ethanolamine

CAS No. 141-43-5

Formula: C2H7NO
Basic Info

Ethanolamine is used in the preparation of various pharmaceutical compounds and inhibitors. Substituted carboxamides are synthesized using Ethanolamine that show potent antitumor activity. Also used in the synthesis of aminoquinolones which display anti-plasmodial activity.

Formula
C2H7NO
Molecular Weight
61.0831
Exact Mass
61.0528
LogP
-0.3623
PSA
46.25
Synonyms

1-Amino-2-butanol

amino-2-butanol

2-Hydroxyethylamine

2-Aminoethanol

1-Amino-butan-2-ol

2-Butanol,1-amino

Ethanol, 2-amino-

NH2CH2CH2OH

Monobutanolamine

mono-sec-butanolamine

1-amino-2-hydroxy-butane

2-Aminoethanol,2-Aminoethyl alcohol,ETA

dl-1-amino-2-butanol

aminomethylpropanol

2-hydroxybutylamine

1-amino-2-hydroxy-ethane

Ethanolamine

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Properties
Appearance & Physical State
clear liquid
Density
1.012
Boiling Point
170ºC
Melting Point
10.3ºC
Flash Point
85ºC
Refractive Index
1.453-1.455
Water Solubility
miscible
Stability
Stable. Flammable; incompatible with strong oxidizing agents, strong acids. Hygroscopic.
Storage Condition
Store at RT.
Vapor Density
2.1 (vs air)
Vapor Pressure
0.2 mm Hg ( 20 °C)
Safety Info
RTECS
KJ5775000
Safety Statements
S26-S36/37/39-S45
WGK Germany
1
Risk Statements
R20/21/22; R34
RIDADR
UN 2491
Hazard Class
8
Packing Group
III
Caution Statement
P261; P273; P301 + P312 + P330; P303 + P361 + P353; P304 + P340 + P310; P305 + P351 + P338
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name ethanolamine

1.2 Other means of identification

Product number -
Other names Ethanolamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Specialized Industrial Chemicals
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 4

Acute toxicity - Dermal, Category 4

Skin corrosion, Category 1B

Acute toxicity - Inhalation, Category 4

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H302 Harmful if swallowed

H312 Harmful in contact with skin

H314 Causes severe skin burns and eye damage

H332 Harmful if inhaled

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

Response

P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P321 Specific treatment (see ... on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P363 Wash contaminated clothing before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P310 Immediately call a POISON CENTER/doctor/…

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
ethanolamine ethanolamine 141-43-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Vapor irritates eyes and nose. Liquid causes local injury to mouth, throat, digestive tract, skin, and eyes. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic bases/Amines and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Irritating vapors generated when heated. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Cautiously neutralize spilled liquid. Then wash away with plenty of water.

6.3 Methods and materials for containment and cleaning up

Accidental release measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations ... Keep in suitable, closed containers for disposal.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants, strong acids, aluminium and food and feedstuffs. Dry. Ventilation along the floor.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Hygroscopic. Handle and store under inert gas.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 3 ppm (8 mg/cu m).

Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 6 ppm (15 mg/cu m).

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state clear liquid
Colour Colorless, viscous liquid or solid (below 51 deg F)
Odour Unpleasant, ammonia-like
Melting point/ freezing point 140°C(lit.)
Boiling point or initial boiling point and boiling range 170°C(lit.)
Flammability Class IIIA Combustible Liquid: Fl.P. at or above 60°C and below 93.33°C.Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit Lower flammable limit: 3.0% by volume; Upper flammable limit: 23.5% by volume at 140°C
Flash point 91°C
Auto-ignition temperature 780°C
Decomposition temperature no data available
pH 25% aqueous solution: 12.1; 0.1 N aqueous solution: 12.05
Kinematic viscosity 18.95 cP at 25°C; 5.03 cP at 60°C
Solubility In water:miscible
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 0.2 mm Hg ( 20 °C)
Density and/or relative density 1.012g/mLat 25°C(lit.)
Relative vapour density 2.1 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Chemical stability: Absorbs carbon dioxide (CO2) from air. Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Combustible liquid.ETHANOLAMINE is a base. Reacts with organic acids (acetic acid, acrylic acid), inorganic acids (hydrochloric acid, hydrofluoric acid, nitric acid, sulfuric acid, chlorosulfonic acid), acetic anhydride, acrolein, acrylonitrile, cellulose, epichlorohydrin, mesityl oxide, beta-propiolactone, vinyl acetate. Emits toxic fumes of nitrogen oxides when heated to decomposition [Sax, 9th ed., 1996, p. 1498].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Incompatible materials: Strong acids and oxidizing agents, iron, copper, brass, rubber.

