Diethylene glycol

CAS No. 111-46-6

Formula: C4H10O3
Basic Info

Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. DEG is a widely used solvent. It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century.

Formula
C4H10O3
Molecular Weight
106.12
Exact Mass
106.063
LogP
-1.0124
PSA
49.69
Synonyms

Ethanol, 2,2‘-oxybis-

2,2'-Oxydiethanol

DEG

Bis(2-hydroxyethyl)ether

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Properties
Appearance & Physical State
Clear liquid
Density
1.11
Boiling Point
245ºC
Melting Point
-10ºC
Freezing Point
-10.45℃
Flash Point
143ºC
Refractive Index
1.445-1.448
Water Solubility
SOLUBLE
Stability
Stable under normal temperatures and pressures.
Storage Condition
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. Store protected from moisture.
Vapor Density
2.14 (vs air)
Vapor Pressure
0.01 mm Hg ( 20 °C)
Safety Info
RTECS
ID5950000
Safety Statements
S46
WGK Germany
1
Risk Statements
R22
HS Code
2909410000
Hazard Codes
Hazard Declaration
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethylene glycol

1.2 Other means of identification

Product number -
Other names 2,2'-Oxydiethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food Additives: CARRIER_SOLVENT
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

Storage

none

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
Diethylene glycol Diethylene glycol 111-46-6 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest.

In case of skin contact

Rinse skin with plenty of water or shower.

In case of eye contact

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

If swallowed

Give one or two glasses of water to drink. Rinse mouth. Refer immediately for medical attention. See Notes.

4.2 Most important symptoms/effects, acute and delayed

Ingestion of large amounts may cause degeneration of kidney and liver and cause death. Liquid may cause slight skin irritation. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Supportive Care: The patient should be resuscitated with isotonic crystalloidal fluids, and acidosis should be corrected. Early treatment with a competitive ADH inhibitor (e.g., 4-methylpyrazole or ethanol), hemodialysis, and supportive care offer the best hope for patient recovery.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Alcohol foam, water, carbon dioxide, dry chemical

5.2 Specific hazards arising from the chemical

This chemical is combustible.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

6.3 Methods and materials for containment and cleaning up

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Dry. Well closed. Separated from strong oxidants.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Clear liquid
Colour Colorless syrupy liquid
Odour Practically odorless
Melting point/ freezing point -7°C(lit.)
Boiling point or initial boiling point and boiling range 245°C(lit.)
Flammability Combustible.
Lower and upper explosion limit / flammability limit 1.6%-10.8%
Flash point 143°C
Auto-ignition temperature 227.78°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 0.30 cP at 25°C
Solubility In water:SOLUBLE
Partition coefficient n-octanol/water (log value) log Kow = -1.47 (est)
Vapour pressure 0.01 mm Hg ( 20 °C)
Density and/or relative density 1.116g/mLat 20°C
Relative vapour density 2.14 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Low volatility

10.3 Possibility of hazardous reactions

Slight, when exposed to heat or flame; can react with oxidizing materials.DIETHYLENE GLYCOL is incompatible with strong oxidizing agents. It is also incompatible with strong bases. It can react with sulfuric acid and other dehydrating agents, nitric acid, oxygen, hydrogen peroxide, perchloric acid and strong acids. Mixtures with sodium hydroxide decompose exothermically when heated to 230°C.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

... Can react with oxidizing materials ... Mixtures with sodium hydroxide decompose exothermically when heated to 230°C and release explosive hydrogen gas.

