Benzene

CAS No. 71-43-2

Formula: C6H6
Basic Info

Benzene is a natural constituent of crude oil, and is one of the most elementary petrochemicals. It is used mainly as an intermediate to make other chemicals. About 80% of benzene is consumed in the production of three chemicals, ethylbenzene, cumene, and cyclohexane. As a gasoline (petrol) additive, benzene increases the octane rating and reduces knocking.

Formula
C6H6
Molecular Weight
78.1118
Exact Mass
78.047
LogP
1.6866
PSA
0
Synonyms

Phene

Benzole

Benzolo

Benzen

Annulene

Fenzen

Benzeen

[6]Annulene (not recommended)

Benzol (historic/German)

Cyclohexa-1,3,5-triene

1,3,5-Cyclohexatriene

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Properties
Appearance & Physical State
clear colorless liquid with a petroleum-like odor
Density
0.8786
Boiling Point
80ºC
Melting Point
5.5ºC
Flash Point
-11ºC
Refractive Index
1.5011
Water Solubility
0.18 g/100 mL
Stability
Stable. Substances to be avoided include strong oxidizing agents, sulfuric acid, nitric acid, halogens. Highly flammable.
Storage Condition
0-6ºC
Vapor Density
2.77 (vs air)
Vapor Pressure
166 mm Hg ( 37.7 °C)
Safety Info
RTECS
CY1400000
Safety Statements
S53-S45
WGK Germany
3
Risk Statements
R45; R46; R11; R36/38; R48/23/24/25; R65
HS Code
2707100000
RIDADR
UN 1114 3/PG 2
Hazard Class
3
Packing Group
II
Caution Statement
P201; P210; P280; P308 + P313; P370 + P378; P403 + P235
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name benzene

1.2 Other means of identification

Product number -
Other names Benzole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Hydrocarbons (contain hydrogen and carbon atoms), Volatile organic compounds
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 2

Skin irritation, Category 2

Eye irritation, Category 2

Aspiration hazard, Category 1

Germ cell mutagenicity, Category 1B

Carcinogenicity, Category 1A

Specific target organ toxicity – repeated exposure, Category 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H225 Highly flammable liquid and vapour

H315 Causes skin irritation

H319 Causes serious eye irritation

H304 May be fatal if swallowed and enters airways

H340 May cause genetic defects

H350 May cause cancer

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P270 Do not eat, drink or smoke when using this product.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P331 Do NOT induce vomiting.

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P314 Get medical advice/attention if you feel unwell.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
benzene benzene 71-43-2 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Do NOT induce vomiting. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Dizziness, excitation, pallor, followed by flushing, weakness, headache, breathlessness, chest constriction, nausea, and vomiting. Coma and possible death. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Benzene and Related Compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Approach fire from upwind to avoid hazardous vapors. Use water spray, dry chemical, foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool.

5.2 Specific hazards arising from the chemical

Behavior in Fire: Vapor is heavier than air and may travel considerable distance to a source of ignition and flash back. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

For spills on water, contain with booms or barriers, use surface acting agents to thicken spilled materials. Remove trapped materials with suction hoses.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof. Separated from food and feedstuffs, oxidants and halogens. Store in an area without drain or sewer access.Keep in well closed containers in a cool place and away from fire.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration.

Recommended Exposure Limit: 10 Hour Time-Weighted Average: 0.1 ppm.

Recommended Exposure Limit: 15 Minute Short-Term Exposure Limit: 1 ppm.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear colorless liquid with a petroleum-like odor
Colour Clear, colorless liquid
Odour Aromatic odor
Melting point/ freezing point -11°C(lit.)
Boiling point or initial boiling point and boiling range 80°C(lit.)
Flammability Highly flammable.
Lower and upper explosion limit / flammability limit Lower flammable limit: 1.2% by volume; Upper flammable limit: 7.8% by volume
Flash point -11°C
Auto-ignition temperature 561.67°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 0.604 mPa.s at 25°C
Solubility In water:0.18 g/100 mL
Partition coefficient n-octanol/water (log value) log Kow = 2.13
Vapour pressure 166 mm Hg ( 37.7 °C)
Density and/or relative density 0.874g/mLat 25°C(lit.)
Relative vapour density 2.77 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

