2-Chloro-4-hydroxybenzaldehyde

CAS No. 56962-11-9

Formula: C7H5ClO2
Basic Info

2-Chloro-4-hydroxybenzaldehyde is a useful synthetic intermediate. It was used in the synthesis of 4-hydroxybiphenylcarboxaldehyde oximes as estrogen receptor-β ligands. It can also be used to prepare leukotriene biosynthesis inhibitors.

Formula
C7H5ClO2
Molecular Weight
156.566
Exact Mass
155.998
LogP
1.8581
PSA
37.3
Synonyms

Benzaldehyde, 2-chloro-4-hydroxy-

2-Chloro-4-hydroxy-benzaldehyde

3-chloro-4-formylphenol

2-Chlor-4-hydroxy-benzaldehyde

Benzaldehyde,2-chloro-4-hydroxy

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Properties
Density
1.404g/cm3
Boiling Point
272.5ºC at 760mmHg
Melting Point
145-147ºC
Flash Point
118.6ºC
Safety Info
Safety Statements
S26-S37/39
WGK Germany
3
Risk Statements
R36/37/38
HS Code
2913000090
Hazard Codes
Spectrum
NMR Spectrum 1H NMR : Predict
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Analysis Methods
Kovats' RI, non-polar column, isothermal
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Column Shape
Capillary
Active Phase(℃)
SE-30
Retention index
1524.
Temperature Control
160.
Method
isothermal
Comments
Column length: 25. m; Column diameter: 0.32 mm
Reference
Evans, M.B.Haken, J.K.Dispersion and selectivity indices in gas chromatography. IV. Chlorinated aromatic compoundsJ. Chromatogr.1989, 468, 373-382.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Capillary
Active Phase(℃)
SE-30
Retention index
1524.
Temperature Control
160.
Method
isothermal
Comments
N2; Column length: 25. m; Column diameter: 0.3 mm
Reference
Korhonen, I.O.O.Knuutinen, J.Gas-liquid chromatographic analyses. XXVII. Separation of chlorinated 4-hydroxybenzaldehydes on a capillary column coated with non-polar SE-30 stationary phaseJ. Chromatogr.1984, 292, 2, 345-353.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Capillary
Active Phase(℃)
SE-30
Retention index
1520.
Temperature Control
180.
Method
isothermal
Comments
N2; Column length: 25. m; Column diameter: 0.3 mm
Reference
Korhonen, I.O.O.Knuutinen, J.Gas-liquid chromatographic analyses. XXVII. Separation of chlorinated 4-hydroxybenzaldehydes on a capillary column coated with non-polar SE-30 stationary phaseJ. Chromatogr.1984, 292, 2, 345-353.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Capillary
Active Phase(℃)
SE-30
Retention index
1514.
Temperature Control
200.
Method
isothermal
Comments
N2; Column length: 25. m; Column diameter: 0.3 mm
Reference
Korhonen, I.O.O.Knuutinen, J.Gas-liquid chromatographic analyses. XXVII. Separation of chlorinated 4-hydroxybenzaldehydes on a capillary column coated with non-polar SE-30 stationary phaseJ. Chromatogr.1984, 292, 2, 345-353.
Van Den Dool and Kratz RI, non-polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
SE-30
Retention index
1523.
Temperature Control
Method
temperature ramp
Comments
N2, 10. K/min; Column length: 25. m; Column diameter: 0.3 mm; T<sub>start</sub>: 100. C
Reference
Korhonen, I.O.O.Knuutinen, J.Gas-liquid chromatographic analyses. XXVII. Separation of chlorinated 4-hydroxybenzaldehydes on a capillary column coated with non-polar SE-30 stationary phaseJ. Chromatogr.1984, 292, 2, 345-353.
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