imipramine

CAS No. 50-49-7

Formula: C19H24N2
Basic Info

Imipramine (G 22355), sold as Tofranil and also known as melipramine, is a tricyclic antidepressant (TCA) of the dibenzazepine group. Imipramine is mainly used in the treatment of major depression and enuresis (inability to control urination).
It has also been evaluated for use in panic disorder.

Formula
C19H24N2
Molecular Weight
280.407
Exact Mass
280.194
LogP
3.94
PSA
6.48
Synonyms

Berkomine

Melipramine

Melipramin

[14C]-Imipramine

Antideprin

3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine

Nelipramin

[3H]-Imipramine

Tofranil

3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine

Intalpram

Imidobenzyle

Dimipressin

Imipramine

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Properties
Density
1.041g/cm3
Boiling Point
403.1ºC at 760mmHg
Flash Point
179.7ºC
Refractive Index
1.574
Safety Info
HS Code
2933990090
Spectrum
NMR Spectrum 1H NMR : Predict
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Synthesis Route
1.Synthesis Route
2.Synthesis Route
3.Synthesis Route
Toxicity
ACUTE TOXICITY DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Human - man
Dose/Duration
71428 ug/kg/10D-I
Toxic Effects
Behavioral--rigidity (including catalepsy)<br>Skin and Appendages--sweating<br>Nutritional and Gross Metabolic--body temperature increase
Reference
Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977- Volume(issue)/page/year: 23,480,1997
ACUTE TOXICITY DATA
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Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Oral
Species Observed
Human - woman
Dose/Duration
150 mg/kg
Toxic Effects
Behavioral--coma<br>Cardiac--other changes<br>Vascular--BP lowering not characterized in autonomic section
Reference
Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 33,51,1995
ACUTE TOXICITY DATA
expand collapse
Type of Test
LDLo - Lowest published lethal dose
Exposure Route
Oral
Species Observed
Human - man
Dose/Duration
71 mg/kg
Toxic Effects
Behavioral--convulsions or effect on seizure threshold<br>Cardiac--change in rate<br>Endocrine--changes in luteinizing hormone
Reference
Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 19,239,1982

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