9-aminoacridine

CAS No. 90-45-9

Formula: C13H10N2
Basic Info

9-Aminoacridine is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.

Formula
C13H10N2
Molecular Weight
194.232
Exact Mass
194.084
LogP
3.5514
PSA
38.91
Synonyms

9-Aminoacridine

9-Acridinamine

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Properties
Appearance & Physical State
yellow crystals or powder
Density
1.268g/cm3
Boiling Point
413.5ºC at 760 mmHg
Melting Point
241ºC
Flash Point
233.2ºC
Refractive Index
1.78
Stability
Stable. Incompatible with strong oxidizing agents.
Safety Info
RTECS
AR7300000
Safety Statements
S26; S36
WGK Germany
3
Risk Statements
R36/37/38
RIDADR
UN 2811
Hazard Class
6.1(b)
Packing Group
III
Hazard Codes
Spectrum
NMR Spectrum 1H NMR : 400 MHz in DMSO-d6
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IR Spectrum IR : nujol mull
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Mass Spectrum Mass
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Analysis Methods
Van Den Dool and Kratz RI, non-polar column, temperature ramp
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Column Shape
Packed
Active Phase(℃)
SE-30
Retention index
2240.
Temperature Control
Method
temperature ramp
Comments
N2, Chromosorb W, 130. C @ 2. min, 8. K/min, 290. C @ 8. min; Column length: 1.8 m
Reference
Perrigo, B.J.Peel, H.W.The use of retention indices and temperature-programmed gas chromatography in analytical toxicologyJ. Chromatogr. Sci.1981, 19, 5, 219-226.
Normal alkane RI, non-polar column, custom temperature program
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Column Shape
Other
Active Phase(℃)
Methyl Silicone
Retention index
2240.
Temperature Control
Method
custom temperature program
Comments
Program: not specified
Reference
Ardrey, R.E.Moffat, A.C.Gas-liquid chromatographic retention indices of 1318 substances of toxicological interest on SE-30 or OV-1 stationary phaseJ. Chromatogr.1981, 220, 3, 195-252.
Toxicity
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Intraperitoneal
Species Observed
Rodent - mouse
Dose/Duration
68 mg/kg
Toxic Effects
Lungs, Thorax, or Respiration--respiratory stimulation
Reference
Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry. (Publications & Information Directorate, Council of Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012, India) V.14B- 1976- Volume(issue)/page/year: 26,318,1987
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Subcutaneous
Species Observed
Rodent - mouse
Dose/Duration
80 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year: 28,1,1947
MUTATION DATA
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Type of Test
Mutation in microorganisms
Exposure Route
Species Observed
Dose/Duration
1 ug/plate
Toxic Effects
--
Reference
Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 35,792,1987

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