phosgene

CAS No. 75-44-5

Formula: CCl2O
Basic Info

Phosgene is the chemical compound with the formula COCl2. This colorless gas gained infamy as a chemical weapon during World War I where it was responsible for about 85% of the 100,000 deaths caused by chemical weapons. It is also a valued industrial reagent and building block in synthesis of pharmaceuticals and other organic compounds. In low concentrations, its odor resembles freshly cut hay or grass. In addition to its industrial production, small amounts occur from the breakdown and the combustion of organochlorine compounds, such as those used in refrigeration systems. The chemical was named by combining the Greek words "phos" (meaning light) and "genesis" (birth); it does not mean it contains any phosphorus (cf. phosphine).

Formula
CCl2O
Molecular Weight
98.9161
Exact Mass
97.9326
LogP
1.584
PSA
17.07
Synonyms

Phlsgene

Phosgenegas

Fosgen

carbonic dichloride

dichloro-ketone

carbonyl chloride

combatgas

Phosgen

thionyl chloride

Fosgene

Fosgeen

PHOSGENE

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Properties
Appearance & Physical State
colourless gas
Density
1.523 g/cm3
Boiling Point
8.2ºC at 760 mmHg
Melting Point
-118ºC
Flash Point
4ºC
Refractive Index
1.419
Storage Condition
2-8ºC
Vapor Pressure
1180 mm Hg ( 20 °C)
Safety Info
RTECS
SY5600000
Safety Statements
9-26-36/37/39-45-62-28
WGK Germany
2
Risk Statements
R26; R34; R67; R65; R63; R48/20; R11
HS Code
2812103000
RIDADR
UN 3384
Hazard Class
2.3
Caution Statement
P210; P261; P280; P301 + P310; P305 + P351 + P338; P310
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name phosgene

1.2 Other means of identification

Product number -
Other names Phlsgene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Phosgene is a widely used chemical intermediate, primarily manufactured in the preparation of many organic chemicals. Phosgene is used for the synthesis of isocyanate-based polymers, carbonic acid esters, and acid chlorides. It is also used in the manufacture of dyestuffs, some insecticides, and pharmaceuticals and in metallurgy. In the past, phosgene was used as a chemical warfare agent (in WWI and WWII).
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Gases under pressure: Compressed gas

Skin corrosion, Category 1B

Acute toxicity - Inhalation, Category 2

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H314 Causes severe skin burns and eye damage

H330 Fatal if inhaled

Precautionary statement(s)
Prevention

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P271 Use only outdoors or in a well-ventilated area.

P284 [In case of inadequate ventilation] wear respiratory protection.

Response

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P320 Specific treatment is urgent (see ... on this label).

Storage

P410+P403 Protect from sunlight. Store in a well-ventilated place.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
phosgene phosgene 75-44-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Half-upright position. Administration of oxygen may be needed. Refer immediately for medical attention.

In case of skin contact

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention.

In case of eye contact

Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

Phosgene is a lung toxicant that causes damage to the capillaries, bronchioles and alveoli of the lungs, by decomposition to hydrochloric acid. There is little immediate irritant effect upon the respiratory tract, and the warning properties of the gas are therefore very slight. Pulmonary edema, bronchopneumonia and occasionally lung abscesses develop. Degenerative changes in the nerves have been reported as later developments. A concentration of 25 ppm is dangerous for exposures lasting 30-60 minutes and 50 ppm is rapidly fatal after even short exposure. (EPA, 1998)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

/PREHOSPITAL/ Quickly access for a patent airway, ensure adequate respiration and pulse. If trauma is suspected, maintain cervical immobilization manually and apply a cervical collar and a backboard when feasible. ... If victims can walk, lead them out of the Hot Zone to the Decontamination Zone. Victims who are unable to walk may be removed on backboards or gurneys; if these are not available, carefully carry or drag victims to safety. Victims should be kept warm and quiet; any activity subsequent to exposure may increase the likelihood of death.

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use remote equipment wherever possible. Use water spray to keep fire-exposed containers cool. Extinguish fire using agent suitable for surrounding fire.

