sodium nitrite

CAS No. 7632-00-0

Formula: NNaO2
Basic Info

Sodium nitrite is the inorganic compound with the chemical formula NaNO2. It is a white to slightly yellowish crystalline powder that is very soluble in water and is hygroscopic. It is a useful precursor to a variety of organic compounds, such as pharmaceuticals, dyes, and pesticides, but it is probably best known as a food additive to prevent botulism.
It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Formula
NNaO2
Molecular Weight
68.9953
Exact Mass
68.9827
LogP
0.2506
PSA
52.49
Synonyms

Sodium nitrite solution

SODIUM NITRITE

Caswell No. 782

Sodium,nitrite

sodium nitrile

Filmerine

Erinitrit

Nitrous acid,sodium salt

Diazotizing salts

Nitrite,sodium

Anti-rust

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Properties
Appearance & Physical State
white to off-white powder
Density
2.168
Boiling Point
320ºC
Melting Point
271ºC
Water Solubility
820 g/L (20 ºC)
Stability
Stable. Incompatible with reducing agents, strong oxidizing agents, organics and other flammable materials, finely powdered metals. Contact with combustible material may lead to fire. Hygroscopic.
Storage Condition
2-8ºC
Safety Info
RTECS
RA1225000
Safety Statements
S45-S61
WGK Germany
3
Risk Statements
R25; R50; R8
HS Code
2834299090
RIDADR
UN 3219
Hazard Class
5.1
Packing Group
III
Caution Statement
P210; P220; P221; P305 + P351 + P338; P370 + P378
Hazard Codes
Hazard Declaration
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name sodium nitrite

1.2 Other means of identification

Product number -
Other names Sodium,nitrite

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Oxidizing solids, Category 3

Acute toxicity - Oral, Category 3

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H272 May intensify fire; oxidizer

H301 Toxic if swallowed

H400 Very toxic to aquatic life

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P220 Keep away from clothing and other combustible materials.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P273 Avoid release to the environment.

Response

P370+P378 In case of fire: Use ... to extinguish.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P391 Collect spillage.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
sodium nitrite sodium nitrite 7632-00-0 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

no data available

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state white to off-white powder
Colour no data available
Odour no data available
Melting point/ freezing point 271ºC
Boiling point or initial boiling point and boiling range 320ºC
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point no data available
Auto-ignition temperature 490°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:820 g/L (20 ºC)
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure no data available
Density and/or relative density 2.168
Relative vapour density no data available
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1500 IMDG: UN1500 IATA: UN1500

14.2 UN Proper Shipping Name

ADR/RID: SODIUM NITRITE
IMDG: SODIUM NITRITE
IATA: SODIUM NITRITE

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
sodium nitrite sodium nitrite 7632-00-0 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 16, 2017
Revision Date Aug 16, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Section 1: Product Identification
   Chemical Name:       Sodium nitrite, 97+% (ACS)    
   CAS Registry Number:       7632-00-0    
   Formula:       NaNO2    
   EINECS Number:       231-555-9    
   Chemical Family:       inorganic compound    
   Synonym:       Nitrous acid, sodium salt    

Section 2: Composition and Information on Ingredients
   Ingredient       CAS Number       Percent       ACGIH (TWA)       OSHA (PEL)    
   Title compound       7632-00-0       100%       no data       no data    

Section 3: Hazards Identification
   Irritating to eyes, skin, and respiratory tract. Toxic by inhalation and if swallowed. May cause heritable genetic
   Emergency Overview:
   damage, harm to the unborn child, and impair fertility.
   Primary Routes of Exposure:       Ingestion, inhalation, skin, eyes.    
   Eye Contact:       Causes irritation, redness and pain.    
   Skin Contact:       Causes irritation, redness and pain. May be absorbed through the skin.    
   Inhalation:       Toxic. Causes irritation to the respiratory tract, and in large amounts, poisoning.    
   Toxic. Ingestion of as little as 1/2 ounce may cause nitrite poisoning including intense cyanosis, nausea,
   Ingestion:
   dizziness, vomiting, collapse, coma, and death.
   Irritating to eyes, skin, and respiratory tract. Toxic by inhalation and if swallowed. Nitrite poisoning may cause
   Acute Health Affects:       cyanosis, nausea, dizziness, vomiting, collapse, rapid heart beat, irregular breathing, coma, convulsions,    
   circulatory collapse and death. May cause harm to the unborn child.
   Chronic Health Affects:       May cause heritable genetic damage and impair fertility.    
   NTP:       No    
   IARC:       No    
   OSHA:       No    

SECTION 4: First Aid Measures
   Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
   Eye Exposure:
   assistance in keeping their eye lids open. Get immediate medical attention.
   Wash the affected area immediately with water. Remove contaminated clothing if necessary. Seek medical
   Skin Exposure:
   assistance if irritation persists.
   Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
   Inhalation:
   in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
   Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
   Ingestion:
   vomiting only if directed by medical personnel.

