N-methylpyrrolidin-2-one

CAS No. 872-50-4

Formula: C5H9NO
Basic Info

N-Methyl-2-pyrrolidone (NMP) is an organic compound consisting of a 5-membered lactam. It is a colorless liquid, although impure samples can appear yellow. It is miscible with water and with most common organic solvents. It also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide. It is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials.

Formula
C5H9NO
Molecular Weight
99.1311
Exact Mass
99.0684
LogP
0.1765
PSA
20.31
Synonyms

N-methyl-pyrrolidinone

N-methyl-2-pyridone-5-carboxamide

1-methylpyrrolidin-2-one

N-methyl-pyrrolidin-2-one

1-Methyl-2-pyrrolidinone

1-methyl-2-oxo-pyrrolidine

2-Pyrrolidinone, 1-methyl-

1,6-Dihydro-N-methyl-6-oxonicotinamide

n-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide

n-methyl-2-pyrrolidinone

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Properties
Appearance & Physical State
colourless or light yellow liquid with an amine odour
Density
1.033
Boiling Point
202ºC
Melting Point
-24ºC
Flash Point
91ºC
Refractive Index
n20/D 1.479
Water Solubility
>=10 g/100 mL at 20 ºC
Stability
Stable, but decomposes upon exposure to light. Combustible. Incompatible with strong oxidizing agents, strong acids, reducing agents, bases.
Storage Condition
2-8ºC
Vapor Density
3.4 (vs air)
Vapor Pressure
0.29 mm Hg ( 20 °C)
Safety Info
RTECS
UY5790000
Safety Statements
S41
WGK Germany
1
Risk Statements
R36/38
HS Code
2933990090
RIDADR
UN 1268 3/PG 3
Caution Statement
P201; P280; P305 + P351 + P338; P308 + P313
Hazard Codes
Hazard Declaration
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-methylpyrrolidin-2-one

1.2 Other means of identification

Product number -
Other names N-methyl-pyrrolidin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Adhesives and sealant chemicals,Intermediates,Paint additives and coating additives not described by other categories,Plating agents and surface treating agents,Processing aids, not otherwise listed,Processing aids, specific to petroleum production,Solvents (for cleaning or degreasing),Solvents (which become part of product formulation or mixture)
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

Reproductive toxicity, Category 1B

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H315 Causes skin irritation

H319 Causes serious eye irritation

H335 May cause respiratory irritation

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

Response

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P308+P313 IF exposed or concerned: Get medical advice/ attention.

Storage

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
N-methylpyrrolidin-2-one N-methylpyrrolidin-2-one 872-50-4 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Refer for medical attention.

In case of skin contact

Rinse skin with plenty of water or shower.

In case of eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

If swallowed

Rinse mouth. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Inhalation of hot vapors can irritate nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Repeated and prolonged skin contact produces a mild, transient irritation. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic oxides of nitrogen may be formed in fire. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb liquid in sand or inert absorbent. Store and dispose of according to local regulations. Wash away remainder with plenty of water.

6.3 Methods and materials for containment and cleaning up

Spillage Disposal: Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Dry. Ventilation along the floor. Separated from strong oxidants, strong acids, strong bases, copper and plastics.Small quantities can be stored in polyethylene, polypropylene, or clear glass bottles.

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state colourless or light yellow liquid with an amine odour
Colour Clear liquid
Odour Mild amine odor
Melting point/ freezing point -24°C(lit.)
Boiling point or initial boiling point and boiling range 202°C(lit.)
Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 91°C
Auto-ignition temperature 270°C
Decomposition temperature no data available
pH pH = 7.7-8
Kinematic viscosity 1.65 cP at 25°C
Solubility In water:>=10 g/100 mL at 20 ºC
Partition coefficient n-octanol/water (log value) log Kow = -0.38
Vapour pressure 0.29 mm Hg ( 20 °C)
Density and/or relative density 1.028g/mLat 25°C(lit.)
Relative vapour density 3.4 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

NMP shows unlimited shelf life in tightly closed containers, slight discoloration does not impair its quality.

10.3 Possibility of hazardous reactions

Combustible when exposed to heat, open flame, or powerful oxidizers.This amine is a very mild chemical base. It does tend to neutralize acids to form salts plus water. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Reacts with sulfur or carbon disulfide at high temperatures and pressures.