5.2 Specific hazards arising from the chemical

When heated to decomposition or on contact with water or steam, it will react to produce toxic and corrosive fumes. Reacts violently with aluminum; tert-butyl azido formate; 2,4-hexadiyn-1,6-diol; isopropyl alcohol; potassium; sodium; hexafluoro isopropylidene; amino lithium; lithium. Stable in steel containers if dry. Avoid moisture. (EPA, 1998)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Shut off cylinder if possible. Remove gas with fine water spray. Isolate the area until the gas has dispersed.

6.3 Methods and materials for containment and cleaning up

For liquid spills, cover with sodium bicarbonate or an equal mixture of soda ash and slaked lime. After mixing, spray water from an atomizer with great precaution. Transfer slowly into a large container of water. ... For gas spills, allow gas to flow into a mixed solution of caustic soda and slaked lime. If possible, keep in a hood until cylinder is emptied.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Fireproof if in building. Isolated from work area. Separated from incompatible materials. See Chemical Dangers. Cool. Dry. Ventilation along the floor.Phosgene must be stored to avoid contact with water, moisture, or steam since violent reactions occur. Store in tightly closed, steel containers in an isolated area away from the work area and separated form all other materials, as well as sunlight. Although phosgene in anhydrous equipment is not corrosive to ordinary metals, in presence of moisture, use monel, tantalum, or glass-lined storage containers. Phosgene should be stored away from heating and cooling ducts. Containers should be frequently inspected for leaks.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.1 ppm (0.4 mg/cu m).

Recommended Exposure Limit: 15 Min Ceiling Value: 0.2 ppm (0.8 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state colourless gas
Colour Colorless gas [Note: A fuming liquid below 47 degrees F. Shipped as a liquefied compressed gas].
Odour Suffocating odor; when diluted with air there is an odor reminiscent of moldy hay
Melting point/ freezing point -118ºC
Boiling point or initial boiling point and boiling range 8.2ºC at 760 mmHg
Flammability Not combustible.
Lower and upper explosion limit / flammability limit no data available
Flash point 4°C
Auto-ignition temperature Not flammable (USCG, 1999)
Decomposition temperature no data available
pH no data available
Kinematic viscosity 6.8488X10-4 Pa.s at 263.15 K
Solubility Very slightly soluble
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 1180 mm Hg ( 20 °C)
Density and/or relative density 0.924g/mLat 25°C
Relative vapour density 3.4 (EPA, 1998) (Relative to Air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

NONCOMBUSTIBLEThe gas is heavier than air.Vapors are heavier than air. They will spread along the ground and collect and stay in poorly-ventilated, low-lying, or confined areas (e.g., sewers, basements, and tanks).Hazardous concentrations may develop quickly in enclosed, poorly-ventilated, or low-lying areas. Keep out of these areas. Stay upwind.Phosgene (CG) liquid sinks in water.PHOSGENE is water reactive. Incompatible with strong oxidizing agents, alcohols, amines, alkali. May react violently with aluminum, alkali metals (lithium, potassium, sodium), alcohols (isopropyl alcohol, 2,4-hexadiyn-1,6-diol), sodium azide [Bretherick, 5th ed., 1995, p. 134]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Phosgene reacts with phosphate or silicate salts, yielding water-reactive and toxic POCl3 with phosphates (Dunlap, K.L. 2005. Phosgene. In Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc.).

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Violent reaction with strong oxidizers, amines, aluminum. Attacks metals in the presence of water. Attacks plastic, rubber, and coatings.

10.6 Hazardous decomposition products

... When heated to decomposition ... it will react to produce toxic and corrosive fumes of /carbon monoxide/ and /hydrogen chlorides/.

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: LC50 Rat inhalation 0.334 mg/L (10 min exposure)
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

EPA-II

Reproductive toxicity

No information is available on the reproductive or developmental effects of phosgene in humans or animals.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

no data available

12.3 Bioaccumulative potential

Phosgene is extremely volatile and hydrolyzes rapidly in water (20 seconds at 0°C(1)), suggesting that bioconcentration will not be an important environmental fate process(SRC).

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of phosgene can be estimated to be 2.2(SRC). According to a classification scheme(2), this estimated Koc value suggests that phosgene is expected to have very high mobility in soil.

