Ethylbutylamine

CAS No. 13360-63-9

Formula: C6H15N
Basic Info

N-Ethylbutylamine is used as a reagent in the synthesis of substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands.

Formula
C6H15N
Molecular Weight
101.19
Exact Mass
101.12
LogP
1.7869
PSA
12.03
Synonyms

1-Butanamine, N-ethyl-

N-Butylethylamine

N-Ethyl-n-butylamine

N-Ethyl-1-butylamine

N-Ethylbutan-1-amine

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Properties
Appearance & Physical State
A colorless liquid with an ammonia-like odor.
Density
0.74
Boiling Point
108ºC
Melting Point
-77.8ºC
Flash Point
18ºC
Refractive Index
1.404-1.406
Water Solubility
partly soluble
Stability
Stable under normal temperatures and pressures.
Storage Condition
Flammables area
Vapor Density
3.5 (vs air)
Vapor Pressure
18 mm Hg ( 20 °C)
Safety Info
RTECS
EO4880000
Safety Statements
S16-S33-S36/37/39-S45
WGK Germany
1
Risk Statements
R11; R22; R34
HS Code
2921199090
RIDADR
UN 2733
Hazard Class
3
Packing Group
II
Hazard Codes
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
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IR Spectrum IR : liquid film
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Mass Spectrum Mass spectrum (electron ionization)
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Analysis Methods
Kovats' RI, non-polar column, isothermal
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Column Shape
Packed
Active Phase(℃)
Apiezon L
Retention index
753.
Temperature Control
100.
Method
isothermal
Comments
N2, Chromosorb GAW; Column length: 2.7 m
Reference
Golovnya, R.V.Zhuravleva, N.L.Svetlova, N.I.Grigor'eva, D.N.Gas-chromatographic separation of secondary normal alphatic aminesJ. Anal. Chem. USSR (Engl. Transl.)1980, 35, 10, 1280-1285.
Normal alkane RI, non-polar column, custom temperature program
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Column Shape
Capillary
Active Phase(℃)
Methyl Silicone
Retention index
744.
Temperature Control
Method
custom temperature program
Comments
Program: not specified
Reference
Zenkevich, I.G.Dependence of Gas Chromatographic Retention Indices on Dynamics Molecular CharacteristicsZh. Fiz. Khim.1999, 73, 5, 905-910.
Toxicity
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
310 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(3),106,1974
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - mouse
Dose/Duration
418 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(3),106,1974
OTHER MULTIPLE DOSE TOXICITY DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
1092 mg/kg/26W-I
Toxic Effects
Liver--other changes<br>Nutritional and Gross Metabolic--conditioned vitamin deficiency
Reference
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(3),106,1974

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