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /nitrogen oxides/.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Guinea pig oral 620 mg/kg body weight
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill); Concentration: >375 mg/L for 24 hr /Conditions of bioassay not specified in source examined
  • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water flea); Conditions: static; Concentration: 140 mg/L for 24 hr
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: 2-Aminoethanol, present at 100 mg/L, reached 49.2% (nitrogen dioxide end product)and 93.6% (ammonia end product) of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 ppm in the Japanese MITI test(1). 2-Aminoethanol achieved 91.8% biodegradation after 28 days in a OECD Guideline 301B Sturm Test and 93.4% after 22 days in a Sealed vessel test(2). 2-Aminoethanol, present at 10 ppm, reached 34% of its theoretical BOD in 5 days and 40% of its theoretical BOD in 20 days using a sewage inoculum(3). Other screening studies using a sewage inoculum gave similar results: 2.5 ppm test concentration, 5 day, 61-84% theoretical BOD(4); test concentration not specified, 10 day, 65% theoretical BOD(5); test concentration not specified, 5 day, 71% theoretical BOD, and 98% COD removal(6); 2.5 ppm test concentration, 5, 10, 20 and 50 days - 0, 58.4, 64, 75% theoretical BOD, respectively(7). In a Modified OECD Screening test, 2-aminoethanol, present at 20 mg/L, achieved 94% after 28 days using fresh inoculum and 99% after 28 days using preconditioned inoculum. In the Modified Sturm tests, 2-aminoethanol reached 97% DOC and 92% of its theoretical CO2 in 28 days using fresh inoculum; the compound also reached 96% DOC and 62% of its theoretical CO2 after 28 days using preconditioned inoculum(8). Using an activated sludge inoculum and the Closed Bottle, CO2 Evolution, and MITI tests, 2-aminoethanol starting concentrations of 7.64, 25.4, 76.4, and 100 mg/L exhibited 64.4, 91.4, and 71.2% O2 consumption, respectively, after 28 days; all tests had a lag time of approximately 5 days(9). Using an activated sludge inoculum and the Manometric Respirometry test, 2-aminoethanol starting concentration of 76.4 mg/L exhibited 83.0% O2 consumption, after 28 days with a lag time of approximately 5 days(9).

12.3 Bioaccumulative potential

An estimated BCF of 3.2 was calculated in fish for 2-aminoethanol(SRC), using a log Kow of -1.31(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). [

12.4 Mobility in soil

The Koc of 2-aminoethanol is estimated as 0.59(SRC), using a log Kow of -1.31(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2-aminoethanol is expected to have very high mobility in soil. Adsorption can be affected by the acidity of the soil(SRC). The pKa of 2-aminoethanol is 9.5(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2491 IMDG: UN2491 IATA: UN2491

14.2 UN Proper Shipping Name

ADR/RID: ETHANOLAMINE or ETHANOLAMINE SOLUTION
IMDG: ETHANOLAMINE or ETHANOLAMINE SOLUTION
IATA: ETHANOLAMINE or ETHANOLAMINE SOLUTION

14.3 Transport hazard class(es)

ADR/RID: 8 IMDG: 8 IATA: 8

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
ethanolamine ethanolamine 141-43-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: Ethanolamine scintillation grade (CO2 absorber) Material Safety Data Sheet
Synonym: 2-Aminoethanol; Monoethanolamin
CAS: 141-43-5
Section 1 - Chemical Product   MSDS Name:Ethanolamine scintillation grade (CO2 absorber) Material Safety Data Sheet
Synonym:2-Aminoethanol; Monoethanolamin

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
141-43-5 Ethanolamine, scintillation grade 100 205-483-3
Hazard Symbols: C
Risk Phrases: 20/21/22 34

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed. Causes burns.Corrosive.Combustible liquid.
Potential Health Effects
Eye:
Causes eye burns. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes moderate skin irritation. Harmful if absorbed through the skin. Causes skin burns. May cause dermatitis. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May be harmful if swallowed. May cause systemic effects.
Inhalation:
Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects. Inhalation at high concentrations may cause CNS depression and asphixiation.
Chronic:
May cause liver and kidney damage. Effects may be delayed.

Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Vapors mixed with air can explode when ignited. Combustible liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Do not ingest or inhale. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from heat and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 141-43-5: United Kingdom, WEL - TWA: 3 ppm TWA; 7.6 mg/m3 TWA United Kingdom, WEL - STEL: 6 ppm STEL; 15 mg/m3 STEL United States OSHA: 3 ppm TWA; 6 mg/m3 TWA Belgium - TWA: 3 ppm VLE; 7.6 mg/m3 VLE Belgium - STEL: 6 ppm VLE; 15 mg/m3 VLE France - VME: 3 ppm VME; 8 mg/m3 VME Germany: 2 ppm TWA; 5.1 mg/m3 TWA Germany: Skin absorber Japan: 3 ppm OEL; 7.5 mg/m3 OEL Malaysia: 3 ppm TWA; 7.5 mg/m3 TWA Netherlands: 3 ppm STEL; 7.6 mg/m3 STEL Netherlands: 1 ppm MAC; 2.5 mg/m3 MAC Russia: 0.5 mg/m3 TWA Spain: 3 ppm VLA-ED; 7.5 mg/m3 VLA-ED Spain: 6 ppm VLA-EC; 15 mg/m3 VLA-EC Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: colorless
Odor: ammonia-like
pH: 12.1 @ 1N
Vapor Pressure: .48 mm Hg @ 20C
Viscosity: 24 cP 20 C
Boiling Point: 170 deg C
Freezing/Melting Point: 10 deg C
Autoignition Temperature: 780 deg C ( 1,436.00 deg F)
Flash Point: 185 deg F ( 85.00 deg C)
Explosion Limits, lower: 5.5
Explosion Limits, upper: 17
Decomposition Temperature: Not available.
Solubility in water: Miscible in water.
Specific Gravity/Density: 1.018 @ 20C
Molecular Formula: C2H7NO
Molecular Weight: 61.0551

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures. Absorbs carbon dioxide from the air.
Conditions to Avoid:
Incompatible materials, ignition sources, acids, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Reacts violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, cellulose, chlorosulfonic acid, epichlorohydrin, HCl, HF, mesityl oxide, HNO3, oleum, H2SO4, b-propiolactone, vinyl acetate. To fight fire, use foam, alcohol foam, dry chemical.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 141-43-5: KJ5775000 LD50/LC50:
CAS# 141-43-5: Draize test, rabbit, eye: 250 ug Severe; Oral, mouse: LD50 = 700 mg/kg; Oral, rabbit: LD50 = 1 gm/kg; Oral, rat: LD50 = 1720 mg/kg; Skin, rabbit: LD50 = 1 mL/kg.
Carcinogenicity:
Ethanolamine, scintillation grade - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Fish: Goldfish: LC50 = 170.0 mg/L; 96 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 13.7 mg/L; 30 minutes; Microtox test

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: ETHANOLAMINE
Hazard Class: 8
UN Number: 2491
Packing Group: III
IMO
Shipping Name: ETHANOLAMINE
Hazard Class: 8
UN Number: 2491
Packing Group: III
RID/ADR
Shipping Name: ETHANOLAMINE
Hazard Class: 8
UN Number: 2491
Packing group: III

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 141-43-5: 1
Canada
CAS# 141-43-5 is listed on Canada's DSL List.
CAS# 141-43-5 is listed on Canada's Ingredient Disclosure List.
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CAS# 141-43-5 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
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IR Spectrum IR : CCl4 solution
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Mass Spectrum Mass spectrum (electron ionization)
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Raman Spectrum Raman : 4880 A,150M,liquid
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Analysis Methods
Kovats' RI, polar column, isothermal
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Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1402.
Temperature Control
150.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1470.
Temperature Control
152.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1450.
Temperature Control
179.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1411.
Temperature Control
180.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1413.
Temperature Control
200.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Toxicity
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
1720 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,417,1977
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Intraperitoneal
Species Observed
Rodent - rat
Dose/Duration
67 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70. Volume(issue)/page/year: 2,289,1968
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Subcutaneous
Species Observed
Rodent - rat
Dose/Duration
1500 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 23(9),55,1979

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