4-(4-aminophenyl)aniline

CAS No. 92-87-5

Formula: C12H12N2
Basic Info

Benzidine (trivial name), also called 1,1'-biphenyl-4,4'-diamine (systematic name), is an organic compound with the formula (C6H4NH2)2. It is an aromatic amine. It is a component of a test for cyanide. Related derivatives are used in the production of dyes. Benzidine has been linked to bladder and pancreatic cancer.

Formula
C12H12N2
Molecular Weight
184.237
Exact Mass
184.1
LogP
3.6804
PSA
52.04
Synonyms

BENZIDINE

[1,1‘-Biphenyl]-4,4‘-diamine

biphenyl-4,4'-diamine

4,4'-Bianiline

p-Diaminodiphenyl

Fast Corinth Base B

4,4'-Biphenyldiamine

4,4'-Diaminobiphenyl

4,4'-Diaminodiphenyl

p,p'-diaminobiphenyl

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Properties
Appearance & Physical State
off-white solid
Density
1.25
Boiling Point
402ºC
Melting Point
128ºC
Flash Point
11ºC
Refractive Index
1.667
Water Solubility
Sparingly soluble.
Stability
Stable. Combustible. Incompatible with strong oxidizing agents.
Storage Condition
2-8ºC
Safety Info
RTECS
DC9625000
Safety Statements
S53-S45-S60-S61
WGK Germany
3
Risk Statements
R45; R22; R50/53
HS Code
2921590020
RIDADR
UN 1885
Hazard Class
6.1(a)
Packing Group
II
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4-aminophenyl)aniline

1.2 Other means of identification

Product number -
Other names BENZIDINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Benzidines/Aromatic amines
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Carcinogenicity, Category 1A

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H302 Harmful if swallowed

H350 May cause cancer

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P391 Collect spillage.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
4-(4-aminophenyl)aniline 4-(4-aminophenyl)aniline 92-87-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Wear protective gloves when administering first aid.

In case of eye contact

Rinse with plenty of water (remove contact lenses if easily possible).

If swallowed

Rinse mouth.

4.2 Most important symptoms/effects, acute and delayed

Poisonous if inhaled, swallowed or absorbed through skin. May cause contact dermatitis, irritation or sensitization. Ingestion may cause nausea and vomiting. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aniline and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Contain highly toxic NOx fumes. Behavior in Fire: Produces highly toxic fumes. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Cover the spill with a 9:1 mixture of sand and soda ash.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Well closed. Store in an area without drain or sewer access.KEEP WELL CLOSED & PROTECTED FROM LIGHT.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers benzidine to be a potential occupational carcinogen.

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state off-white solid
Colour White or slightly-reddish, crystalline powder
Odour no data available
Melting point/ freezing point 128ºC
Boiling point or initial boiling point and boiling range 402ºC
Flammability Combustible Solid, but difficult to burn.Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 11ºC
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:Sparingly soluble.
Partition coefficient n-octanol/water (log value) log Kow= 1.34
Vapour pressure Low (NIOSH, 2016)
Density and/or relative density 1.25
Relative vapour density 6.36 (Relative to Air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

DARKENS ON EXPOSURE TO AIR & LIGHT

10.3 Possibility of hazardous reactions

Benzidine itself does not burn or burns with difficulty.BENZIDINE forms insoluble salts with sulfuric acid. Can be diazotized, acetylated and alkylated. Is hypergolic with red fuming nitric acid . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Benzidine is hypergolic (will ignite spontaneously) with red fuming nitric acid.

10.6 Hazardous decomposition products

When heated to decomp it emits highly toxic fumes of /nitrogen oxides/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 309 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

NTP: Known to be a human carcinogen

Reproductive toxicity

No information is available on the reproductive or developmental effects of benzidine in humans and animals.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: Pimephales promelas (fathead minnow) > 20,000 ug/l/96 hr /Conditions of bioassay not specified
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

At concentrations of 60 to 120 mg/l, benzidine inhibited the oxygen uptake of sludge that had been acclimated to aniline; at concentrations of 40 to 80 mg/l, the oxygen uptake of unacclimated sludge was also inhibited. At ug/l concentrations, however, benzidine was partially degraded.

