1-naphthol

CAS No. 90-15-3

Formula: C10H8O
Basic Info

1-Naphthol, or α-naphthol, is a fluorescent organic compound with the formula C10H7OH. It is a white solid. It is an isomer of 2-naphthol differing by the location of the hydroxyl group on the naphthalene ring. The naphthols are naphthalene homologues of phenol, with the hydroxyl group being more reactive than in the phenols. Both isomers are soluble in simple alcohols, ethers, and chloroform. They are precursors to a variety of useful compounds. Naphthols (both 1 and 2 isomers) are used as biomarkers for livestock and humans exposed to polycyclic aromatic hydrocarbons.

Formula
C10H8O
Molecular Weight
144.17
Exact Mass
144.058
LogP
2.5454
PSA
20.23
Synonyms

furro er

nakotrb

[14C]-1-Naphthol

1-Naphthol

naphthalen-1-ol

Zoba ERN

1-hydroxynaphthalene

1-naphtol

Ursol ERN

1-naphthalenol

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Properties
Appearance & Physical State
pale grey to brown solid
Density
1.224
Boiling Point
278-280ºC
Melting Point
94-98ºC
Flash Point
125ºC
Refractive Index
1.6224
Stability
Stable, but air and light sensitive - store under inert gas. Incompatible with strong bases, strong oxidizing agents.
Storage Condition
Store in dark
Safety Info
RTECS
QL2800000
Safety Statements
S2-S22-S26-S37/39
WGK Germany
1
Risk Statements
R21/22; R37/38; R41
HS Code
2907151000
RIDADR
UN 1759
Hazard Class
6.1
Packing Group
III
Caution Statement
P273; P280; P302 + P352 + P312; P305 + P351 + P338 + P310; P501
Hazard Codes
Spectrum
NMR Spectrum 1H NMR : 400 MHz in CDCl3
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IR Spectrum IR : KBr disc
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Mass Spectrum Mass
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Raman Spectrum Raman : 4880 A,200 M,powder
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Toxicity
SKIN/EYE IRRITATION DATA
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Type of Test
Standard Draize test
Exposure Route
Administration onto the skin
Species Observed
Rodent - rabbit
Dose/Duration
500 mg/24H
Toxic Effects
--
Reference
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 25-4/1973
ACUTE TOXICITY DATA
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Type of Test
LD50 - Lethal dose, 50 percent kill
Exposure Route
Oral
Species Observed
Rodent - rat
Dose/Duration
1870 mg/kg
Toxic Effects
Details of toxic effects not reported other than lethal dose value--
Reference
Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: FYI-OTS-0885-0443
ACUTE TOXICITY DATA
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Type of Test
LC50 - Lethal concentration, 50 percent kill
Exposure Route
Inhalation
Species Observed
Rodent - rat
Dose/Duration
>420 mg/m3/1H
Toxic Effects
Sense Organs and Special Senses (Eye)--lacrimation<br>Gastrointestinal--changes in structure or function of salivary glands
Reference
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 25-4/1973

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