p-cresol

CAS No. 106-44-5

Formula: C7H8O
Basic Info

para-Cresol, also 4-methylphenol, is an organic compound with the formula CH3C6H4(OH). It is a colourless solid that is widely used intermediate in the production of other chemicals. It is a derivative of phenol, an isomer of o-cresol and m-cresol.

Formula
C7H8O
Molecular Weight
108.138
Exact Mass
108.058
LogP
1.7006
PSA
20.23
Synonyms

KRESOL-PARA

1PO

p-Toluol

4-Cresol

Paracresol

FEMA 2337

p-Kresol

p-Cresol

4-Methylphenol

Phenol, 4-methyl-

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Properties
Appearance & Physical State
Clear to to slightly amber semi solid
Density
1.034
Boiling Point
202ºC
Melting Point
32-34ºC
Flash Point
89ºC
Refractive Index
1.5312 (20ºC)
Water Solubility
20 g/L (20 ºC)
Stability
Stable. Combustible. Incompatible with strong oxidizing agents. Air and light-sensitive. Hygroscopic.
Storage Condition
2-8ºC
Vapor Density
3.72 (vs air)
Vapor Pressure
1 mm Hg ( 20 °C)
Safety Info
RTECS
GO6475000
Safety Statements
S36/37/39-S45
WGK Germany
1
Risk Statements
R24/25; R34
HS Code
29071200
RIDADR
UN 2076/3455
Hazard Class
6.1
Packing Group
II
Caution Statement
P280; P301 + P310; P305 + P351 + P338; P310
Hazard Codes
Hazard Declaration
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name p-cresol

1.2 Other means of identification

Product number -
Other names Phenol, 4-methyl-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Skin corrosion, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

H311 Toxic in contact with skin

H314 Causes severe skin burns and eye damage

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/…

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
p-cresol p-cresol 106-44-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

no data available

4.3 Indication of immediate medical attention and special treatment needed, if necessary

no data available

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

no data available

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Clear to to slightly amber semi solid
Colour no data available
Odour no data available
Melting point/ freezing point 53°C(lit.)
Boiling point or initial boiling point and boiling range 202°C(lit.)
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 85°C
Auto-ignition temperature 558.89°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:20 g/L (20 ºC)
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 1 mm Hg ( 20 °C)
Density and/or relative density 1.034g/mLat 25°C(lit.)
Relative vapour density 3.72 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

no data available

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

no data available

12.4 Mobility in soil

no data available

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN3455 IMDG: UN3455 IATA: UN3455

14.2 UN Proper Shipping Name

ADR/RID: CRESOLS, SOLID
IMDG: CRESOLS, SOLID
IATA: CRESOLS, SOLID

14.3 Transport hazard class(es)

ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
p-cresol p-cresol 106-44-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: p-Cresol Material Safety Data Sheet
Synonym: 4-Cresol; p-Cresylic Acid; 1-Hydroxy-4-Methylbenzene; p-Hydroxytoluene; 4-Hydroxytoluene; p-Methylphenol
CAS: 106-44-5
Section 1 - Chemical Product   MSDS Name:p-Cresol Material Safety Data Sheet
Synonym:4-Cresol; p-Cresylic Acid; 1-Hydroxy-4-Methylbenzene; p-Hydroxytoluene; 4-Hydroxytoluene; p-Methylphenol

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
106-44-5 p-Cresol >98 203-398-6
Hazard Symbols: T C
Risk Phrases: 34 24/25

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Causes burns. Toxic in contact with skin and if swallowed.Corrosive.Toxic.Hygroscopic (absorbs moisture from the air).Light sensitive.
Potential Health Effects
Eye:
Causes eye burns. May result in corneal injury. Contact with liquid is corrosive to the eyes and causes severe burns. May cause conjunctivitis and keratitis.
Skin:
May be absorbed through the skin in harmful amounts. Causes severe skin irritation and burns. May cause sensitization by skin contact.
Ingestion:
May cause severe and permanent damage to the digestive tract. May cause vascular collapse and damage. Causes severe digestive tract burns with abdominal pain, vomiting, and possible death. May cause kidney, liver and spleen damage. Rapidly absorbed from the gastrointestinal tract. Cresols may cause abnormalities of the central nervous system, respiratory system, spleen and pancreas.
Inhalation:
May be fatal if inhaled. Irritation may lead to chemical pneumonitis and pulmonary edema. May cause liver and kidney damage. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. Causes chemical burns to the respiratory tract. May cause headache. May cause nausea and possible vomiting.
Chronic:
May cause liver and kidney damage. Repeated exposure may cause sensitization dermatitis. May cause appetite loss, diarrhea, skin abnormalities, and digestive tract disturbances.