A dangerous fire hazard when exosed to heat or flame. ... Ignites on contact with sodium peroxide + water, dioxygenyl tetrafluoroborate, iodine heptafluoride, and dioxygen difluoride.The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.Benzene vapors are heavier than air. They will spread along the ground and collect and stay in poorly-ventilated, low-lying, or confined areas (e.g., sewers, basements, and tanks).Hazardous concentrations may develop quickly in enclosed, poorly-ventilated, or low-lying areas. Keep out of these areas. Stay upwind.Benzene liquid is less dense than water and will float on the surface of water.BENZENE reacts vigorously with allyl chloride or other alkyl halides even at -70° C in the presence of ethyl aluminum dichloride or ethyl aluminum sesquichloride. Explosions have been reported [NFPA 491M 1991]. Ignites in contact with powdered chromic anhydride [Mellor 11:235 1946-47]. Incompatible with oxidizing agents such as nitric acid. Mixtures with bromine trifluoride, bromine pentafluoride, iodine pentafluoride, iodine heptafluoride and other interhalogens can ignite upon heating [Bretherick 5th ed. 1995]. Benzene and cyanogen halides yield HCl as a byproduct (Hagedorn, F. H. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.). The reaction of benzene and trichloroacetonitrile evolves toxic chloroform and HCl gases. (Hagedorn, F., H.-P. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Reacts violently with iodine pentafluoride.

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 3306 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

NTP: Known to be a human carcinogen. EPA: Known human carcinogen. IARC: Carcinogenic to humans

Reproductive toxicity

There is some evidence from human epidemiological studies of reproductive and developmental toxicity of benzene, however the data do not provide conclusive evidence of a link between exposure and effect (4). Animal studies have provided limited evidence that exposure to benzene may affect reproductive organs, however these effects were only observed at exposure levels over the maximum tolerated dose . Adverse effects on the fetus, including low birth weight, delayed bone formation, and bone marrow damage, have been observed where pregnant animals were exposed to benzene by inhalation.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Salmo trutta (brown trout) yearlings; Conditions: static bioassay; Concentration: 12 mg/L for 1 hr
  • Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static, 20°C, pH 8.2, hardness 130 mg/L CaCO3; Concentration: 18000 ug/L for 24 hr (95% confidence interval: 14810-21900 ug/L); Effect: intoxication, immobilization />99.7% purity
  • Toxicity to algae: EC50; Species: Chlorella vulgaris (Green Algae); Conditions: freshwater, static, 20°C; Concentration: 525000 ug/L for 24 hr; Effect: growth, general /formulation
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Benzene present at 100 mg/L, reached 40% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). Benzene reached 24% of its theoretical oxygen demand in a non-acclimated microbial population after 15 days(2). Aerobic biodegradation of benzene was studied in pre-equilibrated soil-water slurry microcosms(3). Using an enriched aerobic bacterial culture, benzene began to degrade 12 hrs after incubation in an aqueous(soil-free) solution with 50% of benzene degrading after 60 hrs and almost complete degradation within 90 hrs. Using a pre-equilibrated soil-water slurry microcosm, benzene did not begin to degrade until 3 days after application and reached complete degradation after about 12 days(3).

12.3 Bioaccumulative potential

Benzene has BCFs ranging from 1.1-20(1). According to a classification scheme(2), this BCF range suggests the potential for bioconcentration in aquatic organisms is low. The uptake and elimination rate constants for benzene in fathead minnows were studied(3). Fathead minnows were found to have an average uptake rate of 7 L/kg/hr with an average elimination rate of 0.384/hr which corresponds to a BCF of 19(3). In a study of BCF values for various aquatic species, benzene was found to have a BCF value of 3.5 in eels(4), 4.4 in pacific herring(5), and 4.3 in goldfish(6).

12.4 Mobility in soil

An experimentally derived log Koc of 1.93 (Koc = 85) was obtained via reverse phase HPLC (high performance liquid chromatography) with a cyanopropyl column and a mobile phase of water(1). According to a classification scheme(2), this estimated Koc value suggests that benzene is expected to have high mobility in soil. The sorption equilibrium for benzene in a soil/water mixture (ratio soil/water 0.12 kg/l) took 72 hrs(3). The Koc for benzene has also been experimentally determined to be 79(4).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1114 IMDG: UN1114 IATA: UN1114

