o-toluidine

CAS No. 95-53-4

Formula: C7H9N
Basic Info

O-toluidine (ortho-toluidine) is an organic compound with the chemical formula C7H9N. This arylamine is a colorless to pale-yellow liquid with a poor solubility in water.

Formula
C7H9N
Molecular Weight
107.153
Exact Mass
107.073
LogP
2.1584
PSA
26.02
Synonyms

2-methylphenylamine

o-Toluidine

Benzenamine, 2-methyl-

1-amino-2-methylbenzene

2-methylbenzenamine

2-Toluidine

2-methyl-aniline

toluidines

o-Toluidyna

0-Toluidine

o-Toluide

ortho-methyl aniline

o-Toluidin

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Properties
Appearance & Physical State
light yellow to light amber liquid
Density
1.008
Boiling Point
199-200ºC
Melting Point
-23ºC
Flash Point
85ºC
Refractive Index
1.571-1.573
Water Solubility
1.5 g/100 mL (25 ºC)
Stability
Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air.
Storage Condition
2-8ºC
Vapor Density
3.7 (vs air)
Vapor Pressure
0.26 mm Hg ( 25 °C)
Safety Info
RTECS
XU2975000
Safety Statements
S45-S53-S61
WGK Germany
3
Risk Statements
R23/25; R36; R45; R50
HS Code
29214300
RIDADR
UN 1708
Hazard Class
6.1
Packing Group
II
Hazard Codes
MSDS
SDS 1.0
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SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name o-toluidine

1.2 Other means of identification

Product number -
Other names o-Toluidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. The principal commercial use of o-toluidine is in the manufacture of dyes. It is also used in the manufacture of rubber vulcanization accelerators, hypnotic and anesthetic pharmaceuticals, and pesticides.
Uses advised against no data available

1.4 Supplier's details

Company MOLBASE (Shanghai) Biotechnology Co., Ltd.
Address Floor 4 & 5, Building 12, No. 1001 North Qinzhou Road,
Xuhui District, Shanghai, China
Telephone +86(21)64956998
Fax +86(21)54365166

1.5 Emergency phone number

Emergency phone number +86-400-6021-666
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Oral, Category 3

Eye irritation, Category 2

Acute toxicity - Inhalation, Category 3

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

2.2 GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Danger

Hazard statement(s)

H301 Toxic if swallowed

H319 Causes serious eye irritation

H331 Toxic if inhaled

H350 May cause cancer

H400 Very toxic to aquatic life

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P273 Avoid release to the environment.

Response

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P337+P313 If eye irritation persists: Get medical advice/attention.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P311 Call a POISON CENTER/doctor/…

P308+P313 IF exposed or concerned: Get medical advice/ attention.

P391 Collect spillage.

Storage

P405 Store locked up.

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Disposal

P501 Dispose of contents/container to ...

2.3 Other hazards which do not result in classification

none

3.Composition/information on ingredients

3.1 Substances

Chemical name Common names and synonyms CAS number EC number Concentration
o-toluidine o-toluidine 95-53-4 none 100%

4.First-aid measures

4.1 Description of necessary first-aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.

In case of skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.

In case of eye contact

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

If swallowed

Rinse mouth. Refer immediately for medical attention.

4.2 Most important symptoms/effects, acute and delayed

Absorption of toxic quantities by any route causes cyanosis (blue discoloration of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation. (USCG, 1999)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aniline and related compounds/

5.Fire-fighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use dry chemical, carbon dioxide, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full facepieces and are operated in a pressure-demand or other positive-pressure mode.

5.2 Specific hazards arising from the chemical

Special Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire. (USCG, 1999)

5.3 Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions

Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

7.Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Separated from strong oxidants, strong acids and food and feedstuffs. Well closed. Ventilation along the floor. Keep in the dark. Store in an area without drain or sewer access.Before entering confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. o-Toluidine must be stored to avoid contact with strong oxidizers (such as chlorine, bromine, and fluorine) because violent reactions occur. Store in tightly closed containers in a cool, well-ventilated area away from heat. Sources of ignition, such as smoking and open flames, are prohibited where o-toluidine is used, handled, or stored in a manner that could creats a potential fire or explosion hazard. A regulated, marked area should be established where this chemical is handled, used, or stored ...

8.Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

NIOSH considers o-toluidine to be a potential occupational carcinogen.

NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. Skin notation.

