(Z)-1,3-dichloropropene

CAS No. 10061-01-5

Formula: C3H4Cl2
Basic Info

Formula
C3H4Cl2
Molecular Weight
110.97
Exact Mass
109.969
LogP
1.9777
PSA
0
Synonyms

1-Propene, 1,3-dichloro-, (Z)-

1,3-dichloro-propene

1,3-dichloro-1-propene

Z-1,3-dichloropropene

cis-1,3-Dichloropropene

cis-1,3-dichloro-1-propene

trans-1,3-dichloropropene

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Properties
Appearance & Physical State
Colorless
Density
1.225
Boiling Point
104ºC
Flash Point
24ºC
Refractive Index
1.4675
Stability
Stable. Flammable. Incompatible with strong oxidizing agents, aluminium and its alloys, active metals, halogens, some metal salts. May be light sensitive.
Storage Condition
0-6ºC
Vapor Pressure
30.4mmHg at 25°C
Safety Info
Safety Statements
S36/37-S45-S60-S61
Risk Statements
R10; R20/21; R25; R36/37/38; R43; R50/53
RIDADR
UN 2047
Hazard Class
3.2
Packing Group
III
Caution Statement
P261; P273; P280; P301 + P310; P305 + P351 + P338; P312
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (Z)-1,3-dichloropropene

1.2 Other means of identification

Product number -
Other names 1-Propene, 1,3-dichloro-, (Z)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Flammable liquids, Category 3

Acute toxicity - Oral, Category 3

Acute toxicity - Dermal, Category 3

Skin irritation, Category 2

Eye irritation, Category 2

Skin sensitization, Category 1

Acute toxicity - Inhalation, Category 4

Aspiration hazard, Category 1

Specific target organ toxicity – single exposure, Category 3

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H226 Flammable liquid and vapour

H301 Toxic if swallowed

H311 Toxic in contact with skin

H315 Causes skin irritation

H319 Causes serious eye irritation

H317 May cause an allergic skin reaction

H332 Harmful if inhaled

H304 May be fatal if swallowed and enters airways

H335 May cause respiratory irritation

H410 Very toxic to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

P233 Keep container tightly closed.

P240 Ground and bond container and receiving equipment.

P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

P242 Use non-sparking tools.

P243 Take action to prevent static discharges.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P273 Avoid release to the environment.

Response

P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].

P370+P378 In case of fire: Use ... to extinguish.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/...

P312 Call a POISON CENTER/doctor/…if you feel unwell.

P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P331 Do NOT induce vomiting.

P391 Collect spillage.

Storage

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
(Z)-1,3-dichloropropene (Z)-1,3-dichloropropene 10061-01-5 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms/effects, acute and delayed

SYMPTOMS: Symptoms of exposure to this compound may include local irritation of the eyes skin and respiratory tract; dermatitis, gasping, coughing, substernal pain, extreme respiratory distress, lacrimation, central nervous system depression, skin irritation, acute gastrointestinal distress with pulmonary congestion and edema. It also may cause injury to the liver, kidneys and heart. ACUTE/CHRONIC HAZARDS: This compound may cause irritation to the skin, eyes, and mucous membranes. It may also cause lacrimation. When heated to decomposition it emits toxic fumes.

