4-Chloronitrobenzene

CAS No. 100-00-5

Formula: C6H4ClNO2
Basic Info

4-Nitrochlorobenzene is the organic compound with the formula ClC6H4NO2. It is a pale yellow solid. 4-Nitrochlorobenzene is a common intermediate in the production of a number of industrially useful compounds, including common antioxidants found in rubber. Other isomers with the formula ClC6H4NO2 include 2-nitrochlorobenzene and 3-nitrochlorobenzene.

Formula
C6H4ClNO2
Molecular Weight
157.554
Exact Mass
156.993
LogP
2.7714
PSA
45.82
Synonyms

1-chloro-4-nitrobenzene

Benzene, 1-chloro-4-nitro-

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Properties
Appearance & Physical State
light yellow crystals
Density
1.298
Boiling Point
242ºC
Melting Point
81-84ºC
Flash Point
127ºC
Refractive Index
1.5376 (100ºC)
Water Solubility
Insoluble
Stability
Stable. Combustible. Incompatible with strong oxidizing agents, hydroxides. Reacts violently with sodium methoxide in methanol.
Storage Condition
Store in a cool, dry place. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.
Vapor Density
5.4 (vs air)
Vapor Pressure
0.09 mm Hg ( 25 °C)
Safety Info
RTECS
CZ1050000
Safety Statements
S28-S36/37-S45-S61
WGK Germany
2
Risk Statements
R23/24/25; R40; R48/20/21/22; R51/53; R68
HS Code
29049085
RIDADR
UN 1578
Hazard Class
6.1
Packing Group
II
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloronitrobenzene

1.2 Other means of identification

Product number -
Other names 1-chloro-4-nitrobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Acute toxicity - Inhalation, Category 3

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 2

Specific target organ toxicity – repeated exposure, Category 2

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

H311 Toxic in contact with skin

H331 Toxic if inhaled

H341 Suspected of causing genetic defects

H351 Suspected of causing cancer

H411 Toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P273 Avoid release to the environment.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P311 Call a POISON CENTER/doctor/…

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P314 Get medical advice/attention if you feel unwell.

P391 Collect spillage.

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
4-Chloronitrobenzene 4-Chloronitrobenzene 100-00-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!).

4.2 Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Anoxia; unpleasant taste; anemia; methemoglobinemia Target Organs: Blood, liver, kidneys, cardiovascular system, spleen, bone marrow, reproductive system (NIOSH, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aromatic hydrocarbons and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water may cause foaming or frothing. Use water spray, dry chemical, foam, or carbon dioxide. /chloronitrobenzens/

5.2 Specific hazards arising from the chemical

This compound is combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents. Do NOT let this chemical enter the environment. Personal protection: complete protective clothing including self-contained breathing apparatus.

6.3 Methods and materials for containment and cleaning up

Evacuate persons not wearing protective equipment from area of spill or leak until clean-up is complete. Remove all ignition sources. Dampen spilled material with alcohol to avoid dust, then transfer material to a suitable container. Use HEPA vacuum or wet method to reduce dist during clean-up. Do not dry sweep. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from combustible substances, reducing agents and food and feedstuffs. Keep in a well-ventilated room.Store in cool, dry, well-ventilated location. Separate from alkalies and oxidizing materials. /Chloronitrobenzenes/

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers p-nitrochlorobenzene to be a potential occupational carcinogen.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state light yellow crystals
Colour Monoclinic prisms
Odour Sweet odor
Melting point/ freezing point 230°C(lit.)
Boiling point or initial boiling point and boiling range 242°C(lit.)
Flammability Solid that does not burn, or burns with difficulty.Combustible. Many reactions may cause fire or explosion.
Lower and upper explosion limit / flammability limit no data available
Flash point 107°C(lit.)
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity 1.07X10-3 Pa-s at 356.65 deg K
Solubility In water:Insoluble
Partition coefficient n-octanol/water (log value) log Kow = 2.39
Vapour pressure 0.09 mm Hg ( 25 °C)
Density and/or relative density 1.298
Relative vapour density 5.4 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

FIRE HAZARD SLIGHT WHEN EXPOSED TO HEAT OR FLAME.P-NITROCHLOROBENZENE reacts with oxidizing agents. Reacts violently and finally explosively when added to a solution of sodium methoxide in methanol. . Unstable when heated.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

A strong oxidizer. Reacts violently with oxidizers, combustibles, alkalis, sodium methoxide, and reducing materials.

