4-Methyl-2-pentanone

CAS No. 108-10-1

Formula: C6H12O
Basic Info

Methyl isobutyl ketone (MIBK) is the organic compound with the formula (CH3)2CHCH2C(O)CH3. This colourless liquid, a ketone, is used as a solvent for gums, resins, paints, varnishes, lacquers, and nitrocellulose.

Formula
C6H12O
Molecular Weight
100.159
Exact Mass
100.089
LogP
1.6215
PSA
17.07
Synonyms

4-methylpentan-2-one

2-Pentanone, 4-methyl-

Methyl Isobutyl Ketone

4-Methyl-2-pe

Isopropylacetone

Isobutyl methyl ketone

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Properties
Appearance & Physical State
Clear liquid
Density
0.7978
Boiling Point
117.4ºC
Melting Point
-84ºC
Flash Point
14ºC
Refractive Index
1.395-1.397
Water Solubility
17 g/L (20 ºC)
Storage Condition
2-8ºC
Vapor Density
3.5 (vs air)
Vapor Pressure
15 mm Hg ( 20 °C)
Safety Info
RTECS
SA9275000
Safety Statements
S16-S29-S9
WGK Germany
1
Risk Statements
R11; R20; R36/37; R66
HS Code
2914130000
RIDADR
UN 1245
Hazard Class
3
Packing Group
II
Caution Statement
P210; P261; P305 + P351 + P338
Hazard Codes
Hazard Declaration
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Methyl-2-pentanone

1.2 Other means of identification

Product number -
Other names 4-methylpentan-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 2

Eye irritation, Category 2

Acute toxicity - Inhalation, Category 4

Specific target organ toxicity – single exposure, Category 3

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H225 Highly flammable liquid and vapour

H319 Causes serious eye irritation

H332 Harmful if inhaled

H335 May cause respiratory irritation

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/…if you feel unwell.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
4-Methyl-2-pentanone 4-Methyl-2-pentanone 108-10-1 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Vapor causes irritation of eyes and nose; high concentrations cause anesthesia and depression. Liquid dries out skin and may cause dermatitis; irritates eyes but does not injure them. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

INHALATION: Symptoms: Cough. Diarrhea. Dizziness. Headache. Nausea. Sore throat. Unconsciousness. Vomiting. Weakness. Loss of appetite. First aid: Fresh air, rest. Refer for medical attention. SKIN: Symptoms: Dry skin. Redness. Pain. First aid: Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention. EYES: Symptoms: Redness. Pain. First aid: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. INGESTION: Symptoms: Abdominal pain. First aid: Rinse mouth. Do NOT induce vomiting. Refer for medical attention.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

... Water should not be used, since this may cause the fire to spread, though a water spray can be used to cool containers.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Irritating vapors are generated when heated. Behavior in Fire: Vapors may travel a considerable distance and ignite. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or similar material and deposit in sealed containers. Oil-skimming equipment and sorbent foams can be applied to slick if done immediately. Keep this chemical out of a confined space ... because of the possibility of an explosion ... It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from strong oxidants. Well closed.... OPEN LIGHTS OR OTHER AGENCIES LIABLE TO IGNITE THE VAPOR SHOULD BE EXCLUDED FROM THOSE AREAS WHERE LIQUID IS BEING STORED OR USED. /KETONES/

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 50 ppm (205 mg/cu m).

Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 75 ppm (300 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Clear liquid
Colour Colorless liquid
Odour Pleasant odor
Melting point/ freezing point -85°C(lit.)
Boiling point or initial boiling point and boiling range 117-118°C
Flammability Class IB Flammable Liquid: Fl.P. below 22.78°C and BP at or above 37.78°C.Highly flammable.
Lower and upper explosion limit / flammability limit Lower flammable limit: 1.2% by volume @ 200 deg F (93°C); Upper flammable limit: 8.0% by volume @ 200 deg F (93°C)
Flash point 14°C
Auto-ignition temperature 448.89°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:17 g/L (20 ºC)
Partition coefficient n-octanol/water (log value) log Kow = 1.31
Vapour pressure 15 mm Hg ( 20 °C)
Density and/or relative density 0.801g/mLat 25°C(lit.)
Relative vapour density 3.5 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

STABLE LIQUID

10.3 Possibility of hazardous reactions

Flammable liquid when exposed to heat, flame, or oxidizers.The vapour mixes well with air, explosive mixtures are easily formed.METHYL ISOBUTYL KETONE is incompatible with caustic soda and other strong alkalis, hydrochloric acid, sulfuric acid and other strong inorganic acids, amines and oxidizing agents such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. It reacts violently with potassium tert-butoxide. It reacts vigorously with reducing materials. .