4.3 Indication of immediate medical attention and special treatment needed, if necessary

1. FLUSH contaminating fumigants from the skin and eyes with copious amounts of water or saline for at least 15 minutes. Some fumigants are corrosive to the cornea and may cause BLINDNESS. Specialized medical treatment should be obtained promptly following removal of toxicant by copious flushing with clean water. Skin contamination may cause BLISTERING and deep chemical burns. Absorption of some fumigants across the skin may be sufficient to cause systemic poisoning in the absence of fumigant inhalation. For all these reasons, decontamination of eyes and skin must must be IMMEDIATE and THOROUGH. 2. REMOVE victims of fumigant inhalation to FRESH AIR immediately. Even though initial symptoms and signs are mild, keep the victim quiet, in a semi-reclining position. Minimum pohysical activity limits the likehood ofpulmonary edema. 3. If victim is not breathing, clear the airway of secretions and RESUSCITATE with positive pressure oxygen apparatus. If this is not available, use chest compression to sustain respiration. If victim is pulseless, employ cardiac resuscitation. 4. If PULMONARY EDEMA is evident, there are several measures available to sustain life. Medical judgement must be relied upon, however, in the management of each case. The following procedures are generally recommended: A. Put the victim in a SITTING position with a backrest. B. Use intermittent and/or continuous positive pressure OXYGEN to relieve hypoxemia. ... C. Slowly administer FUROSEMIDE, 40 mg, or SODIUM ETHACRYNATE, 50 mg, to reduce venous load by inducing diuresis. ... D. Morphine in small doses (5-10 mg), slowly, iv to allay anxiety and promote deeper respiratory excursions. E. Administer AMINOPHYLLINE (0.25-0.50 gm) slowly, iv. ... F. Digitalization may be considered, but there is a serious risk of arrhythmias in an anoxic and toxic myocardium. G. TRACHEOSTOMY may be necessary in some cases to facilitate aspiration of large amounts of pulmonary edema fluid. H. Epinephrine, atorpine, and expectorants are generally not helpful, and may complicate treatment. I. Watch for RECURRENT PULMONARY EDEMA, even up to 2 weeks after the initial episode. Limit victim's physical activity for at least 4 weeks. Severe physical weakness usually indicates persistent pulmonary injury. Serial pulmonary function testing may be useful in assessing recovery. 5. Combat SHOCK by placing victim in the Trendelenburg position and administering plasma, whole blood, and/or electrolyte and glucose solutions intravenously, with great care, to avoid pulmonary edema. Central venous pressure should be monitored continously. Vasopressor amines must be given with great caution, because of the irritability of the myocardium. 6. Control CONVULSIONS. Seizures are most likely to occur in poisonings by methyl bromide, hydrogen cyanide, acrylonitrile, phosphine, and carbon disulfide. ... /Fumigant poisoning/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Fires involving this compound can be controlled using a dry chemical, carbon dioxide or Halon extinguisher.

5.2 Specific hazards arising from the chemical

Flash point data for this chemical are not available, however literature sources indicate that this material is flammable.

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state Colorless
Colour COLORLESS LIQUID
Odour CHLOROFORM-LIKE ODOR
Melting point/ freezing point 211°C(dec.)(lit.)
Boiling point or initial boiling point and boiling range 104°C(lit.)
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 23°C
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility less than 1 mg/mL at 20.5°C
Partition coefficient n-octanol/water (log value) log Kow = 2.06
Vapour pressure 30.4mmHg at 25°C
Density and/or relative density 1.225g/mLat 25°C(lit.)
Relative vapour density 1.4 AT 37.8 DEG C (AIR= 1)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

A dangerous fire hazard when exposed to heat, flame, or oxidizers.CIS-1,3-DICHLORO-1-PROPENE may be sensitive to light. Reacts with aluminum, aluminum alloys, other active metals and some metal salts and halogens. Can react vigorously with oxidizing materials.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

... /CIS-TRANS MIXTURE/ REACTS READILY WITH ALUMINUM, ALUMINUM ALLOYS, OTHER ACTIVE METALS & SOME METAL SALTS & HALOGENS.

10.6 Hazardous decomposition products

When heated to decomposition it emits toxic fumes of /hydrogen chloride/.

11.Toxicological information

Acute toxicity

  • Oral: no data available
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

A3: Confirmed animal carcinogen with unknown relevance to humans. /1,3-Dichloropropene/

