piperazine

CAS No. 110-85-0

Formula: C4H10N2
Basic Info

Piperazine is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste.
The piperazines are a broad class of chemical compounds, many with important pharmacological properties, which contain a core piperazine functional group.

Formula
C4H10N2
Molecular Weight
86.1356
Exact Mass
86.0844
LogP
-0.1632
PSA
24.06
Synonyms

PIPERAZINE CHIPS

Diethylenediamine

PIPERAZINE

1,4-Diazacyclohexane

Trimetazidine Hydrochloride Impurity G

1,4-Diazacyclohexan

1,4-DIAZACYCLOHEXANE, CERTIFIED REFERENCE MATERIAL

1,4-Diazacyclohexane,Diethylenediamine

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Properties
Appearance & Physical State
needle-like white or colorless crystals
Density
1.1
Boiling Point
146-148ºC
Melting Point
107-111ºC
Flash Point
65ºC
Refractive Index
1.424
Water Solubility
150 g/L (20 ºC)
Stability
Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
Storage Condition
Store in dark
Vapor Pressure
0.8 mm Hg ( 20 °C)
Safety Info
RTECS
TK7800000
Safety Statements
S22-S26-S36/37/39-S45-S61
WGK Germany
1
Risk Statements
R34; R42/43; R52/53
HS Code
2933599090
RIDADR
UN 2579
Hazard Class
8
Packing Group
III
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name piperazine

1.2 Other means of identification

Product number -
Other names PIPERAZINE CHIPS

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

no data available

2.2 GHS label elements, including precautionary statements

Pictogram(s) no data available
Signal word

no data available

Hazard statement(s)

no data available

Precautionary statement(s)
Prevention

no data available

Response

no data available

Storage

no data available

Disposal

no data available

2.3 Other hazards which do not result in classification

no data available

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
piperazine piperazine 110-85-0 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Piperazine is a combustible liquid. Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers. Piperazine may burn, but does not readily ignite. Extinguish fire using an agent suitable for type of surrounding fire. Poisonous gases including nitrogen oxides and hydrogen chloride (hydrochloride) are produced in fire. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. Containers may explode in fire. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156.

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong acids, strong oxidants, acid anhydrides, metals and food and feedstuffs. Dry. Well closed.Piperazine must be stored to avoid contact with oxidizers (such as perchlorates, peroxides, permanganates, chlorates, and nitrates) since violent reactions occur. . Sources of ignition such as smoking and open flames are prohibited where piperazine is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Store in tightly closed containers in a cool, well vented area away form oxidizers. Where possible, automatically transfer material from drums or other storage containers to process containers. Metal containers involving the transfer of this chemical should be grounded and bonded. Wherever this chemical is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state needle-like white or colorless crystals
Colour Plates or leaflets from ethanol
Odour Typical amine odor
Melting point/ freezing point 107-111ºC
Boiling point or initial boiling point and boiling range 146-148ºC
Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit Flammability limits = 1.6 to 12.5 vol%
Flash point 65ºC
Auto-ignition temperature 728.12 deg K
Decomposition temperature no data available
pH pH = 10.8-11.8 (10% aqueous solution)
Kinematic viscosity no data available
Solubility In water:150 g/L (20 ºC)
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 0.8 mm Hg ( 20 °C)
Density and/or relative density 1.1
Relative vapour density 3 (Relative to Air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable at temperatures to 270°C and in neutral or acid media /Piperazine hydrochloride/

10.3 Possibility of hazardous reactions

Combustible when exposed to heat or flame.PIPERAZINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Absorbs carbon dioxide from the air, which can cause dry crystals to seem to melt. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. This compound is sensitive to light; it absorbs water and carbon dioxide from air. This compound may be corrosive to aluminum, magnesium and zinc. .

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium, and zinc.

10.6 Hazardous decomposition products

When heated to decomposition it emits highly toxic fumes of /nitrogen oxide/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 4,900 mg/kg /Piperazine hydrochloride/
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Piperazine, present at 100 mg/L, reached 1.4% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(1). In a total organic carbon (TOC) die-away test, piperazine, at an initial concentration of 36 ppm, was degraded by greater than 51% after 28 days in 3 out of 4 artificial river water inocula containing river water microorganisms collected in both spring and autumn(2). Only 0-15% biodegradation occured after 28 days in the fourth inoculum, which contained river water microorganisms collected during the spring(2). Piperazine, at 20 ppm, was degraded by 20% in river water and 77% in sea water after 3 days using the cultivation method(3).

12.3 Bioaccumulative potential

BCF values less than 0.3 to 0.9 and less than 3.9 were measured using orange-red killifish (Oryzias latipes) which were exposed to 1 and 0.1 ppm, respectively, over an 8-week period(1). According to a classification scheme(2), these BCF values suggest the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of piperazine is estimated as 3.6(SRC), using a log Kow of -1.50(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that piperazine is expected to have very high mobility in soil. Measured pKa values of 9.73 (first nitrogen) and 5.33 (second nitrogen)(4), indicate that this compound will primarily exist in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2579 IMDG: UN2579 IATA: UN2579

