3-aminophenol

CAS No. 591-27-5

Formula: C6H7NO
Basic Info

1-Amino-3-Hydroxybenzene is used in the preparation of inhibitors of mammalian carbonic anhydrase isoforms. Also used in the preparation of quinoline tethered fluorescent carbon dots for regulated anticancer discovery.

Formula
C6H7NO
Molecular Weight
109.126
Exact Mass
109.053
LogP
1.5556
PSA
46.25
Synonyms

Fouramine EG

3-amino-phenol

3-Amino-1-hydroxybenzene

Phenol,3-amino

1-Amino-3-hydroxybenzene

M-AMINOPHENOL

3-Hydroxyaniline

3-Aminophenol

amino-3-hydroxybenzene

meta-amino phenol

meta-hydroxyaniline

Phenol, 3-amino-

Futramine EG

m-Hydroxyaniline

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Properties
Appearance & Physical State
white crystals
Density
1.21g/cm3
Boiling Point
164ºC (11 mmHg)
Melting Point
121-124ºC
Flash Point
155ºC
Water Solubility
35 g/L (20 ºC)
Stability
Stable. Combustible. Incompatible with strong oxidizing agents, bases, mineral acids. May be light or air-sensitive.
Storage Condition
Store in a cool, dry place. Keep container closed when not in use.
Safety Info
RTECS
SJ4900000
Safety Statements
S28-S61
WGK Germany
2
Risk Statements
R20/22; R51/53
HS Code
2922299090
RIDADR
UN 2512
Hazard Class
6.1
Packing Group
III
Hazard Codes
Spectrum
NMR Spectrum 1H NMR : 400 MHz in DMSO-d6
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IR Spectrum IR : KBr disc
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Mass Spectrum Mass spectrum (electron ionization)
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UV Spectrum UV/Visible spectrum
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Analysis Methods
Kovats' RI, non-polar column, custom temperature program
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Column Shape
Packed
Active Phase(℃)
SE-30
Retention index
1335.
Temperature Control
Method
custom temperature program
Comments
Chromosorb W HMDS (80-100 mesh); Column length: 2.9 m; Program: not specified
Reference
Grzybowski, J.Lamparczyk, H.Nasal, A.Radecki, A.Relationship between the retention indices of phenols on polar and non-polar stationary phasesJ. Chromatogr.1980, 196, 2, 217-223.
Normal alkane RI, non-polar column, custom temperature program
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Column Shape
Capillary
Active Phase(℃)
SE-30
Retention index
1335.
Temperature Control
Method
custom temperature program
Comments
Program: not specified
Reference
Peterson, K.L.Counter-Propagation Neural Networks in the Modeling and Prediction of Kovats Indices for Substituted PhenolsAnal. Chem.1992, 64, 4, 379-386.
Normal alkane RI, non-polar column, custom temperature program
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Column Shape
Capillary
Active Phase(℃)
OV-1, SE-30, Methyl silicone, SP-2100, OV-101, DB-1, etc.
Retention index
1335.
Temperature Control
Method
custom temperature program
Comments
Hydrogen; Column length: 50. m; Column diameter: 0.32 mm; Program: not specified
Reference
Waggott, A.Davies, I.W.Identification of organic pollutants using linear temperature programmed retention indices (LTPRIs) - Part II1984, retrieved from http://dwi.defra.gov.uk/research/completed-research/reports/dwi0383.pdf.
Toxicity
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration onto the skin
Species Observed
Rodent - rabbit
Dose/Duration
12500 ug/24H
Toxic Effects
--
Reference
Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 15,607,1977
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Rodent - rabbit
Dose/Duration
100 mg/24H
Toxic Effects
--
Reference
Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,688,1986
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
924 mg/kg
Toxic Effects
Peripheral Nerve and Sensation--spastic paralysis with or without sensory change<br>Behavioral--excitement<br>Lungs, Thorax, or Respiration--other changes
Reference
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(1),49,1988

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