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: The reported half-lives for 1,3-dichloropropene (isomer not specified) were 12 days in Catlin silt loam soil and 54 days in Fuquay loamy sand soil(1). The major nonvolatile degradates isolated from the soils were cis/trans-3-chloroprop-2-en-1-ol (3-chloroallyl alcohol) and cis/trans-3-chloroprop-2-enoic acid (3-chloroacrylic acid)(1). Numerous naturally-occurring carboxylic acids were also identified as degradates(1). Twelve weeks after radiolabeled cis-1,3-dichloropropene was added to soil and stored in sealed containers, 19% remained in sandy loam and 10% remained in medium loam(2). After 20 weeks, 5% remained in sandy loam and 3% remained in the medium loam(2). The half-life of the dichloropropene was 3-4 weeks in sandy loam. The primary degradation product was cis-3-chloroallyl alcohol(2). It was possible that some of the parent compound was lost by volatilization(2). In another study, after intensive treatment of 10 soils with cis-1,3-dichloropropene, all soils were adapted and showed enhanced biodegradation of this compound(3). Cis- and trans-1,3-dichloropropene disappeared in sandy soils (15-20°C, closed containers) at a rate of 2.5-3%/day (with an avg half-life of 24 days) (4). The half-life of 1,3-dichloropropene (cis and trans isomers) in 13 aerobic soils at 20°C ranged from 6-17 days(5).

12.3 Bioaccumulative potential

An estimated BCF of 8 was calculated for cis-1,3-dichloropropene(SRC), using a log Kow of 2.06(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The calculated Freundlich adsorption coefficients (Kd) for 1,3-dichloropropene (isomers not specified) were 0.23 and 0.32 for loamy sand and sand soils, respectively(1); Kd was 0.49 and 1.09 for clay soils(1). The avg max Koc values were 20 for sand, 25 for loamy sand, and 41 and 42 for two clay soils(1). The avg Koc of cis-1,3-dichloropropene in 3 soils with organic carbon contents of 3.19, 10.4, and 55.1% was 27(2). According to a classification scheme(3), Koc values from 25 to 42 suggest that cis-1,3-dichloropropene is expected to have very high mobility in soil(SRC). In 30-cm columns of sand, loamy sand, and Florida clay, 1,3-dichloropropene (isomers not specified) leached when more than 25 inches of water were applied(1); a total of 1.9% to 4.6% of the applied (unaged) radioactivity remained in the soils and 70% to 84% was found in the leachate(1). Aged (eg, 31 days) 1,3-dichloropropene (isomers not specified) residues were very mobile, with 25.6% to 32.0% of the applied radioactivity in the leachates of 30-cm columns of loamy sand soil(1). 1,3-Dichloropropene (isomers not specified) and the degradates 3-chloroallyl alcohol, chloroacrylic acid, and composite carboxylic acids (including acetic acid, oxalic acid, and propionic acid) were detected in both the leachates and the upper 2-cm soil segment extracts(1).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN2047 IMDG: UN2047 IATA: UN2047

14.2 UN Proper Shipping Name

ADR/RID: DICHLOROPROPENES
IMDG: DICHLOROPROPENES
IATA: DICHLOROPROPENES

14.3 Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

14.4 Packing group, if applicable

ADR/RID: III IMDG: III IATA: III

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
(Z)-1,3-dichloropropene (Z)-1,3-dichloropropene 10061-01-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Not Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Not Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Not Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Not Listed.

16.Other information

Information on revision

Creation Date Aug 10, 2017
Revision Date Aug 10, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Section I.Chemical Product and Company Identification
    Chemical Name        cis-1,3-Dichloropropene    
    (1mg/ml in Methanol) [for Water Analysis]
    Portland OR
    Not available.
    Synonym
    Chemical Formula        C3H4Cl2    
    CAS Number        10061-01-5    
    67-56-1 (Methanol)

Section II.        Composition and Information on Ingredients    
    CAS Number Percent (%)        TLV/PEL        Toxicology Data    
    Chemical Name
    cis-1,3-Dichloropropene        Ca. 0.13%        This chemical is classified as a (Methanol)    
    10061-01-5
    (1mg/ml in Methanol) [for Water Analysis]        possible carcinogen. There is Rat LD50 (oral) 5600 mg/kg    
    67-56-1 (Methanol)        Ca. 99.87% (Methanol)    
    no acceptable exposure limit for Rabbit LD50 (dermal) 15800 mg/kg
    a carcinogen.        Rat LD50 (inhalation) 64000 ppm/4H    