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Able to form unstable and explosive peroxides on contact with air. Reacts violently with strong oxidizers, potassium tert-butoxide, strong acids, aliphatic amines, reducing agents.

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: LD50 Mouse oral 2850 mg/kg bw
  • Inhalation: LC50 Rat inhalation 8.2-16.4 mg/L/4 hr
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

EPA-1, TLV-A3

Reproductive toxicity

No information is available on the reproductive or developmental effects of methyl isobutyl ketone in humans. Maternal toxicity and neurological effects and increased liver and kidney weights in fetuses were observed in rats and mice exposed to methyl isobutyl ketone by inhalation.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50 Pimephales promelas (fathead minnow) 505 mg/L 96 hr flow-through bioassay, wt 0.12 g, water hardness 45.5 mg/L CaCO3, temp: 25 + or - 1°C, pH 7.5, dissolved oxygen greater than 60% of saturation
  • Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (/Water flea/) 78 mg/L/21 day; reproduction rate.
  • Toxicity to algae: EC50; Species: Scenedesmus subspicatus (Green algae, Log growth phase); Conditions: freshwater, static, 24°C, pH 8.0-9.3; Concentration: 980 mg/L for 48 hr; Effect: decreased population biomass
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: The theoretical BOD of methyl isobutyl ketone (5 ppm) in seawater was measured as 27.6% and 30.6% over a 5 day incubation period(1). The theoretical BOD of methyl isobutyl ketone in freshwaters seeded with settled domestic sewage was 56%, 66%, 69% and 69%, over 5, 10, 15 and 20 day incubation periods(2). The theoretical BOD of methyl isobutyl ketone in synthetic seeded seawaters with settled domestic sewage was 15%, 46%, 50% and 53%, over 5, 10, 15 and 20 day incubation periods(2). The theoretical BOD of a 100 mg/L sample of methyl isobutyl ketone in an activated sludge inoculum was 84% over a 2 week incubation period(3). Methyl isobutyl ketone was degraded 78-84% with a degradation rate of 0.24 1/hr in experiments using activated sludge inoculum, 100 mg/L of methyl isobutyl ketone, 30 mg/L biomass and a temperature of 28°C for 28 days(4). Methyl isobutyl ketone had influent concns of 8100, 8100 and 190 ug/L and effluent concns of 27.5, 40.5 and <10 ug/L using an activated sludge with a daily mass loading of COD/bacterial mass ratios of 0.1, 0.36 and 0.48, respectively(5). Methyl isobutyl ketone was degraded from 855 ug/L to 143 ug/L in 12 hours and from 3385 ug/L to 1098 ug/L in 8 hours using activated sludge that was acclimated for 3 weeks(6). In a wastewater stream, a BOD of 2.06 g of oxygen/g and a COD of 2.16 g of oxygen/g for methyl isobutyl ketone were found(7).

12.3 Bioaccumulative potential

An estimated BCF of 2 was calculated in fish for methyl isobutyl ketone(SRC), using a log Kow of 1.31(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of methyl isobutyl ketone is estimated as 120(SRC), using a log Kow of 1.31(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that methyl isobutyl ketone is expected to have high mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1245 IMDG: UN1245 IATA: UN1245

14.2 UN Proper Shipping Name

ADR/RID: METHYL ISOBUTYL KETONE
IMDG: METHYL ISOBUTYL KETONE
IATA: METHYL ISOBUTYL KETONE

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
4-Methyl-2-pentanone 4-Methyl-2-pentanone 108-10-1 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : 4-Methyl-2-pentanone    
    REACH No.        : 01-2119473980-30-XXXX    
    CAS-No.        : 108-10-1    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 2), H225
    Acute toxicity, Inhalation (Category 4), H332
    Eye irritation (Category 2), H319
    Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    F Highly flammable        R11    
    R66
    Xi Irritant        R36/37    
    Xn Harmful        R20    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Danger    
    Hazard statement(s)
    H225        Highly flammable liquid and vapour.    
    H319        Causes serious eye irritation.    
    H332        Harmful if inhaled.    
    H335        May cause respiratory irritation.    
    Precautionary statement(s)
    P210        Keep away from heat/sparks/open flames/hot surfaces. - No smoking.    
    P261        Avoid breathing vapours.    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    Supplemental Hazard information (EU)
    EUH066        Repeated exposure may cause skin dryness or cracking.    
  Other hazards - none

