mifepristone

CAS No. 84371-65-3

Formula: C29H35NO2
Basic Info

A progesterone receptor antagonist with partial agonist activity. Abortifacient.

Formula
C29H35NO2
Molecular Weight
429.594
Exact Mass
429.267
LogP
5.4065
PSA
40.54
Synonyms

Mifepristone

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Properties
Appearance & Physical State
Pale Yellow Solid
Density
1.18 g/cm3
Boiling Point
628.6ºC at 760 mmHg
Melting Point
195-198ºC
Flash Point
334ºC
Refractive Index
1.623
Stability
Stable at normal temperatures and pressures.
Storage Condition
2-8ºC
Safety Info
RTECS
KG2955000
Safety Statements
53-22-36/37/39-45
WGK Germany
3
Risk Statements
R60
Caution Statement
P201; P308 + P313
Hazard Codes
Hazard Declaration
Caution Statement
Spectrum
NMR Spectrum 13C NMR : in CDCl3
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Downstream Product
Toxicity
REPRODUCTIVE DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Human - woman
Dose/Duration
12 mg/kg,female 7 week(s) after conception
Toxic Effects
Reproductive-Fertility-abortion
Reference
Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 56,32,1991
REPRODUCTIVE DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Human - woman
Dose/Duration
14 mg/kg,female 7-8 week(s) after conception
Toxic Effects
Reproductive-Fertility-post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
Reference
Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 35,307,1987
REPRODUCTIVE DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Human - woman
Dose/Duration
12 mg/kg,female 6 week(s) after conception
Toxic Effects
Reproductive-Fertility-abortion
Reference
European Journal of Obstetrics, Gynecology and Reproductive Biology. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.3- 1973- Volume(issue)/page/year: 28,249,1988

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