12.3 Bioaccumulative potential

In a 42 day experiment in a flow-through tank in which bluegills were exposed to 14C-benzidine, the BCF was 40 in the edible portion of the fish(1). The depuration half-life of the 14C-residues was about 7 days(1). After 3 days in a model ecosystem, the BCF for fish, mosquitos, snail and algae were 55, 457, 646 and 1,585(2). Based on a classification scheme(3), the BCF values of benzidine in fish suggests bioconcentration in aquatic organisms is moderate(SRC).

12.4 Mobility in soil

Benzidine exists as a neutral molecule, and as a singly and doubly ionized cation under acidic conditions (acid dissociation constants pKa1 and pKa2 are 4.3 and 3.3, respectively)(1,9) and adsorption to soil is sensitive to the soil pH. In a study of the adsorption of benzidine to 14 soils and sediments, it was found that the Freundlich adsorption constant was not correlated with any soil property such as % organic carbon but rather with pH(1). The pH controls the amount of benzidine in the ionized form and sorption increases as the pH decreases, that is, as a greater fraction of the total benzidine occurs in the ionic form. The Freundlich adsorption constant for the 14 soils and sediments ranged from 50 to 3,940 on a molar basis. The adsorption curve is highly non-linear with the average value of 1/n in the Freundlich adsorption equation being 0.5(1). In another study with 4 soils, the Freundlich adsorption constants ranged from 7,600 to 21,000 and the mean 1/n was 0.768(6). Even though the adsorption curves were not linear, Koc values were estimated to range from 227,000 to 882,000(6). Koc values for benzidine adsorbed to 3 estuarine sediments containing 0.93, 1.36, and 3.01% organic carbon were 4,899, 462, and 3,307, respectively(4). For adsorption to Chesapeake Bay sediment, the Freundlich adsorption constant was 6,025 and 1/n was 0.75 at pH 7.9(5). Adsorption increased as pH decreased, indicating that the protonated form of benzidine is more strongly bound to colloids than the neutral form(5). A sequential extraction procedure was used to show that benzidine binds to soil in two phases(7). Initially a reversible equilibrium is established followed by covalent bonding to soil organic matter, primarily humic acids(7). The benzidine concentration in soil solution decreases rapidly over the first 6 hours and then more slowly(8). After 48 hrs the level of benzidine in soil solution remains constant, 6-22 ppb for soil application rates of 30-50 ppm(8). Benzidine adsorbs to clay minerals forming a blue-colored species, the adsorption increasing with decreasing pH(2). Aromatic amines like benzidine are known to form covalent bonds with humic materials, adding to quinone-like structures followed by a slow oxidation(3,9). According to a classification scheme(10), the Koc values from sediment and soil(4,6) suggest that benzidine is expected to have very low or no mobility in soil(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1885 IMDG: UN1885 IATA: UN1885

14.2 UN Proper Shipping Name

ADR/RID: BENZIDINE
IMDG: BENZIDINE
IATA: BENZIDINE

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
4-(4-aminophenyl)aniline 4-(4-aminophenyl)aniline 92-87-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 17, 2017
Revision Date Aug 17, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Section 1. Chemical Product and Company Identification
    Benzidine
    Common Name/
    Trade Name
    Benzidine

Section 3. Hazards Identification
    Hazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant, permeator), of eye
    Potential Acute Health
    contact (irritant).
    Effects
    CARCINOGENIC EFFECTS: Classified A1 (Confirmed for human.) by ACGIH, 1 (Proven for human.) by IARC, 1 (Clear
    Potential Chronic Health
    evidence. Known to be a human carcinogen) by NTP, + (Proven. Cancer suspect agent) by OSHA.
    Effects
    MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    The substance may be toxic to kidneys, liver.
    Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4. First Aid Measures
    Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
    Eye Contact
    15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if irritation occurs.
    Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
    Skin Contact
    Not available.
    Serious Skin Contact
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get    
    medical attention.
    Serious Inhalation        Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband.    
    If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek
    medical attention.
    Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
    Ingestion
    unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
    clothing such as a collar, tie, belt or waistband.
    Not available.
    Serious Ingestion

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Not available.
    Flash Points
    Not available.
    Flammable Limits
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards in
    Risks of explosion of the product in presence of static discharge: Not available.
    Presence of Various
    Substances
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    When heated to decomposition it emits very toxic fumes of nitrogen oxides. Material in powder form, capable of
    Special Remarks on
    creating a dust explosion.
    Fire Hazards
    Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
    Special Remarks on
    explosion hazard.
    Explosion Hazards
    Benzidine

Section 6. Accidental Release Measures
    Use appropriate tools to put the spilled solid in a convenient waste disposal container.
    Small Spill
    Large Spill        Use a shovel to put the material into a convenient waste disposal container.    

