acridine

CAS No. 260-94-6

Formula: C13H9N
Basic Info

Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. It is a planar molecule that is structurally related to anthracene with one of the central CH groups replaced by nitrogen. Like the related molecule pyridine and quinoline, acridine is mildly basic. It is an almost colorless solid. There are no commercial applications of acridines but at one time acridine dyes were popular. It crystallizes in needles.

Formula
C13H9N
Molecular Weight
179.217
Exact Mass
179.073
LogP
3.388
PSA
12.89
Synonyms

Acrydine

benzoquinolinylidene

Akridin

10-Azaanthracene

2,3-Benzoquinoline

Acridine

2,3,5,6-Dibenzopyridine

9-Azaanthracene

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Properties
Appearance & Physical State
colourless to light yellow crystals
Density
1.005
Boiling Point
346ºC
Melting Point
105-110ºC
Flash Point
153.8ºC
Refractive Index
1.726
Stability
Stable. Combustible. Incompatible with strong oxidizing agents.
Storage Condition
Refrigerator
Vapor Pressure
0.000113mmHg at 25°C
Safety Info
RTECS
AR7175000
Safety Statements
S26-S36/37/39-S45
WGK Germany
3
Risk Statements
R22; R36/37/38
HS Code
2933990090
RIDADR
UN 2713 6.1/PG 3
Hazard Class
6.1
Packing Group
III
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name acridine

1.2 Other means of identification

Product number -
Other names Acrydine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
acridine acridine 260-94-6 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

Inhalation irritates respiratory system and causes sneezing, crying, and vomiting. Contact with liquid irritates eyes, skin, and mucous membranes. At high temperature and during sun exposure, damage to the cornea, skin, and mucous membranes may occur following the liberation of acridine vapor. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Minimum/Potential Fatal Human Dose

3. 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB).

Absorption, Distribution and Excretion

ACRIDINE WAS RAPIDILY ACCUM FROM WATER BY FATHEAD MINNOWS. EQUIL CONCN WITHIN 24 HR @ CONCN FACTOR ((ACRIDINE)FISH,WET WT/(ACRIDINE)WATER) OF 125 +/- 10. DEPURATION WAS RAPID. NET ELIMINATION RATE WAS 0.23/HR (ACRIDINE)FISH @ EQUILIBRIUM.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

If material on fire or involved in fire: Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fire. Behavior in Fire: Sublimes before melting (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

...MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED...

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state colourless to light yellow crystals
Colour RHOMBOHEDRAL NEEDLES OR PRISMS FROM ALCOHOL; MONOCLINIC, ORTHORHOMBIC
Odour no data available
Melting point/ freezing point 189°C(lit.)
Boiling point or initial boiling point and boiling range 61°C/12mmHg(lit.)
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 65°C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH A WEAK BASE, COLORS LITMUS PAPER BLUE
Kinematic viscosity no data available
Solubility SLIGHTLY SOL IN HOT WATER; VERY SOL IN ALCOHOL, ETHER, BENZENE AND CARBON DISULFIDE
Partition coefficient n-octanol/water (log value) Log P= 3.40
Vapour pressure 0.000113mmHg at 25°C
Density and/or relative density 1.005
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

VOLATILE WITH STEAM

10.3 Possibility of hazardous reactions

ACRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. Burns to give toxic oxides of nitrogen.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

STABILITY: This chemical undergoes photo-oxidation after irradiation in indoor sunlight or by fluorescent light in organic solvents. Solutions of this chemical in benzene oxidize under the influence of light and air. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions.REACTIVITY: This chemical is incompatible with strong oxidizers. It readily undergoes nitration and halogenation. Ozone, chromic acid and chlorinating agents oxidize this compound. This chemical may react with organic and inorganic oxidants including various electrophiles, peroxides, nitrogen oxides and sulfur oxides. Hydrogenation occurs with platinum oxide.

10.6 Hazardous decomposition products

WHEN HEATED TO DECOMPOSITION, ACRIDINE EMITS TOXIC FUMES.

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

EPA-B2, IARC-1, NIOSH-Ca, NTP-R, TLV-A2

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

The biodegradation of acridine at concentrations from 0.1 to 20 mg/l was measured in river die-away tests using Green River water; over 11 days this compound was not significantly biodegraded at any measured concentration(1). Acridine at 500 mg/kg soil was measurably present for 83 days in chernozem soil samples at a temperature of 19°C(2). A half-life of 3 days in soil was reported for acridine when present at a concentration of 5 mg/kg(3). Acridine, initially present in a groundwater sample at 22.5 ug/ml, was inoculated with creosote-contaminated surface soil; 19, 37, 91.5, 91, and 91% of this compound was biodegraded following 1, 3, 5, 8, and 14 days incubation(4). The sterile control was not degraded over 14 days(4). During solid-phase bioremediation of creosote/PCP contaminated surface soils, unamended soils, containing acridine initially at 46.8 mg/landfarming chamber (3 kg) biodegraded this compound by 83% over 12 weeks(5). In similar experiments using surficial soil, 32% biodegradation was reported over 12 weeks with an initial acridine concentration of 14569.7 mg/landfarming chamber (3 kg)(5). The presence of 9-acridinone in groundwater samples possibly indicates that this compound may be the final product of the biodegradation of acridine in contaminated aquifers(6).

