salicylic acid

CAS No. 69-72-7

Formula: C7H6O3
Basic Info

Salicylic acid (from Latin salix, willow tree) is a monohydroxybenzoic acid, a type of phenolic acid and a beta hydroxy acid. It has the formula C7H6O3. This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone. It is derived from the metabolism of salicin. In addition to serving as an important active metabolite of aspirin (acetylsalicylic acid), which acts in part as a prodrug to salicylic acid, it is probably best known for its use as a key ingredient in topical anti-acne products. The salts and esters of salicylic acid are known as salicylates. The medicinal part of the plant is the inner bark.
It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

Formula
C7H6O3
Molecular Weight
138.121
Exact Mass
138.032
LogP
1.0904
PSA
57.53
Synonyms

phenol-carboxylic acid

Keralyt

Ionil

Saligel

Salonil

verrugon

2-hydroxy-benzoic acid

Duoplant

Freezone

Benzoic acid, 2-hydroxy-

Rutranex

Stri-Dex

SAX

o-hydroxybenzoic acid

Salicylic acid

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Properties
Appearance & Physical State
white to off-white crystalline powder
Density
1.44
Boiling Point
211ºC (20 mmHg)
Melting Point
158-161ºC
Flash Point
157ºC
Refractive Index
1.565
Water Solubility
1.8 g/L (20 ºC)
Stability
Stable. Substances to be avoided include oxidizing agents, strong bases, iodine, fluorine. Combustible. Sensitive to light.
Storage Condition
Store at RT.
Vapor Density
4.8 (vs air)
Vapor Pressure
1 mm Hg ( 114 °C)
Safety Info
RTECS
VO0525000
Safety Statements
S26-S37/39
WGK Germany
1
Risk Statements
R22; R36/37/38; R41
HS Code
2918211000
Caution Statement
P280; P301 + P312 + P330; P305 + P351 + P338 + P310
Hazard Codes
Hazard Declaration
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name salicylic acid

1.2 Other means of identification

Product number -
Other names Salicylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Serious eye damage, Category 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H302 Harmful if swallowed

H318 Causes serious eye damage

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P310 Immediately call a POISON CENTER/doctor/…

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
salicylic acid salicylic acid 69-72-7 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Inhalation of dust irritates nose and throat. Vomiting may occur spontaneously if large amounts are swallowed. Contact with eyes causes irritation, marked pain, and corneal injury which should heal. Prolonged or repeated skin contact may cause marked irritation or even a mild burn. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Management of acute salicylic acid poisoning includes prevention of absorption, correction of acid-base, fluid and electrolyte imbalance and enhancing of the drug elimination. Respiratory alkalosis needs no specific treatment, but severe acidosis requires at least a partial correction with sodium bicarbonate. Hypokalemia may be aggravated by administration of sodium bicarbonate. Thus, potassium may need repletion. However, if large amounts of water and electrolytes are given to the patient, the sodium and water load may precipitate pulmonary edema. Sedative and depressive drugs must be avoided. Tetany may be corrected with the use of calcium gluconate. Due to the delayed effects of salicylate overdose, the patient must be kept under observation for at least 24 hours.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

WATER, FOAM, CARBON DIOXIDE, DRY CHEM

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Irritating vapors of unburned material and phenol may form in fire. Behavior in Fire: Sublimes and forms vapor or dust that may explode (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: P2 filter respirator for harmful particles. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants.Salicylic acid should be stored in well-closed containers. Salicylic acid collodion should be stored in tight containers at 15-30°C. Because the collodion is flammable, it should not be stored near heat or an open flame. Salicylic acid plaster should be stored in well-closed containers, preferably at 15-30°C. The Trans-Ver-Sal plaster should be stored at a temperature less than 37.8°C.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state white to off-white crystalline powder
Colour White crystals, fine needles, or fluffy white crystalline powder
Odour SYNTHETIC ACID IS ODORLESS
Melting point/ freezing point 295°C(lit.)
Boiling point or initial boiling point and boiling range 211°C(lit.)
Flammability Combustible.
Lower and upper explosion limit / flammability limit Lower 1.1% @ 392 deg F (200°C)
Flash point 157°C
Auto-ignition temperature 1004 deg F (540°C)
Decomposition temperature no data available
pH pH of saturated solution: 2.4
Kinematic viscosity no data available
Solubility In water:1.8 g/L (20 ºC)
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 1 mm Hg ( 114 °C)
Density and/or relative density 1.44
Relative vapour density 4.8 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

GRADUALLY DISCOLORS IN SUNLIGHT

10.3 Possibility of hazardous reactions

SLIGHT WHEN EXPOSED TO HEAT OF FLAME; CAN REACT WITH OXIDIZING MATERIALSDust explosion possible if in powder or granular form, mixed with air.SALICYLIC ACID is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Incompatability: Iron salts, spirit nitrous ether, lead acetate, iodine.

