chloroform

CAS No. 67-66-3

Formula: CHCl3
Basic Info

Chloroform, or trichloromethane, is an organic compound with formula CHCl3. It is a colorless, sweet-smelling, dense liquid that is produced on a large scale as a precursor to PTFE and refrigerants, but the latter application is declining. It is one of the four chloromethanes and a trihalomethane.

Formula
CHCl3
Molecular Weight
119.378
Exact Mass
117.914
LogP
1.9864
PSA
0
Synonyms

HCC20

r20

TCM

Trichloromethane

SOLVENT MC

CHCl3

Chloroform

freon20

Methane, trichloro-

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Properties
Appearance & Physical State
Colorless liquid
Density
1.492 g/mL at 25 °C(lit.)
Boiling Point
61 °C
Melting Point
-63 °C
Flash Point
60.5-61.5°C
Refractive Index
n20/D 1.445(lit.)
Water Solubility
8 g/L (20 ºC)
Storage Condition
2-8°C
Vapor Density
4.1 (vs air)
Vapor Pressure
160 mm Hg ( 20 °C)
Safety Info
RTECS
FS9100000
Safety Statements
S9; S16; S26; S36; S36/37
WGK Germany
3
Risk Statements
R45; R11; R23/24/25; R36/37/38; R48/20/22
HS Code
2903130000
RIDADR
UN 1888 6.1/PG 3
Hazard Class
6.1
Packing Group
III
Caution Statement
P201; P261; P304 + P340 + P312; P305 + P351 + P338; P308 + P313; P403 + P233
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name chloroform

1.2 Other means of identification

Product number -
Other names HCC20

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Volatile organic compounds
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Inhalation, Category 3

Carcinogenicity, Category 2

Specific target organ toxicity – repeated exposure, Category 1

Reproductive toxicity, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H302 Harmful if swallowed

H315 Causes skin irritation

H319 Causes serious eye irritation

H331 Toxic if inhaled

H351 Suspected of causing cancer

H372 Causes damage to organs through prolonged or repeated exposure

H361d

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P311 Call a POISON CENTER/doctor/…

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P314 Get medical advice/attention if you feel unwell.

Storage

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
chloroform chloroform 67-66-3 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Rest. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

It is classified as moderately toxic. Probable oral lethal dose for humans is 0.5 to 5 g/kg (between 1 ounce and 1 pint) for a 150 lb. person. The mean lethal dose is probably near 1 fluid ounce (44 g). It is a human suspected carcinogen. Also, it is a central nervous system depressant and a gastrointestinal irritant. It has caused rapid death attributable to cardiac arrest and delayed death from liver and kidney damage. (EPA, 1998)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Halogenated aliphatic hydrocarbons and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray to keep fire-exposed containers cool. Extinguish fire using agent suitable for surrounding fire.

5.2 Specific hazards arising from the chemical

Container may explode in the heat of fire. When heated it liberates phosgene, hydrogen chloride, chlorine and toxic and corrosive oxides of carbon and chlorine. Chloroform explodes when in contact with aluminum powder or magnesium powder or with alkali metals (e.g., lithium, sodium, and potassium) and dinitrogen tetroxide. It reacts vigorously with acetone in the presence of potassium hydroxide or calcium hydroxide. It is oxidized by strong oxidizers such as chromic acid forming phosgene and chlorine. It reacts vigorously with triisopropylphosphine. It develops acidity from prolonged exposure to air and light. (EPA, 1998)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

1. Ventilate area of spill or leak. 2. Collect for reclamation or absorb in vermiculite, dry sand, earth, or a similar material.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Ventilation along the floor.Keep in tightly closed containers; storage code: LI

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers chloroform to be a potential occupational carcinogen.

Recommended Exposure Limit: 60 Min Short-Term Exposure Limit: 2 ppm (9.78 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Colorless liquid
Colour Clear, colorless liquid
Odour Pleasant, etheric, nonirritating
Melting point/ freezing point -63 °C
Boiling point or initial boiling point and boiling range 60.5-61.5°C(lit.)
Flammability Noncombustible LiquidNot combustible. See Notes. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 60.5-61.5°C
Auto-ignition temperature Not flammable (USCG, 1999)
Decomposition temperature no data available
pH no data available
Kinematic viscosity 5.63 millipoises at 20°C; 5.10 millipoises at 30°C
Solubility In water:8 g/L (20 ºC)
Partition coefficient n-octanol/water (log value) log Kow = 1.97
Vapour pressure 160 mm Hg ( 20 °C)
Density and/or relative density 1.48g/mLat 25°C
Relative vapour density 4.1 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Decomposes at ordinary temp in sunlight in the absence of air, and in the dark in the presence of air.