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN3489 IMDG: UN3489 IATA: UN3489

14.2 UN Proper Shipping Name

ADR/RID: TOXIC BY INHALATION LIQUID, FLAMMABLE, CORROSIVE, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50
IMDG: TOXIC BY INHALATION LIQUID, FLAMMABLE, CORROSIVE, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50
IATA: TOXIC BY INHALATION LIQUID, FLAMMABLE, CORROSIVE, N.O.S. with an LC50 lower than or equal to 1000 ml/m3 and saturated vapour concentration greater than or equal to 10 LC50

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: I IMDG: I IATA: I

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
phosgene phosgene 75-44-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 16, 2017
Revision Date Aug 16, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: Phosgene solution in toluene Material Safety Data Sheet
Synonym: None
CAS: 75-44-5
Section 1 - Chemical Product   MSDS Name:Phosgene solution in toluene Material Safety Data Sheet
Synonym:None

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
75-44-5 Phosgene 12.5 200-870-3
Hazard Symbols: T+ F
Risk Phrases: 11 26/27/28 63 67

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Highly flammable. Very toxic by inhalation, in contact with skin and if swallowed. Possible risk of harm to the unborn child. Vapours may cause drowsiness and dizziness.
Potential Health Effects
Eye:
Causes eye irritation. May result in corneal injury. Vapors may cause eye irritation.
Skin:
May cause skin irritation. May be absorbed through the skin in harmful amounts. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
Ingestion:
Aspiration hazard. May cause irritation of the digestive tract. May cause effects similar to those for inhalation exposure. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Inhalation of vapor may cause respiratory tract irritation.
May cause liver and kidney damage. May cause heart disturbances, possibly leading to cardiac arrest and death.
Chronic:
Chronic exposure to organic solvents has been associated with various neurotoxic effects including permanent brain and nervous system damage. Prolonged or repeated skin contact may cause dermatitis. May cause cardiac sensitization and severe heart abnormalities.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Possible aspiration hazard. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Causes cardiac sensitization to endogenous catelcholamines which may lead to cardiac arrhythmias. Do NOT use adrenergic agents such as epinephrine or pseudoepinephrine.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors can travel to a source of ignition and flash back. Flammable Liquid. Can release vapors that form explosive mixtures at temperatures above the flashpoint.
Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water.
Extinguishing Media:
Use dry chemical, carbon dioxide, or alcohol-resistant foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Scoop up with a nonsparking tool, then place into a suitable container for disposal. Use water spray to disperse the gas/vapor.
Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous.
Do not get on skin or in eyes. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.
Flammables-area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 75-44-5: United Kingdom, WEL - TWA: 0.02 ppm TWA; 0.08 mg/m3 TWA United Kingdom, WEL - STEL: 0.06 ppm STEL; 0.25 mg/m3 STEL United States OSHA: 0.1 ppm TWA; 0.4 mg/m3 TWA Belgium - TWA: 0.02 ppm VLE; 0.08 mg/m3 VLE Belgium - STEL: 0.1 ppm VLE; 0.4 mg/m3 VLE France - VLE: 0.1 ppm VLE; 0.4 mg/m3 VLE Germany: 0.02 ppm TWA; 0.082 mg/m3 TWA Japan: 0.1 ppm OEL; 0.4 mg/m3 OEL Malaysia: 0.1 ppm TWA; 0.40 mg/m3 TWA Netherlands: 0.1 ppm STEL; 0.4 mg/m3 STEL Netherlands: 0.02 ppm MAC; 0.08 mg/m3 MAC Russia: 0.5 mg/m3 TWA Spain: 0.02 ppm VLA-ED; 0.08 mg/m3 VLA-ED Spain: 0.1 ppm VLA-EC; 0.4 mg/m3 VLA-EC CAS# 108-88-3: United Kingdom, WEL - TWA: 50 ppm TWA; 191 mg/m3 TWA United Kingdom, WEL - STEL: 150 ppm STEL; 574 mg/m3 STEL United States OSHA: 200 ppm TWA; 300 ppm Ceiling Belgium - TWA: 50 ppm VLE; 191 mg/m3 VLE France - VME: 100 ppm VME; 375 mg/m3 VME France - VLE: 150 ppm VLE; 550 mg/m3 VLE Germany: 50 ppm TWA; 190 mg/m3 TWA Germany: Skin absorber Japan: 50 ppm OEL; 188 mg/m3 OEL Malaysia: 50 ppm TWA; 188 mg/m3 TWA Netherlands: 40 ppm MAC; 150 mg/m3 MAC Russia: 50 mg/m3 TWA Spain: 50 ppm VLA-ED; 191 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: green
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 111 deg C @ toluene
Freezing/Melting Point: 95 deg C @ toluene
Autoignition Temperature: Not applicable.
Flash Point: 4 deg C ( 39.20 deg F)
Explosion Limits, lower: 1.2
Explosion Limits, upper: 7
Decomposition Temperature: Not available.
Solubility in water: Insoluble in water.
Specific Gravity/Density: 0.91
Molecular Formula: Mixture
Molecular Weight: 0