Section 4 - FIRST AID MEASURES
  Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May polymerize explosively when involved in a fire. Material is a solid at room temperature that melts upon moderate heating into a combustible liquid with a flash point below 200F(93.3C).
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, or water spray.
For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section).
Remove all sources of ignition. Provide ventilation. Evacuate unnecessary personnel.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. If the water content is below approximately 0.3% and the temperature exceeds 268F (120C), violent corrosion of aluminum and its alloys may occur.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 106-44-5: Japan: 5 ppm OEL; 22 mg/m3 OEL Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Solid
Color: colorless to light yellow
Odor: phenol-like
pH: Not available.
Vapor Pressure: 1 mm Hg @ 53C
Viscosity: Not available.
Boiling Point: 396 deg F
Freezing/Melting Point: 35 deg C
Autoignition Temperature: 1038 deg F ( 558.89 deg C)
Flash Point: 187 deg F ( 86.11 deg C)
Explosion Limits, lower: 1.1% @ 150C
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: 22.6g/L @ 40C.
Specific Gravity/Density: 1.03 (water=1)
Molecular Formula: C7H8O
Molecular Weight: 108.0554

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions. Low melting point solid.
Conditions to Avoid:
Incompatible materials, light, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, strong acids, bases, active metals, coatings, nitric acid, plastics, rubber, aliphatic amines, amides, chlorosulfonic acid, oleum, alkalies.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, cresol.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 106-44-5: GO6475000 LD50/LC50:
CAS# 106-44-5: Draize test, rabbit, eye: 103 mg Severe; Draize test, rabbit, skin: 517 mg/24H Severe; Inhalation, rat: LC50 = >710 mg/m3/1H; Inhalation, rat: LC50 = 29 mg/m3; Oral, mouse: LD50 = 344 mg/kg; Oral, mouse: LD50 = 160 mg/kg; Oral, rabbit: LD50 = 620 mg/kg; Oral, rat: LD50 = 207 mg/kg; Oral, rat: LD50 = 270 mg/kg; Skin, rabbit: LD50 = 301 mg/kg; Skin, rabbit: LD50 = 301 mg/kg; Skin, rat: LD50 = 750 mg/kg; Skin, rat: LD50 = 750 mg/kg.
Carcinogenicity:
p-Cresol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Fish: Fathead Minnow: LC50 = 19-28.6 mg/L; 96 Hr.; UnspecifiedFish: LC50 = 19-28.6 mg/L; 96 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 1.6 mg/L; 15 Minutes; Microtox testGoldfish (soft water) TLm=49.1-19ppm/24-96H Bluegill (soft water) TLm=22.2-20.8ppm/24-96H Fathead minnow (hard water) TLm=18-13.4ppm/24-96H Guppy (hard water) TLm=18-50ppm/24-96H

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: CRESOLS
Hazard Class: 6.1 (8)
UN Number: 2076
Packing Group: II
IMO
Shipping Name: CRESOLS, LIQUID or SOLID
Hazard Class: 6.1 (8)
UN Number: 2076
Packing Group: II
RID/ADR
Shipping Name: CRESOLS
Hazard Class: 6.1
UN Number: 2076
Packing group: II
USA RQ: CAS# 106-44-5: 100 lb final RQ; 45.4 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T C
Risk Phrases:
R 24/25 Toxic in contact with skin and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 106-44-5: 2
Canada
CAS# 106-44-5 is listed on Canada's DSL List.
CAS# 106-44-5 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 106-44-5 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 400 MHz in CDCl3
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IR Spectrum IR : CCl4 solution
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Mass Spectrum Mass spectrum (electron ionization)
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Raman Spectrum Raman : 4880 A,200 M,powder
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UV Spectrum UV/Visible spectrum
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