Biological limit values

no data available

8.2 Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

Wear dust mask when handling large quantities.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state light yellow to light amber liquid
Colour Light yellow liquid becoming reddish brown on exposure to air and light
Odour Aromatic aniline-like odor
Melting point/ freezing point -46°C(lit.)
Boiling point or initial boiling point and boiling range 201°C
Flammability Class IIIA Combustible Liquid: Fl.P. at or above 60°C and below 93.33°C.Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit Lower flammable limit: 1.5% by volume, upper limit not determined
Flash point 86°C(lit.)
Auto-ignition temperature 482.22°C (USCG, 1999)
Decomposition temperature no data available
pH no data available
Kinematic viscosity 3.823 mPa-s at 25°C
Solubility In water:1.5 g/100 mL (25 ºC)
Partition coefficient n-octanol/water (log value) log Kow = 1.32
Vapour pressure 0.26 mm Hg ( 25 °C)
Density and/or relative density 1.008
Relative vapour density 3.7 (vs air)
Particle characteristics no data available

10.Stability and reactivity

10.1 Reactivity

no data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Flammable when exposed to heat or flame.As a result of flow, agitation, etc., electrostatic charges can be generated.TOLUIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. Emits very toxic oxides of nitrogen when heated to decomposition. Undergoes a hypergolic reaction with red fuming nitric acid [Kit and Evered, 1960, p. 239, 242].

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

Hypergolic reaction with red fuming nitric acid. Can react with oxidizing materials.

10.6 Hazardous decomposition products

When heated to decomposition, it emits toxic fumes of hydrochloric acid and nitrogen oxides.

11.Toxicological information

Acute toxicity

  • Oral: LD50 Rat oral 940 mg/kg
  • Inhalation: LC50 Rat male inhalation 862 ppm (3827 mg/cu m) for 4 hr.
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

There is sufficient evidence in humans for the carcinogenicity of ortho-toluidine. There is sufficient evidence in experimental animals for the carcinogenicity of ortho-toluidine. Overall evaluation ortho-Toluidine is carcinogenic to humans (Group 1).

Reproductive toxicity

Limited information regarding the reproductive or developmental effects of inhaled or ingested o-toluidine was located. One Russian study reported an increased frequency of tumors in offspring of mice injected with o-toluidine during gestation.

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1 Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: LC50; Species: Daphnia magna (water flea); Conditions: temp 20 +/- 1°C, pH 7.37 -7.73, dissolved O2 8.4 - 8.8 mg/L; Concentration: 0.0306 mg/L for 21 days (95% confidence limits: 0.0219 - 0.0438 mg/L)
  • Toxicity to algae: EC50; Species: Selenastrum capricornutum (Algae); Conditions: shaking (100 rpm), 23 +/- 2°C, pH 7.76-7.82 (0 hr), 8.02-10.00 (72 hr); Concentration: 30.9 mg/L (95 % confidence limits: 20.5-46.6 mg/l) for 72 hr; Effect: biomass /99% pure
  • Toxicity to microorganisms: no data available

12.2 Persistence and degradability

AEROBIC: Biodegradation results of 2-aminotoluene showed: 100% degradation in 6 hr using an activated sludge inoculum(1); 56% of theoretical BOD utilized in 5 days with a sewage seed(2); 100% of theoretical BOD in 8 days using an activated sludge inoculum acclimated to aniline(3); 97.7% removal in 5 days with activated sludge(4). Using activated sludge from the wastewater treatment plant used to treat effluent known to contain 2-aminotoluene, 92% chemical oxygen demand removal was obtained in a 24 hr incubation with the chemical(5). 2-Aminotoluene, present at 100 mg/L, reached 65% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(6). Complete degradation was obtained in 64 days with a soil inoculum(7). Six laboratories obtained >90% degradation of 2-aminotoluene in 7 days in two screening tests designed to simulate surface waters and polluted river water(8). 500 ppm of 2-aminotoluene completely degraded in 3 days in a Chernozem soil, leaving degradation products that persisted for over 90 days(9). Approximately 90% of 2-aminotoluene was degraded in 15 days under aerobic conditions using an inoculum prepared from water samples collected from a polluted river; less than 20% degradation was observed in 15 days using an inoculum prepared from water samples collected from a non-polluted river(10). 2-Aminotoluene, present at 2 mg/L, reached 41% of its theoretical BOD in 5 days using water from the Songhua River in China as an inoculum(11). The mean biodegradation rate constant and half-life measured for 50 ug/L 2-aminotoluene in a sludge inoculum were 8.8X10-6/sec and 22 hours, respectively(12). These data indicate that biodegradation of 2-aminotoluene will be an important environmental fate process(SRC).