Section III. Hazards Identification
    Acute Health Effects        Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.    
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
    eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    Chronic Health Effects        CARCINOGENIC EFFECTS : Neoplastic by RTECS criteria    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Tumorigenic Effects:
    Mouse TDLo (Subcutaneous) 9240 mg/kg/77 weeks intermittent
    Toxic Effects:
    Tumorigenic- Neoplastic by RTECS criteria
    Tumorigenic- Tumors at site of application.
    DEVELOPMENTAL TOXICITY: Reproductive Effects:
    Rat TCLo (Inhalation) 20000 pm/7 hours. Female 1-22 days of pregnancy.
    Toxic Effects:
    Specific Developmental Abnormalities- Musculoskeletal system
    Specific Developmental Abnormalities- Cardiovascular (circulatory) system
    Specific Developmental Abnormalities- Urogenital system
    Rat TDLo (Oral) 35295 mg/kg. Female 1-15 days of pregnancy
    Toxic Effects:
    Effects on Fertility- Female fertility index
    Effects on Fertility- Pre-implantation mortality
    Effects on Fertility- Post-implantation mortality
    Mouse TDLo (Oral) 4gm/kg. Female 7 days of pregnancy
    Toxic Effects:
    Specific Developmental Abnormalities- Craniofacial (including nose and tongue)
    Specific Developmental Abnormalities- Musculoskeletal system
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
    many human organs.

Section IV.        First Aid Measures    
    Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
    Eye Contact
    minutes. Get medical attention.
    In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
    Skin Contact
    and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
    Inhalation        If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or    
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    Continued on Next Page
    cis-1,3-Dichloropropene
    (1mg/ml in Methanol) [for Water Analysis]
    INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
    Ingestion
    Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
    material was ingested; the absence of such signs, however, is not conclusive.

Section V.        Fire and Explosion Data    
    464°C (867.2°F) (Methanol)
    Flammable.        Auto-Ignition    
    Flammability
    Flash Points        Flammable Limits        LOWER: 5.5% UPPER: 44% (Methanol)    
    23.9°C (75°F).
    12°C (53.6°F). (Methanol)
    Combustion Products        These products are toxic carbon oxides (CO, CO2), halogenated compounds    
    WARNING: Highly toxic HCl gas is produced during combustion.
    Fire Hazards
    Not available.
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards
    Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media
    Flammable liquid.
    SMALL FIRE: Use DRY chemical powder.
    and Instructions
    LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent pressure
    build-up, autoignition or explosion. Consult with local fire authorities before attempting large scale fire-fighting operations.

Section VI.        Accidental Release Measures    
    Spill Cleanup        Flammable material. Toxic material. Environmentally hazardous material. Irritating material. Heat sensitive material.    
    Hygroscopic material.
    Instructions
    Keep away from heat. Mechanical exhaust required. Stop leak if without risk. Absorb with DRY earth, sand or other
    non-combustible material. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
    vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Consult federal, state, and/or local
    authorities for assistance on disposal.

Section VII. Handling and Storage
    Handling and Storage        FLAMMABLE. TOXIC. ENVIRONMENTAL HAZARD. IRRITANT. HEAT SENSITIVE. HYGROSCOPIC. FREEZE. Keep    
    locked up.. Keep away from heat. Mechanical exhaust required. Avoid excessive heat and light. DO NOT ingest. Do not
    Information
    breathe gas/fumes/ vapor/spray. Wear suitable protective clothing. If ingested, seek medical advice immediately and show
    the container or the label. Treat symptomatically and supportively.
    Always store away from incompatible compounds such as oxidizing agents.

Section VIII. Exposure Controls/Personal Protection
    Engineering Controls        Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective    
    threshold limit value. Ensure that eyewash station and safety shower is proximal to the work-station location.
    Personal Protection        Splash goggles. Lab coat. Vapor respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid    
    inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
    product.
    Exposure Limits        This chemical is classified as a possible carcinogen. There is no acceptable exposure limit for a carcinogen.    

