poly(vinylpyrrolidone)

CAS No. 9003-39-8

Formula: C6H9NO
Basic Info

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone:

Formula
C6H9NO
Molecular Weight
111.142
Exact Mass
111.068
LogP
0.6902
PSA
20.31
Synonyms

k60

Polyvinylpyrrolidone

PVP

Kollidon K25

Kollidon K-90

k25

POP

Kollidon 25

k115

pvp2

pvp3

K-30

pvp4

PVPD

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Properties
Appearance & Physical State
White powder.
Density
1.144g/cm3
Boiling Point
217.6ºC at 760 mmHg
Melting Point
130ºC
Flash Point
93.9ºC
Stability
Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
Storage Condition
Store at RT.
Safety Info
RTECS
TR8370000
Safety Statements
S24/25
WGK Germany
1
HS Code
3905990000
Spectrum
NMR Spectrum 1H NMR : Predict
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IR Spectrum IR : 45% H2O solution
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Synthesis Route
1.Synthesis Route
Precursor
Toxicity
ACUTE TOXICITY DATA
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Type of Test
LDLo - Lowest published lethal dose
Exposure Route
Oral
Species Observed
Rodent - mouse
Dose/Duration
3 gm/kg
Toxic Effects
Gastrointestinal--hypermotility, diarrhea<br>Tumorigenic--neoplastic by RTECS criteria<br>Details of toxic effects not reported other than lethal dose value--<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Details of toxic effects not reported other than lethal dose value--<br>Details of toxic effects not reported other than lethal dose value--<br>Liver--tumors<br>Liver--tumors<br>Endocrine--tumors<br>Liver--tumors<br>Endocrine--tumors<br>Reproductive-Tumorigenic effects-uterine tumors<br>Reproductive-Tumorigenic effects-uterine tumors
Reference
Biomaterials, Medical Devices, and Artificial Organs. (New York) V.1-14, 1973-86. For publisher information, see BACOEZ. Volume(issue)/page/year: 12,1,1984
TUMORIGENIC DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Intraperitoneal
Species Observed
Rodent - rat
Dose/Duration
2500 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Tumorigenic--neoplastic by RTECS criteria<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Endocrine--tumors<br>Liver--tumors<br>Liver--tumors<br>Liver--tumors<br>Skin and Appendages--tumors<br>Endocrine--tumors<br>Reproductive-Tumorigenic effects-uterine tumors<br>Reproductive-Tumorigenic effects-uterine tumors<br>Endocrine--tumors<br>Endocrine--tumors<br>Reproductive-Tumorigenic effects-ovarian tumors<br>Reproductive-Tumorigenic effects-ovarian tumors
Reference
AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 67,589,1959
TUMORIGENIC DATA
expand collapse
Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Subcutaneous
Species Observed
Rodent - rat
Dose/Duration
2500 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--<br>Tumorigenic--equivocal tumorigenic agent by RTECS criteria<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Tumorigenic--neoplastic by RTECS criteria<br>Tumorigenic--Carcinogenic by RTECS criteria<br>Cardiac--tumors<br>Endocrine--tumors<br>Endocrine--tumors<br>Liver--tumors<br>Liver--tumors<br>Endocrine--tumors<br>Reproductive-Tumorigenic effects-uterine tumors<br>Reproductive-Tumorigenic effects-uterine tumors<br>Reproductive-Tumorigenic effects-uterine tumors<br>Endocrine--tumors
Reference
AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 67,589,1959
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