CAS No. 110-91-8

Formula: C4H9NO
Basic Info

Morpholine is an organic chemical compound having the chemical formula O(CH2CH2)2NH. This heterocycle features both amine and ether functional groups. Because of the amine, morpholine is a base; its conjugate acid is called morpholinium. For example, treating morpholine with hydrochloric acid makes the salt morpholinium chloride.

Molecular Weight
Exact Mass






BASF 238





expand collapse

Appearance & Physical State
aqueous solution with a fishlike odor
Boiling Point
Melting Point
Freezing Point
Flash Point
Refractive Index
Water Solubility
Stable. Flammable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides. Hygroscopic.
Storage Condition
Store at R.T.
Vapor Density
3 (vs air)
Vapor Pressure
31 mm Hg ( 38 °C)
Safety Info
Safety Statements
WGK Germany
Risk Statements
R10; R20/21/22; R34
HS Code
UN 2054/1760
Hazard Class
Packing Group
Hazard Codes
SDS 1.0
expand collapse
Download/Modify | Technical supported by For US version, EU version (23 languages) and more, please refer to


According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name morpholine

1.2 Other means of identification

Product number -
Other names 1,4-Oxazinan

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Corrosion inhibitors and anti-scaling agents,Functional fluids (closed systems),Functional fluids (open systems),Intermediates,Processing aids, not otherwise listed
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 3

Acute toxicity - Oral, Category 4

Acute toxicity - Dermal, Category 4

Skin corrosion, Category 1B

Acute toxicity - Inhalation, Category 4

2.2 GHS label elements, including precautionary statements

Signal word


Hazard statement(s)

H226 Flammable liquid and vapour

H302 Harmful if swallowed

H312 Harmful in contact with skin

H314 Causes severe skin burns and eye damage

H332 Harmful if inhaled

Precautionary statement(s)

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.


P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/…

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.


P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.


P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification


3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
morpholine morpholine 110-91-8 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. See Notes.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

VAPOR: Irritating to eyes, nose and throat. If inhaled, will cause nausea, headache, or difficult breathing. LIQUID: Irritating to skin and eyes. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use dry chemical, carbon dioxide, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full facepieces and are operated in a pressure-demand or other positive-pressure mode.

5.2 Specific hazards arising from the chemical

FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Irritating vapors are generated when heated. Vapor is heavier than air and may travel some distance to source of ignition and flash back. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Spill handling: evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants and acids. Dry.Before entering confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. Morpholine must be stored to avoid contact with strong acids, such as nitric acid, and strong oxidizers, such as chlorine dioxide, bromine, nitrates, and permanganates, since violent reactions occur.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 20 ppm (70 mg/cu m); skin.

Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 30 ppm (105 mg/cu m), skin.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state aqueous solution with a fishlike odor
Colour Colorless liquid
Odour Characteristic amine
Melting point/ freezing point 82°C(lit.)
Boiling point or initial boiling point and boiling range 129°C
Flammability Class IC Flammable Liquid: Fl.P. at or above 22.78°C and below 37.78°C.Flammable. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit Lower flammable limit: 1.4% by volume; Upper flammable limit: 11.2% by volume
Flash point 32°C(lit.)
Auto-ignition temperature 310°C (USCG, 1999)
Decomposition temperature no data available
pH Strong base
Kinematic viscosity 2.23 cP at 20°C
Solubility In water:MISCIBLE
Partition coefficient n-octanol/water (log value) log Kow = -0.86
Vapour pressure 31 mm Hg ( 38 °C)
Density and/or relative density 0.994
Relative vapour density 3 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

A very dangrous fire hazard when exposed to flame, heat, or oxidizers.MORPHOLINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Sensitive to moisture. Reacts readily with oxidizing agents .

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Violent reaction and fire may result when the product is mixed with oxidizing agents, such as perchlorates, nitrates, permanganates, chromates, nitric acid, halogens, peroxides, and some cleaning solutions containing acids.

10.6 Hazardous decomposition products

When heated to decomposition it emits highly toxic fumes of /nitric oxide/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Guinea pig oral 595 mg/kg
  • Inhalation: LC50 Mouse inhalation 1.32 mg/L/2 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available


Evaluation: No epidemiological data relevant to the carcinogenicity of morpholine were available. There is inadequate evidence in experimental animals for the carcinogenicity of morpholine. Overall evaluation: Morpholine is not classifiable as to its carcinogenicity to humans (Group 3).