Section IX. Physical and Chemical Properties
    Liquid. (Clear. Colorless, amber.)        Solubility    
    Physical state @ 20°C        Soluble in ether, benzene, chloroform,    
    water.
    1.224 (water=1)        Miscible with hydrocarbons, halgenated    
    Specific Gravity
    0.79 (Methanol)        solvents, esters, and ketones.    
    Molecular Weight        110.97        Partition Coefficient        The product is more soluble in oil;    
    32.04 (Methanol)        log(oil/water) = 2.1    
    Boiling Point        104.3°C (219.7°F)        Vapor Pressure        3.5 kPa (@ 20°C)    
    64°C (147.2°F) (Methanol)        97.68 mmHg (@ 20°C) (Methanol)    
    Melting Point        -98°C (-144.4°F) (Methanol)        Vapor Density        1.4 (Air = 1)    
    1.1 (Air = 1) (Methanol)
    Not available.        Not available.    
    Refractive Index        Volatility    
    Critical Temperature        Not available.        Odor        Chloroform like, sharp, sweet, penetrating,    
    irritating odor.
    Not available.        Not available.    
    Viscosity        Taste    
    Continued on Next Page
    cis-1,3-Dichloropropene
    (1mg/ml in Methanol) [for Water Analysis]

Section X.        Stability and Reactivity Data    

This material is stable if stored under proper conditions. (See Section VII for instructions)
    Stability
    Conditions of Instability        Avoid excessive heat and light.    
    Incompatibilities
    Reactive with oxidizing agents, reducing agents, acids, acid chlorieds, acid anhydrides, and alkali metals.

Section XI. Toxicological Information
    UC8325000
    RTECS Number
    Routes of Exposure        Eye Contact. Ingestion. Inhalation.    
    (Methanol)
    Toxicity Data
    Rat LD50 (oral) 5600 mg/kg
    Rabbit LD50 (dermal) 15800 mg/kg
    Rat LD50 (inhalation) 64000 ppm/4H
    Chronic Toxic Effects        CARCINOGENIC EFFECTS : Neoplastic by RTECS criteria    
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Tumorigenic Effects:
    Mouse TDLo (Subcutaneous) 9240 mg/kg/77 weeks intermittent
    Toxic Effects:
    Tumorigenic- Neoplastic by RTECS criteria
    Tumorigenic- Tumors at site of application.
    DEVELOPMENTAL TOXICITY: Reproductive Effects:
    Rat TCLo (Inhalation) 20000 pm/7 hours. Female 1-22 days of pregnancy.
    Toxic Effects:
    Specific Developmental Abnormalities- Musculoskeletal system
    Specific Developmental Abnormalities- Cardiovascular (circulatory) system
    Specific Developmental Abnormalities- Urogenital system
    Rat TDLo (Oral) 35295 mg/kg. Female 1-15 days of pregnancy
    Toxic Effects:
    Effects on Fertility- Female fertility index
    Effects on Fertility- Pre-implantation mortality
    Effects on Fertility- Post-implantation mortality
    Mouse TDLo (Oral) 4gm/kg. Female 7 days of pregnancy
    Toxic Effects:
    Specific Developmental Abnormalities- Craniofacial (including nose and tongue)
    Specific Developmental Abnormalities- Musculoskeletal system
    Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many
    human organs.
    Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
    Acute Toxic Effects
    Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
    is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
    occasionally, blistering.
    Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

