linoleic acid

CAS No. 60-33-3

Formula: C18H32O2
Basic Info

Linoleic acid (LA) is a polyunsaturated omega-6 fatty acid. It is a colorless liquid at room temperature. In physiological literature, it has a lipid number of 18:2 cis,cis-9,12. Linoleic acid is a carboxylic acid with an 18-carbon chain and two cis double bonds; with the first double bond located at the sixth carbon from the methyl end.
Linoleic acid belongs to one of the two families of essential fatty acids, which means that the human body cannot synthesize it from other food components.
The word "linoleic" derived from the Greek word linon (flax). Oleic means "of, relating to, or derived from oil of olive" or "of or relating to oleic acid" because saturating the omega-6 double bond produces oleic acid.

Formula
C18H32O2
Molecular Weight
280.445
Exact Mass
280.24
LogP
5.8845
PSA
37.3
Synonyms

FEMA 3380

Pamolyn

9,12-Octadecadienoic acid (Z,Z)-

Hidiene

cis-9,cis-12-octadecadienoic acid

Linoleic acid

IVELIP

emersol310

9,12-octadecadienoic acid

unifac6550

Linoleic

emersol315

LINOLEATE

cis,cis-9,12-octadecadienoic acid

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Properties
Appearance & Physical State
colourless or light yellow liquid
Density
0.902
Boiling Point
229-230ºC (16 mmHg)
Melting Point
-5ºC
Freezing Point
-5℃
Flash Point
>230 °F
Refractive Index
1.4687-1.4707
Water Solubility
INSOLUBLE
Stability
Stability Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
Storage Condition
2-8ºC
Safety Info
RTECS
RF9990000
Safety Statements
S24/25
WGK Germany
1
Risk Statements
R36
HS Code
2916150000
Caution Statement
P210; P305 + P351 + P338; P370 + P378; P403 + P235
Hazard Codes
Hazard Declaration
Spectrum
NMR Spectrum 1H NMR : 90 MHz in CDCl3
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IR Spectrum IR : CCl4 solution
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Mass Spectrum Mass spectrum (electron ionization)
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Raman Spectrum Raman : 4880 A,200 M,liquid
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Toxicity
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration onto the skin
Species Observed
Human
Dose/Duration
75 mg/3D (Intermittent)
Toxic Effects
--
Reference
Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976, Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Intraperitoneal
Species Observed
Rodent - rat
Dose/Duration
>50 gm/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,327,1970
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - mouse
Dose/Duration
>50 gm/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3728459

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