14.2 UN Proper Shipping Name

ADR/RID: BENZENE
IMDG: BENZENE
IATA: BENZENE

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
benzene benzene 71-43-2 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Benzene    
    REACH No.        : 01-2119447106-44-XXXX    
    CAS-No.        : 71-43-2    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 2), H225
    Carcinogenicity (Category 1A), H350
    Germ cell mutagenicity (Category 1B), H340
    Specific target organ toxicity - repeated exposure (Category 1), H372
    Aspiration hazard (Category 1), H304
    Eye irritation (Category 2), H319
    Skin irritation (Category 2), H315
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    F Highly flammable        R11    
    T Toxic        R48/23/24/25    
    R45
    R46
    Xn Harmful        R65    
    Xi Irritant        R36/38    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Danger    
    Hazard statement(s)
    H225        Highly flammable liquid and vapour.    
    H304        May be fatal if swallowed and enters airways.    
    H315        Causes skin irritation.    
    H319        Causes serious eye irritation.    
    H340        May cause genetic defects.    
    H350        May cause cancer.    
    H372        Causes damage to organs through prolonged or repeated exposure.    
    Precautionary statement(s)
    P201        Obtain special instructions before use.    
    P210        Keep away from heat/sparks/open flames/hot surfaces. - No smoking.    
    P301 + P310        IF SWALLOWED: Immediately call a POISON CENTER or doctor/    
    physician.
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    P308 + P313        IF exposed or concerned: Get medical advice/ attention.    
    P331        Do NOT induce vomiting.    
    Supplemental Hazard        none    
    Statements
    Restricted to professional users.
  Other hazards - none

SECTION 3: Composition/information on ingredients
  Substances
    Formula        : C6H6    
    Molecular Weight        : 78,11 g/mol    
    CAS-No.        : 71-43-2    
    EC-No.        : 200-753-7    
    Registration number        : 01-2119447106-44-XXXX    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
  Benzene
    CAS-No.        71-43-2        Flam. Liq. 2; Skin Irrit. 2; Eye        <= 100 %    
    EC-No.        200-753-7        Irrit. 2; Muta. 1B; Carc. 1A;    
    Index-No.        601-020-00-8        STOT RE 1; Asp. Tox. 1;    
    Registration number        01-2119447106-44-XXXX        H225, H304, H315, H319,    
    H340, H350, H372
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
  Benzene
    CAS-No.        71-43-2        F, T, Carc.Cat.1, Mut.Cat.2,        <= 100 %    
    EC-No.        200-753-7        R45 - R46 - R11 - R36/38 -    
    Index-No.        601-020-00-8        R48/23/24/25 - R65    
    Registration number        01-2119447106-44-XXXX    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides
    Flash back possible over considerable distance., Container explosion may occur under fire conditions.
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
    Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
    form explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation
    of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    charge.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
  Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Face shield and safety glasses Use equipment for eye protection tested and approved under
    appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
    Full contact
    Material: Fluorinated rubber
    Minimum layer thickness: 0,7 mm
    Break through time: 480 min
    Material tested:Vitoject® (KCL 890 / Z677698, Size M)
    Splash contact
    Material: Fluorinated rubber
    Minimum layer thickness: 0,7 mm
    Break through time: 480 min
    Material tested:Vitoject® (KCL 890 / Z677698, Size M)
    data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300,     test method: EN374
    If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
    contact the supplier of the CE approved gloves. This recommendation is advisory only and must
    be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
    anticipated use by our customers. It should not be construed as offering an approval for any
    specific use scenario.
  Body Protection
    Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
    of protective equipment must be selected according to the concentration and amount of the
    dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid    
    Colour: colourless
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        Melting point/range: 5,5 °C - lit.    
    point
    f) Initial boiling point and 80 °C - lit.
    boiling range
    g) Flash point        -11,0 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        Upper explosion limit: 8 %(V)    
    flammability or        Lower explosion limit: 1,3 %(V)    
    explosive limits
    k) Vapour pressure        221,3 hPa at 37,7 °C    
    99,5 hPa at 20,0 °C
    l) Vapour density        no data available    
    m) Relative density        0,874 g/cm3 at 25 °C    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Auto-ignition        562,0 °C    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks. Extremes of temperature and direct sunlight.
  Incompatible materials
    acids, Bases, Halogens, Strong oxidizing agents, Metallic salts
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - rat - 2.990 mg/kg
    LC50 Inhalation - rat - female - 4 h - 44.700 mg/m3
    LD50 Dermal - rabbit - 8.263 mg/kg
  Skin corrosion/irritation
    Skin - rabbit
    Result: Skin irritation
  Serious eye damage/eye irritation
    Eyes - rabbit
    Result: Eye irritation
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
    Laboratory experiments have shown mutagenic effects.
    In vivo tests showed mutagenic effects
    Human
    lymphocyte
    Sister chromatid exchange
    mouse
    lymphocyte
    Mutation in mammalian somatic cells.
    mouse
    Sister chromatid exchange
  Carcinogenicity
    Carcinogenicity - Human - male - Inhalation
    Tumorigenic:Carcinogenic by RTECS criteria. Leukaemia Blood:Thrombocytopenia.
    Carcinogenicity - rat - Oral
    Tumorigenic:Carcinogenic by RTECS criteria. Endocrine:Tumors. Leukaemia
    This is or contains a component that has been reported to be carcinogenic based on its IARC, OSHA,
    ACGIH, NTP, or EPA classification.
    Human carcinogen.
    IARC:        1 - Group 1: Carcinogenic to humans (Benzene)    
  Reproductive toxicity
    Reproductive toxicity - mouse - Intraperitoneal
    Effects on Fertility: Pre-implantation mortality (e.g., reduction in number of implants per female; total
    number of implants per corpora lutea). Effects on Embryo or Fetus: Fetal death.
    Developmental Toxicity - rat - Inhalation
    Effects on Embryo or Fetus: Extra embryonic structures (e.g., placenta, umbilical cord). Effects on Embryo
    or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
    Developmental Toxicity - mouse - Inhalation
    Effects on Embryo or Fetus: Cytological changes (including somatic cell genetic material). Specific
    Developmental Abnormalities: Blood and lymphatic system (including spleen and marrow).
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    May be fatal if swallowed and enters airways.
  Additional Information
    RTECS: CY1400000
    Nausea, Dizziness, Headache, narcosis, Inhalation of high concentrations of benzene may have an initial
    stimulatory effect on the central nervous system characterized by exhilaration, nervous excitation and/or
    giddiness, depression, drowsiness, or fatigue. The victim may experience tightness in the chest,
    breathlessness, and loss of consciousness. Tremors, convulsions, and death due to respiratory paralysis
    or circulatory collapse can occur in a few minutes to several hours following severe exposures. Aspiration
    of small amounts of liquid immediately causes pulmonary edema and hemorrhage of pulmonary tissue.
    Direct skin contact may cause erythema. Repeated or prolonged skin contact may result in drying, scaling
    dermatitis, or development of secondary skin infections. The chief target organ is the hematopoietic
    system. Bleeding from the nose, gums, or mucous membranes and the development of purpuric spots,
    pancytopenia, leukopenia, thrombocytopenia, aplastic anemia, and leukemia may occur as the condition
    progresses. The bone marrow may appear normal, aplastic or hyperplastic, and may not correlate with
    peripheral blood-forming tissues. The onset of effects of prolonged benzene exposure may be delayed for
    many months or years after the actual exposure has ceased., Blood disorders