Section XII.        Ecological Information    
    Not available.
    Ecotoxicity
    Environmental Fate        cis-1,3-Dichloropropene's production and use as a soil fumigant and nematicide is expected to result in its direct release to    
    the environment. If released to air, a vapor pressure of 26 mm Hg at 20 deg C indicates cis-1,3-dichloropropene will exist
    solely as a vapor in the ambient atmosphere. Vapor-phase cis-1,3-dichloropropene will be degraded in the atmosphere by
    reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 46 hrs. If
    released to soil, cis-1,3-dichloropropene is expected to have very high mobility based upon a range of Kocs from 20 to 42.
    Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of
    2.7X10-3 atm-cu m/mole. cis-1,3-Dichloropropene may volatilize from dry soil surfaces based upon its vapor pressure.
    cis-1,3-Dichloropropene is expected to biodegrade in soil and water under aerobic and anaerobic conditions. Under aerobic
    conditions, the half-life for 1,3-dichloropropene was 12 days in a loam soil. Under anaerobic conditions at 25 deg C, in both a
    silty clay loam and sandy loam soil, the half-life was 2.4 days. If released into water, cis-1,3-dichloropropene is not expected
    to adsorb to suspended solids and sediment based upon the Kocs. Volatilization from water surfaces is expected to be an
    important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river
    and model lake are 1.3 and 102 hrs, respectively. An estimated BCF of 8 suggests the potential for bioconcentration in
    aquatic organisms is low. cis-1,3-Dichloropropene degrades by chemical hydrolysis; at pH values of 5, 7, 9, the half-life of
    1,3-dichloropropene was 13.5 days at 20 deg C. Occupational exposure to cis-1,3-dichloropropene may occur through
    inhalation and dermal contact with this compound at workplaces where cis-1,3-dichloropropene is produced or used.
    Occupational exposure may also occur for agricultural workers using this compound as a soil fumigant and nematicide. The
    general population may be exposed to cis-1,3-dichloropropene via inhalation of ambient air and drinking water in areas where
    cis-1,3-dichloropropene is used a soil fumigant and nematicide.
    (Methanol)
    Methanol's production and use as a solvent, fuel additive, and in the production of formaldehyde, acetic acid, and methyl
    tertiary butyl ether (MTBE) may result in its release to the environment through various waste streams. Methanol has been
    identified as a natural emission product from various plants and as a biological decomposition product of biological wastes
    and sewage. If released to the atmosphere, a vapor pressure of 127 mm Hg at 25 deg C indicates that methanol will exist
    solely in the vapor phase. Vapor phase methanol is degraded in the atmosphere by reaction with photochemically-produced
    hydroxyl radicals; the half-life for this reaction in air is estimated to be 17 days. If released to soil, methanol is expected to
    have very high mobility based upon an estimated Koc of 1. Volatilization from moist soil surfaces is expected to be an
    important fate process based upon a Henry's Law constant of 4.55X10-6 atm-cu m/mole. Methanol may also volatilize from
    dry soils based upon it vapor pressure. Biodegradation of methanol in soils is expected to occur rapidly based on half-lives in
    a sandy silt loam from Texas and a sandy loam from Mississippi of 1 and 3.2 days, respectively. If released into water,
    methanol is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from
    water surfaces is expected to be an important fate process based upon this compound's Henry's Law constant. Estimated
    volatilization half-lives for a model river and model lake are 3 and 35 days, respectively. Biodegradation is expected to occur
    Continued on Next Page
    cis-1,3-Dichloropropene
    (1mg/ml in Methanol) [for Water Analysis]
    in natural waters since methanol is degraded quickly in soils and was biodegraded rapidly in various aqueous screening tests
    using sewage seed or activated sludge. BCF values of less than 10, measured in fish suggests bioconcentration in aquatic
    organisms is low. Hydrolysis of methanol and photolysis in sunlit surface waters are not expected since methanol lacks
    functional groups that are susceptible to hydrolysis or photolysis under environmental conditions. Occupational exposure to
    methanol may occur through inhalation and dermal contact with this compound at workplaces where methanol is produced or
    used. Monitoring data indicate that the general population may be exposed to methanol via inhalation of ambient air, and
    ingestion of food and drinking water.