10.6 Hazardous decomposition products

Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides and carbon monoxide.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 3914 mg/kg
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static, 23°C, pH 7, dissolved oxygen 7.8 mg/L; Concentration: 2500 ug/L for 24 hr (95% confidence interval: 1800-3500 ug/L) />99.9% purity
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: In a static die-away system using a sewage sludge seed and a semi-continuous activated sludge system, 1-methyl-2-pyrrolidinone displayed 95% removal after 2 weeks and an average 7 day biodegradability of 95%, respectively(1). 1-Methyl-2-pyrrolidinone at an initial concentration of 210 ppm underwent >98% removal after 24 hrs when inoculated with a sewage sludge seed(2). 1-Methyl-2-pyrrolidinone at an initial concentration of 150 mg/L underwent 94% removal as measured by COD after a 1 day lag period in a screening study using an activated sludge seed(3). In a model flow-through biological treatment apparatus with an 18-hour retention time, 1-methyl-2-pyrrolidinone at an initial concentration of 300 mg/L underwent >98% removal using an activated sewage sludge(4). In a static screening test, 1-methyl-2-pyrrolidinone underwent >90% removal after a 3-5 day acclimation period using a sewage sludge seed(5). 1-Methyl-2-pyrrolidinone, present at 100 mg/L, reached 73% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(6).

12.3 Bioaccumulative potential

An estimated BCF of 3 was calculated in fish for 1-methyl-2-pyrrolidone(SRC), using a log Kow of -0.38(1). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The Koc of 1-methyl-2-pyrrolidone is estimated as 5(SRC), using a log Kow of -0.38(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1-methyl-2-pyrrolidone is expected to have very high mobility in soil. 1-Methyl-2-pyrrolidinone had Rf values of 0.74, 0.65, 0.67, and 1.0 in silt, loam, clay and sand, respectively, in laboratory soil thin layer chromatography (TLC) experiments(4) which is consistent with significant mobility in soil(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1993 IMDG: UN1993 IATA: UN1993

14.2 UN Proper Shipping Name

ADR/RID: FLAMMABLE LIQUID, N.O.S.
IMDG: FLAMMABLE LIQUID, N.O.S.
IATA: FLAMMABLE LIQUID, N.O.S.

14.3 Transport hazard class(es)

ADR/RID: 4.3 IMDG: 4.3 IATA: 4.3

14.4 Packing group, if applicable

ADR/RID: I IMDG: I IATA: I

14.5 Environmental hazards

ADR/RID: no IMDG: no IATA: no

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
N-methylpyrrolidin-2-one N-methylpyrrolidin-2-one 872-50-4 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Section I.Chemical Product and Company Identification
    Chemical Name 1-Methyl-2-pyrrolidone
    Portland OR
    Synonym        N-Methylpyrrolidinone    
    Chemical Formula        C5H9NO    
    CAS Number        872-50-4    

Section II.        Composition and Information on Ingredients    
    Chemical Name        CAS Number Percent (%)        TLV/PEL        Toxicology Data    
    1-Methyl-2-pyrrolidone        872-50-4        Min. 99.0 Not available.        Rat LD50 (oral) 3914mg/kg    
    Rat LD50 (intravenous) 805mg/kg
    (GC)
    Rat LD50 (intraperitoneal)
    2472mg/kg

Section III. Hazards Identification
    Acute Health Effects        Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the    
    eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening,
    or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when
    handling this compound.
    CARCINOGENIC EFFECTS : Not available.
    Chronic Health Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    There is no known effect from chronic exposure to this product. Repeated or prolonged exposure to this compound is
    not known to aggravate existing medical conditions.

Section IV.        First Aid Measures    
    Eye Contact        Check for and remove any contact lenses. IMMEDIATELY flush eyes with running water for at least 15 minutes, keeping    
    eyelids open. COLD water may be used. DO NOT use an eye ointment. Flush eyes with running water for a minimum of
    15 minutes, occasionally lifting the upper and lower eyelids. Seek medical attention. Treat symptomatically and
    supportively.
    Skin Contact        If the chemical gets spilled on a clothed portion of the body, remove the contaminated clothes as quickly as possible,    
    protecting your own hands and body. Place the victim under a deluge shower. If the chemical touches the victim's
    exposed skin, such as the hands: Gently and thoroughly wash the contaminated skin with running water and non-abrasive
    soap. Be particularly careful to clean folds, crevices, creases and groin. COLD water may be used. Cover the irritated
    skin with an emollient. Seek medical attention. Treat symptomatically and supportively. Wash any contaminated clothing
    before reusing.
    If the victim is not breathing, perform artificial respiration. Loosen tight clothing such as a collar, tie, belt or waistband. If
    Inhalation
    breathing is difficult, oxygen can be administered. Seek medical attention. Treat symptomatically and supportively.
    Ingestion        INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.    
    Loosen tight clothing such as a collar, tie, belt, or waistband. If the victim is not breathing, administer artificial respiration.
    Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material
    was ingested; the absence of such signs, however, is not conclusive. Seek immediate medical attention and, if possible,
    show the chemical label. Treat symptomatically and supportively.