Section 7. Handling and Storage
    Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
    Precautions
    ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable
    respiratory equipment. If ingested, seek medical advice immediately and show the container or the label.
    Keep container tightly closed. Keep container in a cool, well-ventilated area.
    Storage

Section 8. Exposure Controls/Personal Protection
    Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
    Engineering Controls
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.    
    Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
    avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
    of a Large Spill
    handling this product.
    Exposure Limits        Not available.    

Section 9. Physical and Chemical Properties
    Solid. (Crystalline powder.)        Not available.    
    Physical state and        O dor    
    appearance
    Not available.
    Taste
    184.24 g/mole
    Molecular Weight
    Beige. White to yellowish. White.
    Color
    Not available.
    pH (1% soln/water)
    401°C (753.8°F)
    Boiling Point
    115°C (239°F) - 128 C.
    Melting Point
    Not available.
    Critical Temperature
    1.25 (Water = 1)
    Specific Gravity
    Not applicable.
    Vapor Pressure
    6.36 (Air = 1)
    Vapor Density
    Not available.
    Volatility
    Not available.
    Odor Threshold
    The product is more soluble in oil; log(oil/water) = 1.3
    Water/Oil Dist. Coeff.
    Not available.
    Ionicity (in Water)
    See solubility in water, diethyl ether.
    Dispersion Properties
    Partially soluble in diethyl ether.
    Solubility
    Very slightly soluble in cold water.
    1 gram dissolves in 2500 ml cold water; 1 gram dissolves in 107 ml boiling water; 1 gram dissolves in 5 ml boiling
    alcohol; 1 gram dissolves in 50 ml ether.
    Other information on Solubility in Water: 322 mg/L at 25 deg. C.
    Benzidine

Section 10. Stability and Reactivity Data
    The product is stable.
    Stability
    Not available.
    Instability Temperature
    Conditions of Instability Excess heat, incompatible materials, dust generation.
    Incompatibility with various Not available.
    substances
    Not available.
    Corrosivity
    Benzidine is hypergollic (will ignite spontaneously) with red fuming nitric acid.
    Special Remarks on
    Reactivity
    Not available.
    Special Remarks on
    Corrosivity
    Will not occur.
    Polymerization

Section 11. Toxicological Information
    Absorbed through skin. Inhalation. Ingestion.
    Routes of Entry
    Acute oral toxicity (LD50): 214 mg/kg [Mouse].
    Toxicity to Animals
    CARCINOGENIC EFFECTS: Classified A1 (Confirmed for human.) by ACGIH, 1 (Proven for human.) by IARC, 1 (Clear
    Chronic Effects on Humans
    evidence. Known to be a human carcinogen) by NTP, + (Proven. Cancer suspect agent) by OSHA.
    MUTAGENIC EFFECTS: Mutagenic for mammalian somatic cells. Mutagenic for bacteria and/or yeast.
    May cause damage to the following organs: kidneys, liver.
    Hazardous in case of ingestion, of inhalation.
    Other Toxic Effects on
    Humans        Slightly hazardous in case of skin contact (irritant, permeator).    
    Not available.
    Special Remarks on
    Toxicity to Animals
    Special Remarks on        May affect genetic material (mutagenic).    
    Chronic Effects on Humans May cause cancer.
    Special Remarks on other        Acute Potential Health Effects:    
    Skin: May cause skin irritation. Can be absorbed through the skin.
    Toxic Effects on Humans
    Eyes: May cause eye irritation.
    Inhalation:
    Ingestion: Harmful if swallowed. It can cause nausea, vomiting. It may cause liver and kidney damage.
    Chronic Potential Health Effects:
    Skin: Prolonged or repeated skin contact may cause skin allergy.

Section 12. Ecological Information
    Not available.
    Ecotoxicity
    Not available.
    BOD5 and COD
    Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    arise.
    The products of degradation are less toxic than the product itself.
    Toxicity of the Products
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation
    Benzidine

Section 13. Disposal Considerations
    Waste must be disposed of in accordance with federal, state and local environmental control
    Waste Disposal
    regulations.

