic:
Possible cancer hazard based on tests with laboratory animals.
Prolonged or repeated skin contact may cause dermatitis. Prolonged or repeated eye contact may cause conjunctivitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis (bluish skin due to deficient oxygenation of blood), rapid heart rate, unconsciousness and possible death. May cause fetal effects. Laboratory experiments have resulted in mutagenic effects.

Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood.
Monitor arterial blood gases, chest x-ray, pulmonary function tests if respiratory tract irritation or respiratory depression is evident.
Monitor methemoglobin and blood sugar levels. Effects may be delayed.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool.
Combustible liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire. Do NOT get water inside containers.
For small fires, use dry chemical, carbon dioxide, or water spray.
For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Place under an inert atmosphere. Do not get water inside containers.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Store protected from light. Handle under an inert atmosphere. Store protected from air.
Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store protected from light. Store under an inert atmosphere.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood.
Exposure Limits CAS# 100-63-0: United States OSHA: 5 ppm TWA; 22 mg/m3 TWA Belgium - TWA: 0.1 ppm VLE; 0.45 mg/m3 VLE Germany: 5 ppm TWA; 22 mg/m3 TWA Germany: Skin absorber Malaysia: 0.1 ppm TWA Spain: 0.1 ppm VLA-ED; 0.45 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: yellow - oily
Odor: weak aromatic odor
pH: pkb=8.79 @ 15C
Vapor Pressure: 1 mm Hg @ 71.8 C
Viscosity: Not available.
Boiling Point: 243.5 deg C (dec)
Freezing/Melting Point: 19.5 deg C
Autoignition Temperature: 173 deg C ( 343.40 deg F)
Flash Point: 88 deg C ( 190.40 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 243.5 deg C
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.098
Molecular Formula: C6H8N2
Molecular Weight: 108.0694

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures. Turns reddish-brown on exposure to light.
Conditions to Avoid:
Incompatible materials, light, ignition sources, exposure to air, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents, lead dioxide, perchloryl fluoride, 2-phenylamino-3-phenyloxazirane, air, isopropylamine, isobutylamine, lead (IV) oxide.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 100-63-0: MV8925000 LD50/LC50:
CAS# 100-63-0: Inhalation, mouse: LC50 = 2120 mg/m3; Inhalation, rat: LC50 = 2610 mg/m3; Oral, mouse: LD50 = 175 mg/kg; Oral, rabbit: LD50 = 80 mg/kg; Oral, rat: LD50 = 188 mg/kg.
Skin, rabbit: LD50 = 90mg/kg; Inhalation, rat: LC50 = 2610 Carcinogenicity:
Phenylhydrazine - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to California: carcinogen, initial date 7/1/92 Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: PHENYLHYDRAZINE
Hazard Class: 6.1
UN Number: 2572
Packing Group: II
IMO
Shipping Name: PHENYLHYDRAZINE
Hazard Class: 6.1
UN Number: 2572
Packing Group: II
RID/ADR
Shipping Name: PHENYLHYDRAZINE
Hazard Class: 6.1
UN Number: 2572
Packing group: II

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 45 May cause cancer.
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 36/38 Irritating to eyes and skin.
R 43 May cause sensitization by skin contact.
R 48/23/24/25 Toxic : danger of serious damage to
health by prolonged exposure through inhalation,
contact with skin and if swallowed.
R 50 Very toxic to aquatic organisms.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 100-63-0: 2
Canada
CAS# 100-63-0 is listed on Canada's DSL List.
CAS# 100-63-0 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 100-63-0 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
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IR Spectrum IR : liquid film
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Mass Spectrum Mass
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Analysis Methods
Normal alkane RI, non-polar column, custom temperature program
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Column Shape
Capillary
Active Phase(℃)
Polydimethyl siloxanes
Retention index
1157.
Temperature Control
Method
custom temperature program
Comments
Program: not specified
Reference
Zenkevich, I.G.Encyclopedia of Chromatography. Derivatization of Carbonyls for GC AnalysisMArcel Dekker, Inc., New York - Basel, 2001, 233.
Toxicity
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
188 mg/kg
Toxic Effects
Behavioral--excitement<br>Behavioral--muscle contraction or spasticity
Reference
Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 30(7-9),191,1965
ACUTE TOXICITY DATA
expand collapse
Type of Test
LC50 - Lethal concentration, 50 percent kill
Exposure Route
Inhalation
Species Observed
Rodent - rat
Dose/Duration
2610 mg/m3
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued. Volume(issue)/page/year: 115,59,1977
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - mouse
Dose/Duration
175 mg/kg
Toxic Effects
Behavioral--convulsions or effect on seizure threshold<br>Behavioral--changes in motor activity (specific assay)
Reference
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 30(8),21,1965

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