SECTION 12: Ecological information
  Toxicity
    Toxicity to fish        LC50 - Oncorhynchus mykiss (rainbow trout) - 5,90 mg/l - 96 h    
    LC50 - Pimephales promelas (fathead minnow) - 15,00 - 32,00 mg/l - 96 h
    LC50 - Lepomis macrochirus (Bluegill) - 230,00 mg/l - 96 h
    NOEC - Pimephales promelas (fathead minnow) - 10,2 mg/l - 7 d
    LOEC - Pimephales promelas (fathead minnow) - 17,2 mg/l - 7 d
    Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 22,00 mg/l - 48 h
    other aquatic
    invertebrates
    EC50 - Daphnia magna (Water flea) - 9,20 mg/l - 48 h
    Toxicity to algae        EC50 - Pseudokirchneriella subcapitata (green algae) - 29,00 mg/l - 72 h    
  Persistence and degradability
    Biodegradability        Result: - Readily biodegradable.    
  Bioaccumulative potential
    Bioaccumulation        Leuciscus idus (Golden orfe) - 3 d    
    - 0,05 mg/l
    Bioconcentration factor (BCF): 10
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    Toxic to aquatic life.

SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
    company.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 1114        IMDG: 1114        IATA: 1114    
  UN proper shipping name
    ADR/RID: BENZENE
    IMDG: BENZENE
    IATA:        Benzene    
  Transport hazard class(es)
    ADR/RID: 3        IMDG: 3        IATA: 3    
  Packaging group
    ADR/RID: II        IMDG: II        IATA: II    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available



SECTION 15 - REGULATORY INFORMATION
N/A


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : parameter in CDCl3
expand collapse
IR Spectrum IR : liquid film
expand collapse
Mass Spectrum Mass
expand collapse
Raman Spectrum Raman : 4880 A,100M,liquid
expand collapse
ESR Spectrum ESR : ANION RADICAL, REDUCTION WITH K-NA IN THF-DME
expand collapse
Toxicity
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Open irritation test
Exposure Route
Administration onto the skin
Species Observed
Rodent - rabbit
Dose/Duration
15 mg/24H
Toxic Effects
--
Reference
American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Standard Draize test
Exposure Route
Administration onto the skin
Species Observed
Rodent - rabbit
Dose/Duration
20 mg/24H
Toxic Effects
--
Reference
Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,25,1986
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Rodent - rabbit
Dose/Duration
88 mg
Toxic Effects
--
Reference
AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 14,387,1956

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