12.3 Bioaccumulative potential

An estimated BCF of 3.5 was calculated for 2-aminotoluene(SRC), using a log Kow of 1.32(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in soil

The measured partition coefficient between sediment and water for 2-aminotoluene ranged from 40 to 250(1). According to a classification scheme(2), these Koc values suggest that 2-aminotoluene is expected to have very high to moderate mobility in soil. A group of investigators found the movement of toluidines through clay (montmorillonite) was not inhibited by sorption(3). The pKa of 2-aminotoluene is 4.44(4), indicating that this compound will exist partially in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(6,7), suggesting that mobility may be much lower in some soils(SRC).

12.5 Other adverse effects

no data available

13.Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1 UN Number

ADR/RID: UN1708 IMDG: UN1708 IATA: UN1708

14.2 UN Proper Shipping Name

ADR/RID: TOLUIDINES, LIQUID
IMDG: TOLUIDINES, LIQUID
IATA: TOLUIDINES, LIQUID

14.3 Transport hazard class(es)

ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packing group, if applicable

ADR/RID: II IMDG: II IATA: II

14.5 Environmental hazards

ADR/RID: yes IMDG: yes IATA: yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name Common names and synonyms CAS number EC number
o-toluidine o-toluidine 95-53-4 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.

16.Other information

Information on revision

Creation Date Aug 12, 2017
Revision Date Aug 12, 2017

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
MSDS
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Name: o-Toluidine Material Safety Data Sheet
Synonym: 2-Aminotoluene; 2-Methylaniline; 2-Methylbenzenamine; ortho-Methylaniline; 1-Amino-2-Methylbenzene; 1-Methyl-2-Aminobenzene
CAS: 95-53-4
Section 1 - Chemical Product   MSDS Name:o-Toluidine Material Safety Data Sheet
Synonym:2-Aminotoluene; 2-Methylaniline; 2-Methylbenzenamine; ortho-Methylaniline; 1-Amino-2-Methylbenzene; 1-Methyl-2-Aminobenzene

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
95-53-4
Hazard Symbols: T N
Risk Phrases:

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic by inhalation and if swallowed. Irritating to eyes. May cause cancer. Very toxic to aquatic organisms.Light sensitive.Air sensitive.Cancer suspect agent.Dangerous for the environment.
Potential Health Effects
Eye:
Causes severe eye irritation. May result in corneal injury.
Skin:
Causes skin irritation. May be absorbed through the skin. Causes symptoms similar to those of inhalation. May cause dermatitis.
Excessive drying of the skin may result from repeated or prolonged contact.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
May cause effects similar to those for inhalation exposure.
Inhalation:
Harmful if inhaled. Causes respiratory tract irritation. May cause anoxia, characterized by weakness, headache, dizziness, confusion, cyanosis, weak and irregular heart beat, collapse, unconsciousness, convulsions, coma and death. Exposure produces central nervous system depression. May cause kidney damage. May cause headache and cyanosis of the lips, mucous membranes and fingernail beds and the tongue. Clinical signs of intoxication with o-toluidine in humans have included methemoglobinemia, hematuria, marked renal & bladder irritation, & physiological & psychological disturbances.
o-Toluidine has been absorbed via the respiratory tract & skin.
Chronic:
Chronic inhalation may cause effects similar to those of acute inhalation. May cause kidney injury. May cause cancer according to animal studies. Absorption into the body leads to the formation of methemoglobin which in sufficient concentrations causes cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). This substance has caused adverse reproductive and fetal effects in laboratory animals. The chronic (long-term) effects in workers exposed to o-toluidine include anemia, anorexia, weight loss, skin lesions, central nervous system depression, cyanosis, and methemoglobinemia.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood.
Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. Cleansing of the entire contaminated area of the body is of utmost importance.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible liquid and vapor. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Provide ventilation. Approach spill from upwind.
Use water spray to cool and disperse vapors and protect personnel.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Avoid contact with air and sunlight. Use only with adequate ventilation. Keep away from heat and flame.
Storage:
Keep away from heat and flame. Keep away from sources of ignition.
Do not store in direct sunlight. Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light and air. Material darkens on exposure to air. Separate from oxidizing materials.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear chemical goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: clear slightly yellow
Odor: amine-like
pH: Not available.
Vapor Pressure: 0.26 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 200 deg C
Freezing/Melting Point: -16 deg C
Autoignition Temperature: 482 deg C ( 899.60 deg F)
Flash Point: 85 deg C ( 185.00 deg F)
Explosion Limits, lower: 1.50 vol %
Explosion Limits, upper: Not available.
Decomposition Temperature: >200 deg C
Solubility in water: Slightly soluble.
Specific Gravity/Density: 1.0000 g/cm3
Molecular Formula: C7H9N
Molecular Weight: 107.15