10.3 Possibility of hazardous reactions

Not combustible.The vapour is heavier than air.A mixture of acetone and CHLOROFORM in a residue bottle exploded. Since addition of acetone to chloroform in the presence of base will result in a highly exothermic reaction, it is thought that a base was in the bottle. [MCA Case History 1661(1970)]. Powdered aluminum and carbon tetrachloride (also methyl chloride and chloroform or mixtures of these chemicals) exploded when heated (to 153° C) and by impact, [Chem. Eng. News 32:258(1954); UL Bull. Research 34 (1945), ASESB Pot. Incid. 39(1968)]. An inadequately cooled addition of sodium to a chloroform-methanol mixture (sodium methoxide) caused a violent explosion, [MCA Case History No. 693]. It is incompatible with dinitrogen tetraoxide, fluorine, sodium metal and alcohols, nitromethane, and triisopropylphosphine.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Mixtures with dinitrogen tetraoxide are explosive when subjected to shock of 25 g TNT equiv or less.

10.6 Hazardous decomposition products

The products of oxidative breakdown include phosgene, hydrogen chloride, chlorine, carbon dioxide, and water.

11.Toxicological information

Acute toxicity

  • Oral: LD50 White rat oral 2180 mg/kg
  • Inhalation: LC50 Rat inhalation 47,702 mg/cu m/4 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

EPA: Probable human carcinogen. IARC: Possibly carcinogenic to humans. NTP: Reasonably anticipated to be a human carcinogen

Reproductive toxicity

Little information is available on the reproductive or developmental effects of chloroform in humans, via any route of exposure. A possible association between certain birth outcomes (e.g., low birth weight, cleft palate) and consumption of contaminated drinking water was reported. However, because multiple contaminants were present, the role of chloroform is unclear. Animal studies have demonstrated developmental effects, such as decreased fetal body weight, fetal resorptions, and malformations in the offspring of animals exposed to chloroform via inhalation. Reproductive effects, such as decreased conception rates, decreased ability to maintain pregnancy, and an increase in the percentage of abnormal sperm were observed in animals exposed to chloroform through inhalation. Animal studies have noted decreased fetal weight, increased fetal resorptions, but no evidence of birth defects, in animals orally exposed to chloroform.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Danio rerio (Zebra danio); Conditions: freshwater, flow through, 23°C, pH 8.15; Concentration: 121000 ug/L for 48 hr
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, renewal, 25°C, pH >7; Concentration: 79000 ug/L for 24 hr; Effect: behavior, equilibrium
  • Toxicity to algae: EC50; Species: Scenedesmus subspicatus (Green algae, log growth phase); Conditions: freshwater, static, 24°C, pH 8.0-9.3; Concentration: 560000 ug/L for 48 hr; Effect: decreased population biomass
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

Chloroform was reduced from 0.12 mg/L to <40 ug/L after anaerobic digestion at 25°C for 53 days and then was digested aerobically for 20 days which reduced chloroform to a not detected level(1). Chloroform was not degraded aerobically or anaerobically in an aquifer storage and recovery site(2).

12.3 Bioaccumulative potential

The BCF values for chloroform range from 2.9-10.35(1). A log bioconcentration factor <1 for 4 species of fish have been reported(2,3). An experimental log BCF of 0.78 was also reported for chloroform(4). According to a classification scheme(5), these BCF values suggest the potential for bioconcentration in aquatic organisms is low.

12.4 Mobility in soil

A soil sorption study was conducted on chloroform in three distinctly different soils(1). Soils used were from Missouri (composed of 11.4% sand, 52.7% silt, 33.4% clay, 2.4% organic matter, at pH 6.9), California (composed of 45.1% sand, 35.2% silt, 21.7% clay, organic matter 1.7%, at pH 8.1), and Florida (composed of 91.7% sand, 6.3% silt, 2.0% clay, 1.6% organic matter, at pH 4.7)(1). The ratio of the amount of contaminant adsorbed in micrograms per gram of soil to the equilibrium concn in ppm was used to calculate a Kd value of 2.133 in the Missouri soil, 1.941 in the California soil, and 1.763 in the Florida soil(1). These values correspond to a Koc value ranging from 153-196 based upon the relationship between Kd and Koc(2). Chloroform is adsorbed most strongly to peat moss, less strongly to clay, very slightly to dolomite limestone and not at all to sand(3). The Koc values measured for 2 soils was 34; 3 other soils with the lowest organic carbon content in the same study gave no appreciable adsorption(4). Field experiments in which chloroform was injected into an aquifer and the concn in a series of observation wells determined, demonstrated that chloroform is very poorly retained by aquifer material (retardation factor 2-4), less so than other C1- and C2-halogenated compounds studied(4-5). Laboratory percolation studies with a sandy soil gave similar results (retardation factor <1.5)(6). Chloroform was reported to have a Koc of 65(7), 55(8), 47(9) and 34(10). According to a classification scheme(11), these Koc values suggest that chloroform is expected to have very high to moderate mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1888 IMDG: UN1888 IATA: UN1888

