6-Aminocaproic acid

CAS No. 60-32-2

Formula: C6H13NO2
Basic Info

Aminocaproic acid (also known as ε-aminocaproic acid, ε-Ahx, or 6-aminohexanoic acid) is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis. For this reason it is effective in treatment of certain bleeding disorders, and it is marketed as Amicar. Aminocaproic acid is also an intermediate in the polymerization of Nylon-6, where it is formed by ring-opening hydrolysis of caprolactam.

Formula
C6H13NO2
Molecular Weight
131.173
Exact Mass
131.095
LogP
1.2904
PSA
63.32
Synonyms

6-amino-n-hexanoic acid

6-amino-n-caproic acid

6-amino-hexanoic acid

Aminocaproic acid

Hexanoic acid, 6-amino-

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Properties
Appearance & Physical State
white crystalline powder
Density
1.042 g/cm3
Boiling Point
255.6ºC at 760 mmHg
Melting Point
204-209ºC
Flash Point
108.4ºC
Water Solubility
SOLUBLE
Storage Condition
2-8ºC
Safety Info
RTECS
MO6300000
Safety Statements
S26-S36
WGK Germany
2
Risk Statements
R36/37/38
HS Code
29224995
Hazard Codes
Spectrum
NMR Spectrum 1H NMR : 400 MHz in D2O
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IR Spectrum IR : KBr disc
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Mass Spectrum Mass spectrum (electron ionization)
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Raman Spectrum Raman : 4880 A,200 M,powder
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Toxicity
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Rodent - rabbit
Dose/Duration
500 mg/24H
Toxic Effects
--
Reference
Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,738,1986
ACUTE TOXICITY DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Human - man
Dose/Duration
1778 mg/kg/8D-I
Toxic Effects
Kidney, Ureter, Bladder--changes in tubules (including acute renal failure, acute tubular necrosis)<br>Kidney, Ureter, Bladder--hematuria<br>Nutritional and Gross Metabolic--body temperature increase
Reference
American Journal of Kidney Diseases. (Grune & Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981- Volume(issue)/page/year: 8,441,1986
ACUTE TOXICITY DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Multiple routes
Species Observed
Human - man
Dose/Duration
14400 mg/kg/59D-I
Toxic Effects
Behavioral--muscle weakness<br>Kidney, Ureter, Bladder--hematuria
Reference
British Journal of Urology. (Longman Group Ltd., POB 11318, Birmingham, AL 35202) V.1- 1929- Volume(issue)/page/year: 60,81,1987

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