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air.
Conditions to Avoid:
Light, exposure to air, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases, nitric acid.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 95-53-4: XU2975000 LD50/LC50:
Not available.
Carcinogenicity:
o-Toluidine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Bacteria: Phytobacterium phosphoreum: EC50 = 13.2 mg/L; 30 min; Microtox testIf released on land, o-toluidine will be lost by a combination of biodegradation, oxidation, and chemical binding to soil components. If released into water, it will also be primarily lost by biodegradation, oxidation and photooxidation. There will also be some adsorption to sediment. Bioconcentration in fish should not be an important fate process. In the atmosphere, o-toluidine will photodegrade (estimated half-life 2.4 hr).

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: TOLUIDINES
Hazard Class: 6.1
UN Number: 1708
Packing Group: II
IMO
Shipping Name: TOLUIDINES
Hazard Class: 6.1
UN Number: 1708
Packing Group: II
RID/ADR
Shipping Name: TOLUIDINES
Hazard Class: 6.1
UN Number: 1708
Packing group: II

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 23/25 Toxic by inhalation and if swallowed.
R 36 Irritating to eyes.
R 45 May cause cancer.
R 50 Very toxic to aquatic organisms.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/Safety data sheets.
WGK (Water Danger/Protection)
CAS# 95-53-4: 3
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 95-53-4 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 95-53-4: OEL-AUSTRALIA:TWA 2 ppm (9 mg/m3);Skin;Carcinogen
OEL-BELGIUM:TWA 2 ppm (8.8 mg/m3);Skin;Carcinogen
OEL-CZECHOSLOVAKIA:TWA 5 mg/m3;STEL 20 mg/m3 JAN9
OEL-DENMARK:TWA 2 ppm (9 mg/m3);Skin;Carcinogen
OEL-FINLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin;CAR
OEL-FRANCE:TWA 2 ppm (9 mg/m3);Carcinogen
OEL-FRANCE;CAR (salts)
OEL-GERMANY;Skin;Carcinogen
OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3);Skin
OEL-POLAND:TWA 3 mg/m3
OEL-RUSSIA:TWA 0.5 mg/m3;STEL 1 mg/m3;Skin;Carcinogen
OEL-SWEDEN;Carcinogen
OEL-SWITZERLAND:TWA 2 ppm (9 mg/m3);Skin;Carcinogen
OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin
OEL-UNITED KINGDOM:TWA 2 ppm (9 mg/m3);STEL 5 ppm (22 mg/m3)
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 95-53-4 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A
Spectrum
NMR Spectrum 1H NMR : 400 MHz in CDCl3
expand collapse
IR Spectrum IR : CCl4 solution
expand collapse
Mass Spectrum Mass
expand collapse
Analysis Methods
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1796.
Temperature Control
179.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1807.
Temperature Control
180.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1808.
Temperature Control
200.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Kovats' RI, polar column, isothermal
expand collapse
Column Shape
Packed
Active Phase(℃)
PEG-2000
Retention index
1814.
Temperature Control
200.
Method
isothermal
Comments
He, Celite 545 (44-60 mesh); Column length: 3. m
Reference
Anderson, A.Jurel, S.Shymanska, M.Golender, L.Gas-liquid chromatography of some aliphatic and heterocyclic mono- and pollyfunctional amines. VII. Retention indices of amines in some polar and unpolar stationary phasesLatv. PSR Zinat. Akad. Vestis Kim. Ser.1973, 1, 51-63.
Van Den Dool and Kratz RI, non-polar column, temperature ramp
expand collapse
Column Shape
Capillary
Active Phase(℃)
DB-1
Retention index
1032.7
Temperature Control
Method
temperature ramp
Comments
30. m/0.25 mm/0.25 μm, He, 3. K/min; T<sub>start</sub>: 40. C; T<sub>end</sub>: 325. C
Reference
Sun, G.Stremple, P.Retention index characterization of flavor, fragrance, and many other compounds on DB-1 and DB-XLB2003, retrieved from http://www.chem.agilent.com/cag/cabu/pdf/b-0279.pdf.

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