Section 14. Transport Information
    CLASS 6.1: Poisonous material.
    DO T Cl assi fi cati on
    : Benzidine UNNA: 1885 PG: II
    Identification
    Not available.
    Special Provisions for
    Transport
    DO T (Pi ctograms)

Section 15. Other Regulatory Information and Pictograms
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    Federal and State
    cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Benzidine
    Regulations
    California prop. 65 (no significant risk level): Benzidine: 1e-006 mg/day (value)
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause cancer which would require a warning under the statute: Benzidine
    Connecticut carcinogen reporting list.: Benzidine
    Connecticut hazardous material survey.: Benzidine
    Illinois chemical safety act: Benzidine
    New York release reporting list: Benzidine
    Rhode Island RTK hazardous substances: Benzidine
    Pennsylvania RTK: Benzidine
    Minnesota: Benzidine
    Massachusetts RTK: Benzidine
    Massachusetts spill list: Benzidine
    New Jersey: Benzidine
    New Jersey spill list: Benzidine
    Louisiana spill reporting: Benzidine
    California Director's List of Hazardous Substances: Benzidine
    TSCA 5(a)2 final significant rules: Benzidine
    TSCA 8(c) calls for record of SAR: Benzidine
    TSCA 8(d) H and S data reporting: Benzidine: Effective date: 6/1/87; Sunset date: 6/1/97
    SARA 302/304/311/312 extremely hazardous substances: Benzidine
    SARA 313 toxic chemical notification and release reporting: Benzidine
    CERCLA: Hazardous substances.: Benzidine: 1 lbs. (0.4536 kg)
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    California
    cause cancer which would require a warning under the statute: Benzidine
    Proposition 65
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: No products were found.
    OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
    Other Regulations
    EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.
    202-199-1).
    Canada: Listed on Canadian Non-Domestic Substance List (NDSL).
    China: Listed on National Inventory.
    Japan: Not listed on National Inventory (ENCS).
    Korea: Listed on National Inventory (KECI).
    Philippines: Listed on National Inventory (PICCS).
    Australia: Listed on AICS.
    CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
    Other Classifications        WHMIS (Canada)    
    CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
    Class D-2B: Material causing other toxic effects (TOXIC).
    Benzidine
    DSCL (EEC)        R22- Harmful if swallowed.        S45- In case of accident or if you feel unwell,    
    R45- May cause cancer.        seek medical advice immediately (show the    
    R50/53- Very toxic to aquatic        label where possible).    
    organisms, may cause long-term        S53- Avoid exposure - obtain special instructions    
    adverse effects in the aquatic        before use.    
    environment.        S60- This material and its container must be    
    disposed of as hazardous waste.
    S61- Avoid release to the environment. Refer to
    special instructions/Safety data sheets.
    Health Hazard
    HMIS (U.S.A.)        2 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    2 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    TDG(Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or equivalent.
    Wear appropriate respirator when ventilation
    is inadequate.
    Safety glasses.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : Predict
expand collapse
IR Spectrum IR : nujol mull
expand collapse
Toxicity
TUMORIGENIC DATA
expand collapse
Type of Test
TCLo - Lowest published toxic concentration
Exposure Route
Inhalation
Species Observed
Human - man
Dose/Duration
17600 ug/m3/14Y-C
Toxic Effects
Tumorigenic--Carcinogenic by RTECS criteria<br>Kidney, Ureter, Bladder--hematuria<br>Kidney, Ureter, Bladder--tumors
Reference
Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 27,1,1973
TUMORIGENIC DATA
expand collapse
Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
108 mg/kg/27D-I
Toxic Effects
Tumorigenic--Carcinogenic by RTECS criteria<br>Skin and Appendages--tumors
Reference
Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 28,924,1968
TUMORIGENIC DATA
expand collapse
Type of Test
TCLo - Lowest published toxic concentration
Exposure Route
Inhalation
Species Observed
Rodent - rat
Dose/Duration
10 mg/m3/56W-I
Toxic Effects
Tumorigenic--equivocal tumorigenic agent by RTECS criteria<br>Liver--tumors<br>Blood--leukemia
Reference
Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 69,68,1970

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