54-42-2 structure, C9H11IN2O5

5-iodo-2'-deoxyuridine

CAS No.

54-42-2

Formula:

C9H11IN2O5

Basic Info

Idoxuridine is an anti-herpesvirus antiviral drug.
It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing. It is used only topically due to cardiotoxicity. It was synthesized by William Prusoff in the late 1950s. Initially developed as an anticancer drug, idoxuridine became the first antiviral agent in 1962.

Formula
C9H11IN2O5
Molecular Weight
354.099
Exact Mass
353.971
LogP
-1.2181
PSA
104.55
Synonyms

5-Iodo-2'-deoxyuridine

Idoxuridine

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Properties

Appearance & Physical State
White powder.
Density
2.14g/cm3
Melting Point
155-180ºC
Refractive Index
30 ° (C=1, 1mol/L NaOH)
Water Solubility
1.6 g/L (20 ºC)
Stability
Stable under normal temperatures and pressures.
Storage Condition
2-8ºC

Safety Info

RTECS
YU7700000
Safety Statements
S53-S45
WGK Germany
3
Risk Statements
R45; R46; R61
HS Code
2934999090
Hazard Codes

Synthesis Route

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