10.6 Hazardous decomposition products

...WHEN HEATED TO DECOMPOSITION IT EMITS VERYY TOXIC FUMES OF /NITROGEN OXIDES AND HYDROGEN CHLORIDE./

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 530 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Evaluation: There is inadequate evidence in humans for the carcinogenicity of chloronitrobenzenes. There is inadequate evidence in experimental animals for the carcinogenicity of chloronitrobenzenes. Overall evaluation: Chloronitrobenzenes are not classifiable as to their carcinogenicity to humans (Group 3). /Chloronitrobenzenes/

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50 Lepomis macrochirus (bluegill sunfish) 70 ug/L for 96 hr, static
  • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea, <24 hr old); Conditions: freshwater, static, 20°C, pH 8.2, hardness 250 mg/L CaCO3, dissolved oxygen >6.5 mg/L; Concentration: 6700 ug/L for 48 hr (95% confidence interval: 3200-10000 ug/L) />98% purity
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: 10 ug/mL 1-chloro-4-nitrobenzene inoculated with a mixed culture of microorganisms in soil was observed to be resistant to biodegradation (significant ring cleavage, as measured by UV absorbance, was not detected after 64 days)(1). 1-Chloro-4-nitrobenzene , present at 100 mg/L, reached 0 percent of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(2).

12.3 Bioaccumulative potential

Carp exposed to solutions containing 0.15 ppm 1-chloro-4-nitrobenzene for 8 weeks had BCF values ranging from 5.8-20.9, and carp exposed to solutions containing 0.015 ppm 1-chloro-4-nitrobenzene had BCF values ranging from 7.5-18.1(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-chloro-4-nitrobenzene can be estimated to be 310(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-chloro-4-nitrobenzene is expected to have moderate mobility in soil(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1578 IMDG: UN1578 IATA: UN1578

14.2 UN Proper Shipping Name

ADR/RID: CHLORONITROBENZENES, SOLID
IMDG: CHLORONITROBENZENES, SOLID
IATA: CHLORONITROBENZENES, SOLID

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
4-Chloronitrobenzene 4-Chloronitrobenzene 100-00-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Section I.Chemical Product and Company Identification
    Chemical Name 4-Chloronitrobenzene
    Portland OR
    Synonym        Benzene, 1-chloro-4-nitro- (CA INDEX NAME);    
    1-Chloro-4-nitrobenzene
    Chemical Formula        C6H4ClNO2    
    CAS Number        100-00-5    

Section II.        Composition and Information on Ingredients    
    CAS Number Percent (%)        TLV/PEL        Toxicology Data    
    Chemical Name
    4-Chloronitrobenzene        Min. 98.0 (GC) This chemical is classified as a Rat LD50 (oral) 420 mg/kg    
    100-00-5
    carcinogen. There is no        Rabbit LD50 (dermal) 3040 mg/kg    
    acceptable exposure limit for a Rat LD50 (intraperitoneal) 420
    carcinogen.        mg/kg    
    This compound is classified as
    a possible mutagen. There is
    no acceptable exposure limit for
    a mutagen.

Section III. Hazards Identification
    Acute Health Effects        Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.    
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
    eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Skin contact may result in sensitization. Always cover all exposed skin with an impermeable layer and use proper eye
    protection. A OSHA/MSHA approved dust and vapor respirator is required when working with this material.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    Chronic Health Effects        CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Tumorigenic effects.
    Mouse TD Oral 390 gm/kg for 78 weeks continuous
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Vascular - Tumors
    Liver - Tumors
    Mouse TDLo Oral 194 gm/kg for 78 weeks continuous
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Vascular - Tumors
    Liver - Tumors
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TCLo Inhalation 24 ppm for 6 hours, male 13 weeks prior to mating
    Toxic Effects:
    Paternal Effects - Spermatogenesis
    Mouse TDLo Oral 58 gm/kg, male 15 weeks prior to mating
    Toxic Effects:
    Effects on Newborn - Live birth index
    Effects on Newborn - Viability index
    Effects on Newborn - Growth statistics
    Mouse TDLo Oral 250 mg/kg, female multigenerations
    Toxic Effects:
    Specific Developmental Abnormalities - Blood and lymphatic system
    Specific Developmental Abnormalities - Hepatobiliary system
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
    many human organs.
    Continued on Next Page
    4-Chloronitrobenzene

Section IV.        First Aid Measures    
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15    
    minutes. Get medical attention.
    Skin Contact        In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing    
    and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
    Inhalation        If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or    
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    Ingestion        INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.    
    Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
    material was ingested; the absence of such signs, however, is not conclusive.

