Formaldehyde

CAS No. 50-00-0

Formula: CH2O
Basic Info

Formaldehyde is used in various organic synthesis and reactions. It is used in the textile industry in the area of crosslinking molecules to vary the properties of fabrics. In the food industry it is used to reinforce and improve packaging of meats and produce. It can help improve the water resistance of biodegradable collagen films.

Formula
CH2O
Molecular Weight
30.026
Exact Mass
30.0106
LogP
0.451
PSA
17.07
Synonyms

formalith

Formalin

Morbicid

Formic aldehyde

Methanal

Oxymethylene

Formaldehyde

Formol

Oxomethane

fannoform

Methylene glycol

Oxomethylene

HCHO

lysoform

Methylene oxide

Methyl aldehyde

superlysoform

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Properties
Appearance & Physical State
Colorless gas
Density
0.8153 g/cm3 (−20 °C)
Boiling Point
-19 °C
Melting Point
-92 °C
Flash Point
50 °C (122 °F) for 37 % formaldehyde (15 % methanol)(closed cup); 85 °C (185 °F) for 37 % formaldehyde (methanol free)(closed cup)
Refractive Index
7 g/L (25 ºC)
Water Solubility
soluble, > 100 g/100 ml(20 °C)
Stability
Stable. Combustible. Incompatible with strong oxidizing agents.
Storage Condition
2-8ºC
Vapor Density
300ºC
Vapor Pressure
>1 atm (20 °C)
Safety Info
RTECS
LP8925000
Safety Statements
S26;S36/37/39;S45;S51;S53;S60
WGK Germany
2
Risk Statements
R23/24/25; R34; R43; R45
HS Code
2912110000
RIDADR
UN 2209 8 / PGIII
Hazard Class
8
Packing Group
III
Caution Statement
P201; P260; P280; P301 + P310 + P330; P303 + P361 + P353; P304 + P340 + P310; P305 + P351 + P338; P308 + P311
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Formaldehyde

1.2 Other means of identification

Product number -
Other names superlysoform

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Formaldehyde is used predominantly as a chemical intermediate. It also has minor uses in agriculture, as an analytical reagent, in concrete and plaster additives, cosmetics, disinfectants, fumigants, photography, and wood preservation. One of the most common uses of formaldehyde in the U.S is manufacturing urea-formaldehyde resins, used in particleboard products. Formaldehyde (as urea formaldehyde foam) was extensively used as an insulating material until 1982 when it was banned by the U.S. Consumer Product Safety Commission.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Skin corrosion, Category 1B

Skin sensitization, Category 1

Acute toxicity - Inhalation, Category 3

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

H311 Toxic in contact with skin

H314 Causes severe skin burns and eye damage

H317 May cause an allergic skin reaction

H331 Toxic if inhaled

H341 Suspected of causing genetic defects

H350 May cause cancer

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/…

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P311 Call a POISON CENTER/doctor/…

P308+P313 IF exposed or concerned: Get medical advice/ attention.

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Formaldehyde Formaldehyde 50-00-0 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Seek medical attention if you feel unwell.

In case of eye contact

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

4.2 Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, skin and/or eye contact Symptoms: Irritation eyes, nose, throat, respiratory system; lacrimation (discharge of tears); cough; wheezing; [potential occupational carcinogen] Target Organs: Eyes, respiratory system (NIOSH, 2016)

The probable oral lethal dose for humans is 0.5-5 g/kg, or between 1 ounce and 1 pint for a 150 pound person. Acute -- below 1 ppm, odor perceptible to most. 2-3 ppm, mild tingling of eyes. 4-5 ppm, increased discomfort, mild lacrimation. 10 ppm, profuse lacrimation; can be withstood only for few minutes. 10-20 ppm, breathing difficult, cough, severe burning of nose and throat. 50-100 ppm, acute irritation of respiratory tract, very serious injury likely. Skin -- primary irritation from strong solutions, gas. Delayed -- sensitization dermatitis. Suspected carcinogen. Effects in women include menstrual disorders and secondary sterility. Solutions splashed in eyes have caused injuries ranging from severe, permanent corneal opacification and loss of vision to minor discomfort. In people sensitized to formaldehyde, late asthmatic reactions may be provoked by brief exposures at approximately 3 ppm. (EPA, 1998)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