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Brachydanio rerio (zebra fish); Conditions: 22°C, pH 7.5, hardness 250 mg/L CaCO3, no aeration; Concentration: >1000 mg/L for 96 hr
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (water flea); Conditions: static, 20-22°C, pH 7.6-7.7; Concentration: 100 mg/L for 24 hr; Effect: immobilization
  • Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (green algae); Conditions: freshwater, static; Concentration: 28000 ug/L for 96 hr; Effect: growth, general /analytical grade product
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Morpholine, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Morpholine degraded 87% after 28 days with a 16 day lag period during an OECD Manometric Respirometry test using a sapromat system and 89% after a 16 day lag period using an oxitop system(2). However, it proved to be readily biodegradable in the 28-day OECD screening test and inherently biodegradable in a 31-day Zahn-Wellens test, exhibiting a final degradation level of >90% in both tests(3). An adaptation period of 7-20 days was required before degradation occurred. The final level of degradation was also >90% in a laboratory-scale wastewater treatment plant, but the adaptation period was 10-21 days(3).

12.3 Bioaccumulative potential

Bioconcentrationw were measured in carp over a 6 week period. With starting concentrations of 5 ppm and 0.5 ppm the measured bioconcentrations were less than 0.3 to 0.65 and less than 2.8 at morpholine, respectively(1). According to a classification scheme(2), these BCF ranges suggest the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of morpholine is estimated as 7.4(SRC), using a log Kow of -0.86(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that morpholine is expected to have very high mobility in soil. The pKa of morpholine is 8.49(4), indicating that this compound will almost entirely exist in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods


The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2054 IMDG: UN2054 IATA: UN2054

14.2 UN Proper Shipping Name


14.3 Transport hazard class(es)


14.4 Packing group, if applicable


14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
morpholine morpholine 110-91-8 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%


  • IPCS - The International Chemical Safety Cards (ICSC), website:
  • HSDB - Hazardous Substances Data Bank, website:
  • IARC - International Agency for Research on Cancer, website:
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
  • CAMEO Chemicals, website:
  • ChemIDplus, website:
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
  • Germany GESTIS-database on hazard substance, website:
  • ECHA - European Chemicals Agency, website:

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
expand collapse
Name: Morpholine 99+% Material Safety Data Sheet
Synonym: Diethylene imidoxide; Diethylene oximide; 1-Oxa-4-azacyclohexane; Tetrahydro-1,4-oxazine
CAS: 110-91-8
Section 1 - Chemical Product   MSDS Name:Morpholine 99+% Material Safety Data Sheet
Synonym:Diethylene imidoxide; Diethylene oximide; 1-Oxa-4-azacyclohexane; Tetrahydro-1,4-oxazine

CAS# Chemical Name content EINECS#
110-91-8 Morpholine >99.0 203-815-1
Hazard Symbols: F C
Risk Phrases: 10 20/21/22 34

Flammable. Harmful by inhalation, in contact with skin and if swallowed. Causes burns.Corrosive.
Potential Health Effects
Causes eye burns. Vapor or mist may cause irritation and severe burns. Contact with liquid is corrosive to the eyes and causes severe burns. May cause chemical conjunctivitis and corneal damage.
Contact with liquid is corrosive and causes severe burns and ulceration. Substance is rapidly absorbed through the skin. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
May cause severe and permanent damage to the digestive tract.
Aspiration hazard. Causes gastrointestinal tract burns. May cause liver and kidney damage. May cause perforation of the digestive tract. Ingestion of large amounts may cause CNS depression. May cause systemic effects.
Irritation may lead to chemical pneumonitis and pulmonary edema. May cause liver and kidney damage. Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation in the chest.
Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion.

  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water.

  General Information: Use proper personal protective equipment as indicated in Section 8.
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section).
Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.

Section 7 - HANDLING and STORAGE
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes.
Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame.
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels.
Exposure Limits CAS# 110-91-8: United Kingdom, WEL - TWA: 20 ppm TWA; 72 mg/m3 TWA United Kingdom, WEL - STEL: 30 ppm STEL; 109 mg/m3 STEL United States OSHA: 20 ppm TWA; 70 mg/m3 TWA Belgium - TWA: 20 ppm VLE; 72 mg/m3 VLE France - VME: 20 ppm VME; 70 mg/m3 VME France - VLE: 30 ppm VLE; 105 mg/m3 VLE Germany: 10 ppm TWA; 36 mg/m3 TWA Germany: Skin absorber Malaysia: 20 ppm TWA; 71 mg/m3 TWA Netherlands: 20 ppm MAC; 70 mg/m3 MAC Russia: 1.5 mg/m3 TWA Russia: 0.5 mg/m3 STEL Spain: 10 ppm VLA-ED; 36 mg/m3 VLA-ED Spain: 20 ppm VLA-EC; 72 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear chemical splash goggles. Wear safety glasses and chemical goggles if splashing is possible.
Wear appropriate protective gloves to prevent skin exposure.
Wear appropriate protective clothing to prevent skin exposure.
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Physical State: Liquid
Color: clear, colorless
Odor: characteristic odor - amine-like
pH: >7.0 (basic).
Vapor Pressure: 6.6 mm Hg @ 20
Viscosity: 2.23 cP 20 C
Boiling Point: 262 deg F
Freezing/Melting Point: 23 deg F
Autoignition Temperature: 555 deg F ( 290.56 deg C)
Flash Point: 98 deg F ( 36.67 deg C)
Explosion Limits, lower: 1.4
Explosion Limits, upper: 11.2
Decomposition Temperature: 489 F
Solubility in water: >500 mg/l (20 C)
Specific Gravity/Density: 1.0 (water=1)
Molecular Formula: C4H9NO
Molecular Weight: 87.12

  Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Ignition sources, metals, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, alcohols, phenols, vinyl acetate, isocyanates, alkylene oxides, organic anhydrides, epichlorohydrin, cresol, aldehydes, ketones, acrylates, substituted allyls, glycols, caprolactam solution.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, ammonia and/or derivatives.
Hazardous Polymerization: Has not been reported.

CAS# 110-91-8: QD6475000 LD50/LC50:
CAS# 110-91-8: Draize test, rabbit, eye: 2 mg Severe; Draize test, rabbit, skin: 995 mg/24H Severe; Inhalation, mouse: LC50 = 1320 mg/m3/2H; Inhalation, rat: LC50 = 8000 ppm/8H; Oral, mouse: LD50 = 525 mg/kg; Oral, rat: LD50 = 1450 mg/kg; Skin, rabbit: LD50 = 500 uL/kg.
Morpholine - Not listed by ACGIH, IARC, or NTP.
See actual entry in RTECS for complete information.

Fish: Bluegill/Sunfish: LC50 = 350.0 mg/L; 96 Hr.; Static conditions, 18-22 degrees CWater flea Daphnia: LC50 = 100.0-119.0 mg/L; 24 Hr.; UnspecifiedAlgae: EC50 = 28.0 mg/L; 96 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 57.0 mg/L; 30 minutes; Microtox test

  Dispose of in a manner consistent with federal, state, and local regulations.

Shipping Name: MORPHOLINE
Hazard Class: 8
UN Number: 2054
Packing Group: I
Shipping Name: MORPHOLINE
Hazard Class: 8
UN Number: 2054
Packing Group: I
Shipping Name: MORPHOLINE
Hazard Class: 3
UN Number: 2054
Packing group: III

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: F C
Risk Phrases:
R 10 Flammable.
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 36 Wear suitable protective clothing.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
WGK (Water Danger/Protection)
CAS# 110-91-8: 2
CAS# 110-91-8 is listed on Canada's DSL List.
CAS# 110-91-8 is listed on Canada's Ingredient Disclosure List.
CAS# 110-91-8 is listed on the TSCA inventory.

NMR Spectrum 1H NMR : 400 MHz in CDCl3
expand collapse
IR Spectrum IR : liquid film
expand collapse
Mass Spectrum Mass
expand collapse
Raman Spectrum Raman : 4880 A,200 M,liquid
expand collapse
Analysis Methods
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Active Phase(℃)
Retention index
Temperature Control
50. m/0.3 mm/0.4 μm, He
Zhuravleva, I.L.Evaluation of the polarity and boiling points of nitrogen-containing heterocyclic compounds by gas chromatographyRuss. Chem. Bull. (Engl. Transl.)2000, 49, 2, 325-328.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Active Phase(℃)
Retention index
Temperature Control
Ar, Gas Chrom Q (80-100 mesh); Column length: 3. m
Tiess, D.Gaschromatographische Retentionsindices von 125 leicht- bis mittelflüchtigen organischen Substanzen toxikologisch-analytischer Relevanz auf SE-30Wiss. Z. Wilhelm-Pieck-Univ. Rostock Math. Naturwiss. Reihe1984, 33, 6-9.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Active Phase(℃)
Retention index
Temperature Control
He, Celite 545 (44-60 mesh); Column length: 3. m
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Active Phase(℃)
Retention index
Temperature Control
He, Celite 545 (44-60 mesh); Column length: 3. m
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Active Phase(℃)
Retention index
Temperature Control
He, Celite 545 (44-60 mesh); Column length: 3. m
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
expand collapse
Type of Test
Standard Draize test
Exposure Route
Administration onto the skin
Species Observed
Rodent - rabbit
995 mg/24H
Toxic Effects
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 10-4/1970
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Species Observed
Rodent - rat
1450 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 10,25,1968
expand collapse
Type of Test
LC50 - Lethal concentration, 50 percent kill
Exposure Route
Species Observed
Rodent - rat
8000 ppm/8H
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,85,1974

Related Compound Information

Coming Soon
Coming Soon
Coming Soon