Section V.        Fire and Explosion Data    
    510°C (950°F)
    Flammability        May be combustible at high temperature.        Auto-Ignition    
    LOWER: 1.5% UPPER: 9.6%
    Flash Points        127°C (260.6°F)        Flammable Limits    
    Combustion Products        These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), halogenated compounds.    
    WARNING: Highly toxic HCl gas is produced during combustion.
    Fire Hazards
    Not available.
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media
    SMALL FIRE: Use DRY chemical powder.
    LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
    and Instructions
    Consult with local fire authorities before attempting large scale fire-fighting operations.

Section VI.        Accidental Release Measures    
    Spill Cleanup        Toxic material. Irritating material. This material is a skin sensitizer. Carcinogenic material. Possibly mutagenic material.    
    Environmentally hazardous material.
    Instructions
    Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
    vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all sources of ignition. Consult
    federal, state, and/or local authorities for assistance on disposal.

Section VII. Handling and Storage
    TOXIC. IRRITANT. SENSITIZER. CARCINOGEN. POSSIBLE MUTAGEN. ENVIRONMENTAL HAZARD. Keep locked up.
    Handling and Storage
    Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool
    Information
    place. Avoid excessive heat and light. DO NOT ingest. Do not breathe dust. Wear suitable protective clothing. If ingested,
    seek medical advice immediately and show the container or the label. Treat symptomatically and supportively.
    Always store away from incompatible compounds such as oxidizing agents, combustible materials, alkalis (bases).

Section VIII. Exposure Controls/Personal Protection
    Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
    Engineering Controls
    exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
    below the exposure limit.
    Personal Protection        Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid    
    inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
    product.
    Exposure Limits        This chemical is classified as a carcinogen. There is no acceptable exposure limit for a carcinogen.    
    This compound is classified as a possible mutagen. There is no acceptable exposure limit for a mutagen.

Section IX. Physical and Chemical Properties
    Solid. (Crystal ~ powder,        Solubility    
    Physical state @ 20°C        Freely soluble in boiling alcohol,    
    slightly pale yellow ~ yellow-green.)
    ether, carbon disulfide.
    Soluble in methanol, benzene.
    1.520 (water=1)
    Specific Gravity
    Sparingly soluble in cold alcohol.
    Insoluble in water (0.45g/L 20°C).
    Molecular Weight        157.55        Partition Coefficient        LOG Pow: 2.39    
    Boiling Point        242°C (467.6°F)        2 Pa (@ 30°C)    
    Vapor Pressure
    Melting Point        84°C (183.2°F)        Vapor Density        5.44 (Air = 1)    
    Not available.        Not available.    
    Refractive Index        Volatility    
    Critical Temperature        Not available.        Odor        Characteristic.    
    Not available.        Not available.    
    Viscosity        Taste    
    Continued on Next Page
    4-Chloronitrobenzene

Section X.        Stability and Reactivity Data    
    Stability    
This material is stable if stored under proper conditions. (See Section VII for instructions)    
    Conditions of Instability        Avoid excessive heat and light.    
    Incompatibilities
    Reactive with oxidizing agents, combustible materials, alkalis (bases).

Section XI. Toxicological Information
    CZ1050000
    RTECS Number
    Routes of Exposure        Eye Contact. Ingestion. Inhalation.    
    Rat LD50 (oral) 420 mg/kg
    Toxicity Data
    Rabbit LD50 (dermal) 3040 mg/kg
    Rat LD50 (intraperitoneal) 420 mg/kg
    Chronic Toxic Effects        CARCINOGENIC EFFECTS : Carcinogenic by RTECS criteria.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Tumorigenic effects.
    Mouse TD Oral 390 gm/kg for 78 weeks continuous
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Vascular - Tumors
    Liver - Tumors
    Mouse TDLo Oral 194 gm/kg for 78 weeks continuous
    Toxic Effects:
    Tumorigenic - Carcinogenic by RTECS criteria
    Vascular - Tumors
    Liver - Tumors
    DEVELOPMENTAL TOXICITY: Reproductive effects.
    Rat TCLo Inhalation 24 ppm for 6 hours, male 13 weeks prior to mating
    Toxic Effects:
    Paternal Effects - Spermatogenesis
    Mouse TDLo Oral 58 gm/kg, male 15 weeks prior to mating
    Toxic Effects:
    Effects on Newborn - Live birth index
    Effects on Newborn - Viability index
    Effects on Newborn - Growth statistics
    Mouse TDLo Oral 250 mg/kg, female multigenerations
    Toxic Effects:
    Specific Developmental Abnormalities - Blood and lymphatic system
    Specific Developmental Abnormalities - Hepatobiliary system
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many
    human organs.
    Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
    Acute Toxic Effects
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
    is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Skin contact may result in sensitization. Always cover all exposed skin with an impermeable layer and use proper eye
    protection. A OSHA/MSHA approved dust and vapor respirator is required when working with this material.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