SECTION 5: Fire Fighting Measures
   Flash Point:       no data    
   Autoignition Temperature:       no data    
   Explosion Limits:       no data    
   Extinguishing Medium:       carbon dioxide or dry powder    
   If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
   Special Fire Fighting Procedures:
   self- contained breathing apparatus and full protective clothing.
   Hazardous Combustion and       If involved in a fire, this material may emit toxic and corrosive fumes of nitrogen oxides.    
   Decomposion Products:
   Unusual Fire or Explosion Hazards: Metal nitrites are oxidizers. Contact with combustible materials can lead to fires and/or explosions.

SECTION 6: Accidental Release Measures
   Spill and Leak Procedures:       Do not mix spilled powder with any combustible materials. Sweep up the solid and dilute with water.    

SECTION 7: Handling and Storage
   Handling and Storage:       Store in a cool, dry place in a tightly sealed container.    

SECTION 8: Exposure Controls and Personal Protection
   Eye Protection:       Always wear approved safety glasses when handling a chemical substance in the laboratory.    
   Skin Protection:       Wear protective clothing and gloves. Consult with glove manufacturer to determine the proper type of glove.    
   Ventilation:       Handle the material in an efficient fume hood.    
   If ventilation is not available a respirator should be worn. The use of respirators requires a Respiratory
   Respirator:
   Protection Program to be in compliance with 29 CFR 1910.134.
   Ventilation:       Handle the material in an efficient fume hood.    
   Additional Protection:       No additional protection required.    

SECTION 9: Physical and Chemical Properties
   Color and Form:       white powder    
   Molecular Weight:       69    
   Melting Point:       271°    
   Boiling Point:       320°C dec.    
   Vapor Pressure:       not applicable    
   Specific Gravity:       2.168    
   Odor:       none    
   Solubility in Water:

SECTION 10: Stability and Reactivity
   Stability:       hygroscopic    
   Hazardous Polymerization:       No hazardous polymerization    
   Conditions to Avoid:       may burst into flame or explode in contact with organic matter in the presence of heat or friction.    
   ammonium salts, cellulose, cyanides, lithium, potassium plus ammonia, sodium thiosulfate, aminoguanide
   Incompatibility:
   salts, butadiene, reluctant.
   Decomposition Products:       nitrogen oxides and sodium oxide.    

SECTION 11: Toxicological Information
   Administration into the eye (rabbit); Standard Draize test: 500 mg/24H. Oral (human); TDLo: 14 mg/kg. Oral
   (human-man); LDLo: 321 mg/kg. Oral (human-man); TDLo: 1714 ug/kg/70M. Oral (human); LDLo: 71 mg/kg.
   RTECS Data:       Oral (human-child); LDLo: 22 mg/kg. Oral (rat); LD50: 180 mg/kg. Inhalation (rat); LC50: 5500 ug/m3/4H.    
   Subcutaneous (rat); LD50: 96600 ug/kg. Intravenous (rat); LD50: 65 mg/kg. Oral (rat); TDLo: 180 mg/kg/8D-I.
   Oral (rat); TDLo: 2190 gm/kg/2Y-C. Oral (rat); TDLo: 660 mg/kg. Oral (mouse): TDLo: 480mg/Kg.
   Carcinogenic Effects:       Data available    
   Mutagenic Effects:       Mutagen    
   Tetratogenic Effects:       Reproductive effector    

SECTION 12: Ecological Information
   Ecological Information:       Very toxic to aquatic organisms.    

SECTION 13: Disposal Considerations
   Disposal:       Dispose of according to local, state and federal regulations.    

SECTION 14: Transportation
   Shipping Name (CFR):       Sodium nitrite    
   Hazard Class (CFR):       5.1    
   Additional Hazard Class (CFR):       NA    
   Packaging Group (CFR):       III    
   UN ID Number (CFR):       UN# 1500    
   Shipping Name (IATA):       Sodium nitrite    
   Hazard Class (IATA):       5.1    
   Additional Hazard Class (IATA):       NA    
   Packaging Group (IATA):       III    
   UN ID Number (IATA):       UN# 1500    

SECTION 15: Regulatory Information
   TSCA:       Listed in the TSCA inventory.    
   SARA (Title 313):       Title compound regulated under Sec. 313.    
   Second Ingredient:       none    


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
IR Spectrum IR : nujol mull
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ESR Spectrum ESR : REACTION OF NANO2/NAHSO3 WITH CE(IV)
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Toxicity
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Rodent - rabbit
Dose/Duration
500 mg/24H
Toxic Effects
--
Reference
Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku, Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,15,1972
ACUTE TOXICITY DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Human
Dose/Duration
14 mg/kg
Toxic Effects
Behavioral--changes in motor activity (specific assay)<br>Vascular--regional or general arteriolar or venous dilation<br>Gastrointestinal--nausea or vomiting
Reference
Deutsche Medizinische Wochenschrift. (Stuttgart, Fed. Rep. Ger.) V.1-104, 1875-1979. Volume(issue)/page/year: 74,961,1949
ACUTE TOXICITY DATA
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Type of Test
LDLo - Lowest published lethal dose
Exposure Route
Oral
Species Observed
Human - man
Dose/Duration
321 mg/kg
Toxic Effects
Behavioral--coma<br>Lungs, Thorax, or Respiration--cyanosis<br>Blood--methemoglobinemia-carboxyhemoglobin
Reference
Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965- Volume(issue)/page/year: 28,289,1992

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