14.2 UN Proper Shipping Name

ADR/RID: PIPERAZINE
IMDG: PIPERAZINE
IATA: PIPERAZINE

14.3 Transport hazard class(es)

ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
piperazine piperazine 110-85-0 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 14, 2017
Revision Date Aug 14, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: Piperazine anhydrous 99% Material Safety Data Sheet
Synonym: Antitren; 1,4-Diethylenediamine; N,N-Diethylenediamine; Hexahydro-1,4-diazine; Piperazidine; Pyrazine hexahydrat
CAS: 110-85-0
Section 1 - Chemical Product   MSDS Name:Piperazine anhydrous 99% Material Safety Data Sheet
Synonym:Antitren; 1,4-Diethylenediamine; N,N-Diethylenediamine; Hexahydro-1,4-diazine; Piperazidine; Pyrazine hexahydrat

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
110-85-0 Piperazine, anhydrous 100 203-808-3
Hazard Symbols: C
Risk Phrases: 34 42/43 52/53

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Causes burns. May cause sensitization by inhalation and skin contact. Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.Corrosive.Hygroscopic (absorbs moisture from the air).Light sensitive.
Potential Health Effects
Eye:
Contact with eyes may cause severe irritation, and possible eye burns.
Skin:
May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. Contact with skin causes irritation and possible burns, especially if the skin is wet or moist.
Ingestion:
May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns.
Inhalation:
May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. May cause asthmatic attacks due to allergic sensitization of the respiratory tract. Causes chemical burns to the respiratory tract.
Chronic:
Prolonged or repeated skin contact may cause sensitization dermatitis and possible destruction and/or ulceration. Prolonged or repeated exposure may cause permanent eye damage. Repeated exposure may cause allergic respiratory reaction (asthma).

Section 4 - FIRST AID MEASURES
  Eyes: Get medical aid immediately. Gently lift eyelids and flush continuously with water.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Do not get on skin or in eyes. Do not ingest or inhale.
Storage:
Keep away from heat, sparks, and flame. Store in a cool, dry place.
Corrosives area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 110-85-0: United Kingdom, WEL - TWA: 0.1 mg/m3 TWA United Kingdom, WEL - STEL: 0.3 mg/m3 STEL Belgium - TWA: 0.1 mg/m3 VLE Belgium - STEL: 0.3 mg/m3 VLE Germany: 0.1 mg/m3 TWA Spain: 0.1 mg/m3 VLA-ED Spain: 0.3 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Solid
Color: Not available.
Odor: Ammonia-like odor.
pH: Not available.
Vapor Pressure: .8 mm Hg
Viscosity: Not available.
Boiling Point: 145.0 - 146.0 deg C @ 760.00mm Hg
Freezing/Melting Point: 108.00 - 110.00 deg C
Autoignition Temperature: 340 deg C ( 644.00 deg F)
Flash Point: 82 deg C ( 179.60 deg F)
Explosion Limits, lower: 4.00 vol %
Explosion Limits, upper: 14.00 vol %
Decomposition Temperature:
Solubility in water: practically insoluble in ether
Specific Gravity/Density:
Molecular Formula: C4H10N2
Molecular Weight: 86.14

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents; strong acids; acid chlorides; acid anhydrides; light; moisture; dicyanofurazan.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 110-85-0: TK7800000 LD50/LC50:
CAS# 110-85-0: Draize test, rabbit, eye: 250 ug Severe; Draize test, rabbit, eye: 250 ug/24H Severe; Inhalation, mouse: LC50 = 5400 mg/m3/2H; Oral, mouse: LD50 = 600 mg/kg; Oral, rat: LD50 = 1900 mg/kg; Skin, rabbit: LD50 = 4 mL/kg.
Carcinogenicity:
Piperazine, anhydrous - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: PIPERAZINE
Hazard Class: 8
UN Number: 2579
Packing Group: III
IMO
Shipping Name: PIPERAZINE, SOLID or SOLUTION
Hazard Class: 8
UN Number: 2579
Packing Group: III
RID/ADR
Shipping Name: PIPERAZINE
Hazard Class: 8
UN Number: 2579
Packing group: III

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
R 42/43 May cause sensitization by inhalation and
skin contact.
R 52/53 Harmful to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 22 Do not breathe dust.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 110-85-0: 2
Canada
CAS# 110-85-0 is listed on Canada's DSL List.
CAS# 110-85-0 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 110-85-0 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : parameter in CDCl3
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IR Spectrum IR : nujol mull
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Mass Spectrum Mass spectrum (electron ionization)
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UV Spectrum UV/Visible spectrum
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Analysis Methods
Kovats' RI, non-polar column, isothermal
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Column Shape
Packed
Active Phase(℃)
PMS-100
Retention index
852.
Temperature Control
130.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, non-polar column, isothermal
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Column Shape
Packed
Active Phase(℃)
PMS-100
Retention index
852.
Temperature Control
150.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PMS-100
Retention index
870.
Temperature Control
180.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1386.
Temperature Control
150.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1390.
Temperature Control
152.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Toxicity
ACUTE TOXICITY DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Human - child
Dose/Duration
75 mg/kg
Toxic Effects
Behavioral--sleep<br>Gastrointestinal--nausea or vomiting
Reference
Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,478,1969
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
1900 mg/kg
Toxic Effects
Behavioral--excitement<br>Behavioral--changes in motor activity (specific assay)<br>Behavioral--muscle contraction or spasticity
Reference
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Subcutaneous
Species Observed
Rodent - rat
Dose/Duration
3700 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982

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