Acetic anhydride

CAS No. 108-24-7

Formula: C4H6O3
Basic Info

Acetic Anhydride is a very useful synthetic intermediate. It is a reagent used generally in acetylation reactions in organic chemistry, primarily cellulose acetate and film material. It is also used in the production of aspirin, which is prepared by the acetylation of salicylic acid.

Formula
C4H6O3
Molecular Weight
102.089
Exact Mass
102.032
LogP
0.096
PSA
43.37
Synonyms

Acetic acid, anhydride

acetyl acetate

Acetic acid anhydride

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Properties
Appearance & Physical State
Colorless liquid
Density
1.087
Boiling Point
140 °C
Melting Point
-73.1 °C
Flash Point
130 °F
Refractive Index
n20/D 1.390(lit.)
Water Solubility
REACTS
Stability
Stability Flammable. Incompatible with strong oxidizing agents, water, strong bases, alcohols.
Storage Condition
Store at RT.
Vapor Density
3.5 (vs air)
Vapor Pressure
10 mm Hg ( 36 °C)
Safety Info
RTECS
AK1925000
Safety Statements
S26; S39; S45; S36/37/39
WGK Germany
3
Risk Statements
R11; R20/21/22; R37/38; R41; R34; R20/21;
HS Code
29152400
RIDADR
UN 2924 3/PG 2
Hazard Class
8
Packing Group
II
Caution Statement
P210; P260; P280; P304 + P340 + P310; P305 + P351 + P338; P370 + P378
Hazard Declaration
Spectrum
NMR Spectrum 1H NMR : Predict
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IR Spectrum LIQUID (NEAT)
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Analysis Methods
Normal alkane RI, non-polar column, temperature ramp
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Column Shape
Capillary
Active Phase(℃)
OV-101
Retention index
706.
Temperature Control
Method
temperature ramp
Comments
25. m/0.20 mm/0.10 μm, N2/He, 6. K/min; T<sub>start</sub>: 50. C; T<sub>end</sub>: 250. C
Reference
Zenkevich, I.G.Experimentally measured retention indices.2005.
Normal alkane RI, non-polar column, custom temperature program
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Column Shape
Capillary
Active Phase(℃)
Polydimethyl siloxanes
Retention index
706.
Temperature Control
Method
custom temperature program
Comments
Program: not specified
Reference
Zenkevich, I.G.Encyclopedia of Chromatography. Derivatization of Amines, Amino Acids, Amides and Imides for GC AnalysisMarcel Dekker, Inc, New York - Basel, 2001, 224.
Normal alkane RI, non-polar column, custom temperature program
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Column Shape
Capillary
Active Phase(℃)
Methyl Silicone
Retention index
699.
Temperature Control
Method
custom temperature program
Comments
Program: not specified
Reference
Zenkevich, I.G.Korolenko, L.I.Khralenkova, N.B.Desorption with solvent vapor as a method of sample preparation in the sorption preconcentration of organic-compounds from the air of a working area and from industrial-waste gasesJ. Appl. Chem. USSR (Engl. Transl.)1995, 50, 10, 937-944.
Normal alkane RI, polar column, temperature ramp
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Column Shape
Capillary
Active Phase(℃)
DB-Wax
Retention index
1236.
Temperature Control
Method
temperature ramp
Comments
He, 40. C @ 2. min, 2. K/min; Column length: 60. m; Column diameter: 0.25 mm; T<sub>end</sub>: 200. C
Reference
Umano, K.Hagi, Y.Nakahara, K.Shyoji, A.Shibamoto, T.Volatile chemicals formed in the headspace of a heated D-glucose/L-cysteine Maillard model systemJ. Agric. Food Chem.1995, 43, 8, 2212-2218.
Normal alkane RI, polar column, temperature ramp
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Column Shape
Capillary
Active Phase(℃)
Carbowax 20M
Retention index
1240.
Temperature Control
Method
temperature ramp
Comments
He, 60. C @ 4. min, 2. K/min; Column length: 50. m; Column diameter: 0.25 mm; T<sub>end</sub>: 180. C
Reference
Kawakami, M.Kobayashi, A.Kator, K.Volatile constituents of Rooibos tea (Aspalathus linearis) as affected by extraction processJ. Agric. Food Chem.1993, 41, 4, 633-636.

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