SECTION 3: Composition/information on ingredients
  Substances
    Synonyms        : Isobutyl methyl ketone    
    Methyl isobutyl ketone
    Isopropylacetone
    Formula        : C6H12O    
    Molecular Weight        : 100,16 g/mol    
    CAS-No.        : 108-10-1    
    EC-No.        : 203-550-1    
    Registration number        : 01-2119473980-30-XXXX    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  4-Methylpentan-2-one
    CAS-No.        108-10-1        Flam. Liq. 2; Acute Tox. 4; Eye <= 100 %    
    EC-No.        203-550-1        Irrit. 2; STOT SE 3; H225,    
    Index-No.        606-004-00-4        H319, H332, H335, EUH066    
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  4-Methylpentan-2-one
    CAS-No.        108-10-1        F, Xn, R11 - R20 - R36/37 -        <= 100 %    
    EC-No.        203-550-1        R66    
    Index-No.        606-004-00-4    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
    Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
    form explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Splash contact
    Material: butyl-rubber
    Minimum layer thickness: 0,3 mm
    Break through time: 212 min
    Material tested:Butoject® (KCL 897 / Z677647, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
    of protective equipment must be selected according to the concentration and amount of the
    dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid    
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        Melting point/range: -80 °C - lit.    
    point
    f) Initial boiling point and 117 - 118 °C - lit.
    boiling range
    g) Flash point        14 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        Upper explosion limit: 8 %(V)    
    flammability or        Lower explosion limit: 1,2 %(V)    
    explosive limits
    k) Vapour pressure        20 hPa at 20 °C    
    l) Vapour density        3,46 - (Air = 1.0)    
    m) Relative density        0,801 g/cm3 at 25 °C    
    n) Water solubility        ca.20 g/l    
    o) Partition coefficient: n- log Pow: 1,31
    octanol/water
    p) Auto-ignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    Surface tension        23,6 mN/m at 20 °C    
    Relative vapour density 3,46 - (Air = 1.0)

SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
    Test for peroxide formation before distillation or evaporation. Test for peroxide formation or discard after 1
    year.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks. Extremes of temperature and direct sunlight.
  Incompatible materials
    Oxidizing agents, Strong bases
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - rat - 2.080 mg/kg
    LC50 Inhalation - rat - 4 h - 8,2 - 16,4 mg/m3
    LD50 Dermal - rabbit - > 16.000 mg/kg
  Skin corrosion/irritation
    Skin - rabbit
    Result: Mild skin irritation - 24 h
  Serious eye damage/eye irritation
    Eyes - rabbit
    Result: Moderate eye irritation - 24 h
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    IARC:        2B - Group 2B: Possibly carcinogenic to humans (4-Methylpentan-2-one)    
  Reproductive toxicity
    Developmental Toxicity - mouse - Inhalation
    Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Effects on Embryo or Fetus:
    Fetal death.
    Developmental Toxicity - mouse - Inhalation
    Specific Developmental Abnormalities: Central nervous system. Specific Developmental Abnormalities:
    Musculoskeletal system. Specific Developmental Abnormalities: Cardiovascular (circulatory) system.
  Specific target organ toxicity - single exposure
    May cause respiratory irritation.
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: SA9275000
    Blurred vision, Dermatitis, To the best of our knowledge, the chemical, physical, and toxicological
    properties have not been thoroughly investigated.

SECTION 12: Ecological information
  Toxicity
    Toxicity to fish        LC0 - Leuciscus idus melanotus - 480 mg/l - 48 h    
    Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 1.550 - 3.623 mg/l - 24 h
    other aquatic
    invertebrates
    Toxicity to algae        EC50 - Desmodesmus subspicatus (green algae) - 980 - 2.000 mg/l - 48 h    
  Persistence and degradability
    Biodegradability        Biotic/Aerobic - Exposure time 7 d    
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    no data available

SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
    company.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 1245        IMDG: 1245        IATA: 1245    
  UN proper shipping name
    ADR/RID: METHYL ISOBUTYL KETONE
    IMDG: METHYL ISOBUTYL KETONE
    IATA:        Methyl isobutyl ketone    
  Transport hazard class(es)
    ADR/RID: 3        IMDG: 3        IATA: 3    
  Packaging group
    ADR/RID: II        IMDG: II        IATA: II    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available



SECTION 15 - REGULATORY INFORMATION
N/A


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 400 MHz in CDCl3
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IR Spectrum IR : liquid film
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Mass Spectrum Mass spectrum (electron ionization)
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Raman Spectrum Raman : 4880 A,200 M,liquid
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