10.6 Hazardous decomposition products

When heated to decomposition it emits acrid smoke and irritating fumes.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 15.6 g/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill fish); Conditions: static bioassay, filtered tap water, temperature 20°C; Concentration: 1,000 mg/L for 96 hours.
  • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea, age < or =24 hr); Conditions: freshwater, static, 20-22°C, pH 7.6-7.7; Concentration: 10000000 ug/L for 24 hr /formulated product
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Diethylene glycol, present at 30 mg/L, reached 90% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 100 mg/L in the Japanese MITI test(1). The compound, present at 100 mg/L, showed 59% (rate constant of 0.081/day, 5 day lag period) and 89% degradation (0.173/day, 5 day lag period) using the Sapromat and Oxitop systems, respectively, in manometric respirometry tests using activated sludge at 30 mg/L dry matter(2). Biodegradation of 44% and 78% degradation were reported when using seawater as inoculum in a shake flask die-away test (chemical concentration of 5-30 DOC/L) and the closed bottle oxygen consumption test (test chemical concentration of 2-10 mg/L), respectively, both incubated at 15-20°C for 28 to 60 days; however, high carbon levels may have compromised the test results(3).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for diethylene glycol(SRC), using an estimated log Kow of -1.5(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of diethylene glycol can be estimated to be 1(SRC). According to a classification scheme(2), this estimated Koc value suggests that diethylene glycol is expected to have very high mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.2 UN Proper Shipping Name

ADR/RID: unknown
IMDG: unknown
IATA: unknown

14.3 Transport hazard class(es)

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.4 Packing group, if applicable

ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
Diethylene glycol Diethylene glycol 111-46-6 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: Digol (Diethylene Glycol) Material Safety Data Sheet
Synonym: 2,2'-Oxydiethanol; Diethylene glycol; Diglycol; Dihydroxydiethyl ether; 2,2'-Dihydroxyethyl ether; Ethylene diglycol; 3-Oxa-1,5-pentanediol; Bis(2-hydroxyethyl)ether; DEG
CAS: 111-46-6
Section 1 - Chemical Product   MSDS Name:Digol (Diethylene Glycol) Material Safety Data Sheet
Synonym:2,2'-Oxydiethanol; Diethylene glycol; Diglycol; Dihydroxydiethyl ether; 2,2'-Dihydroxyethyl ether; Ethylene diglycol; 3-Oxa-1,5-pentanediol; Bis(2-hydroxyethyl)ether; DEG

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
111-46-6 Diethylene glycol 100 203-872-2
Hazard Symbols: XN
Risk Phrases: 22

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful if swallowed.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
May cause mild eye irritation.
Skin:
May cause mild skin irritation. May be absorbed through the skin.
Ingestion:
May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Human fatalities have been reported from acute poisoning.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Inhalation of heated or misted form may cause pulmonary edema.
Chronic:
Adverse reproductive effects have been reported in animals. A long term rat feeding study showed that 1% diethylene glycol in the diet over a 2-year period resulted in slight growth depression, a few calcium oxalate bladder stones, minimal kidney damage, and occasional liver damage. At 4% dietary level, there was increased mortality, a marked depression of growth rate, bladder stones, severe kidney damage, and moderate liver damage. In addition, bladder tumors appeared rather frequently.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treatment options include ipecac/lavage, activated charcoal, cathartics--admisitered within two hours of ingestion. Hemodialysis should be considered in severe intoxication.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool.
Extinguishing Media:
Water or foam may cause frothing. Alcohol foam, water fog, carbon dioxide, dry chemical.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Use with adequate ventilation. Avoid breathing vapors from heated material. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Wash clothing before reuse. Avoid breathing spray or mist.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Good general ventilation should be sufficient to control airborne levels.
Exposure Limits CAS# 111-46-6: United Kingdom, WEL - TWA: 23 ppm TWA; 101 mg/m3 TWA United Kingdom, WEL - STEL: 69 ppm STEL; 303 mg/m3 STEL Germany: 10 ppm TWA; 44 mg/m3 TWA Russia: 10 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Viscous liquid
Color: colorless
Odor: practically odorless
pH: Not available.
Vapor Pressure: 0.01 mm Hg @ 30 deg C
Viscosity: 0.30 cP @ 25 deg C
Boiling Point: 245 deg C
Freezing/Melting Point: -10 deg C
Autoignition Temperature: 224 deg C ( 435.20 deg F)
Flash Point: 124 deg C ( 255.20 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble.
Specific Gravity/Density: 1.11
Molecular Formula: C4H10O3
Molecular Weight: 106.12