Vapor or dust irritates eyes, mucous membranes, and skin; may cause dermatitis. Ingestion of solid or of a solution in water irritates mouth, throat, and stomach and may cause death. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Emergency and supportive measures: 1. Maintain open airway and assist ventilation if necessary. 2. Inhalation. Treat bronchospasm and pulmonary edema if they occur. Administer supplemental oxygen, and observe for at least 4 to 6 hours. 3. Ingestion. a. Treat coma and shock if they occur. b. Administer intravenous saline or other crystalloids to replace fluid losses caused by gastroenteritis. Avoid fluid overload in patients with inhalation exposure because of the risk of pulmonary edema. c. Treat metabolic acidosis with sodium bicarbonate.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, dry chemical, alcohol foam, or carbon dioxide. Use water to keep fire exposed containers cool. If leak or spill has not ignited, use water spray to disperse vapors, and to protect men attempting to stop leak. Water spray may be used to flush spills away from exposures and to dilute spills to nonflammable mixtures.

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. For UN3508, be aware of possible short circuiting as this product is transported in a charged state. (ERG, 2016)

Toxic vapors such as carbon dioxide and carbon monoxide are generated during combustion. Explosion hazard: when aqueous formaldehyde solutions are heated above their flash points, a potential for explosion hazard exists. High formaldehyde concentration or methanol content lowers flash point. Reacts with nitrogen oxides at about 180; the reaction becomes explosive. Also reacts violently with perchloric acid-aniline, performic acid, nitromethane, magnesium carbonate, and hydrogen peroxide. When heated, irritant formaldehyde gas evolved from solution. The main products of decomposition are carbon monoxide and hydrogen. Metals such as platinum, copper, chromia, and alumina also catalyze the formation of methanol, methylformate, formic acid, carbon dioxide, and methane. Reacts with peroxide, nitrogen oxide, and performic acid causing explosions. Can react with hydrogen chloride or other inorganic chlorides to form bis-chloromethylether (BCME), a known carcinogen. Very reactive, combines readily with many substances, 40% solution is powerful reducing agent. Incompatible with amines, azo compounds, dithiocarbamates, alkali and alkaline earth metals, nitrides, nitro compounds, unsaturated aliphatics and sulfides, organic peroxides, oxidizing agents, and reducing agents. Aqueous solutions are unstable. Commercial formaldehyde-alcohol solutions are stable. Gas is stable in absence of water. Avoid oxidizing and alkaline materials. Hazardous polymerization may occur. Compound will polymerize with active organic materials such as phenol. Will polymerize violently in the presence of caustics and nitrides; (amines) exothermic reaction, (Azo compound) exothermic reaction giving off nitrogen gas, (caustics) heat generation and violent polymerization, (dithiocarbamates) formation of flammable gases and toxic fumes, formation of carbon disulfide may result, (alkali and alkaline earth metals) heat generation and formation of a flammable hydrogen gas. (EPA, 1998)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)

Behavior in Fire: Changes to formaldehyde gas, which is highly flammable. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Evacuate danger area! Consult an expert! Personal protection: gas-tight chemical protection suit including self-contained breathing apparatus. Remove all ignition sources. Turn off gas at source if possible. Remove gas with fine water spray.

6.3 Methods and materials for containment and cleaning up

Use fluorocarbon water spray, Cellosize and Hycar to diminish vapors. Sodium carbonate, ammonium hydroxide, or sodium sulfite can neutralize the spill.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Cool. Separated from incompatible materials. See Chemical Dangers.... Minimum storage temperature to prevent polymerization range from 83 deg F for 37% formaldehyde containing 0.05% methyl alcohol to 29 deg F for formaldehyde containing 15% methyl alcohol.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 0.016 ppm. /Formaldehyde/ /Formalin (as formaldehyde)/

Recommended Exposure Limit: 15 Minute Ceiling Value: 0.1 ppm. /Formaldehyde/ /Formalin (as formaldehyde)/