Section V. Fire and Explosion Data
    269°C (516.2°F)
    Combustible.        Auto-Ignition    
    Flammability
    Flammable Limits
    Flash Points        LOWER: 1.3% UPPER: 9.5%    
    86°C (186.8°F).
    Combustion Products        These products are toxic carbon oxides (CO, CO 2), nitrogen oxides (NO, NO2).    
    Fire Hazards
    No specific information is available regarding the flammability of this compound in the presence of various materials.
    Continued on Next Page
    872-50-4erNINGS(Intern
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    No additional information is available regarding the risks of explosion.
    Fire Fighting Media
    SMALL FIRE: Use DRY chemicals, CO 2, water spray or foam.
    LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
    and Instructions

Section VI.        Accidental Release Measures    
    Spill Cleanup
    Irritating material. Combustible material.
    Keep away from heat and sources of ignition. Mechanical exhaust required. Stop leak if without risk. Finish cleaning the
    Instructions
    spill by rinsing any contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities
    for assistance on disposal.

Section VII. Handling and Storage
    Handling and Storage        IRRITANT. COMBUSTIBLE. HYGROSCOPIC. STORE UNDER NITROGEN. Keep away from heat and sources of    
    ignition. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool place. Avoid
    Information
    excessive heat and light. DO NOT ingest. Do not breathe gas, fumes, vapor or spray. In case of insufficient ventilation,
    wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label.
    Treat symptomatically and supportively. Avoid contact with skin and eyes.
    Always store away from incompatible compounds such as oxidizing agents, acids.

Section VIII. Exposure Controls/Personal Protection
    Engineering Controls        Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their    
    respective threshold limit value. Ensure that eyewash station and safety shower is proximal to the work-station location.
    Personal Protection        Splash goggles. Lab coat. Vapor respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid    
    inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling
    this product.
    Exposure Limits        Not available.    

Section IX. Physical and Chemical Properties
    Solubility
    Physical state @ 20°C        Colorless liquid.        Soluble in cold water, hot water, ether and    
    acetone.
    1.03
    Specific Gravity
    Molecular Weight        99.13        Partition Coefficient        Not available.    
    Boiling Point        202°C (395.6°F)        Vapor Pressure        0.29 mm of Hg (@ 20°C)    
    Melting Point        -23°C (-9.4°F)        Vapor Density        3.4 (Air = 1) @ 20°C    
    Not available.        Volatility        Not available.    
    Refractive Index
    Critical Temperature        Not available.        Odor        Not available.    
    Viscosity        Not available.        Taste        Not available.    

Section X.        Stability and Reactivity Data    
    Stability    
This material is stable if stored under proper conditions. (See Section VII for instructions)    
    Conditions of Instability        Avoid excessive heat and light. Hygroscopic; keep container tightly closed. Store under nitrogen.    
    Incompatibilities
    Highly reactive with oxidizing agents, acids.

Section XI. Toxicological Information
    RTECS Number        UY5790000    
    Eye contact. Inhalation. Ingestion. Skin contact.
    Routes of Exposure
    Toxicity Data        Rat LD50 (oral) 3914mg/kg    
    Rat LD50 (intravenous) 805mg/kg
    Rat LD50 (intraperitoneal) 2472mg/kg
    Chronic Toxic Effects        CARCINOGENIC EFFECTS : Not available.    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    There is no known effect from chronic exposure to this product. Repeated or prolonged exposure to this compound is not known
    to aggravate existing medical conditions.
    Acute Toxic Effects        Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye is    
    characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering. Follow safe industrial hygiene practices and always wear proper protective equipment when handling
    this compound.
    Continued on Next Page
    1-Methyl-2-pyrrolidone

Section XII.        Ecological Information    
    Ecotoxicity        Not available.    
    1-Methyl-2-pyrrolidinone is used as a solvent in a wide variety of commercial applications. It may be released to the
    Environmental Fate
    environment as a fugitive emission during its production and use. 1-Methyl-2-pyrrolidinone may be a naturally occurring
    compound. If released to soil, 1-methyl-2-pyrrolidinone has the potential to biodegrade under aerobic conditions. It is
    expected to display very high mobility in soil. 1-Methyl-2-pyrrolidinone may slowly volatilize from dry soil to the
    atmosphere, but it is not expected to significantly volatilize from moist soil. If released to water, screening studies indicate
    that 1-methyl-2-pyrrolidinone will biodegrade under aerobic conditions after a short lag period. A calculated
    bioconcentration factor of 0.16 indicates that 1-methyl-2-pyrrolidinone is not expected to significantly bioconcentrate in fish
    and aquatic organisms nor is it expected to significantly adsorb to sediment or suspended organic matter. An estimated
    Henry's Law constant of 1.56X10E-8 atm-cu m/mole at 25 deg indicates that 1-methyl-2-pyrrolidinone is not expected to
    significantly volatilize from water to the atmosphere. The estimated half-life for volatilization of 1-methyl-2-pyrrolidinone
    from a model river is 2335 days. If released to the atmosphere, 1-methyl-2-pyrrolidinone is expected to undergo a
    gas-phase reaction with photochemically produced hydroxyl radicals with an estimated half-life of 5.2 hrs. It may undergo
    atmospheric removal by wet deposition processes. Occupational exposure to 1-methyl-2-pyrrolidinone may occur by
    inhalation or dermal contact during its production and use. The general population may be exposed to
    1-methyl-2-pyyrolidinone by the ingestion of foods in which it is contained or by the ingestion of contaminated drinking
    water. (HSDB)