14.2 UN Proper Shipping Name

ADR/RID: CHLOROFORM
IMDG: CHLOROFORM
IATA: CHLOROFORM

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
chloroform chloroform 67-66-3 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 16, 2017
Revision Date Aug 16, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: Chloroform, Extra Dry, with Molecular Sieves Material Safety Data Sheet
Synonym: Formyl Trichloride; Methane Trichloride; Methane, Trichloro-; Methenyl Trichloride; Methyl Trichloride; Trichlormethan; Trichloroform; Trichloromethane.
CAS: 67-66-3
Section 1 - Chemical Product MSDS Name: Chloroform, Extra Dry, with Molecular Sieves Material Safety Data Sheet
Synonym: Formyl Trichloride; Methane Trichloride; Methane, Trichloro-; Methenyl Trichloride; Methyl Trichloride; Trichlormethan; Trichloroform; Trichloromethane.
SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
||||| | 25377-72-4 |Amylene | <1.0 | 246-916-6
SECTION 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful if swallowed. Irritating to skin. Limited evidence of a carcinogenic effect. Harmful : danger of serious damage to health by prolonged exposure through inhalation and if swallowed.Light sensitive. Potential Health Effects
Eye:
Causes moderate eye irritation. Contact with liquid causes immediate burning pain, tearing, and reddening of the conjunctiva.
Skin:
Causes mild skin irritation.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May cause cardiac disturbances. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. Possible aspiration hazard. May cause hallucinations and distorted perceptions.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause cardiac sensitization and possible failure. Inhalation of large amounts may cause respiratory stimulation, followed by respiratory depression, convulsions and possible death due to respiratory paralysis. May be absorbed through the lungs. Causes irritation of the mucous membrane and upper respiratory tract.
Chronic:
Possible cancer hazard based on tests with laboratory animals. Prolonged or repeated skin contact may cause dermatitis. May cause reproductive and fetal effects. Effects may be delayed. Laboratory experiments have resulted in mutagenic effects. Toxicity may be increased by exposure to alcohol, steroids, and ketones. Prolonged exposure may cause liver, kidney, and heart damage.
SECTION 4 - FIRST AID MEASURES
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Causes cardiac sensitization to endogenous catelcholamines which may lead to cardiac arrhythmias. Do NOT use adrenergic agents such as epinephrine or pseudoepinephrine. Persons with liver, kidney, or central nervous system diseases may be at increased risk from exposure to this product. Alcoholic beverage consumption may enhance the toxic effects of this substance. Effects may be delayed.
SECTION 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Substance is nonflammable. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire. Do NOT get water inside containers. Do NOT use straight streams of water. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use water spray, fog or regular foam. Cool containers with flooding quantities of water until well after fire is out.
SECTION 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.
SECTION 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Do not ingest or inhale. Store protected from light.
Storage:
Do not store in direct sunlight. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from acids. Do not store near alkaline substances. Separate from strong mineral acids.
SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Clear liquid
Color: Not available.
Odor: sweetish odor
pH: Not available.
Vapor Pressure: 213 mbar @ 20 deg C
Viscosity: 0.56 mPa.s 20 deg C
Boiling Point: 61 deg C @ 760.00mm Hg
Freezing/Melting Point: -63 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: 8g/l water (20C)
Specific Gravity/Density: 1.4890g/cm3
Molecular Formula: CHCl3
Molecular Weight: 119.38
SECTION 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions. Light sensitive.
Conditions to Avoid:
High temperatures, incompatible materials, light.
Incompatibilities with Other Materials:
Strong oxidizing agents, aluminum, fluorine, magnesium, sodium potassium, lithium, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), dinitrogen tetraoxide, sodium + methanol, potassium-tert-butoxide, chemically active metals, Attacks some forms of plastics, rubbers, and coatings., nitrogen tetroxide, acetone + alkali, disilane, perchloric acid + phosphorus pentoxide, sodium methylate, triisopropylphosphine, sodium methoxide + methanol.