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Formaldehyde/ /Formalin (as formaldehyde)/

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Colorless gas
Colour Nearly colorless gas [Note: Often used in an aqueous solution]. /Pure formaldehyde/
Odour Pungent, suffocating odor
Melting point/ freezing point 250°C(dec.)(lit.)
Boiling point or initial boiling point and boiling range 98°C(lit.)
Flammability Flammable GasExtremely flammable.
Lower and upper explosion limit / flammability limit Lower flammable limit: 7.0% by volume; Upper flammable limit: 73% by volume
Flash point 64°C
Auto-ignition temperature 300°C
Decomposition temperature 120-180°C
pH pH: 2.8 to 4.0 /Formaldehyde soln/
Kinematic viscosity 0.1421 cP at 25°C
Solubility In water:soluble, > 100 g/100 ml(20 °C)
Partition coefficient n-octanol/water (log value) log Kow = 0.35
Vapour pressure >1 atm (20 °C)
Density and/or relative density 1.09g/mLat 20°C
Relative vapour density 1.03 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

On standing, especially in the cold, may become cloudy, and on exposure to very low temperature ppt of trioxymethylene formed; in air it slowly oxidizes to formic acid /40% solution/.

10.3 Possibility of hazardous reactions

Flammable liquid when exposed to heat or flame; can react vigorously with oxidizers. ... The gas is a more dangerous fire hazard than the vapor.The gas mixes well with air, explosive mixtures are easily formed.Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.FORMALDEHYDE (ENVIRONMENTALLY HAZARDOUS SUBSTANCES, SOLID, N.O.S.) may react violently with strong oxidizing agents (hydrogen peroxide, performic acid, perchloric acid in the presence of aniline, potassium permanganate, nitromethane). May react with bases (sodium hydroxide, potassium hydroxide, ammonia), and with nitrogen dioxide (explosive reaction around 180°C). May react with hydrochloric acid to form highly toxic bis(chloromethyl) ether. Polymerization reaction with phenol may develop sudden destructive pressure [Bretherick, 5th ed., 1995, p.168]. May generate flammable and/or toxic gases in combination with azo, diazo compounds, dithiocarbamates, nitrides, and strong reducing agents. May generate toxic formaldehyde gas when heated. Can react with air to give first peroxo acids, and ultimately formic acid. These reactions are activated by light, catalyzed by salts of transition metals, and are autocatalytic (catalyzed by the products of the reaction). Incompatible with liquid oxygen.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

(Amines) exothermic reaction, (AZO cmpd) exothermic reaction giving off nitrogen gas, (caustics) heat generation and violent polymerization, (dithiocarbamates) formation of flammable gasses and toxic fumes, formation of carbon disulfide may result, (alkali and alkaline earth metals) heat generation and formation of flammable hydrogen gas, (nitrides) heat generation, formation of flammable ammonia gas and violent polymerization, (nitro compd) heat generation, (unsaturated aliphatics and sulfides) heat generation, (organic peroxides) violent reaction, (oxidizing agents) heat generation, fire, and decomposition, (reducing agents) heat generation and formation of flammable gasses. /From table/

10.6 Hazardous decomposition products

Uncatalyzed decomposition is very slow below 300°C; extrapolation of kinetic data to 400°C indicates that the rate of decomposition is about 0.44%/min at 101 kPa (1 atm). The main products are carbon monoxide and hydrogen. Metals such as platinium, copper, chromia, and alumina also catalyze the formation of methanol, methylformate, formic acid, carbon dioxide, and methane.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 100 mg/kg /SRP: percent solution not specified/
  • Inhalation: LC50 Rat inhalation 0.82 mg/L (1/2 hour)
  • Dermal: LD50 Rabbit percutaneous 270 mg/kg /Formalin/