12.3 Bioaccumulative potential

In a static bioconcentration test, a BCF value of 1300 was measured in the guppy, Poecilia reticulata(1). Rate constants for uptake and depuration were 40.8 and 0.031/hour, respectively(1). An equilibrium BCF of 30 was measured for acridine in Daphnia pulex; rate constants for uptake and depuration were 109.6 and 0.47/hour, respectively(2). A BCF value of 126 was measured in fathead minnows(3). Fathead minnows, exposed to 100 ug/L acridine in a flow-through spring water system, rapidly accumulated acridine directly from the water with concentrations of about 12 ug/g wet attained in the fish after 24 hours giving a BCF of 125(4). Further exposure did not result in higher levels of acridine in these fish(4). Rate constants for uptake and depuration were 14 and 0.112/hour, respectively(4). Uncontaminated water rapidly contained measurable concentrations of acridine once minnows containing this compound were added to the water; this suggests that acridine can be eliminated without metabolic alteration as well as through metabolic degradation(4). Minnows exposed to acridine-contaminated sediment and a low level of dissolved acridine did not accumulate much acridine from the sediment(4). According to a classification scheme(5), these BCF values suggest that bioconcentration in aquatic organisms is low to very high depending on the aquatic organism studied(SRC); however, this compound appears to be readily depurated in several organisms. Mussels, Elliptio complanata, did not accumulate detectable concentrations of acridine following three weeks exposure to contaminated sediments in the St. Mary's River in 1985 (detection limit= 1 ug/kg wet weight)(6).

12.4 Mobility in soil

Fourteen soil and sediment samples, collected from the Ohio, Missouri, Mississippi, and Illinois rivers and their watersheds had a wide range in pH (4.54-8.34), total clay (6.8 to 69.1%), organic carbon (0.11 to 2.38%), and expanding clay (2.0 to 60.0%). Koc values for acridine added to these soils/sediments ranged from 5500 to 30,909 with an average value of 12,910(1). According to a recommended classification scheme(2), these measured Koc values suggest that acridine will be immobile in soil(SRC). Adsorption of acridine to silica was measured in a continuous-flow column. The extent of adsorption was greater when the solution pH was below the pKa of acridine(pKa= 5.68(3)) than when it was above(4). Therefore, mobility should be greater in a sand soil when the pH is above the pKa of acridine and adsorption is greatest when the solution pH equals acridine's pKa(4). Sorption of acridine to two low organic carbon subsurface materials with similar properties but different equilibrium pH values when saturated with water was measured(5). Higher sorption was reported for the Loring subsoil (0.24% organic carbon, pH 4.85) than the Anvil Points subsoil (0.58% organic carbon, pH 8.15), consistent with compound ionization and preferential retention of the organic cation over the neutral compound(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2713 IMDG: UN2713 IATA: UN2713

14.2 UN Proper Shipping Name

ADR/RID: ACRIDINE
IMDG: ACRIDINE
IATA: ACRIDINE

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
acridine acridine 260-94-6 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 11, 2017
Revision Date Aug 11, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: Acridine 98% Material Safety Data Sheet
Synonym: Dibenzo[b,e]pyridine; 2,3-Benzoquinoline
CAS: 260-94-6
Section 1 - Chemical Product   MSDS Name:Acridine 98% Material Safety Data Sheet
Synonym:Dibenzo[b,e]pyridine; 2,3-Benzoquinoline

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
260-94-6 Acridine 98.0 205-971-6
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.Lachrymator (substance which increases the flow of tears).Light sensitive.
Potential Health Effects
Eye:
Causes eye irritation. Lachrymator (substance which increases the flow of tears). May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. Inhalation of dust causes irritation of the nose and throat, coughing and sneezing. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub eyes or keep eyes closed.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Store protected from light. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 260-94-6: United States OSHA: 0.2 mg/m3 TWA (as benzene soluble fraction) (listed under Coal tar pitches).
Belgium - TWA: (listed as coal tar pitches): 0.2 mg/m3 VLE France - VME: (listed as coal tar pitches): 0.2 mg/m3 VME (vapors mists, benzene-soluble fraction) Germany: (listed as coal tar pitches): 0.2 mg/m3 VME (vapors and mists, benzene-soluble fraction) Malaysia: (listed as coal tar pitches): 0.2 mg/m3 TWA (as benzene solubles) Spain: (listed as coal tar pitches): 0.2 mg/m3 VLA-ED (benzene soluble fraction) Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Color: yellow
Odor: None reported.
pH: Not available.
Vapor Pressure: 1 mm Hg @ 129 deg C
Viscosity: Not available.
Boiling Point: 345.5 deg C @ 760 mm Hg
Freezing/Melting Point: 107.00 - 110.00 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: 38.4 mg/L @ 24C
Specific Gravity/Density:
Molecular Formula: C13H9N
Molecular Weight: 179.0697