Hazardous Decomposition Products:
Hydrogen chloride, irritating and toxic fumes and gases, carbon dioxide, chlorine, phosgene gas.
Hazardous Polymerization: Will not occur.
SECTION 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 67-66-3: FS9100000 CAS# 25377-72-4 unlisted.
LD50/LC50:
CAS# 67-66-3: Draize test, rabbit, eye: 20 mg/24H Moderate; Draize
test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 47702 mg/m3/4H; Oral, mouse: LD50 = 36 mg/kg; Oral, rat: LD50 = 695 mg/kg;
Skin, rabbit: LD50 = >20 gm/kg. CAS# 25377-72-4.
Carcinogenicity:
Chloroform - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Amylene - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.
SECTION 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Channel catfish: LC50 = 75 ppm; 96 Hr; UnspecifiedFish: Rainbow
trout: LC50 = 43.8 mg/L; 96 Hr; Static bioassayFish: Fathead Minnow: LC50 = 129.0 mg/L; 96 Hr; Static bioassay (pH = 7.6-8.3)Fish:
Bluegill/Sunfish: LC50 = 100.0 mg/L; 96 Hr; Static bioassayWater
flea Daphnia: EC50 = 28.9 mg/L; 48 Hr; Static bioassayThe majority of the environmental releases from industrial uses are to the atmosphere; releases to water and land will be primarily lost by evaporation and will end up in the atmosphere. Release to the atmosphere may be transported long distances and will photodegrade with a half-life of a few months. Spills and other releases on land
SECTION 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations.
SECTION 14 - TRANSPORT INFORMATION IATA
Shipping Name: CHLOROFORM
Hazard Class: 6.1
UN Number: 1888
Packing Group: III IMO
Shipping Name: CHLOROFORM
Hazard Class: 6.1
UN Number: 1888
Packing Group: III RID/ADR
Shipping Name: CHLOROFORM
Hazard Class: 6.1
UN Number: 1888
Packing group: III
SECTION 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed. R 38 Irritating to skin. R 40 Limited evidence of a carcinogenic effect.
R 48/20/22 Harmful : danger of serious damage to health by prolonged exposure through inhalation and if swallowed.
Safety Phrases:
S 36/37 Wear suitable protective clothing and gloves. WGK (Water Danger/Protection) CAS# 67-66-3: 3 CAS# 25377-72-4: No information available. United Kingdom Occupational Exposure Limits United Kingdom Maximum Exposure Limits Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 67-66-3 is not listed on Canada's Ingredient Disclosure List. CAS# 25377-72-4 is not listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 67-66-3: OEL-ARAB Republic of Egypt:TWA 10 ppm (50 mg/m3) OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Carcinogen OEL-AUSTRIA:TWA 10 ppm (50 mg/m3) OEL-BELGIUM:TWA 10 ppm (49 mg/m3);Carcinogen JAN9 OEL-CZECHOSLOVAKIA:TWA 10 mg/m3;STEL 20 mg/m3 OEL-DENMARK:TWA 2 ppm (10 mg/m3);Carcinogen OEL-FINLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm;Skin;CAR OEL-FRANCE:TWA 5 ppm (25 mg/m3);STEL 50 ppm (250 mg/m3);CAR OEL-GERMANY:TWA 10 ppm (50 mg/m3);Carcinogen JAN9 OEL-HUNGARY:STEL 10 mg/m3 OEL-INDIA:TWA 10 ppm (50 mg/m3);Carcinogen OEL-JAPAN:TWA 50 ppm (240 mg/m3);Carcinogen OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3) OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3) OEL-POLAND:TWA 50 mg/m3 OEL-RUSSIA:TWA 50 ppm OEL-SWEDEN:TWA 2 ppm (10 mg/m3);STEL 5 ppm (25 mg/m3);CAR OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm (100 mg/m3) OEL-THAILAND:TWA 50 ppm (240 mg/m3) OEL-TURKEY:TWA 50 ppm (240 mg/m3) OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);STEL 50 ppm (225 mg/m3) OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV US FEDERAL TSCA CAS# 67-66-3 is not listed on the TSCA inventory. It is for research and development use only. CAS# 25377-72-4 is not listed on the TSCA inventory. It is for research and development use only.
SECTION 16 - ADDITIONAL INFORMATION
MSDS Creation Date: 1/16/2002 Revision #2 Date: 7/09/2002 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages.

SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
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IR Spectrum IR : liquid film
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Mass Spectrum Mass
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Raman Spectrum Raman : 4880 A,100M,liquid
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