N-phenylhydroxylamine

CAS No. 100-65-2

Formula: C6H7NO
Basic Info

N-Phenylhydroxylamine is a useful synthetic intermediate. It was used as a reagent to prepare 6-halo-2-amino-3-formylchromones as potential topoisomerase inhibitor anticancer agents. It was also used in the synthesis of N-(chlorophenyl)cycloalkyl-hydroxamic acids and N-phenyl-N-hydroxycyclohexylacetamide with anti-viral activities.

Formula
C6H7NO
Molecular Weight
109.126
Exact Mass
109.053
LogP
1.5607
PSA
32.26
Synonyms

N-Phenylhydroxylamine

Benzenamine, N-hydroxy-

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Properties
Appearance & Physical State
tan powder or crystals
Density
1.214g/cm3
Boiling Point
215.8ºC at 760mmHg
Melting Point
83 - 84ºC
Flash Point
120.2ºC
Refractive Index
1.649
Stability
Unstable - deteriorates with storage. Incompatible with strong oxidizing agents.
Vapor Pressure
0.085mmHg at 25°C
Safety Info
Safety Statements
S45
Risk Statements
R25
HS Code
2928000090
RIDADR
UN 2811
Spectrum
NMR Spectrum 1H NMR : 400 MHz in CDCl3
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IR Spectrum IR : nujol mull
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Mass Spectrum Mass spectrum (electron ionization)
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ESR Spectrum ESR : OXIDATION WITH BPO IN ETHER
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Toxicity
ACUTE TOXICITY DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Administration onto the skin
Species Observed
Human
Dose/Duration
500 ug/kg
Toxic Effects
Skin and Appendages--primary irritation (after topical exposure)
Reference
Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 35,401,1895
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
100 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(3),68,1979
ACUTE TOXICITY DATA
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Type of Test
LDLo - Lowest published lethal dose
Exposure Route
Subcutaneous
Species Observed
Rodent - rat
Dose/Duration
40 mg/kg
Toxic Effects
Kidney, Ureter, Bladder--hematuria<br>Blood--methemoglobinemia-carboxyhemoglobin
Reference
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 182,118,1936

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