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions. Volatile in steam.
Conditions to Avoid:
Incompatible materials, light, dust generation, excess heat.
Incompatibilities with Other Materials:
Contact with strong ozidizers may cause fire and explosion..
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 260-94-6: AR7175000 LD50/LC50:
CAS# 260-94-6: Oral, mouse: LD50 = 500 mg/kg; Oral, rat: LD50 = 2 gm/kg.
Carcinogenicity:
Acridine - NTP: Known carcinogen (listed as Coal tar pitches).
IARC: Group 1 carcinogen (listed as Coal tar pitches).
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Bacteria: Phytobacterium phosphoreum: EC50 = 6.66-7.47 mg/L; 5,15,30 minutes; Microtox test; 15 degrees C

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: ACRIDINE
Hazard Class: 6.1
UN Number: 2713
Packing Group: III
IMO
Shipping Name: ACRIDINE
Hazard Class: 6.1
UN Number: 2713
Packing Group: III
RID/ADR
Shipping Name: ACRIDINE
Hazard Class: 6.1
UN Number: 2713
Packing group: III

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 260-94-6: No information available.
Canada
CAS# 260-94-6 is listed on Canada's NDSL List.
CAS# 260-94-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 260-94-6 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
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IR Spectrum IR : nujol mull
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Mass Spectrum Mass
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ESR Spectrum ESR : ANION RADICAL, REDUCTION WITH K-METAL AT RT
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Analysis Methods
Kovats' RI, non-polar column, temperature ramp
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Column Shape
Packed
Active Phase(℃)
OV-101
Retention index
1800.
Temperature Control
Method
temperature ramp
Comments
N2, Chromosorb G HP, 100. C @ 3. min, 30. K/min, 310. C @ 5. min; Column length: 0.6 m
Reference
Maurer, H.H.Detection of anticonvulsants and their metabolites in urine within a general unknown analysis procedure using computerized gas chromatography-mass spectrometryArch. Toxicol.1990, 64, 7, 554-561.
Van Den Dool and Kratz RI, non-polar column, temperature ramp
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Column Shape
Capillary
Active Phase(℃)
DB-5
Retention index
1819.
Temperature Control
Method
temperature ramp
Comments
30. m/0.26 mm/0.25 μm, He, 50. C @ 4. min, 6. K/min, 300. C @ 20. min
Reference
Rostad, C.E.Pereira, W.E.Kovats and Lee retention indices determined by gas chromatography/mass spectrometry for organic compounds of environmental interestJ. Hi. Res. Chromatogr. Chromatogr. Comm.1986, 9, 6, 328-334.
Van Den Dool and Kratz RI, non-polar column, temperature ramp
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Column Shape
Capillary
Active Phase(℃)
SE-52
Retention index
1808.
Temperature Control
Method
temperature ramp
Comments
He, 50. C @ 5. min, 6. K/min; Column length: 33.3 m; Column diameter: 0.50 mm; T<sub>end</sub>: 320. C
Reference
Beernaert, H.Gas Chromatographic Analysis of Polyclylic Aromatic HydrocarbonsJ. Chromatogr.1979, 173, 1, 109-118.
Van Den Dool and Kratz RI, non-polar column, custom temperature program
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Column Shape
Capillary
Active Phase(℃)
5 % Phenyl methyl siloxane
Retention index
1784.
Temperature Control
Method
custom temperature program
Comments
25. m/0.31 mm/0.52 μm, He; Program: 50C(2min) =&gt; (20C/min) =&gt; 120C =&gt; (7C/min) =&gt; 310C(10min)
Reference
Yasuhara, A.Shiraishi, H.Nishikawa, M.Yamamoto, T.Uehiro, T.Nakasugi, O.Okumura, T.Kenmotsu, K.Fukui, H.Nagase, M.Ono, Y.Kawagoshi, Y.Baba, K.Noma, Y.Determination of organic components in leachates from hazardous waste disposal sites in Japan by gas chromatography-mass spectrometryJ. Chromatogr. A1997, 774, 1-2, 321-332.
Normal alkane RI, non-polar column, custom temperature program
expand collapse
Column Shape
Capillary
Active Phase(℃)
Polydimethyl siloxane, unknown content of Ph-groups
Retention index
1806.
Temperature Control
Method
custom temperature program
Comments
Program: not specified
Reference
Geldon, A.L.Ground Water Hydrology of the Central Raton Basin, Colorado and New MexicoUS Geological Survey, US Government Printing Office, 1989, 104.
Toxicity
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
2 gm/kg
Toxic Effects
Behavioral--somnolence (general depressed activity)<br>Gastrointestinal--necrotic changes<br>Blood--changes in erythrocyte (RBC) count
Reference
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(9),56,1970
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - mouse
Dose/Duration
500 mg/kg
Toxic Effects
Sense Organs and Special Senses (Eye)--lacrimation<br>Behavioral--somnolence (general depressed activity)<br>Behavioral--excitement
Reference
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(9),56,1970
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Subcutaneous
Species Observed
Rodent - mouse
Dose/Duration
400 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year: 28,1,1947

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