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

There is sufficient evidence in humans for the carcinogenicity of formaldehyde. Formaldehyde causes cancer of the nasopharynx and leukaemia. Also, a positive association has been observed between exposure to formaldehyde and sinonasal cancer. There is sufficient evidence in experimental animals for the carcinogenicity of formaldehyde. The Working Group was not in full agreement on the evaluation of formaldehyde causing leukaemias in humans, with a small majority viewing the evidence as sufficient of carcinogenicity and the minority viewing the evidence as limited. Particularly relevant to the discussions regarding sufficient evidence was a recent study accepted for publication which, for the first time, reported aneuploidy in blood of exposed workers characteristic of myeloid leukaemia and myelodysplastic syndromes, with supporting information suggesting a decrease in the major circulating blood-cell types and in circulating haematological precursor cells. The authors and Working Group felt that this study needed to be replicated. Formaldehyde is carcinogenic to humans (Group 1).

Reproductive toxicity

An increased incidence of menstrual disorders were observed in female workers using urea-formaldehyde resins. However, possible confounding factors were not evaluated in this study. A study of hospital equipment sterilizing workers did not report an association between formaldehyde exposure and increased spontaneous abortions. Developmental effects, such as birth defects, have not been observed in animal studies with formaldehyde.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow trout) weight 0.63 g; Conditions: static; Concentration: 118 ppm for 96 hr (95% confidence limit: 99.7-140 ppm) /37% AI formulated product
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static; Concentration: 14600 ug/L for 48 hr (95% confidence interval: 11300-18000 ug/L); Effect: intoxication, immobilization /37% purity
  • Toxicity to algae: EC50; Species: Scenedesmus subspicatus (Green Algae); Conditions: freshwater, static; Concentration: 211000 ug/L for 49-79 min; Effect: population, decreased photosynthesis /formulation
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Formaldehyde, present at 100 mg/L, reached 91% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified the compound as readily biodegradable(1). Using OECD Guide-line 301D (Ready Biodegradability: Closed Bottle Test), formaldehyde achieved 90% in 28 days using non-acclimated inoculum which classified the compound as readily biodegradable(2). Formaldehyde in aqueous effluent was degraded by activated sludge and sewage in 48-72 hr(3-6). In a die-away test using water from a stagnant lake, degradation was complete in 30 hours under aerobic conditions(6). Other biodegradation screening tests gave half-lives ranging from <1 to 17.3 days(7-12).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated for formaldehyde(SRC), using a log Kow of 0.35(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Experiments performed on a variety of fish and shrimp showed no bioconcentration of formaldehyde(4,5).

12.4 Mobility in soil

The Koc of formaldehyde is estimated as 8(SRC), using a log Kow of 0.35(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that formaldehyde is expected to have very high mobility in soil(SRC). Formaldehyde gas adsorbs on clay minerals to a degree at high gas concentrations which is an important quality in its use as a soil fumigant(4). In addition, formaldehyde may interact with humic substances in soil(5) resulting in decreased mobility.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2209 IMDG: UN2209 IATA: UN2209

14.2 UN Proper Shipping Name

ADR/RID: FORMALDEHYDE SOLUTION with not less than 25% formaldehyde
IMDG: FORMALDEHYDE SOLUTION with not less than 25% formaldehyde
IATA: FORMALDEHYDE SOLUTION with not less than 25% formaldehyde