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 111-46-6: ID5950000 LD50/LC50:
CAS# 111-46-6: Draize test, rabbit, eye: 50 mg Mild; Draize test, rabbit, skin: 500 mg Mild; Oral, mouse: LD50 = 23700 mg/kg; Oral, mouse: LD50 = 2300 mg/kg; Oral, rabbit: LD50 = 4400 mg/kg; Oral, rat: LD50 = 12565 mg/kg; Oral, rat: LD50 = 12000 mg/kg; Skin, rabbit: LD50 = 11890 mg/kg.
Oral, human: LDLo = 1000 mg/kg.
Carcinogenicity:
Diethylene glycol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Fish: Fathead Minnow: LC50 = >100.0 mg/L; 96 Hr.; Static ConditionWater flea Daphnia: LC50 = 0.3-1.0 mg/L; 96 Hr.; Static ConditionBacteria: Phytobacterium phosphoreum: EC50 = 228 mg/L; 15 minutes; Microtox test

Section 13 - DISPOSAL CONSIDERATIONS
  Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
S 46 If swallowed, seek medical advice immediately
and show this container or label.
WGK (Water Danger/Protection)
CAS# 111-46-6: 1
Canada
CAS# 111-46-6 is listed on Canada's DSL List.
CAS# 111-46-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 111-46-6 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
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IR Spectrum IR : liquid film
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Mass Spectrum Mass
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Raman Spectrum Raman : 4880 A,150M,liquid
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Analysis Methods
Kovats' RI, non-polar column, isothermal
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Column Shape
Packed
Active Phase(℃)
Apiezon L
Retention index
927.
Temperature Control
160.
Method
isothermal
Comments
Celite 545
Reference
Bogoslovsky, Yu.N.Anvaer, B.I.Vigdergauz, M.S.Chromatographic constants in gas chromatography (in Russian)Standards Publ. House, Moscow, 1978, 192.
Kovats' RI, non-polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
Apiezon L
Retention index
925.
Temperature Control
170.
Method
isothermal
Comments
&nbsp;
Reference
Singliar, M.Dykyj, J.Gas chromatography of glycol ethersCollect. Czech. Chem. Commun.1969, 34, 3, 767-775.
Kovats' RI, polar column, isothermal
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Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1989.
Temperature Control
200.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Van Den Dool and Kratz RI, non-polar column, temperature ramp
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Column Shape
Capillary
Active Phase(℃)
Ultra-2
Retention index
967.
Temperature Control
Method
temperature ramp
Comments
25. m/0.32 mm/0.52 μm, H2, 8. K/min; T<sub>start</sub>: 50. C; T<sub>end</sub>: 310. C
Reference
Poskrobko, J.Linkiewicz, M.Jaworski, M.Analysis of high-boiling ethoxylates of methyl, ethyl and butyl alcohols, with the use of gas chromatographyChem. Anal. (Warsaw)1994, 39, 2, 153-159.
Van Den Dool and Kratz RI, polar column, temperature ramp
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Column Shape
Capillary
Active Phase(℃)
Supelcowax-10
Retention index
1975.
Temperature Control
Method
temperature ramp
Comments
30. m/0.25 mm/0.25 μm, He, 3. K/min, 230. C @ 30. min; T<sub>start</sub>: 50. C
Reference
Moreira, R.F.A.Trugo, L.C.Pietroluongo, M.de Maria, C.A.B.Flavor composition of cashew (Anacardium occidentale) and marmeleiro (Croton species) honeysJ. Agric. Food Chem.2002, 50, 26, 7616-7621.
Toxicity
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration onto the skin
Species Observed
Human
Dose/Duration
112 mg/3D (Intermittent)
Toxic Effects
--
Reference
Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976, Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration onto the skin
Species Observed
Rodent - rabbit
Dose/Duration
500 mg
Toxic Effects
--
Reference
Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,731,1969
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Rodent - rabbit
Dose/Duration
50 mg
Toxic Effects
--
Reference
Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 42,355,1931

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