Section XIII. Disposal Considerations
    Waste Disposal        Recycle to process, if possible. Consult your local or regional authorities. You may be able to dissolve or mix material with    
    a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state, and local regulations when disposing of this substance.

Section XIV. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    PIN Number        Not applicable.    
    Proper Shipping Name        Not applicable.    
    Packing Group (PG)        Not applicable.    
    DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This product is ON the EPA Toxic Substance Control Act (TSCA) inventory.    
    (EPA)
    WHMIS Classification        WHMIS CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F).    
    WHMIS CLASS D-2B: Material causing other toxic effects (TOXIC).
    (Canada)
    EINECS Number (EEC) 212-828-1
    EEC Risk Statements
    R36/38- Irritating to eyes and skin.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : Predict
expand collapse
Mass Spectrum Mass spectrum (electron ionization)
expand collapse
UV Spectrum UV/Visible spectrum
expand collapse
Analysis Methods
Kovats' RI, polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
Carbowax 20M
Retention index
1646.
Temperature Control
Method
temperature ramp
Comments
2. K/min; Column length: 50. m; Column diameter: 0.22 mm; T<sub>start</sub>: 80. C; T<sub>end</sub>: 200. C
Reference
Nishimura, O.Yamaguchi, K.Mihara, S.Shibamoto, T.Volatile Constituents of Guava Fruits (Psidium guajava L.) and Canned PureeJ. Agric. Food Chem.1989, 37, 1, 139-142.
Van Den Dool and Kratz RI, polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
DB-Wax
Retention index
1678.
Temperature Control
Method
temperature ramp
Comments
30. m/0.25 mm/0.5 μm, He, 40. C @ 5. min, 4. K/min, 250. C @ 15. min
Reference
Pozo-Bayon M.A.Ruiz-Rodriguez A.Pernin K.Cayot N.Influence of eggs on the aroma composition of a sponge cake and on the aroma release in model studies on flavored sponge cakesJ. Agric. Food Chem.2007, 55, 4, 1418-1426.
Van Den Dool and Kratz RI, polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
Stabilwax
Retention index
1660.
Temperature Control
Method
temperature ramp
Comments
60. m/0.25 mm/0.25 μm, He, 40. C @ 5. min, 3. K/min, 240. C @ 10. min
Reference
Cros S.Lignot B.Bourseau P.Jaouen P.Reverse osmosis for the production of aromatic concentrates from mussel cooking juices: a technical assessmentDesalination2005, 180, 1-3, 263-269.
Van Den Dool and Kratz RI, polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
Stabilwax
Retention index
1660.
Temperature Control
Method
temperature ramp
Comments
60. m/0.25 mm/0.25 μm, He, 40. C @ 5. min, 3. K/min, 240. C @ 10. min
Reference
Cros, S.Lignot, B.Bourseau, P.Jaouen, P.Prost, C.Desalination of mussel cooking juices by electrodialysis: effect on the aroma profileJ. Food Eng.2005, 69, 4, 425-436.
Van Den Dool and Kratz RI, polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
DB-Wax
Retention index
1665.
Temperature Control
Method
temperature ramp
Comments
30. m/0.32 mm/0.5 μm, 40. C @ 3. min, 2. K/min, 245. C @ 20. min
Reference
Aubert, C.GünataAmbid, C.Baumes, R.Changes in physicochemical characteristics and volatile constituents of yellow- and white-fleshed nectarines during maturation and artificial ripeningJ. Agric. Food Chem.2003, 51, 10, 3083-3091.
Toxicity
SKIN/EYE IRRITATION DATA
expand collapse
Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Rodent - rabbit
Dose/Duration
100 mg
Toxic Effects
--
Reference
Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,475,1988
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
3914 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1581,1976
ACUTE TOXICITY DATA
expand collapse
Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Intraperitoneal
Species Observed
Rodent - rat
Dose/Duration
2472 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,1581,1976
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