10.6 Hazardous decomposition products

When heated to decomp it emits acrid smoke and irritating fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Mouse oral 480 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea, <24 hr neonate); Conditions: freshwater, static, 21°C, pH 7.45; Concentration: 1060 mg/L for 24 hr; Effect: intoxication, immobilization /99.5% purity
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Salicylic acid biodegraded rapidly under differing sets of agricultural practices in Pahokee muck soil(1). In October, soil planted to grass, fallow soil, and soil with sugar cane cover at 25°C, 43, 17 and 21%, respectively, of the radiolabeled salicylic acid was emitted as CO2/cu cm of soil/min(1). In January, 26, 7 and 11%, respectively, of the starting material was emitted as CO2/cu cm of soil/min(1).[(1) Tate RL III; Appl Environ Microbiol 37: 1085-90 (1979)] Full text: PMC243358

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated for salicylic acid(SRC), using a log Kow of 2.26(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of salicylic acid is estimated as 404(SRC), using a log Kow of 2.26(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that salicylic acid is expected to have moderate mobility in soil. The pKa of salicylic acid is 2.98(4), indicating that this compound will primarily exist in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.2 UN Proper Shipping Name

ADR/RID: unknown
IMDG: unknown
IATA: unknown

14.3 Transport hazard class(es)

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.4 Packing group, if applicable

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
salicylic acid salicylic acid 69-72-7 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: Salicylic Acid reagent ACS Material Safety Data Sheet
Synonym: Benzoic acid, 2-hydroxy-; o-Hydroxybenzoic acid; 2-Hydroxybenzoic acid; Orthohydroxybenzoic aci
CAS: 69-72-7
Section 1 - Chemical Product   MSDS Name:Salicylic Acid reagent ACS Material Safety Data Sheet
Synonym:Benzoic acid, 2-hydroxy-; o-Hydroxybenzoic acid; 2-Hydroxybenzoic acid; Orthohydroxybenzoic aci

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
69-72-7 Salicylic acid ca.100 200-712-3
Hazard Symbols: XN
Risk Phrases: 22 36/38

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful if swallowed. Irritating to eyes and skin.Light sensitive.Moisture sensitive.
Potential Health Effects
Eye:
Causes severe eye irritation. May result in corneal injury.
Skin:
Contact with skin causes irritation and possible burns, especially if the skin is wet or moist. If absorbed, may cause symptoms similar to those for ingestion. May cause skin rash and eruptions.
Ingestion:
Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause "salicylism"; characterized by headache, dizziness, ringing in the ears, hearing difficulty, visual disturbances, mental confusion, drowsiness, sweating thirst, hyperventilation, nausea, vomiting and diarrhea. May be harmful if swallowed. Severe salicylate intoxication may cause central nervous system disturbances such as convulsions and coma, skin eruptions, and alteration in the acid-base balance.
Inhalation:
Causes irritation of the mucous membrane and upper respiratory tract.
Chronic:
May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. May cause salicylism with effects similar to those of skin absorption. May cause damage to the kidneys and pancrease.

Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Follow with gastric lavage with activated charcoal. If available, administer ferric hexacyanoferrate as a gastrointestinal trapping agent. Persons with pre-existing skin disorders, eye problems, or impaired kidney function may be more susceptible to the effects of this substance.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Water or foam may cause frothing. Use agent most appropriate to extinguish fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage:
Keep away from sources of ignition. Do not store in direct sunlight.
Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystalline powder
Color: white
Odor: odorless - slight phenolic odor
pH: 2.4
Vapor Pressure: 0.000082 mm Hg
Viscosity: Not available.
Boiling Point: 211 deg C @ 20.00mm Hg
Freezing/Melting Point: 158 - 160 deg C
Autoignition Temperature: 535 deg C ( 995.00 deg F)
Flash Point: 157 deg C ( 314.60 deg F)
Explosion Limits, lower: 1.1 % @ 392F
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Soluble.
Specific Gravity/Density: 1.4400g/cm3
Molecular Formula: C7H6O3
Molecular Weight: 138.12

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures. Moisture sensitive.
Light sensitive. Darkens on exposure to light.
Conditions to Avoid:
High temperatures, incompatible materials, light, moisture, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents, lead acetate, iron salts, alkalis, iodine, spirit nitrous ether.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 69-72-7: VO0525000 LD50/LC50:
CAS# 69-72-7: Draize test, rabbit, eye: 100 mg Severe; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = >900 mg/m3/1H; Oral, mouse: LD50 = 480 mg/kg; Oral, rabbit: LD50 = 1300 mg/kg; Oral, rat: LD50 = 891 mg/kg; Skin, rabbit: LD50 = >10 gm/kg; Skin, rat: LD50 = >2 gm/kg.
Carcinogenicity:
Salicylic acid - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Bacteria: Phytobacterium phosphoreum: EC50 = 214 mg/L; 5 min; Microtox testAdsorption, volatilization and bioconcentration are not expected to be important environmental fate processes.
Biodegradation is expected to be the dominant removal mechanism from soil and water. It may also undergo photochemical degradation in sunlit environmental media.
Other Dangerous to aquatic life in high concentrations.

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36/38 Irritating to eyes and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28 After contact with skin, wash immediately
with...
S 39 Wear eye/face protection.
WGK (Water Danger/Protection)
CAS# 69-72-7: 1
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
CAS# 69-72-7 is listed on Canada's DSL List.
CAS# 69-72-7 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 69-72-7 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum Predict 1H proton NMR
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IR Spectrum IR : KBr disc
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Mass Spectrum Mass
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Raman Spectrum Raman : 4880 A,200 M,powder
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ESR Spectrum ESR : OXIDATION WITH CERIC SULPHATE IN H2SO4
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