Section XIII. Disposal Considerations
    Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
    Waste Disposal
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
    DOT Classification        DOT CLASS 3: Flammable liquid.    
    DOT CLASS 6.1: Toxic material.
    PIN Number
    Proper Shipping Name        Flammable liquid, toxic, n.o.s.    
    II
    Packing Group (PG)
    DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40    
    CFR 720.36 (C) for those products not on the inventory list:
    (EPA)
    (i) These products are supplied solely for use in research and development by or under the supervision of a technically
    qualified individual as defined in 40 CFR 720.0 et sec.
    (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
    supplied on an MSDS sheet.
    WHMIS Classification        CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).    
    CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
    (Canada)
    EINECS Number (EEC)        233-195-8    
    200-659-6 (Methanol)
    EEC Risk Statements        R10- Flammable.    
    R18- In use, may form flammable/explosive vapor-air mixture.
    R23/24/25- Toxic by inhalation, in contact with skin and if swallowed.
    R51- Toxic to aquatic organisms.
    R53- May cause long-term adverse effects in the aquatic environment.
    R36/37/38- Irritating to eyes, respiratory system and skin.
    R45- May cause cancer.
    Japanese Regulatory Data        ENCS no.: 2-125    


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : Predict
expand collapse
Analysis Methods
Normal alkane RI, non-polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
SE-54
Retention index
750.
Temperature Control
Method
temperature ramp
Comments
36. m/0.25 mm/0.25 μm, 5. K/min; T<sub>start</sub>: 35. C; T<sub>end</sub>: 240. C
Reference
Huang, C.Liang, H.Han, S.The analysis of organic compounds in waste water by gas extraction/thermal desorption/gas chromatography-mass spectrometryChin. J. Chromatogr.1996, 14, 6, 421-424.
Normal alkane RI, non-polar column, custom temperature program
expand collapse
Column Shape
Capillary
Active Phase(℃)
OV-1, SE-30, Methyl silicone, SP-2100, OV-101, DB-1, etc.
Retention index
724.
Temperature Control
Method
custom temperature program
Comments
Hydrogen; Column length: 50. m; Column diameter: 0.32 mm; Program: not specified
Reference
Waggott, A.Davies, I.W.Identification of organic pollutants using linear temperature programmed retention indices (LTPRIs) - Part II1984, retrieved from http://dwi.defra.gov.uk/research/completed-research/reports/dwi0383.pdf.
Normal alkane RI, polar column, custom temperature program
expand collapse
Column Shape
Capillary
Active Phase(℃)
Superox 0.6; Carbowax 20M
Retention index
1183.
Temperature Control
Method
custom temperature program
Comments
Hydrogen; Column length: 50. m; Column diameter: 0.32 mm; Program: not specified
Reference
Waggott, A.Davies, I.W.Identification of organic pollutants using linear temperature programmed retention indices (LTPRIs) - Part II1984, retrieved from http://dwi.defra.gov.uk/research/completed-research/reports/dwi0383.pdf.
Normal alkane RI, polar column, custom temperature program
expand collapse
Column Shape
Capillary
Active Phase(℃)
Carbowax 400, Carbowax 20M, Carbowax 1540, Carbowax 4000, Superox 06, PEG 20M, etc.
Retention index
1183.
Temperature Control
Method
custom temperature program
Comments
Hydrogen; Column length: 50. m; Column diameter: 0.32 mm; Program: not specified
Reference
Waggott, A.Davies, I.W.Identification of organic pollutants using linear temperature programmed retention indices (LTPRIs) - Part II1984, retrieved from http://dwi.defra.gov.uk/research/completed-research/reports/dwi0383.pdf.
Toxicity
TUMORIGENIC DATA
expand collapse
Type of Test
TDLo - Lowest published toxic dose
Exposure Route
Subcutaneous
Species Observed
Rodent - mouse
Dose/Duration
9240 mg/kg/77W-I
Toxic Effects
Tumorigenic--neoplastic by RTECS criteria<br>Tumorigenic--tumors at site of application
Reference
JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 63,1433,1979
MUTATION DATA
expand collapse
Type of Test
Mutation in microorganisms
Exposure Route
Species Observed
Dose/Duration
20 ug/plate
Toxic Effects
--
Reference
Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,1915,1977
MUTATION DATA
expand collapse
Type of Test
Unscheduled DNA synthesis
Exposure Route
Species Observed
Dose/Duration
100 umol/L
Toxic Effects
--
Reference
Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 20,263,1983
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