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat.
Incompatibilities with Other Materials:
Toluene is incompatible with bromine trifluoride, 1,3-dichloro-5,5-dimethyl-2,4-imidazolididione, dinitrogen tetroxide, concentrated nitric acid, nitric acid + sulfuric acid, silver perchlorate, strong oxidizers.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 75-44-5: SY5600000 CAS# 108-88-3: XS5250000 LD50/LC50:
Not available.
CAS# 108-88-3: Draize test, rabbit, eye: 870 ug Mild; Draize test, rabbit, eye: 2 mg/24H Severe; Draize test, rabbit, skin: 435 mg Mild; Draize test, rabbit, skin: 500 mg Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, mouse: LC50 = 400 ppm/24H; Inhalation, mouse: LC50 = 30000 mg/m3/2H; Inhalation, mouse: LC50 = 19900 mg/m3/7H; Inhalation, mouse: LC50 = 10000 mg/m3; Inhalation, rat: LC50 = 49 gm/m3/4H; Oral, rat: LD50 = 636 mg/kg; Skin, rabbit: LD50 = 14100 uL/kg.
Carcinogenicity:
Phosgene - Not listed by ACGIH, IARC, or NTP.
Toluene - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Cas# 108-88-3: LC50(96Hr.) = 24.0 mg/L Rainbow trout LC50(96Hr) = 24.0 mg/L Bluegill EC50(48Hr) = 310-313 mg/L Photobacterium phosphoreum

Section 13 - DISPOSAL CONSIDERATIONS
  Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

Section 14 - TRANSPORT INFORMATION
 
IATA
No information available.
IMO
No information available.
RID/ADR
No information available.
USA RQ: CAS# 75-44-5: 10 lb final RQ; 4.54 kg final RQ
USA RQ: CAS# 108-88-3: 1000 lb final RQ; 454 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ F
Risk Phrases:
R 11 Highly flammable.
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
R 63 Possible risk of harm to the unborn child.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 29 Do not empty into drains.
S 33 Take precautionary measures against static
discharges.
WGK (Water Danger/Protection)
CAS# 75-44-5: 2
CAS# 108-88-3: 2
Canada
CAS# 75-44-5 is listed on Canada's DSL List.
CAS# 108-88-3 is listed on Canada's DSL List.
CAS# 75-44-5 is listed on Canada's Ingredient Disclosure List.
CAS# 108-88-3 is listed on Canada's Ingredient Disclosure List.
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CAS# 75-44-5 is listed on the TSCA inventory.
CAS# 108-88-3 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 13C NMR : Predict
expand collapse
Mass Spectrum Mass spectrum (electron ionization)
expand collapse
Analysis Methods
Normal alkane RI, non-polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
OV-101
Retention index
416.
Temperature Control
Method
temperature ramp
Comments
25. m/0.20 mm/0.10 μm, N2/He, 6. K/min; T<sub>start</sub>: 50. C; T<sub>end</sub>: 250. C
Reference
Zenkevich, I.G.Experimentally measured retention indices.2005.
Normal alkane RI, non-polar column, custom temperature program
expand collapse
Column Shape
Capillary
Active Phase(℃)
Porapack Q
Retention index
425.
Temperature Control
Method
custom temperature program
Comments
Program: not specified
Reference
Zenkevich, I.G.Rodin, A.A.Gas chromatographic identification of some volatile toxic fluorine containing compounds by precalculated retention indicesJ. Ecol. Chem. (Rus.)2004, 13, 1, 22-28.

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