thiourea

CAS No. 62-56-6

Formula: CH4N2S
Basic Info

Thiourea is an organosulfur compound with the formula SC(NH2)2 . It is structurally similar to urea, except that the oxygen atom is replaced by a sulfur atom, but the properties of urea and thiourea differ significantly. Thiourea is a reagent in organic synthesis. "Thioureas" refers to a broad class of compounds with the general structure (R1R2N)(R3R4N)C=S. Thioureas are related to thioamides, e.g. RC(S)NR2, where R is methyl, ethyl, etc.
General chemical structure of a thiourea

Formula
CH4N2S
Molecular Weight
76.1209
Exact Mass
76.0095
LogP
0.5893
PSA
84.13
Synonyms

THU

250g

Thiocarbamidsaeure-amid

thio-ure

thiouree

Thiurea

Thiocarbamide

Thiourea

THIO

Tsizp 34

Sulourea

carbamimidothioic acid

Isothioharnstoff

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Properties
Appearance & Physical State
white crystals
Density
1.405
Boiling Point
186.8ºC at 760 mmHg
Melting Point
171-175ºC
Flash Point
66.8ºC
Refractive Index
1.637 (30ºC)
Water Solubility
13.6 g/100 mL (20 ºC)
Stability
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents, metallic salts, proteins, hydrocarbons. May react violently with acrolein.
Storage Condition
Store at RT.
Safety Info
RTECS
YU2800000
Safety Statements
S36/37-S61
WGK Germany
2
Risk Statements
R22; R40; R51/53; R63
HS Code
2930909090
RIDADR
UN 2877/2811
Hazard Class
6.1
Packing Group
III
Caution Statement
P201; P273; P301 + P312 + P330; P308 + P313; P391; P501
Hazard Codes
Hazard Declaration
Spectrum
NMR Spectrum 1H NMR : Predict
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IR Spectrum IR : nujol mull
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Mass Spectrum Mass spectrum (electron ionization)
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Synthesis Route
1.Synthesis Route
Precursor
Downstream Product
Toxicity
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration into the eye
Species Observed
Rodent - rabbit
Dose/Duration
14%
Toxic Effects
--
Reference
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 30(3),42,1986
ACUTE TOXICITY DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Human - woman
Dose/Duration
1660 mg/kg/5W
Toxic Effects
Blood--hemorrhage<br>Blood--granulocytopenia<br>Blood--changes in cell count (unspecified)
Reference
Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 246,179,1944
ACUTE TOXICITY DATA
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Type of Test
LDLo - Lowest published lethal dose
Exposure Route
Unreported
Species Observed
Human - man
Dose/Duration
147 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Poisoning; Toxicology, Symptoms, Treatments, 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970

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