Section XII.        Ecological Information    
    Not available.
    Ecotoxicity
    Environmental Fate        1-Chloro-4-nitrobenzene's production and use as an intermediate in preparing dyes, agricultural and rubber chemicals, may    
    result in its release to the environment through various waste streams. If released to air, a vapor pressure of 0.022 mm Hg at
    25 deg C indicates 1-chloro-4-nitrobenzene will exist solely as a vapor in the atmosphere. Vapor-phase
    1-chloro-4-nitrobenzene will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the
    half-life for this reaction in air is estimated to be 94 days. Weak absorption of UV light greater than 290 nm by
    1-chloro-4-nitrobenzene indicates potential for photolysis by sunlight. If released to soil, 1-chloro-4-nitrobenzene is expected
    to have moderate mobility in soil based on an estimated Koc value of 310. Volatilization from dry soil surfaces may occur
    given a Henry's Law constant of 4.9X10-6 atm-cu m/mole. 1-Chloro-4-nitrobenzene is not expected to volatilize from dry soil
    surfaces based upon its vapor pressure. Screening tests using activated sludge, suggest biodegradation of
    1-chloro-4-nitrobenzene proceeds slowly in water and soil. If released into water, 1-chloro-4-nitrobenzene is expected to
    adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is expected to be
    an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model
    river and model lake are 152 hours and 73 days, respectively. Hydrolysis is not expected to be an important environmental
    fate process since this compound lacks functional groups that hydrolyze under environmental conditions. BCF values of
    5.8-20.9 measured in fish, suggests bioconcentration in aquatic organisms is low. Occupational exposure may occur through
    inhalation and dermal contact with this compound at workplaces where 1-chloro-4-nitrobenzene is produced or used.
    Continued on Next Page
    4-Chloronitrobenzene

Section XIII. Disposal Considerations
    Waste Disposal        Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a    
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
    DOT CLASS 6.1: Toxic material
    DOT Classification
    PIN Number
    Proper Shipping Name        Chloronitrobenzenes, solid    
    Packing Group (PG)        II    
    DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.    
    (EPA)
    WHMIS Classification        CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).    
    CLASS D-2B: Material causing other toxic effects (TOXIC).
    (Canada)
    On DSL.
    EINECS Number (EEC) 202-809-6
    EEC Risk Statements        R23/24/25- Toxic by inhalation, in contact with skin and if swallowed.    
    R36/37/38- Irritating to eyes, respiratory system and skin.
    R43- May cause sensitization by skin contact.
    R45- May cause cancer.
    R46- May cause heritable genetic damage.
    R47- May cause birth defects.
    R51- Toxic to aquatic organisms.
    R53- May cause long-term adverse effects in the aquatic environment.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
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IR Spectrum IR : KBr disc
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Mass Spectrum Mass
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Raman Spectrum Raman : 4880 A,100M,powder
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ESR Spectrum ESR : ANION RADICAL, ELECTROLYTIC REDUCTION
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Toxicity
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
420 mg/kg
Toxic Effects
Behavioral--somnolence (general depressed activity)<br>Liver--fatty liver degeneration<br>Blood--methemoglobinemia-carboxyhemoglobin
Reference
Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW. Volume(issue)/page/year: 17,217,1959
ACUTE TOXICITY DATA
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Type of Test
LCLo - Lowest published lethal concentration
Exposure Route
Inhalation
Species Observed
Rodent - rat
Dose/Duration
16100 mg/m3/4H
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Documentation of the Threshold Limit Values and Biological Exposure Indices, 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1100,1991
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Administration onto the skin
Species Observed
Rodent - rat
Dose/Duration
16 gm/kg
Toxic Effects
Behavioral--food intake (animal)<br>Kidney, Ureter, Bladder--changes in tubules (including acute renal failure, acute tubular necrosis)<br>Blood--methemoglobinemia-carboxyhemoglobin
Reference
Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW. Volume(issue)/page/year: 17,217,1959

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