14.3 Transport hazard class(es)

ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Formaldehyde Formaldehyde 50-00-0 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 11, 2017
Revision Date Aug 11, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Formaldehyde solution, 36.5-38%    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
    CAS-No.        : 50-00-0    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Acute toxicity, Oral (Category 3), H301
    Acute toxicity, Inhalation (Category 3), H331
    Acute toxicity, Dermal (Category 3), H311
    Skin corrosion (Category 1B), H314
    Skin sensitisation (Category 1), H317
    Carcinogenicity (Category 2), H351
    Specific target organ toxicity - single exposure (Category 1), H370
    Specific target organ toxicity - single exposure (Category 3), H335
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    T Toxic        R23/24/25, R39/23/24/25    
    C Corrosive        R34    
    Xn Harmful        R40    
    Xi Irritant        R43    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Danger    
    Hazard statement(s)
    H301 + H311 + H331        Toxic if swallowed, in contact with skin or if inhaled    
    H314        Causes severe skin burns and eye damage.    
    H317        May cause an allergic skin reaction.    
    H335        May cause respiratory irritation.    
    H351        Suspected of causing cancer.    
    H370        Causes damage to organs.    
    Precautionary statement(s)
    P260        Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.    
    P280        Wear protective gloves/ protective clothing/ eye protection/ face    
    protection.
    P301 + P310        IF SWALLOWED: Immediately call a POISON CENTER or doctor/    
    physician.
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    P310        Immediately call a POISON CENTER or doctor/ physician.    
    Supplemental Hazard        none    
    Statements
  According to European Directive 67/548/EEC as amended.
    Hazard symbol(s)        T Toxic    
    R-phrase(s)
    R23/24/25        Toxic by inhalation, in contact with skin and if swallowed.    
    R34        Causes burns.    
    R39/23/24/25        Toxic: danger of very serious irreversible effects through inhalation, in    
    contact with skin and if swallowed.
    R40        Limited evidence of a carcinogenic effect.    
    R43        May cause sensitisation by skin contact.    
    S-phrase(s)
    S26        In case of contact with eyes, rinse immediately with plenty of water and    
    seek medical advice.
    S36/37/39        Wear suitable protective clothing, gloves and eye/face protection.    
    S45        In case of accident or if you feel unwell, seek medical advice immediately    
    (show the label where possible).
  Other hazards - none

SECTION 3: Composition/information on ingredients
  Mixtures
    Synonyms        : Formalin    
    Formula        : CH2O    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Formaldehyde
    CAS-No.        50-00-0        Acute Tox. 3; Skin Corr. 1B; 25 - 50 %    
    EC-No.        200-001-8        Skin Sens. 1; Carc. 2; H301 +    
    Index-No.        605-001-00-5        H311 + H331, H314, H317,    
    H351
  Methanol
    CAS-No.        67-56-1        Flam. Liq. 2; Acute Tox. 3;        10 - 20 %    
    EC-No.        200-659-6        STOT SE 1; H225, H301 +    
    Index-No.        603-001-00-X        H311 + H331, H370    
    Registration number        01-2119433307-44-XXXX    
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Formaldehyde
    CAS-No.        50-00-0        T, Carc.Cat.3, R23/24/25 -        25 - 50 %    
    EC-No.        200-001-8        R34 - R40 - R43    
    Index-No.        605-001-00-5    
  Methanol
    CAS-No.        67-56-1        F, T, R11 - R23/24/25 -        10 - 20 %    
    EC-No.        200-659-6        R39/23/24/25    
    Index-No.        603-001-00-X    
    Registration number        01-2119433307-44-XXXX    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take
    victim immediately to hospital. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    no data available
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove
    all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
    explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13). Keep in suitable, closed
    containers for disposal.
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
    the product.
  Personal protective equipment
  Eye/face protection
    Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection
    tested and approved under appropriate government standards such as NIOSH (US) or EN
    166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: Nitrile rubber
    Minimum layer thickness: 0,4 mm
    Break through time: 480 min
    Material tested:Camatril® (KCL 730 / Z677442, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, The type of protective equipment must be selected
    according to the concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: clear, liquid    
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        no data available    
    point
    f) Initial boiling point and no data available
    boiling range
    g) Flash point        64 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        Upper explosion limit: 73 %(V)    
    flammability or        Lower explosion limit: 7 %(V)    
    explosive limits
    k) Vapour pressure        69 hPa at 37 °C    
    l) Vapour density        1,04 - (Air = 1.0)    
    m) Relative density        1,016 g/cm3 at 20 °C    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Auto-ignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    Relative vapour density 1,04 - (Air = 1.0)

SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks.
  Incompatible materials
    Aniline, Phenol, Isocyanates, Acid anhydrides, Acids, Strong bases, Strong oxidizing agents, Amines,
    Peroxides
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
  Skin corrosion/irritation
    Skin - rabbit
    Result: Corrosive after 3 minutes to 1 hour of exposure - 20 h
    (OECD Test Guideline 404)
  Serious eye damage/eye irritation
    Eyes - rabbit
    Result: Corrosive - 7 d
    (OECD Test Guideline 405)
  Respiratory or skin sensitisation
    Maximisation Test - guinea pig
    Result: Causes sensitisation.
    May cause allergic skin reaction.
    (OECD Test Guideline 406)
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    IARC:        1 - Group 1: Carcinogenic to humans (Formaldehyde)    
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: LP8925000
    Liver - Irregularities - Based on Human Evidence (Formaldehyde)

SECTION 12: Ecological information
  Toxicity
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    Harmful to aquatic life.

SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    This combustible material may be burned in a chemical incinerator equipped with an afterburner and
    scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 2209        IMDG: 2209        IATA: 2209    
  UN proper shipping name
    ADR/RID: FORMALDEHYDE SOLUTION
    IMDG: FORMALDEHYDE SOLUTION
    IATA:        Formaldehyde solution    
  Transport hazard class(es)
    ADR/RID: 8        IMDG: 8        IATA: 8    
  Packaging group
    ADR/RID: III        IMDG: III        IATA: III    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available



SECTION 15 - REGULATORY INFORMATION
N/A


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : parameter in TMS
expand collapse
IR Spectrum GAS (HEATING PARAFORMALDEHYDE; CONCENTRATION UNKNOWN)
expand collapse
Analysis Methods
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
Porapack Q
Retention index
284.
Temperature Control
200.
Method
isothermal
Comments
N2
Reference
Goebel, K.-J.Gaschromatographische Identifizierung Niedrig Siedender Substanzen Mittels Retentionsindices und RechnerhilfeJ. Chromatogr.1982, 235, 1, 119-127.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
SE-30
Retention index
229.
Temperature Control
150.
Method
isothermal
Comments
Celatom AW silanized; Column length: 3.7 m
Reference
Haken, J.K.Nguyen, A.Wainwright, M.S.Application of linear extrathermodynamic relationships to alcohols, aldehydes, ketones, amd ethoxy alcoholsJ. Chromatogr.1979, 179, 1, 75-85.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
Apiezon L
Retention index
249.
Temperature Control
160.
Method
isothermal
Comments
Celite 545
Reference
Bogoslovsky, Yu.N.Anvaer, B.I.Vigdergauz, M.S.Chromatographic constants in gas chromatography (in Russian)Standards Publ. House, Moscow, 1978, 192.
Normal alkane RI, non-polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
OV-101
Retention index
273.
Temperature Control
Method
temperature ramp
Comments
25. m/0.20 mm/0.10 μm, N2/He, 6. K/min; T<sub>start</sub>: 50. C; T<sub>end</sub>: 250. C
Reference
Zenkevich, I.G.Experimentally measured retention indices.2005.
Normal alkane RI, non-polar column, custom temperature program
expand collapse
Column Shape
Capillary
Active Phase(℃)
SPB-1
Retention index
247.
Temperature Control
Method
custom temperature program
Comments
60. m/0.53 mm/5. μm, He; Program: 40C(6min) =&gt; 5C/min =&gt; 80C =&gt; 10C/min =&gt; 200C
Reference
Flanagan, R.J.Streete, P.J.Ramsey, J.D.Volatile Substance AbuseUNODC Technical Series, No 5, United Nations, Office on Drugs and Crime, Vienna International Centre, PO Box 500, A-1400 Vienna, Austria, 1997, 56, retrieved from http://www.odccp.org/pdf/technica
Toxicity
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Standard Draize test
Exposure Route
Administration onto the skin
Species Observed
Human
Dose/Duration
150 ug/3D (Intermittent)
Toxic Effects
--
Reference
Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976, Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Human
Dose/Duration
4 ppm/5M
Toxic Effects
--
Reference
International Journal of Air and Water Pollution. (London, UK) V.4(1-4), 1961. For publisher information, see ATENBP. Volume(issue)/page/year: 4,79,1961
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Non-standard exposure
Exposure Route
Administration into the eye
Species Observed
Human
Dose/Duration
1 ppm/6M
Toxic Effects
--
Reference
American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 44,463,1983
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